ID   TUSC2_MOUSE             Reviewed;         110 AA.
AC   Q9WVF8;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   27-MAR-2024, entry version 130.
DE   RecName: Full=Tumor suppressor candidate 2;
DE   AltName: Full=Fusion 1 protein;
DE            Short=Fus-1 protein;
DE   AltName: Full=PDGFA-associated protein 2;
GN   Name=Tusc2; Synonyms=Fus1, Lgcc, Pdap2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RA   Duh F.-M., Minna J.D., Lerman M.I.;
RT   "Mouse ortholog of the human Fus1 gene.";
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas,
RC   Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- PTM: Myristoylation is required for tumor suppressor activity.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TUSC2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF123387; AAD42286.1; -; mRNA.
DR   EMBL; BC048477; AAH48477.1; -; mRNA.
DR   CCDS; CCDS23495.1; -.
DR   RefSeq; NP_062716.1; NM_019742.4.
DR   AlphaFoldDB; Q9WVF8; -.
DR   STRING; 10090.ENSMUSP00000010198; -.
DR   iPTMnet; Q9WVF8; -.
DR   PhosphoSitePlus; Q9WVF8; -.
DR   MaxQB; Q9WVF8; -.
DR   PaxDb; 10090-ENSMUSP00000010198; -.
DR   ProteomicsDB; 298030; -.
DR   Antibodypedia; 30895; 232 antibodies from 30 providers.
DR   DNASU; 80385; -.
DR   Ensembl; ENSMUST00000010198.5; ENSMUSP00000010198.4; ENSMUSG00000010054.5.
DR   GeneID; 80385; -.
DR   KEGG; mmu:80385; -.
DR   UCSC; uc009rls.1; mouse.
DR   AGR; MGI:1931086; -.
DR   CTD; 11334; -.
DR   MGI; MGI:1931086; Tusc2.
DR   VEuPathDB; HostDB:ENSMUSG00000010054; -.
DR   eggNOG; ENOG502S21H; Eukaryota.
DR   GeneTree; ENSGT00390000008040; -.
DR   HOGENOM; CLU_152285_0_0_1; -.
DR   InParanoid; Q9WVF8; -.
DR   OMA; FYEETHY; -.
DR   OrthoDB; 5404777at2759; -.
DR   PhylomeDB; Q9WVF8; -.
DR   TreeFam; TF314634; -.
DR   BioGRID-ORCS; 80385; 4 hits in 77 CRISPR screens.
DR   ChiTaRS; Tusc2; mouse.
DR   PRO; PR:Q9WVF8; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q9WVF8; Protein.
DR   Bgee; ENSMUSG00000010054; Expressed in right kidney and 233 other cell types or tissues.
DR   ExpressionAtlas; Q9WVF8; baseline and differential.
DR   GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR   GO; GO:0048469; P:cell maturation; IMP:MGI.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:MGI.
DR   GO; GO:0006954; P:inflammatory response; IMP:MGI.
DR   GO; GO:0001779; P:natural killer cell differentiation; IMP:MGI.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IMP:MGI.
DR   GO; GO:0070945; P:neutrophil-mediated killing of gram-negative bacterium; IMP:MGI.
DR   GO; GO:0006909; P:phagocytosis; IMP:MGI.
DR   GO; GO:0032733; P:positive regulation of interleukin-10 production; IMP:MGI.
DR   GO; GO:0051881; P:regulation of mitochondrial membrane potential; IMP:MGI.
DR   GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:MGI.
DR   InterPro; IPR029393; FUS1.
DR   PANTHER; PTHR15453; TUMOR SUPPRESSOR CANDIDATE 2; 1.
DR   PANTHER; PTHR15453:SF8; TUMOR SUPPRESSOR CANDIDATE 2; 1.
DR   Pfam; PF15000; TUSC2; 1.
DR   Genevisible; Q9WVF8; MM.
PE   1: Evidence at protein level;
KW   Lipoprotein; Myristate; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O75896"
FT   CHAIN           2..110
FT                   /note="Tumor suppressor candidate 2"
FT                   /id="PRO_0000148171"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         50
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:17242355,
FT                   ECO:0007744|PubMed:21183079"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   110 AA;  12136 MW;  310698A5CB12DC40 CRC64;
     MGASGSKARG LWPFASTPGG GGPEAAGSEQ SLVRSRARAV PPFVFTRRGS MFYDEDGDLA
     HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDPPRIH VDFPVILYEV
//