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Reviewed, UniProtKB/Swiss-Prot Q9WVE0 (AICDA_MOUSE)

Last modified November 3, 2009. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Activation-induced cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
Gene names
Name: Aicda
Synonyms: Aid
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.

Catalytic activity

Cytidine + H2O = uridine + NH3.

Cofactor

Zinc By similarity.

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
   Biological processmRNA processing
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological processisotype switching

Inferred from mutant phenotype. Source: MGI

mRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred by curator. Source: MGI

   Molecular functioncytidine deaminase activity Ref.1

Inferred from direct assay. Source: MGI

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Activation-induced cytidine deaminase
PRO_0000171688

Sites

Active site581Proton donor By similarity
Metal binding561Zinc; catalytic By similarity
Metal binding871Zinc; catalytic By similarity
Metal binding901Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WVE0-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 18A3BA10CA54BEB2

FASTA19824,031
        10         20         30         40         50         60 
MDSLLMKQKK FLYHFKNVRW AKGRHETYLC YVVKRRDSAT SCSLDFGHLR NKSGCHVELL 

        70         80         90        100        110        120 
FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVAEFLRW NPNLSLRIFT ARLYFCEDRK 

       130        140        150        160        170        180 
AEPEGLRRLH RAGVQIGIMT FKDYFYCWNT FVENRERTFK AWEGLHENSV RLTRQLRRIL 

       190 
LPLYEVDDLR DAFRMLGF 

« Hide

References

[1]"Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells."
Muramatsu M., Sankaranand V.S., Anant S., Sugai M., Kinoshita K., Davidson N.O., Honjo T.
J. Biol. Chem. 274:18470-18476(1999) [PubMed: 10373455] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

AF132979 mRNA. Translation: AAD41793.1.
IPIIPI00125873.
RefSeqNP_033775.1.
UniGeneMm.391503

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9WVE0.

PTM databases

PhosphoSiteQ9WVE0.

Proteomic databases

PRIDEQ9WVE0.

Genome annotation databases

EnsemblENSMUST00000043301; ENSMUSP00000040524; ENSMUSG00000040627; Mus musculus. [Genome view]
GeneID11628.
KEGGmmu:11628.
UCSCuc009dpj.1. mouse.

Organism-specific databases

CTD11628.
MGIMGI:1342279. Aicda.

Phylogenomic databases

HOGENOMQ9WVE0.
HOVERGENQ9WVE0.
OMACWNTFVE.

Enzyme and pathway databases

BRENDA3.5.4.5. 244.

Gene expression databases

ArrayExpressQ9WVE0.
BgeeQ9WVE0.
CleanExMM_AICDA.
GenevestigatorQ9WVE0.
GermOnlineENSMUSG00000040627. Mus musculus.

Family and domain databases

InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR007904. APOBEC_C.
IPR013158. APOBEC_N.
[Graphical view]
PfamPF05240. APOBEC_C. 1 hit.
PF08210. APOBEC_N. 1 hit.
[Graphical view]
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio279183.
SOURCESearch...

Entry information

Entry nameAICDA_MOUSE
AccessionPrimary (citable) accession number: Q9WVE0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1999
Last modified: November 3, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents