Reviewed, UniProtKB/Swiss-Prot Q9WVE0 (AICDA_MOUSE)

Names and origin

Protein names

Recommended name:
    Activation-induced cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase

Gene names

Name:	Aicda
Synonyms:	Aid

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.
Catalytic activity	Cytidine + H2O = uridine + NH3.
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Biological process	mRNA processing
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	isotype switching Inferred from mutant phenotype. Source: MGI mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred by curator. Source: MGI
Molecular function	cytidine deaminase activity Ref.1 Inferred from direct assay. Source: MGI zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Activation-induced cytidine deaminase		PRO_0000171688
Sites
	Active site	58	1	Proton donor By similarity
	Metal binding	56	1	Zinc; catalytic By similarity
	Metal binding	87	1	Zinc; catalytic By similarity
	Metal binding	90	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9WVE0-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 18A3BA10CA54BEB2	FASTA	198	24,031
	10 20 30 40 50 60 MDSLLMKQKK FLYHFKNVRW AKGRHETYLC YVVKRRDSAT SCSLDFGHLR NKSGCHVELL 70 80 90 100 110 120 FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVAEFLRW NPNLSLRIFT ARLYFCEDRK 130 140 150 160 170 180 AEPEGLRRLH RAGVQIGIMT FKDYFYCWNT FVENRERTFK AWEGLHENSV RLTRQLRRIL 190 LPLYEVDDLR DAFRMLGF

References

[1]	"Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells." Muramatsu M., Sankaranand V.S., Anant S., Sugai M., Kinoshita K., Davidson N.O., Honjo T. J. Biol. Chem. 274:18470-18476(1999) [PubMed: 10373455] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF132979 mRNA. Translation: AAD41793.1.
IPI	IPI00125873.
RefSeq	NP_033775.1.
UniGene	Mm.391503
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9WVE0.
PTM databases
PhosphoSite	Q9WVE0.
Proteomic databases
PRIDE	Q9WVE0.
Genome annotation databases
Ensembl	ENSMUST00000043301; ENSMUSP00000040524; ENSMUSG00000040627; Mus musculus. [Genome view]
GeneID	11628.
KEGG	mmu:11628.
UCSC	uc009dpj.1. mouse.
Organism-specific databases
CTD	11628.
MGI	MGI:1342279. Aicda.
Phylogenomic databases
HOGENOM	Q9WVE0.
HOVERGEN	Q9WVE0.
OMA	CWNTFVE.
Enzyme and pathway databases
BRENDA	3.5.4.5. 244.
Gene expression databases
ArrayExpress	Q9WVE0.
Bgee	Q9WVE0.
CleanEx	MM_AICDA.
Genevestigator	Q9WVE0.
GermOnline	ENSMUSG00000040627. Mus musculus.
Family and domain databases
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR007904. APOBEC_C. IPR013158. APOBEC_N. [Graphical view]
Pfam	PF05240. APOBEC_C. 1 hit. PF08210. APOBEC_N. 1 hit. [Graphical view]
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	279183.
SOURCE	Search...

Entry information

Entry name

AICDA_MOUSE

Accession

Primary (citable) accession number: Q9WVE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	November 1, 1999
Last modified:	November 3, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)