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Protein
Submitted name:

Epidermal growth factor receptor

Gene

Egfr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. actin filament binding Source: MGI
  2. ATP binding Source: InterPro
  3. chromatin binding Source: MGI
  4. enzyme binding Source: MGI
  5. epidermal growth factor-activated receptor activity Source: MGI
  6. identical protein binding Source: MGI
  7. kinase activity Source: MGI
  8. protein heterodimerization activity Source: MGI
  9. protein phosphatase binding Source: MGI
  10. protein tyrosine kinase activity Source: MGI
  11. signal transducer activity Source: MGI
  12. transmembrane signaling receptor activity Source: MGI
  13. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. cell morphogenesis Source: MGI
  2. cell proliferation Source: MGI
  3. cell surface receptor signaling pathway Source: MGI
  4. cellular response to estradiol stimulus Source: MGI
  5. cerebral cortex cell migration Source: MGI
  6. digestive tract morphogenesis Source: MGI
  7. embryonic placenta development Source: MGI
  8. epidermal growth factor receptor signaling pathway Source: MGI
  9. epidermis development Source: MGI
  10. hair follicle development Source: MGI
  11. morphogenesis of an epithelial fold Source: MGI
  12. negative regulation of apoptotic process Source: MGI
  13. negative regulation of protein catabolic process Source: MGI
  14. peptidyl-tyrosine phosphorylation Source: MGI
  15. positive regulation of catenin import into nucleus Source: MGI
  16. positive regulation of cell migration Source: MGI
  17. positive regulation of cell proliferation Source: MGI
  18. positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: MGI
  19. positive regulation of DNA repair Source: MGI
  20. positive regulation of DNA replication Source: MGI
  21. positive regulation of epithelial cell proliferation Source: MGI
  22. positive regulation of ERK1 and ERK2 cascade Source: MGI
  23. positive regulation of MAP kinase activity Source: MGI
  24. positive regulation of nitric oxide biosynthetic process Source: MGI
  25. positive regulation of phosphorylation Source: MGI
  26. positive regulation of protein kinase B signaling Source: MGI
  27. positive regulation of protein phosphorylation Source: MGI
  28. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  29. protein autophosphorylation Source: MGI
  30. regulation of cell proliferation Source: MGI
  31. regulation of nitric-oxide synthase activity Source: MGI
  32. regulation of peptidyl-tyrosine phosphorylation Source: MGI
  33. response to UV-A Source: MGI
  34. salivary gland morphogenesis Source: MGI
  35. signal transduction Source: MGI
  36. single organismal cell-cell adhesion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Epidermal growth factor receptorImported
Submitted name:
Epidermal growth factor receptor isoform 3Imported
Submitted name:
Epidermal growth factor receptor, isoform CRA_aImported
Gene namesi
Name:EgfrImported
ORF Names:mCG_140518Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:95294. Egfr.

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: MGI
  2. cell surface Source: MGI
  3. cytoplasm Source: MGI
  4. endocytic vesicle Source: MGI
  5. endosome Source: MGI
  6. endosome membrane Source: MGI
  7. focal adhesion Source: MGI
  8. intracellular Source: MGI
  9. membrane Source: MGI
  10. membrane raft Source: MGI
  11. nucleus Source: MGI
  12. plasma membrane Source: MGI
  13. receptor complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9WVF5.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118799.
HOGENOMiHOG000046308.
HOVERGENiHBG000490.
KOiK04361.
OrthoDBiEOG7V49XM.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000494. rcpt_L-dom.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
SMARTiSM00261. FU. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9WVF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPSGTARTT LLVLLTALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS
60 70 80 90 100
LQRMYNNCEV VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP
110 120 130 140 150
LENLQIIRGN ALYENTYALA ILSNYGTNRT GLRELPMRNL QEILIGAVRF
160 170 180 190 200
SNNPILCNMD TIQWRDIVQN VFMSNMSMDL QSHPSSCPKC DPSCPNGSCW
210 220 230 240 250
GGGEENCQKL TKIICAQQCS HRCRGRSPSD CCHNQCAAGC TGPRESDCLV
260 270 280 290 300
CQKFQDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
310 320 330 340 350
VTDHGSCVRA CGPDYYEVEE DGIRKCKKCD GPCRKVCNGI GIGEFKDTLS
360 370 380 390 400
INATNIKHFK YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE
410 420 430 440 450
ITGFLLIQAW PDNWTDLHAF ENLEIIRGRT KQHGQFSLAV VGLNITSLGL
460 470 480 490 500
RSLKEISDGD VIISGNRNLC YANTINWKKL FGTPNQKTKI MNNRAEKDCK
510 520 530 540 550
AVNHVCNPLC SSEGCWGPEP RDCVSCQNVS RGRECVEKCN ILEGEPREFV
560 570 580 590 600
ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGIM
610 620 630 640 650
GENNTLVWKY ADANNVCHLC HANCTYGCAG PGLQGCEVWP SGYVQWQWIL

KTFWI
Length:655
Mass (Da):72,906
Last modified:November 1, 1999 - v1
Checksum:i6B34063B1BC928CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645532 Genomic DNA. No translation available.
BX255277 Genomic DNA. No translation available.
AF124513 mRNA. Translation: AAD44149.1.
AF275366, AF275364, AF275365 Genomic DNA. Translation: AAG28047.1.
BC023729 mRNA. Translation: AAH23729.1.
AK004883 mRNA. Translation: BAB23641.1.
AK004911 mRNA. Translation: BAB23662.1.
AK004944 mRNA. Translation: BAB23688.1.
CH466574 Genomic DNA. Translation: EDL40666.1.
RefSeqiNP_031938.1. NM_007912.4.
NP_997538.1. NM_207655.2.
UniGeneiMm.420648.
Mm.439882.
Mm.8534.

Genome annotation databases

EnsembliENSMUST00000102884; ENSMUSP00000099948; ENSMUSG00000020122.
GeneIDi13649.
KEGGimmu:13649.
UCSCiuc007ibn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645532 Genomic DNA. No translation available.
BX255277 Genomic DNA. No translation available.
AF124513 mRNA. Translation: AAD44149.1.
AF275366, AF275364, AF275365 Genomic DNA. Translation: AAG28047.1.
BC023729 mRNA. Translation: AAH23729.1.
AK004883 mRNA. Translation: BAB23641.1.
AK004911 mRNA. Translation: BAB23662.1.
AK004944 mRNA. Translation: BAB23688.1.
CH466574 Genomic DNA. Translation: EDL40666.1.
RefSeqiNP_031938.1. NM_007912.4.
NP_997538.1. NM_207655.2.
UniGeneiMm.420648.
Mm.439882.
Mm.8534.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102884; ENSMUSP00000099948; ENSMUSG00000020122.
GeneIDi13649.
KEGGimmu:13649.
UCSCiuc007ibn.1. mouse.

Organism-specific databases

CTDi1956.
MGIiMGI:95294. Egfr.

Phylogenomic databases

GeneTreeiENSGT00760000118799.
HOGENOMiHOG000046308.
HOVERGENiHBG000490.
KOiK04361.
OrthoDBiEOG7V49XM.

Miscellaneous databases

ChiTaRSiEgfr. mouse.
NextBioi284374.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ9WVF5.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000494. rcpt_L-dom.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
SMARTiSM00261. FU. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LiverImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LiverImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LiverImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LiverImported.
  5. "Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms."
    Reiter J.L., Threadgill D.W., Eley G.D., Strunk K.E., Danielsen A.J., Schehl Sinclair C., Pearsall R.S., Green P.J., Yee D., Lampland A.L., Balasubramaniam S., Crossley T.D., Magnuson T.R., James C.D., Maihle N.J.
    Genomics 71:1-20(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H/101Imported and C57BL/6JImported.
    Tissue: LiverImported.
  6. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LiverImported.
  7. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LiverImported.
  8. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. C3Imported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LiverImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LiverImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  14. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9WVF5_MOUSE
AccessioniPrimary (citable) accession number: Q9WVF5
Secondary accession number(s): Q5SVE9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: March 4, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.