Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9WVF8 (TUSC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor suppressor candidate 2
Alternative name(s):
Fusion 1 protein
Short name=Fus-1 protein
PDGFA-associated protein 2
Gene names
Name:Tusc2
Synonyms:Fus1, Lgcc, Pdap2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length110 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Post-translational modification

Myristoylation is required for tumor suppressor activity By similarity.

Sequence similarities

Belongs to the TUSC2 family.

Ontologies

Keywords
   PTMLipoprotein
Myristate
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell maturation

Inferred from mutant phenotype PubMed 17318811. Source: MGI

chemokine (C-C motif) ligand 5 production

Inferred from mutant phenotype PubMed 22513871. Source: MGI

defense response to Gram-negative bacterium

Inferred from mutant phenotype PubMed 24042119. Source: MGI

inflammatory response

Inferred from mutant phenotype PubMed 22513871. Source: MGI

interleukin-15 production

Inferred from mutant phenotype PubMed 17318811. Source: MGI

natural killer cell differentiation

Inferred from mutant phenotype PubMed 17318811. Source: MGI

negative regulation of interleukin-17 production

Inferred from mutant phenotype PubMed 24042119. Source: MGI

neutrophil mediated killing of gram-negative bacterium

Inferred from mutant phenotype PubMed 24042119. Source: MGI

phagocytosis

Inferred from mutant phenotype PubMed 24042119. Source: MGI

positive regulation of interleukin-10 production

Inferred from mutant phenotype PubMed 24042119. Source: MGI

regulation of mitochondrial membrane potential

Inferred from mutant phenotype PubMed 22513871PubMed 24042119. Source: MGI

regulation of reactive oxygen species metabolic process

Inferred from mutant phenotype PubMed 22513871. Source: MGI

response to defense-related host reactive oxygen species production

Inferred from mutant phenotype PubMed 24042119. Source: MGI

   Cellular_componentmitochondrion

Inferred from direct assay PubMed 17318811. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 110109Tumor suppressor candidate 2
PRO_0000148171

Amino acid modifications

Modified residue501Phosphoserine Ref.3
Lipidation21N-myristoyl glycine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WVF8 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 310698A5CB12DC40

FASTA11012,136
        10         20         30         40         50         60 
MGASGSKARG LWPFASTPGG GGPEAAGSEQ SLVRSRARAV PPFVFTRRGS MFYDEDGDLA 

        70         80         90        100        110 
HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDPPRIH VDFPVILYEV 

« Hide

References

« Hide 'large scale' references
[1]"Mouse ortholog of the human Fus1 gene."
Duh F.-M., Minna J.D., Lerman M.I.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF123387 mRNA. Translation: AAD42286.1.
BC048477 mRNA. Translation: AAH48477.1.
CCDSCCDS23495.1.
RefSeqNP_062716.1. NM_019742.4.
UniGeneMm.21739.

3D structure databases

ProteinModelPortalQ9WVF8.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9WVF8.

Proteomic databases

PaxDbQ9WVF8.
PRIDEQ9WVF8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000010198; ENSMUSP00000010198; ENSMUSG00000010054.
GeneID80385.
KEGGmmu:80385.
UCSCuc009rls.1. mouse.

Organism-specific databases

CTD11334.
MGIMGI:1931086. Tusc2.

Phylogenomic databases

eggNOGNOG71519.
GeneTreeENSGT00390000008040.
HOGENOMHOG000007342.
HOVERGENHBG054202.
InParanoidQ9WVF8.
OMAWEAREML.
OrthoDBEOG7TBC4J.
PhylomeDBQ9WVF8.
TreeFamTF314634.

Gene expression databases

BgeeQ9WVF8.
CleanExMM_TUSC2.
GenevestigatorQ9WVF8.

Family and domain databases

InterProIPR029393. FUS1.
[Graphical view]
PANTHERPTHR15453. PTHR15453. 1 hit.
PfamPF15000. TUSC2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio350029.
PROQ9WVF8.
SOURCESearch...

Entry information

Entry nameTUSC2_MOUSE
AccessionPrimary (citable) accession number: Q9WVF8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot