Short transient receptor potential channel 7

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Q9WVC5 (TRPC7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 111. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Short transient receptor potential channel 7
Short name=TrpC7

Alternative name(s):
Transient receptor protein 7
Short name=TRP-7
Short name=mTRP7

Gene names

Name:	Trpc7
Synonyms:	Trp7, Trrp8

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	862 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion.
Subunit structure	Interacts with MX1 and RNF24 By similarity. Interacts (via ANK-repeat domains) with PRKG1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity. Nucleus envelope By similarity.
Post-translational modification	Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity By similarity.
Sequence similarities	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily. [View classification] Contains 4 ANK repeats.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Cell membrane Membrane Nucleus
Domain	ANK repeat Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	manganese ion transport Inferred from direct assay Ref.1. Source: MGI
Cellular_component	integral to membrane Inferred by curator Ref.1. Source: MGI nuclear envelope Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium channel activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 862

862

Short transient receptor potential channel 7

PRO_0000215325

Regions

Topological domain

1 – 351

351

Cytoplasmic Potential

Transmembrane

352 – 372

Helical; Potential

Topological domain

373 – 383

Extracellular Potential

Transmembrane

384 – 404

Helical; Potential

Topological domain

405 – 465

Cytoplasmic Potential

Transmembrane

466 – 486

Helical; Potential

Topological domain

487 – 537

Extracellular Potential

Transmembrane

538 – 558

Helical; Potential

Topological domain

559 – 581

Cytoplasmic Potential

Transmembrane

582 – 602

Helical; Potential

Topological domain

603 – 651

Extracellular Potential

Transmembrane

652 – 672

Helical; Potential

Topological domain

673 – 862

190

Cytoplasmic Potential

Repeat

42 – 71

ANK 1

Repeat

77 – 106

ANK 2

Repeat

108 – 134

ANK 3

Repeat

163 – 192

ANK 4

Amino acid modifications

Modified residue

Phosphothreonine; by PKG/PRKG1 By similarity

Glycosylation

514

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q9WVC5 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: C2EB2CE1A6AF9C3D
Show »

FASTA

862

99,475

        10         20         30         40         50         60 
MLGSNTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS AEYGNIPVVR 

        70         80         90        100        110        120 
KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK ENLARVGDAL LLAISKGYVR 

       130        140        150        160        170        180 
IVEAILSHPA FAQGQRLTLS PLEQELRDDD FYAYDEDGTR FSHDITPIIL AAHCQEYEIV 

       190        200        210        220        230        240 
HILLLKGARI ERPHDYFCKC NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL 

       250        260        270        280        290        300 
TALELSNELA RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNLQVW 

       310        320        330        340        350        360 
SDHHRPSLSR IKLAIKYEVK KFVAHPNCQQ QLLTMWYENL SGLRQQSIAV KFLAVFGVSI 

       370        380        390        400        410        420 
GLPFLAIAYW IAPCSKLGQT LRSPFMKFVA HAVSFTIFLG LLVVNASDRF EGVKTLPNET 

       430        440        450        460        470        480 
FTDYPKQIFR VKTTQFSWTE MLIMKWVLGM IWSECKEIWE EGPREYVLHL WNLLDFGMLS 

       490        500        510        520        530        540 
IFVASFTARF MAFLKASEAQ LYVDQYVQDV TLHNVSLPPE VAYFTYARDK WWPSDPQIIS 

       550        560        570        580        590        600 
EGLYAIAVVL SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL 

       610        620        630        640        650        660 
YSYYRGAKYN PAFTTVEESF KTLFWSIFGL SEVISVVLKY DHKFIENIGY VLYGVYNVTM 

       670        680        690        700        710        720 
VVVLLNMLIA MINNSYQEIE EDADVEWKFA RAKLWLSYFD EGRTLPAPFN LVPSPKSFYY 

       730        740        750        760        770        780 
LIMRIKMCLI ELCQSKAKRC ENDLEMGMLN SKFRKTRYQA GMRNSENLTA NSTFSKPTRY 

       790        800        810        820        830        840 
QKIMKRLIKR YVLKAQVDRE NDEVNEGELK EIKQDISSLR YELLEEKSQA TGELADLIQQ 

       850        860 
LSEKFGKNLN KDHLRVNQGK DI

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References

[1]

"Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor."
Okada T., Inoue R., Yamazaki K., Maeda A., Kurosaki T., Yamakuni T., Tanaka I., Shimizu S., Ikenaka K., Imoto K., Mori Y.
J. Biol. Chem. 274:27359-27370(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF139923 mRNA. Translation: AAD42069.1.
IPI	IPI00280861.
RefSeq	NP_036165.1. NM_012035.2.
UniGene	Mm.62409.
3D structure databases
ProteinModelPortal	Q9WVC5.
SMR	Q9WVC5. Positions 45-199.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4998494.
STRING	10090.ENSMUSP00000022023.
Protein family/group databases
TCDB	1.A.4.1.2. transient receptor potential Ca2+ channel (TRP-CC) family.
PTM databases
PhosphoSite	Q9WVC5.
Proteomic databases
PaxDb	Q9WVC5.
PRIDE	Q9WVC5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000022023; ENSMUSP00000022023; ENSMUSG00000021541.
GeneID	26946.
KEGG	mmu:26946.
UCSC	uc007qtb.1. mouse.
Organism-specific databases
CTD	57113.
MGI	MGI:1349470. Trpc7.
Phylogenomic databases
eggNOG	NOG254238.
GeneTree	ENSGT00680000099764.
HOGENOM	HOG000020590.
HOVERGEN	HBG068337.
InParanoid	Q9WVC5.
KO	K04970.
OMA	KKTRYQA.
OrthoDB	EOG4V436Z.
Gene expression databases
ArrayExpress	Q9WVC5.
Bgee	Q9WVC5.
Genevestigator	Q9WVC5.
GermOnline	ENSMUSG00000021541. Mus musculus.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR005821. Ion_trans_dom. IPR004729. TRP_channel. IPR013555. TRP_dom. IPR005463. TRPC7_channel. IPR002153. TRPC_channel. [Graphical view]
PANTHER	PTHR10117. PTHR10117. 1 hit. PTHR10117:SF9. PTHR10117:SF9. 1 hit.
Pfam	PF12796. Ank_2. 1 hit. PF00520. Ion_trans. 1 hit. PF08344. TRP_2. 1 hit. [Graphical view]
PRINTS	PR01097. TRNSRECEPTRP. PR01648. TRPCHANNEL7.
SMART	SM00248. ANK. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
TIGRFAMs	TIGR00870. trp. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. False negative. PS50088. ANK_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	304881.
SOURCE	Search...

Entry information

Entry name

TRPC7_MOUSE

Accession

Primary (citable) accession number: Q9WVC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	November 1, 1999
Last modified:	May 29, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents