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Q9WVC8

- S26A3_MOUSE

UniProt

Q9WVC8 - S26A3_MOUSE

Protein

Chloride anion exchanger

Gene

Slc26a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.2 Publications

    GO - Molecular functioni

    1. anion:anion antiporter activity Source: MGI
    2. bicarbonate transmembrane transporter activity Source: UniProtKB
    3. chloride transmembrane transporter activity Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. secondary active sulfate transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. bicarbonate transport Source: GOC
    2. cellular response to cAMP Source: UniProtKB
    3. chloride transmembrane transport Source: GOC
    4. chloride transport Source: GOC
    5. intracellular pH elevation Source: UniProtKB
    6. membrane hyperpolarization Source: UniProtKB
    7. sperm capacitation Source: UniProtKB

    Keywords - Biological processi

    Antiport, Transport

    Keywords - Ligandi

    Chloride

    Protein family/group databases

    TCDBi2.A.53.2.3. the sulfate permease (sulp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chloride anion exchanger
    Alternative name(s):
    Down-regulated in adenoma
    Short name:
    Protein DRA
    Solute carrier family 26 member 3
    Gene namesi
    Name:Slc26a3
    Synonyms:Dra
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:107181. Slc26a3.

    Subcellular locationi

    Apical cell membrane By similarity; Multi-pass membrane protein By similarity. Membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail.

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. brush border membrane Source: Ensembl
    3. integral component of plasma membrane Source: MGI
    4. membrane Source: UniProtKB
    5. sperm midpiece Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 757757Chloride anion exchangerPRO_0000080162Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9WVC8.
    PRIDEiQ9WVC8.

    Expressioni

    Tissue specificityi

    Expressed in spermatogenic cells.1 Publication

    Gene expression databases

    BgeeiQ9WVC8.
    CleanExiMM_SLC26A3.
    GenevestigatoriQ9WVC8.

    Interactioni

    Subunit structurei

    Interacts with PDZK1 By similarity. Interacts with CFTR, SLC26A6 and SLC9A3R1.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CftrP263613EBI-6895537,EBI-6115317
    Slc26a6Q8CIW62EBI-6895537,EBI-6895517
    Slc9a3r1P704412EBI-6895537,EBI-1184085

    Protein-protein interaction databases

    IntActiQ9WVC8. 3 interactions.
    STRINGi10090.ENSMUSP00000001254.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVC8.
    SMRiQ9WVC8. Positions 638-711.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini146 – 17530ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei286 – 30621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei343 – 36321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei375 – 39521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei412 – 43221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei439 – 45921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei470 – 49021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei644 – 66421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei702 – 72221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini518 – 713196STASPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    GeneTreeiENSGT00750000117367.
    HOGENOMiHOG000006546.
    HOVERGENiHBG000639.
    InParanoidiB2RTD9.
    KOiK14078.
    OMAiYIVARPV.
    OrthoDBiEOG76T9QT.
    PhylomeDBiQ9WVC8.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    TIGRFAMsiTIGR00815. sulP. 1 hit.
    PROSITEiPS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WVC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIEAIGNQYV VARPVYSTKT FGEEFKKTHR HHKTFLDHLK GCCSCSSQKA    50
    KKIALSLFPI ASWLPAYKIK EWLLSDIVSG ISTGLVAVLQ GLAFALLVNI 100
    PPAYGLYAAF FPVITYFFLG TSRHISVGPF PVLSMMVGVV VTRVVSDPNA 150
    SSELSSSSTE NDSFIEEKVM VAASVTVLSG IIQLLLGVLQ VGFVVIYLSE 200
    SLISGFTTAA AIHVLVSQLK FMLQLPVPAY SDPFSIFKVL ESVFTQIQKT 250
    NIADLVTSVI ILVVVFVFKE INQRYRSKLP VPIPIELIMT VIATGVSYGC 300
    NFEDRFGVAV VGNMSLGFQP PITPSVEVFQ DTIGDSFGIA IVGFAVAFSV 350
    ASVYSLKYDY PIDGNQELIA LGVSNIFTGA FKGFAGSTAL SRSGVQESTG 400
    GKTQVAGLLS AVIVLIVIVA IGFLLQPLQK SVLAALALGN LKGMLMQFAE 450
    IGRLWKKDKY DCLIWIMTFI FAIVLGLGLG LAASVAFQLL TIVFRTQFPK 500
    CSTLANVGRS NIYKNKKNYA EVYEPEGVKI FRCPSPIYFA NIGFFKQKLI 550
    DAVGFSPLRI LRKRNKALKK IRKLQKRGLI QMTPKGFICT SDGFKDSDEE 600
    LDNNQIEELD QPINTTDLPF DIDWNGDLPL NITIPKISLH SLILDFSAVS 650
    FLDVSSMRGL RTILQEFIRI KVDVYIVGTD DDFIDKLARC EFFDDEVTDS 700
    IFFLTIHDAI LHILMKKDYS TSKFNSSQEK ERKFDFTINT NGGLRNRECQ 750
    VPVETKF 757
    Length:757
    Mass (Da):83,590
    Last modified:November 1, 1999 - v1
    Checksum:i32B1AC648BE74A07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF136751 mRNA. Translation: AAD42784.1.
    BC139271 mRNA. Translation: AAI39272.1.
    BC139273 mRNA. Translation: AAI39274.1.
    CCDSiCCDS25863.1.
    RefSeqiNP_067328.1. NM_021353.3.
    UniGeneiMm.490454.

    Genome annotation databases

    EnsembliENSMUST00000001254; ENSMUSP00000001254; ENSMUSG00000001225.
    GeneIDi13487.
    KEGGimmu:13487.
    UCSCiuc007nhj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF136751 mRNA. Translation: AAD42784.1 .
    BC139271 mRNA. Translation: AAI39272.1 .
    BC139273 mRNA. Translation: AAI39274.1 .
    CCDSi CCDS25863.1.
    RefSeqi NP_067328.1. NM_021353.3.
    UniGenei Mm.490454.

    3D structure databases

    ProteinModelPortali Q9WVC8.
    SMRi Q9WVC8. Positions 638-711.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9WVC8. 3 interactions.
    STRINGi 10090.ENSMUSP00000001254.

    Protein family/group databases

    TCDBi 2.A.53.2.3. the sulfate permease (sulp) family.

    Proteomic databases

    MaxQBi Q9WVC8.
    PRIDEi Q9WVC8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001254 ; ENSMUSP00000001254 ; ENSMUSG00000001225 .
    GeneIDi 13487.
    KEGGi mmu:13487.
    UCSCi uc007nhj.1. mouse.

    Organism-specific databases

    CTDi 1811.
    MGIi MGI:107181. Slc26a3.

    Phylogenomic databases

    eggNOGi COG0659.
    GeneTreei ENSGT00750000117367.
    HOGENOMi HOG000006546.
    HOVERGENi HBG000639.
    InParanoidi B2RTD9.
    KOi K14078.
    OMAi YIVARPV.
    OrthoDBi EOG76T9QT.
    PhylomeDBi Q9WVC8.
    TreeFami TF313784.

    Miscellaneous databases

    NextBioi 283993.
    PROi Q9WVC8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WVC8.
    CleanExi MM_SLC26A3.
    Genevestigatori Q9WVC8.

    Family and domain databases

    Gene3Di 3.30.750.24. 2 hits.
    InterProi IPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 2 hits.
    TIGRFAMsi TIGR00815. sulP. 1 hit.
    PROSITEi PS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse down-regulated in adenoma (DRA) is an intestinal Cl(-)/HCO(3)(-) exchanger and is up-regulated in colon of mice lacking the NHE3 Na(+)/H(+) exchanger."
      Melvin J.E., Park K., Richardson L., Schultheis P.J., Shull G.E.
      J. Biol. Chem. 274:22855-22861(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: FVB/N.
      Tissue: Colon.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation."
      Chavez J.C., Hernandez-Gonzalez E.O., Wertheimer E., Visconti P.E., Darszon A., Trevino C.L.
      Biol. Reprod. 86:1-14(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CFTR; SLC26A6 AND SLC9A3R1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiS26A3_MOUSE
    AccessioniPrimary (citable) accession number: Q9WVC8
    Secondary accession number(s): B2RTD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3