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Protein
Submitted name:

Epidermal growth factor receptor

Gene

Egfr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Epidermal growth factor receptorImported
Submitted name:
Epidermal growth factor receptor isoform 3Imported
Submitted name:
Epidermal growth factor receptor, isoform CRA_aImported
Gene namesi
Name:EgfrImported
ORF Names:mCG_140518Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95294. Egfr.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500878645827 – 655Sequence analysisAdd BLAST629

Expressioni

Gene expression databases

BgeeiENSMUSG00000020122.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020329.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 167Recep_L_domainInterPro annotationAdd BLAST111
Domaini184 – 338Furin-likeInterPro annotationAdd BLAST155
Domaini362 – 480Recep_L_domainInterPro annotationAdd BLAST119
Domaini505 – 636GF_recep_IVInterPro annotationAdd BLAST132

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.
GeneTreeiENSGT00760000118799.
HOGENOMiHOG000046308.
HOVERGENiHBG000490.
KOiK04361.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR032675. L_dom-like.
IPR000494. Rcpt_L-dom.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF14843. GF_recep_IV. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
SMARTiSM00261. FU. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF57184. SSF57184. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9WVF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPSGTARTT LLVLLTALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS
60 70 80 90 100
LQRMYNNCEV VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP
110 120 130 140 150
LENLQIIRGN ALYENTYALA ILSNYGTNRT GLRELPMRNL QEILIGAVRF
160 170 180 190 200
SNNPILCNMD TIQWRDIVQN VFMSNMSMDL QSHPSSCPKC DPSCPNGSCW
210 220 230 240 250
GGGEENCQKL TKIICAQQCS HRCRGRSPSD CCHNQCAAGC TGPRESDCLV
260 270 280 290 300
CQKFQDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
310 320 330 340 350
VTDHGSCVRA CGPDYYEVEE DGIRKCKKCD GPCRKVCNGI GIGEFKDTLS
360 370 380 390 400
INATNIKHFK YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE
410 420 430 440 450
ITGFLLIQAW PDNWTDLHAF ENLEIIRGRT KQHGQFSLAV VGLNITSLGL
460 470 480 490 500
RSLKEISDGD VIISGNRNLC YANTINWKKL FGTPNQKTKI MNNRAEKDCK
510 520 530 540 550
AVNHVCNPLC SSEGCWGPEP RDCVSCQNVS RGRECVEKCN ILEGEPREFV
560 570 580 590 600
ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGIM
610 620 630 640 650
GENNTLVWKY ADANNVCHLC HANCTYGCAG PGLQGCEVWP SGYVQWQWIL

KTFWI
Length:655
Mass (Da):72,906
Last modified:November 1, 1999 - v1
Checksum:i6B34063B1BC928CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645532 Genomic DNA. No translation available.
BX255277 Genomic DNA. No translation available.
AF124513 mRNA. Translation: AAD44149.1.
AH009944, AF275365 Genomic DNA. Translation: AAG28047.1.
BC023729 mRNA. Translation: AAH23729.1.
AK004883 mRNA. Translation: BAB23641.1.
AK004911 mRNA. Translation: BAB23662.1.
AK004944 mRNA. Translation: BAB23688.1.
CH466574 Genomic DNA. Translation: EDL40666.1.
RefSeqiNP_031938.1. NM_007912.4.
NP_997538.1. NM_207655.2.
UniGeneiMm.420648.
Mm.439882.
Mm.8534.

Genome annotation databases

EnsembliENSMUST00000102884; ENSMUSP00000099948; ENSMUSG00000020122.
GeneIDi13649.
KEGGimmu:13649.
UCSCiuc007ibn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645532 Genomic DNA. No translation available.
BX255277 Genomic DNA. No translation available.
AF124513 mRNA. Translation: AAD44149.1.
AH009944, AF275365 Genomic DNA. Translation: AAG28047.1.
BC023729 mRNA. Translation: AAH23729.1.
AK004883 mRNA. Translation: BAB23641.1.
AK004911 mRNA. Translation: BAB23662.1.
AK004944 mRNA. Translation: BAB23688.1.
CH466574 Genomic DNA. Translation: EDL40666.1.
RefSeqiNP_031938.1. NM_007912.4.
NP_997538.1. NM_207655.2.
UniGeneiMm.420648.
Mm.439882.
Mm.8534.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020329.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102884; ENSMUSP00000099948; ENSMUSG00000020122.
GeneIDi13649.
KEGGimmu:13649.
UCSCiuc007ibn.1. mouse.

Organism-specific databases

CTDi1956.
MGIiMGI:95294. Egfr.

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.
GeneTreeiENSGT00760000118799.
HOGENOMiHOG000046308.
HOVERGENiHBG000490.
KOiK04361.

Miscellaneous databases

ChiTaRSiEgfr. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020122.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR032675. L_dom-like.
IPR000494. Rcpt_L-dom.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF14843. GF_recep_IV. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
SMARTiSM00261. FU. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF57184. SSF57184. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9WVF5_MOUSE
AccessioniPrimary (citable) accession number: Q9WVF5
Secondary accession number(s): Q5SVE9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.