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Q9WVF8

- TUSC2_MOUSE

UniProt

Q9WVF8 - TUSC2_MOUSE

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Protein

Tumor suppressor candidate 2

Gene
Tusc2, Fus1, Lgcc, Pdap2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cell maturation Source: MGI
  2. chemokine (C-C motif) ligand 5 production Source: MGI
  3. defense response to Gram-negative bacterium Source: MGI
  4. inflammatory response Source: MGI
  5. interleukin-15 production Source: MGI
  6. natural killer cell differentiation Source: MGI
  7. negative regulation of interleukin-17 production Source: MGI
  8. neutrophil mediated killing of gram-negative bacterium Source: MGI
  9. phagocytosis Source: MGI
  10. positive regulation of interleukin-10 production Source: MGI
  11. regulation of mitochondrial membrane potential Source: MGI
  12. regulation of reactive oxygen species metabolic process Source: MGI
  13. response to defense-related host reactive oxygen species production Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate 2
Alternative name(s):
Fusion 1 protein
Short name:
Fus-1 protein
PDGFA-associated protein 2
Gene namesi
Name:Tusc2
Synonyms:Fus1, Lgcc, Pdap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1931086. Tusc2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 110109Tumor suppressor candidate 2PRO_0000148171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity
Modified residuei50 – 501Phosphoserine1 Publication

Post-translational modificationi

Myristoylation is required for tumor suppressor activity By similarity.

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ9WVF8.
PRIDEiQ9WVF8.

PTM databases

PhosphoSiteiQ9WVF8.

Expressioni

Gene expression databases

BgeeiQ9WVF8.
CleanExiMM_TUSC2.
GenevestigatoriQ9WVF8.

Structurei

3D structure databases

ProteinModelPortaliQ9WVF8.

Family & Domainsi

Sequence similaritiesi

Belongs to the TUSC2 family.

Phylogenomic databases

eggNOGiNOG71519.
GeneTreeiENSGT00390000008040.
HOGENOMiHOG000007342.
HOVERGENiHBG054202.
InParanoidiQ9WVF8.
OMAiWEAREML.
OrthoDBiEOG7TBC4J.
PhylomeDBiQ9WVF8.
TreeFamiTF314634.

Family and domain databases

InterProiIPR029393. FUS1.
[Graphical view]
PANTHERiPTHR15453. PTHR15453. 1 hit.
PfamiPF15000. TUSC2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVF8-1 [UniParc]FASTAAdd to Basket

« Hide

MGASGSKARG LWPFASTPGG GGPEAAGSEQ SLVRSRARAV PPFVFTRRGS    50
MFYDEDGDLA HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDPPRIH 100
VDFPVILYEV 110
Length:110
Mass (Da):12,136
Last modified:January 23, 2007 - v3
Checksum:i310698A5CB12DC40
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF123387 mRNA. Translation: AAD42286.1.
BC048477 mRNA. Translation: AAH48477.1.
CCDSiCCDS23495.1.
RefSeqiNP_062716.1. NM_019742.4.
UniGeneiMm.21739.

Genome annotation databases

EnsembliENSMUST00000010198; ENSMUSP00000010198; ENSMUSG00000010054.
GeneIDi80385.
KEGGimmu:80385.
UCSCiuc009rls.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF123387 mRNA. Translation: AAD42286.1 .
BC048477 mRNA. Translation: AAH48477.1 .
CCDSi CCDS23495.1.
RefSeqi NP_062716.1. NM_019742.4.
UniGenei Mm.21739.

3D structure databases

ProteinModelPortali Q9WVF8.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9WVF8.

Proteomic databases

PaxDbi Q9WVF8.
PRIDEi Q9WVF8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000010198 ; ENSMUSP00000010198 ; ENSMUSG00000010054 .
GeneIDi 80385.
KEGGi mmu:80385.
UCSCi uc009rls.1. mouse.

Organism-specific databases

CTDi 11334.
MGIi MGI:1931086. Tusc2.

Phylogenomic databases

eggNOGi NOG71519.
GeneTreei ENSGT00390000008040.
HOGENOMi HOG000007342.
HOVERGENi HBG054202.
InParanoidi Q9WVF8.
OMAi WEAREML.
OrthoDBi EOG7TBC4J.
PhylomeDBi Q9WVF8.
TreeFami TF314634.

Miscellaneous databases

NextBioi 350029.
PROi Q9WVF8.
SOURCEi Search...

Gene expression databases

Bgeei Q9WVF8.
CleanExi MM_TUSC2.
Genevestigatori Q9WVF8.

Family and domain databases

InterProi IPR029393. FUS1.
[Graphical view ]
PANTHERi PTHR15453. PTHR15453. 1 hit.
Pfami PF15000. TUSC2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse ortholog of the human Fus1 gene."
    Duh F.-M., Minna J.D., Lerman M.I.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTUSC2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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