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Q9WVC3

- CAV2_MOUSE

UniProt

Q9WVC3 - CAV2_MOUSE

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Protein

Caveolin-2

Gene

Cav2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).By similarity

GO - Molecular functioni

  1. D1 dopamine receptor binding Source: UniProtKB

GO - Biological processi

  1. caveola assembly Source: UniProtKB
  2. endocytosis Source: MGI
  3. endoplasmic reticulum organization Source: MGI
  4. mitochondrion organization Source: MGI
  5. negative regulation of cell proliferation Source: MGI
  6. negative regulation of endothelial cell proliferation Source: MGI
  7. negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  8. positive regulation of dopamine receptor signaling pathway Source: UniProtKB
  9. positive regulation of endothelial cell proliferation Source: MGI
  10. protein oligomerization Source: MGI
  11. regulation of mitosis Source: Ensembl
  12. skeletal muscle fiber development Source: MGI
  13. synaptic transmission Source: Ensembl
  14. vesicle docking Source: UniProtKB
  15. vesicle fusion Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-2
Gene namesi
Name:Cav2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:107571. Cav2.

Subcellular locationi

Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membranecaveola; Peripheral membrane protein
Note: Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin. Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments (By similarity).By similarity

GO - Cellular componenti

  1. acrosomal membrane Source: MGI
  2. caveola Source: UniProtKB
  3. cell surface Source: Ensembl
  4. cytoplasmic vesicle Source: MGI
  5. cytosol Source: Ensembl
  6. extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
  7. Golgi apparatus Source: UniProtKB-KW
  8. integral component of plasma membrane Source: Ensembl
  9. lipid particle Source: Ensembl
  10. membrane Source: MGI
  11. membrane raft Source: HGNC
  12. nucleus Source: UniProtKB-KW
  13. perinuclear region of cytoplasm Source: UniProtKB
  14. plasma membrane Source: MGI
  15. protein complex Source: MGI
  16. transport vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Caveolin-2PRO_0000144138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Phosphotyrosine; by SRC1 Publication
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei27 – 271Phosphotyrosine; by SRCBy similarity
Modified residuei36 – 361PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells. Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9WVC3.
PaxDbiQ9WVC3.
PRIDEiQ9WVC3.

PTM databases

PhosphoSiteiQ9WVC3.

Expressioni

Gene expression databases

BgeeiQ9WVC3.
CleanExiMM_CAV2.
ExpressionAtlasiQ9WVC3. baseline and differential.
GenevestigatoriQ9WVC3.

Interactioni

Subunit structurei

Monomer or homodimer. Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9WVC3. 1 interaction.
MINTiMINT-4089976.
STRINGi10090.ENSMUSP00000000058.

Structurei

3D structure databases

ProteinModelPortaliQ9WVC3.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini108 – 16255CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei87 – 10721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiNOG74268.
GeneTreeiENSGT00390000014924.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiQ9WVC3.
KOiK12958.
OMAiSTHSFDK.
OrthoDBiEOG7V1FSD.
PhylomeDBiQ9WVC3.
TreeFamiTF315736.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLETEKADV QLFMADDAYS HHSGVDYADP EKYVDSSHDR DPHQLNSHLK
60 70 80 90 100
LGFEDLIAEP ETTHSFDKVW ICSHALFEIS KYVMYKFLTV FLAIPLAFIA
110 120 130 140 150
GILFATLSCL HIWILMPFVK TCLMVLPSVQ TIWKSVTDVV IGPLCTSVGR
160
SFSSVSMQLS HD
Length:162
Mass (Da):18,227
Last modified:November 1, 1999 - v1
Checksum:i9E2E272FEC169458
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF141322 mRNA. Translation: AAD42349.1.
AB049604 mRNA. Translation: BAB61728.1.
AK004663 mRNA. Translation: BAB23453.1.
AK009913 mRNA. Translation: BAB26582.1.
AK151397 mRNA. Translation: BAE30365.1.
AK158419 mRNA. Translation: BAE34498.1.
BC023095 mRNA. Translation: AAH23095.1.
CCDSiCCDS19923.1.
RefSeqiNP_058596.1. NM_016900.4.
UniGeneiMm.396075.

Genome annotation databases

EnsembliENSMUST00000000058; ENSMUSP00000000058; ENSMUSG00000000058.
GeneIDi12390.
KEGGimmu:12390.
UCSCiuc009azm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF141322 mRNA. Translation: AAD42349.1 .
AB049604 mRNA. Translation: BAB61728.1 .
AK004663 mRNA. Translation: BAB23453.1 .
AK009913 mRNA. Translation: BAB26582.1 .
AK151397 mRNA. Translation: BAE30365.1 .
AK158419 mRNA. Translation: BAE34498.1 .
BC023095 mRNA. Translation: AAH23095.1 .
CCDSi CCDS19923.1.
RefSeqi NP_058596.1. NM_016900.4.
UniGenei Mm.396075.

3D structure databases

ProteinModelPortali Q9WVC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9WVC3. 1 interaction.
MINTi MINT-4089976.
STRINGi 10090.ENSMUSP00000000058.

PTM databases

PhosphoSitei Q9WVC3.

Proteomic databases

MaxQBi Q9WVC3.
PaxDbi Q9WVC3.
PRIDEi Q9WVC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000058 ; ENSMUSP00000000058 ; ENSMUSG00000000058 .
GeneIDi 12390.
KEGGi mmu:12390.
UCSCi uc009azm.1. mouse.

Organism-specific databases

CTDi 858.
MGIi MGI:107571. Cav2.

Phylogenomic databases

eggNOGi NOG74268.
GeneTreei ENSGT00390000014924.
HOGENOMi HOG000036550.
HOVERGENi HBG003422.
InParanoidi Q9WVC3.
KOi K12958.
OMAi STHSFDK.
OrthoDBi EOG7V1FSD.
PhylomeDBi Q9WVC3.
TreeFami TF315736.

Miscellaneous databases

NextBioi 281126.
PROi Q9WVC3.
SOURCEi Search...

Gene expression databases

Bgeei Q9WVC3.
CleanExi MM_CAV2.
ExpressionAtlasi Q9WVC3. baseline and differential.
Genevestigatori Q9WVC3.

Family and domain databases

InterProi IPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view ]
PANTHERi PTHR10844. PTHR10844. 1 hit.
Pfami PF01146. Caveolin. 1 hit.
[Graphical view ]
PROSITEi PS01210. CAVEOLIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo."
    Das K., Lewis R.Y., Scherer P.E., Lisanti M.P.
    J. Biol. Chem. 274:18721-18728(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 3T3-L1.
  2. "Identification of mouse caveolin-2 mRNA variant."
    Kogo H., Ishiguro K., Kuwaki S., Fujimoto T.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Inner ear, Lung and Tongue.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  5. "Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1."
    Lee H., Park D.S., Wang X.B., Scherer P.E., Schwartz P.E., Lisanti M.P.
    J. Biol. Chem. 277:34556-34567(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-19.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCAV2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVC3
Secondary accession number(s): Q3TYR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3