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Protein

Tumor suppressor candidate 2

Gene

Tusc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell maturation Source: MGI
  • chemokine (C-C motif) ligand 5 production Source: MGI
  • defense response to Gram-negative bacterium Source: MGI
  • inflammatory response Source: MGI
  • interleukin-15 production Source: MGI
  • natural killer cell differentiation Source: MGI
  • negative regulation of interleukin-17 production Source: MGI
  • neutrophil mediated killing of gram-negative bacterium Source: MGI
  • phagocytosis Source: MGI
  • positive regulation of interleukin-10 production Source: MGI
  • regulation of mitochondrial membrane potential Source: MGI
  • regulation of reactive oxygen species metabolic process Source: MGI
  • response to defense-related host reactive oxygen species production Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate 2
Alternative name(s):
Fusion 1 protein
Short name:
Fus-1 protein
PDGFA-associated protein 2
Gene namesi
Name:Tusc2
Synonyms:Fus1, Lgcc, Pdap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1931086. Tusc2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001481712 – 110Tumor suppressor candidate 2Add BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei50PhosphoserineCombined sources1

Post-translational modificationi

Myristoylation is required for tumor suppressor activity.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ9WVF8.
PaxDbiQ9WVF8.
PRIDEiQ9WVF8.

PTM databases

iPTMnetiQ9WVF8.
PhosphoSitePlusiQ9WVF8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000010054.
CleanExiMM_TUSC2.
ExpressionAtlasiQ9WVF8. baseline and differential.
GenevisibleiQ9WVF8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000010198.

Structurei

3D structure databases

ProteinModelPortaliQ9WVF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TUSC2 family.Curated

Phylogenomic databases

eggNOGiENOG410IYM4. Eukaryota.
ENOG4111PVZ. LUCA.
GeneTreeiENSGT00390000008040.
HOGENOMiHOG000007342.
HOVERGENiHBG054202.
InParanoidiQ9WVF8.
OMAiTRRGSMY.
OrthoDBiEOG09040MTR.
PhylomeDBiQ9WVF8.
TreeFamiTF314634.

Family and domain databases

InterProiView protein in InterPro
IPR029393. FUS1.
PANTHERiPTHR15453. PTHR15453. 1 hit.
PfamiView protein in Pfam
PF15000. TUSC2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGASGSKARG LWPFASTPGG GGPEAAGSEQ SLVRSRARAV PPFVFTRRGS
60 70 80 90 100
MFYDEDGDLA HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDPPRIH
110
VDFPVILYEV
Length:110
Mass (Da):12,136
Last modified:January 23, 2007 - v3
Checksum:i310698A5CB12DC40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123387 mRNA. Translation: AAD42286.1.
BC048477 mRNA. Translation: AAH48477.1.
CCDSiCCDS23495.1.
RefSeqiNP_062716.1. NM_019742.4.
UniGeneiMm.21739.

Genome annotation databases

EnsembliENSMUST00000010198; ENSMUSP00000010198; ENSMUSG00000010054.
GeneIDi80385.
KEGGimmu:80385.
UCSCiuc009rls.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123387 mRNA. Translation: AAD42286.1.
BC048477 mRNA. Translation: AAH48477.1.
CCDSiCCDS23495.1.
RefSeqiNP_062716.1. NM_019742.4.
UniGeneiMm.21739.

3D structure databases

ProteinModelPortaliQ9WVF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000010198.

PTM databases

iPTMnetiQ9WVF8.
PhosphoSitePlusiQ9WVF8.

Proteomic databases

MaxQBiQ9WVF8.
PaxDbiQ9WVF8.
PRIDEiQ9WVF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010198; ENSMUSP00000010198; ENSMUSG00000010054.
GeneIDi80385.
KEGGimmu:80385.
UCSCiuc009rls.1. mouse.

Organism-specific databases

CTDi11334.
MGIiMGI:1931086. Tusc2.

Phylogenomic databases

eggNOGiENOG410IYM4. Eukaryota.
ENOG4111PVZ. LUCA.
GeneTreeiENSGT00390000008040.
HOGENOMiHOG000007342.
HOVERGENiHBG054202.
InParanoidiQ9WVF8.
OMAiTRRGSMY.
OrthoDBiEOG09040MTR.
PhylomeDBiQ9WVF8.
TreeFamiTF314634.

Miscellaneous databases

PROiQ9WVF8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010054.
CleanExiMM_TUSC2.
ExpressionAtlasiQ9WVF8. baseline and differential.
GenevisibleiQ9WVF8. MM.

Family and domain databases

InterProiView protein in InterPro
IPR029393. FUS1.
PANTHERiPTHR15453. PTHR15453. 1 hit.
PfamiView protein in Pfam
PF15000. TUSC2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTUSC2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: February 15, 2017
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.