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Protein

Neuropeptide Y receptor type 1

Gene

NPY1R

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for neuropeptide Y and peptide YY.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 1
Short name:
NPY1-R
Gene namesi
Name:NPY1R
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence analysisAdd
BLAST
Transmembranei35 – 5521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini56 – 8732CytoplasmicSequence analysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini109 – 1168ExtracellularSequence analysis
Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 15417CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini176 – 21136ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini233 – 26028CytoplasmicSequence analysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini282 – 29918ExtracellularSequence analysisAdd
BLAST
Transmembranei300 – 32021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini321 – 38363CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Neuropeptide Y receptor type 1PRO_0000069919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi113 ↔ 198PROSITE-ProRule annotation
Lipidationi338 – 3381S-palmitoyl cysteineSequence analysis
Modified residuei368 – 3681PhosphoserineBy similarity
Modified residuei376 – 3761PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000014934.

Chemistry

BindingDBiQ9WVD0.

Structurei

3D structure databases

ProteinModelPortaliQ9WVD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiQ9WVD0.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTSFSQLE NHSVHYNLSE EKPSFFAFEN DDCHLPLAVI FTLALAYGAV
60 70 80 90 100
IILGVSGNLA LILIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY
110 120 130 140 150
TLMDHWIFGE IMCKLNPFVQ CVSITVSIFS LVLIAVERHQ LIINPRGWRP
160 170 180 190 200
NNRHAYIGIA VIWVLAVASS LPFMIYQVLT DEPFQNVTLD AFKDKLVCFD
210 220 230 240 250
QFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR RNNMMDKMRD
260 270 280 290 300
SKYRSSESKR INIMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL
310 320 330 340 350
LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYETI
360 370 380
AMSTMHTDVS KTSLKQASPL AFKKISCVEN EKI
Length:383
Mass (Da):44,281
Last modified:November 1, 1999 - v1
Checksum:iE53B0D93FA735F8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135061 Genomic DNA. Translation: AAD43060.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135061 Genomic DNA. Translation: AAD43060.1.

3D structure databases

ProteinModelPortaliQ9WVD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000014934.

Chemistry

BindingDBiQ9WVD0.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiQ9WVD0.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPY1R_CAVPO
AccessioniPrimary (citable) accession number: Q9WVD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.