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Protein

Mitochondrial ornithine transporter 1

Gene

Slc25a15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ornithine-citrulline antiporter (PubMed:19287344). Connects the cytosolic and the intramitochondrial reactions of the urea cycle by exchanging cytosolic ornithine with matrix citrulline. The stoichiometry is close to 1:1 (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ornithine transporter 1
Alternative name(s):
Solute carrier family 25 member 15
Gene namesi
Name:Slc25a15
Synonyms:Ornt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1342274 Slc25a15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei110 – 130Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei168 – 188Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei207 – 227Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906511 – 301Mitochondrial ornithine transporter 1Add BLAST301

Proteomic databases

EPDiQ9WVD5
MaxQBiQ9WVD5
PaxDbiQ9WVD5
PRIDEiQ9WVD5

PTM databases

iPTMnetiQ9WVD5
PhosphoSitePlusiQ9WVD5
SwissPalmiQ9WVD5

Expressioni

Tissue specificityi

Widely expressed, with highest levels in the liver, testis and kidney. In the brain, expressed at high levels in the hypothalamus.1 Publication

Gene expression databases

BgeeiENSMUSG00000031482
ExpressionAtlasiQ9WVD5 baseline and differential
GenevisibleiQ9WVD5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033871

Structurei

3D structure databases

ProteinModelPortaliQ9WVD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 91Solcar 1Add BLAST85
Repeati104 – 197Solcar 2Add BLAST94
Repeati207 – 293Solcar 3Add BLAST87

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0763 Eukaryota
ENOG410XNVH LUCA
GeneTreeiENSGT00730000110966
HOGENOMiHOG000168307
HOVERGENiHBG062630
InParanoidiQ9WVD5
KOiK15101
OMAiYNFLFFP
OrthoDBiEOG091G0HVE
PhylomeDBiQ9WVD5
TreeFamiTF314880

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q9WVD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSNPAIQAA IDLTAGAAGG TACVLTGQPF DTMKVKMQTF PDLYRGLTDC
60 70 80 90 100
CLKTYSQVGF RGFYKGTSPA LIANIAENSV LFMCYGFCQQ VVRKVVGLDQ
110 120 130 140 150
QAKLSDLQNA AAGSFASAFA ALVLCPTELV KCRLQTMYEM ETSGKIAASQ
160 170 180 190 200
NTVWSVVKEI FRKDGPLGFY HGLSSTLLRE VPGYFFFFGG YELSRSFFAS
210 220 230 240 250
GRSKDELGPV PLMLSGGFGG ICLWLAVYPV DCIKSRIQVL SMTGKQTGLV
260 270 280 290 300
RTFLSIVKNE GITALYSGLK PTMIRAFPAN GALFLAYEYS RKLMMNQLEA

W
Length:301
Mass (Da):32,823
Last modified:November 1, 1999 - v1
Checksum:i36F232F781785D2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133914 mRNA Translation: AAD45252.1
CCDSiCCDS22175.1
RefSeqiNP_851842.1, NM_181325.4
XP_006509089.1, XM_006509026.3
UniGeneiMm.200907

Genome annotation databases

EnsembliENSMUST00000033871; ENSMUSP00000033871; ENSMUSG00000031482
GeneIDi18408
KEGGimmu:18408
UCSCiuc009lcz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiORNT1_MOUSE
AccessioniPrimary (citable) accession number: Q9WVD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health