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Protein

Mitochondrial ornithine transporter 1

Gene

Slc25a15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-70635. Urea cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ornithine transporter 1
Alternative name(s):
Solute carrier family 25 member 15
Gene namesi
Name:Slc25a15
Synonyms:Ornt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1342274. Slc25a15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei110 – 130Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei168 – 188Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei207 – 227Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906511 – 301Mitochondrial ornithine transporter 1Add BLAST301

Proteomic databases

EPDiQ9WVD5.
MaxQBiQ9WVD5.
PaxDbiQ9WVD5.
PRIDEiQ9WVD5.

PTM databases

iPTMnetiQ9WVD5.
PhosphoSitePlusiQ9WVD5.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in the liver, testis and kidney. In the brain, expressed at high levels in the hypothalamus.1 Publication

Gene expression databases

BgeeiENSMUSG00000031482.
ExpressionAtlasiQ9WVD5. baseline and differential.
GenevisibleiQ9WVD5. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-1843509.
STRINGi10090.ENSMUSP00000033871.

Structurei

3D structure databases

ProteinModelPortaliQ9WVD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 91Solcar 1Add BLAST85
Repeati104 – 197Solcar 2Add BLAST94
Repeati207 – 293Solcar 3Add BLAST87

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0763. Eukaryota.
ENOG410XNVH. LUCA.
GeneTreeiENSGT00730000110966.
HOGENOMiHOG000168307.
HOVERGENiHBG062630.
InParanoidiQ9WVD5.
KOiK15101.
OMAiMHEMASS.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ9WVD5.
TreeFamiTF314880.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSNPAIQAA IDLTAGAAGG TACVLTGQPF DTMKVKMQTF PDLYRGLTDC
60 70 80 90 100
CLKTYSQVGF RGFYKGTSPA LIANIAENSV LFMCYGFCQQ VVRKVVGLDQ
110 120 130 140 150
QAKLSDLQNA AAGSFASAFA ALVLCPTELV KCRLQTMYEM ETSGKIAASQ
160 170 180 190 200
NTVWSVVKEI FRKDGPLGFY HGLSSTLLRE VPGYFFFFGG YELSRSFFAS
210 220 230 240 250
GRSKDELGPV PLMLSGGFGG ICLWLAVYPV DCIKSRIQVL SMTGKQTGLV
260 270 280 290 300
RTFLSIVKNE GITALYSGLK PTMIRAFPAN GALFLAYEYS RKLMMNQLEA

W
Length:301
Mass (Da):32,823
Last modified:November 1, 1999 - v1
Checksum:i36F232F781785D2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133914 mRNA. Translation: AAD45252.1.
CCDSiCCDS22175.1.
RefSeqiNP_851842.1. NM_181325.4.
XP_006509089.1. XM_006509026.3.
UniGeneiMm.200907.

Genome annotation databases

EnsembliENSMUST00000033871; ENSMUSP00000033871; ENSMUSG00000031482.
GeneIDi18408.
KEGGimmu:18408.
UCSCiuc009lcz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133914 mRNA. Translation: AAD45252.1.
CCDSiCCDS22175.1.
RefSeqiNP_851842.1. NM_181325.4.
XP_006509089.1. XM_006509026.3.
UniGeneiMm.200907.

3D structure databases

ProteinModelPortaliQ9WVD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1843509.
STRINGi10090.ENSMUSP00000033871.

PTM databases

iPTMnetiQ9WVD5.
PhosphoSitePlusiQ9WVD5.

Proteomic databases

EPDiQ9WVD5.
MaxQBiQ9WVD5.
PaxDbiQ9WVD5.
PRIDEiQ9WVD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033871; ENSMUSP00000033871; ENSMUSG00000031482.
GeneIDi18408.
KEGGimmu:18408.
UCSCiuc009lcz.2. mouse.

Organism-specific databases

CTDi10166.
MGIiMGI:1342274. Slc25a15.

Phylogenomic databases

eggNOGiKOG0763. Eukaryota.
ENOG410XNVH. LUCA.
GeneTreeiENSGT00730000110966.
HOGENOMiHOG000168307.
HOVERGENiHBG062630.
InParanoidiQ9WVD5.
KOiK15101.
OMAiMHEMASS.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ9WVD5.
TreeFamiTF314880.

Enzyme and pathway databases

ReactomeiR-MMU-70635. Urea cycle.

Miscellaneous databases

ChiTaRSiSlc25a15. mouse.
PROiQ9WVD5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031482.
ExpressionAtlasiQ9WVD5. baseline and differential.
GenevisibleiQ9WVD5. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiORNT1_MOUSE
AccessioniPrimary (citable) accession number: Q9WVD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.