Egfr

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro
transmembrane receptor protein tyrosine kinase activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	ReceptorImported

Molecular function

ReceptorImported

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Epidermal growth factor receptorImported Submitted name: Epidermal growth factor receptor isoform 3Imported Submitted name: Epidermal growth factor receptor, isoform CRA_aImported Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:EgfrImported ORF Names:mCG_140518Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:95294. Egfr.

Subcellular locationⁱ

GO - Cellular componentⁱ

membrane Source: InterPro

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_5010686518	27 – 655	Sequence analysisAdd BLAST		629

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020122.

Bgeeⁱ

ENSMUSG00000020122.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	57 – 167	Recep_L_domainInterPro annotationAdd BLAST	111
Domainⁱ	184 – 338	Furin-likeInterPro annotationAdd BLAST	155
Domainⁱ	362 – 480	Recep_L_domainInterPro annotationAdd BLAST	119
Domainⁱ	505 – 636	GF_recep_IVInterPro annotationAdd BLAST	132

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1025. Eukaryota. ENOG410XNSR. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118799.
HOGENOMⁱ	HOG000046308.
HOVERGENⁱ	HBG000490.
KEGG Orthology (KO) More...KOⁱ	K04361.

Family and domain databases

Gene3Dⁱ	3.80.20.20. 3 hits.
InterProⁱ	View protein in InterPro IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR032778. GF_recep_IV. IPR009030. Growth_fac_rcpt_. IPR032675. L_dom-like. IPR000494. Rcpt_L-dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00757. Furin-like. 1 hit. PF14843. GF_recep_IV. 1 hit. PF01030. Recep_L_domain. 2 hits.
SMARTⁱ	View protein in SMART SM00261. FU. 4 hits.
SUPFAMⁱ	SSF52058. SSF52058. 2 hits. SSF57184. SSF57184. 2 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9WVF5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRPSGTARTT LLVLLTALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS 
        60         70         80         90        100
LQRMYNNCEV VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP 
       110        120        130        140        150
LENLQIIRGN ALYENTYALA ILSNYGTNRT GLRELPMRNL QEILIGAVRF 
       160        170        180        190        200
SNNPILCNMD TIQWRDIVQN VFMSNMSMDL QSHPSSCPKC DPSCPNGSCW 
       210        220        230        240        250
GGGEENCQKL TKIICAQQCS HRCRGRSPSD CCHNQCAAGC TGPRESDCLV 
       260        270        280        290        300
CQKFQDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 
       310        320        330        340        350
VTDHGSCVRA CGPDYYEVEE DGIRKCKKCD GPCRKVCNGI GIGEFKDTLS 
       360        370        380        390        400
INATNIKHFK YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE 
       410        420        430        440        450
ITGFLLIQAW PDNWTDLHAF ENLEIIRGRT KQHGQFSLAV VGLNITSLGL 
       460        470        480        490        500
RSLKEISDGD VIISGNRNLC YANTINWKKL FGTPNQKTKI MNNRAEKDCK 
       510        520        530        540        550
AVNHVCNPLC SSEGCWGPEP RDCVSCQNVS RGRECVEKCN ILEGEPREFV 
       560        570        580        590        600
ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGIM 
       610        620        630        640        650
GENNTLVWKY ADANNVCHLC HANCTYGCAG PGLQGCEVWP SGYVQWQWIL 

KTFWI

Length:655

Mass (Da):72,906

Last modified:November 1, 1999 - v1

Checksum:ⁱ6B34063B1BC928CB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL645532 Genomic DNA. No translation available. BX255277 Genomic DNA. No translation available. AF124513 mRNA. Translation: AAD44149.1. AH009944, AF275365 Genomic DNA. Translation: AAG28047.1. BC023729 mRNA. Translation: AAH23729.1. AK004883 mRNA. Translation: BAB23641.1. AK004911 mRNA. Translation: BAB23662.1. AK004944 mRNA. Translation: BAB23688.1. CH466574 Genomic DNA. Translation: EDL40666.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_031938.1. NM_007912.4. NP_997538.1. NM_207655.2.
UniGeneⁱ	Mm.420648. Mm.439882. Mm.8534.

Genome annotation databases

Ensemblⁱ	ENSMUST00000102884; ENSMUSP00000099948; ENSMUSG00000020122.
GeneIDⁱ	13649.
KEGGⁱ	mmu:13649.
UCSC genome browser More...UCSCⁱ	uc007ibn.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL645532 Genomic DNA. No translation available. BX255277 Genomic DNA. No translation available. AF124513 mRNA. Translation: AAD44149.1. AH009944, AF275365 Genomic DNA. Translation: AAG28047.1. BC023729 mRNA. Translation: AAH23729.1. AK004883 mRNA. Translation: BAB23641.1. AK004911 mRNA. Translation: BAB23662.1. AK004944 mRNA. Translation: BAB23688.1. CH466574 Genomic DNA. Translation: EDL40666.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_031938.1. NM_007912.4. NP_997538.1. NM_207655.2.
UniGeneⁱ	Mm.420648. Mm.439882. Mm.8534.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000102884; ENSMUSP00000099948; ENSMUSG00000020122.
GeneIDⁱ	13649.
KEGGⁱ	mmu:13649.
UCSC genome browser More...UCSCⁱ	uc007ibn.1. mouse.

Organism-specific databases

CTDⁱ	1956.
MGIⁱ	MGI:95294. Egfr.

Phylogenomic databases

eggNOGⁱ	KOG1025. Eukaryota. ENOG410XNSR. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118799.
HOGENOMⁱ	HOG000046308.
HOVERGENⁱ	HBG000490.
KEGG Orthology (KO) More...KOⁱ	K04361.

Miscellaneous databases

ChiTaRSⁱ	Egfr. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020122.

Bgeeⁱ

ENSMUSG00000020122.

Family and domain databases

Gene3Dⁱ	3.80.20.20. 3 hits.
InterProⁱ	View protein in InterPro IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR032778. GF_recep_IV. IPR009030. Growth_fac_rcpt_. IPR032675. L_dom-like. IPR000494. Rcpt_L-dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00757. Furin-like. 1 hit. PF14843. GF_recep_IV. 1 hit. PF01030. Recep_L_domain. 2 hits.
SMARTⁱ	View protein in SMART SM00261. FU. 4 hits.
SUPFAMⁱ	SSF52058. SSF52058. 2 hits. SSF57184. SSF57184. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q9WVF5_MOUSE
Accessionⁱ	Q9WVF5Primary (citable) accession number: Q9WVF5 Secondary accession number(s): Q5SVE9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 1, 1999
	Last sequence update:	November 1, 1999
	Last modified:	July 5, 2017
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - Q9WVF5 (Q9WVF5_MOUSE)

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Epidermal growth factor receptor

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9WVF5 (Q9WVF5_MOUSE)

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Epidermal growth factor receptor

Egfr

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ