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Protein

Tumor suppressor candidate 2

Gene

Tusc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cell maturation Source: MGI
  2. chemokine (C-C motif) ligand 5 production Source: MGI
  3. defense response to Gram-negative bacterium Source: MGI
  4. inflammatory response Source: MGI
  5. interleukin-15 production Source: MGI
  6. natural killer cell differentiation Source: MGI
  7. negative regulation of interleukin-17 production Source: MGI
  8. neutrophil mediated killing of gram-negative bacterium Source: MGI
  9. phagocytosis Source: MGI
  10. positive regulation of interleukin-10 production Source: MGI
  11. regulation of mitochondrial membrane potential Source: MGI
  12. regulation of reactive oxygen species metabolic process Source: MGI
  13. response to defense-related host reactive oxygen species production Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate 2
Alternative name(s):
Fusion 1 protein
Short name:
Fus-1 protein
PDGFA-associated protein 2
Gene namesi
Name:Tusc2
Synonyms:Fus1, Lgcc, Pdap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1931086. Tusc2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 110109Tumor suppressor candidate 2PRO_0000148171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei50 – 501Phosphoserine1 Publication

Post-translational modificationi

Myristoylation is required for tumor suppressor activity.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ9WVF8.
PaxDbiQ9WVF8.
PRIDEiQ9WVF8.

PTM databases

PhosphoSiteiQ9WVF8.

Expressioni

Gene expression databases

BgeeiQ9WVF8.
CleanExiMM_TUSC2.
ExpressionAtlasiQ9WVF8. baseline and differential.
GenevestigatoriQ9WVF8.

Structurei

3D structure databases

ProteinModelPortaliQ9WVF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TUSC2 family.Curated

Phylogenomic databases

eggNOGiNOG71519.
GeneTreeiENSGT00390000008040.
HOGENOMiHOG000007342.
HOVERGENiHBG054202.
InParanoidiQ9WVF8.
OMAiTRRGSMY.
OrthoDBiEOG7TBC4J.
PhylomeDBiQ9WVF8.
TreeFamiTF314634.

Family and domain databases

InterProiIPR029393. FUS1.
[Graphical view]
PANTHERiPTHR15453. PTHR15453. 1 hit.
PfamiPF15000. TUSC2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVF8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGASGSKARG LWPFASTPGG GGPEAAGSEQ SLVRSRARAV PPFVFTRRGS
60 70 80 90 100
MFYDEDGDLA HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDPPRIH
110
VDFPVILYEV
Length:110
Mass (Da):12,136
Last modified:January 23, 2007 - v3
Checksum:i310698A5CB12DC40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123387 mRNA. Translation: AAD42286.1.
BC048477 mRNA. Translation: AAH48477.1.
CCDSiCCDS23495.1.
RefSeqiNP_062716.1. NM_019742.4.
UniGeneiMm.21739.

Genome annotation databases

EnsembliENSMUST00000010198; ENSMUSP00000010198; ENSMUSG00000010054.
GeneIDi80385.
KEGGimmu:80385.
UCSCiuc009rls.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123387 mRNA. Translation: AAD42286.1.
BC048477 mRNA. Translation: AAH48477.1.
CCDSiCCDS23495.1.
RefSeqiNP_062716.1. NM_019742.4.
UniGeneiMm.21739.

3D structure databases

ProteinModelPortaliQ9WVF8.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9WVF8.

Proteomic databases

MaxQBiQ9WVF8.
PaxDbiQ9WVF8.
PRIDEiQ9WVF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010198; ENSMUSP00000010198; ENSMUSG00000010054.
GeneIDi80385.
KEGGimmu:80385.
UCSCiuc009rls.1. mouse.

Organism-specific databases

CTDi11334.
MGIiMGI:1931086. Tusc2.

Phylogenomic databases

eggNOGiNOG71519.
GeneTreeiENSGT00390000008040.
HOGENOMiHOG000007342.
HOVERGENiHBG054202.
InParanoidiQ9WVF8.
OMAiTRRGSMY.
OrthoDBiEOG7TBC4J.
PhylomeDBiQ9WVF8.
TreeFamiTF314634.

Miscellaneous databases

NextBioi350029.
PROiQ9WVF8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WVF8.
CleanExiMM_TUSC2.
ExpressionAtlasiQ9WVF8. baseline and differential.
GenevestigatoriQ9WVF8.

Family and domain databases

InterProiIPR029393. FUS1.
[Graphical view]
PANTHERiPTHR15453. PTHR15453. 1 hit.
PfamiPF15000. TUSC2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse ortholog of the human Fus1 gene."
    Duh F.-M., Minna J.D., Lerman M.I.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTUSC2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.