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Protein
Submitted name:

Epidermal growth factor receptor

Gene

Egfr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Epidermal growth factor receptorImported
Submitted name:
Epidermal growth factor receptor isoform 3Imported
Submitted name:
Epidermal growth factor receptor, isoform CRA_aImported
Gene namesi
Name:EgfrImported
ORF Names:mCG_140518Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95294 Egfr

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_501431336927 – 655Sequence analysisAdd BLAST629

Expressioni

Gene expression databases

BgeeiENSMUSG00000020122

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 167Recep_L_domainInterPro annotationAdd BLAST111
Domaini184 – 338Furin-likeInterPro annotationAdd BLAST155
Domaini362 – 480Recep_L_domainInterPro annotationAdd BLAST119
Domaini505 – 636GF_recep_IVInterPro annotationAdd BLAST132

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1025 Eukaryota
ENOG410XNSR LUCA
GeneTreeiENSGT00760000118799
HOGENOMiHOG000046308
HOVERGENiHBG000490
KOiK04361

Family and domain databases

Gene3Di3.80.20.202 hits
InterProiView protein in InterPro
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
PfamiView protein in Pfam
PF00757 Furin-like, 1 hit
PF14843 GF_recep_IV, 1 hit
PF01030 Recep_L_domain, 2 hits
SMARTiView protein in SMART
SM00261 FU, 4 hits
SUPFAMiSSF57184 SSF57184, 2 hits

Sequencei

Sequence statusi: Complete.

Q9WVF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPSGTARTT LLVLLTALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS
60 70 80 90 100
LQRMYNNCEV VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP
110 120 130 140 150
LENLQIIRGN ALYENTYALA ILSNYGTNRT GLRELPMRNL QEILIGAVRF
160 170 180 190 200
SNNPILCNMD TIQWRDIVQN VFMSNMSMDL QSHPSSCPKC DPSCPNGSCW
210 220 230 240 250
GGGEENCQKL TKIICAQQCS HRCRGRSPSD CCHNQCAAGC TGPRESDCLV
260 270 280 290 300
CQKFQDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
310 320 330 340 350
VTDHGSCVRA CGPDYYEVEE DGIRKCKKCD GPCRKVCNGI GIGEFKDTLS
360 370 380 390 400
INATNIKHFK YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE
410 420 430 440 450
ITGFLLIQAW PDNWTDLHAF ENLEIIRGRT KQHGQFSLAV VGLNITSLGL
460 470 480 490 500
RSLKEISDGD VIISGNRNLC YANTINWKKL FGTPNQKTKI MNNRAEKDCK
510 520 530 540 550
AVNHVCNPLC SSEGCWGPEP RDCVSCQNVS RGRECVEKCN ILEGEPREFV
560 570 580 590 600
ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGIM
610 620 630 640 650
GENNTLVWKY ADANNVCHLC HANCTYGCAG PGLQGCEVWP SGYVQWQWIL

KTFWI
Length:655
Mass (Da):72,906
Last modified:November 1, 1999 - v1
Checksum:i6B34063B1BC928CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645532 Genomic DNA No translation available.
BX255277 Genomic DNA No translation available.
AF124513 mRNA Translation: AAD44149.1
AH009944, AF275365 Genomic DNA Translation: AAG28047.1
BC023729 mRNA Translation: AAH23729.1
AK004883 mRNA Translation: BAB23641.1
AK004911 mRNA Translation: BAB23662.1
AK004944 mRNA Translation: BAB23688.1
CH466574 Genomic DNA Translation: EDL40666.1
RefSeqiNP_031938.1, NM_007912.4
NP_997538.1, NM_207655.2
UniGeneiMm.420648
Mm.439882
Mm.8534

Genome annotation databases

EnsembliENSMUST00000102884; ENSMUSP00000099948; ENSMUSG00000020122
GeneIDi13649
KEGGimmu:13649
UCSCiuc007ibn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ9WVF5_MOUSE
AccessioniPrimary (citable) accession number: Q9WVF5
Secondary accession number(s): Q5SVE9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported