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Protein

Short transient receptor potential channel 7

Gene

Trpc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion.

GO - Molecular functioni

  • calcium channel activity Source: MGI

GO - Biological processi

  • calcium ion transport Source: MGI
  • manganese ion transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-114508. Effects of PIP2 hydrolysis.
R-MMU-139853. Elevation of cytosolic Ca2+ levels.
R-MMU-3295583. TRP channels.

Protein family/group databases

TCDBi1.A.4.1.2. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 7
Short name:
TrpC7
Alternative name(s):
Transient receptor protein 7
Short name:
TRP-7
Short name:
mTRP7
Gene namesi
Name:Trpc7
Synonyms:Trp7, Trrp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1349470. Trpc7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 351351CytoplasmicSequence analysisAdd
BLAST
Transmembranei352 – 37221HelicalSequence analysisAdd
BLAST
Topological domaini373 – 38311ExtracellularSequence analysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence analysisAdd
BLAST
Topological domaini405 – 46561CytoplasmicSequence analysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence analysisAdd
BLAST
Topological domaini487 – 53751ExtracellularSequence analysisAdd
BLAST
Transmembranei538 – 55821HelicalSequence analysisAdd
BLAST
Topological domaini559 – 58123CytoplasmicSequence analysisAdd
BLAST
Transmembranei582 – 60221HelicalSequence analysisAdd
BLAST
Topological domaini603 – 65149ExtracellularSequence analysisAdd
BLAST
Transmembranei652 – 67221HelicalSequence analysisAdd
BLAST
Topological domaini673 – 862190CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Short transient receptor potential channel 7PRO_0000215325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphothreonine; by PKG/PRKG1By similarity
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9WVC5.
PRIDEiQ9WVC5.

PTM databases

iPTMnetiQ9WVC5.
PhosphoSiteiQ9WVC5.

Expressioni

Gene expression databases

BgeeiQ9WVC5.
ExpressionAtlasiQ9WVC5. baseline and differential.
GenevisibleiQ9WVC5. MM.

Interactioni

Subunit structurei

Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.By similarity

Protein-protein interaction databases

MINTiMINT-4998494.
STRINGi10090.ENSMUSP00000022023.

Structurei

3D structure databases

ProteinModelPortaliQ9WVC5.
SMRiQ9WVC5. Positions 3-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 7130ANK 1Add
BLAST
Repeati77 – 10630ANK 2Add
BLAST
Repeati108 – 13427ANK 3Add
BLAST
Repeati163 – 19230ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
InParanoidiQ9WVC5.
KOiK04970.
OMAiYSKPTRY.
OrthoDBiEOG77HDD1.
PhylomeDBiQ9WVC5.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005463. TRPC7_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF9. PTHR10117:SF9. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01648. TRPCHANNEL7.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WVC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSNTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS
60 70 80 90 100
AEYGNIPVVR KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK
110 120 130 140 150
ENLARVGDAL LLAISKGYVR IVEAILSHPA FAQGQRLTLS PLEQELRDDD
160 170 180 190 200
FYAYDEDGTR FSHDITPIIL AAHCQEYEIV HILLLKGARI ERPHDYFCKC
210 220 230 240 250
NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL TALELSNELA
260 270 280 290 300
RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNLQVW
310 320 330 340 350
SDHHRPSLSR IKLAIKYEVK KFVAHPNCQQ QLLTMWYENL SGLRQQSIAV
360 370 380 390 400
KFLAVFGVSI GLPFLAIAYW IAPCSKLGQT LRSPFMKFVA HAVSFTIFLG
410 420 430 440 450
LLVVNASDRF EGVKTLPNET FTDYPKQIFR VKTTQFSWTE MLIMKWVLGM
460 470 480 490 500
IWSECKEIWE EGPREYVLHL WNLLDFGMLS IFVASFTARF MAFLKASEAQ
510 520 530 540 550
LYVDQYVQDV TLHNVSLPPE VAYFTYARDK WWPSDPQIIS EGLYAIAVVL
560 570 580 590 600
SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL
610 620 630 640 650
YSYYRGAKYN PAFTTVEESF KTLFWSIFGL SEVISVVLKY DHKFIENIGY
660 670 680 690 700
VLYGVYNVTM VVVLLNMLIA MINNSYQEIE EDADVEWKFA RAKLWLSYFD
710 720 730 740 750
EGRTLPAPFN LVPSPKSFYY LIMRIKMCLI ELCQSKAKRC ENDLEMGMLN
760 770 780 790 800
SKFRKTRYQA GMRNSENLTA NSTFSKPTRY QKIMKRLIKR YVLKAQVDRE
810 820 830 840 850
NDEVNEGELK EIKQDISSLR YELLEEKSQA TGELADLIQQ LSEKFGKNLN
860
KDHLRVNQGK DI
Length:862
Mass (Da):99,475
Last modified:November 1, 1999 - v1
Checksum:iC2EB2CE1A6AF9C3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139923 mRNA. Translation: AAD42069.1.
CCDSiCCDS26566.1.
RefSeqiNP_036165.1. NM_012035.3.
UniGeneiMm.62409.

Genome annotation databases

EnsembliENSMUST00000022023; ENSMUSP00000022023; ENSMUSG00000021541.
GeneIDi26946.
KEGGimmu:26946.
UCSCiuc007qtb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139923 mRNA. Translation: AAD42069.1.
CCDSiCCDS26566.1.
RefSeqiNP_036165.1. NM_012035.3.
UniGeneiMm.62409.

3D structure databases

ProteinModelPortaliQ9WVC5.
SMRiQ9WVC5. Positions 3-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4998494.
STRINGi10090.ENSMUSP00000022023.

Chemistry

GuidetoPHARMACOLOGYi492.

Protein family/group databases

TCDBi1.A.4.1.2. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

iPTMnetiQ9WVC5.
PhosphoSiteiQ9WVC5.

Proteomic databases

PaxDbiQ9WVC5.
PRIDEiQ9WVC5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022023; ENSMUSP00000022023; ENSMUSG00000021541.
GeneIDi26946.
KEGGimmu:26946.
UCSCiuc007qtb.2. mouse.

Organism-specific databases

CTDi57113.
MGIiMGI:1349470. Trpc7.

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
InParanoidiQ9WVC5.
KOiK04970.
OMAiYSKPTRY.
OrthoDBiEOG77HDD1.
PhylomeDBiQ9WVC5.
TreeFamiTF313147.

Enzyme and pathway databases

ReactomeiR-MMU-114508. Effects of PIP2 hydrolysis.
R-MMU-139853. Elevation of cytosolic Ca2+ levels.
R-MMU-3295583. TRP channels.

Miscellaneous databases

NextBioi304881.
PROiQ9WVC5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WVC5.
ExpressionAtlasiQ9WVC5. baseline and differential.
GenevisibleiQ9WVC5. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005463. TRPC7_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF9. PTHR10117:SF9. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01648. TRPCHANNEL7.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor."
    Okada T., Inoue R., Yamazaki K., Maeda A., Kurosaki T., Yamakuni T., Tanaka I., Shimizu S., Ikenaka K., Imoto K., Mori Y.
    J. Biol. Chem. 274:27359-27370(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTRPC7_MOUSE
AccessioniPrimary (citable) accession number: Q9WVC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.