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Q9WVF8

- TUSC2_MOUSE

UniProt

Q9WVF8 - TUSC2_MOUSE

Protein

Tumor suppressor candidate 2

Gene

Tusc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Biological processi

    1. cell maturation Source: MGI
    2. chemokine (C-C motif) ligand 5 production Source: MGI
    3. defense response to Gram-negative bacterium Source: MGI
    4. inflammatory response Source: MGI
    5. interleukin-15 production Source: MGI
    6. natural killer cell differentiation Source: MGI
    7. negative regulation of interleukin-17 production Source: MGI
    8. neutrophil mediated killing of gram-negative bacterium Source: MGI
    9. phagocytosis Source: MGI
    10. positive regulation of interleukin-10 production Source: MGI
    11. regulation of mitochondrial membrane potential Source: MGI
    12. regulation of reactive oxygen species metabolic process Source: MGI
    13. response to defense-related host reactive oxygen species production Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor suppressor candidate 2
    Alternative name(s):
    Fusion 1 protein
    Short name:
    Fus-1 protein
    PDGFA-associated protein 2
    Gene namesi
    Name:Tusc2
    Synonyms:Fus1, Lgcc, Pdap2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1931086. Tusc2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 110109Tumor suppressor candidate 2PRO_0000148171Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Modified residuei50 – 501Phosphoserine1 Publication

    Post-translational modificationi

    Myristoylation is required for tumor suppressor activity.By similarity

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein

    Proteomic databases

    PaxDbiQ9WVF8.
    PRIDEiQ9WVF8.

    PTM databases

    PhosphoSiteiQ9WVF8.

    Expressioni

    Gene expression databases

    BgeeiQ9WVF8.
    CleanExiMM_TUSC2.
    GenevestigatoriQ9WVF8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVF8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TUSC2 family.Curated

    Phylogenomic databases

    eggNOGiNOG71519.
    GeneTreeiENSGT00390000008040.
    HOGENOMiHOG000007342.
    HOVERGENiHBG054202.
    InParanoidiQ9WVF8.
    OMAiWEAREML.
    OrthoDBiEOG7TBC4J.
    PhylomeDBiQ9WVF8.
    TreeFamiTF314634.

    Family and domain databases

    InterProiIPR029393. FUS1.
    [Graphical view]
    PANTHERiPTHR15453. PTHR15453. 1 hit.
    PfamiPF15000. TUSC2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WVF8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGASGSKARG LWPFASTPGG GGPEAAGSEQ SLVRSRARAV PPFVFTRRGS    50
    MFYDEDGDLA HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDPPRIH 100
    VDFPVILYEV 110
    Length:110
    Mass (Da):12,136
    Last modified:January 23, 2007 - v3
    Checksum:i310698A5CB12DC40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF123387 mRNA. Translation: AAD42286.1.
    BC048477 mRNA. Translation: AAH48477.1.
    CCDSiCCDS23495.1.
    RefSeqiNP_062716.1. NM_019742.4.
    UniGeneiMm.21739.

    Genome annotation databases

    EnsembliENSMUST00000010198; ENSMUSP00000010198; ENSMUSG00000010054.
    GeneIDi80385.
    KEGGimmu:80385.
    UCSCiuc009rls.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF123387 mRNA. Translation: AAD42286.1 .
    BC048477 mRNA. Translation: AAH48477.1 .
    CCDSi CCDS23495.1.
    RefSeqi NP_062716.1. NM_019742.4.
    UniGenei Mm.21739.

    3D structure databases

    ProteinModelPortali Q9WVF8.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9WVF8.

    Proteomic databases

    PaxDbi Q9WVF8.
    PRIDEi Q9WVF8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000010198 ; ENSMUSP00000010198 ; ENSMUSG00000010054 .
    GeneIDi 80385.
    KEGGi mmu:80385.
    UCSCi uc009rls.1. mouse.

    Organism-specific databases

    CTDi 11334.
    MGIi MGI:1931086. Tusc2.

    Phylogenomic databases

    eggNOGi NOG71519.
    GeneTreei ENSGT00390000008040.
    HOGENOMi HOG000007342.
    HOVERGENi HBG054202.
    InParanoidi Q9WVF8.
    OMAi WEAREML.
    OrthoDBi EOG7TBC4J.
    PhylomeDBi Q9WVF8.
    TreeFami TF314634.

    Miscellaneous databases

    NextBioi 350029.
    PROi Q9WVF8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WVF8.
    CleanExi MM_TUSC2.
    Genevestigatori Q9WVF8.

    Family and domain databases

    InterProi IPR029393. FUS1.
    [Graphical view ]
    PANTHERi PTHR15453. PTHR15453. 1 hit.
    Pfami PF15000. TUSC2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse ortholog of the human Fus1 gene."
      Duh F.-M., Minna J.D., Lerman M.I.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiTUSC2_MOUSE
    AccessioniPrimary (citable) accession number: Q9WVF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 85 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3