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Q9WVC0

- SEPT7_RAT

UniProt

Q9WVC0 - SEPT7_RAT

Protein

Septin-7

Gene

Sept7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei89 – 891GTPBy similarity
    Binding sitei115 – 1151GTP; via amide nitrogenBy similarity
    Binding sitei249 – 2491GTP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei264 – 2641GTPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi56 – 638GTPBy similarity
    Nucleotide bindingi194 – 2029GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cilium morphogenesis Source: UniProtKB
    2. mitotic nuclear division Source: UniProtKB-KW
    3. regulation of embryonic cell shape Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Septin-7
    Alternative name(s):
    CDC10 protein homolog
    Gene namesi
    Name:Sept7
    Synonyms:Cdc10
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620469. Sept7.

    Subcellular locationi

    Cytoplasm 1 Publication. Chromosomecentromerekinetochore By similarity. Cytoplasmcytoskeletonspindle By similarity. Cleavage furrow By similarity. Midbody By similarity. Cytoplasmcytoskeletoncilium axoneme By similarity
    Note: Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase By similarity. Associated with actin stress fibers. According to PubMed:15485874, also found in the nucleus.By similarity

    GO - Cellular componenti

    1. axoneme Source: UniProtKB
    2. cleavage furrow Source: UniProtKB-SubCell
    3. condensed chromosome kinetochore Source: UniProtKB-SubCell
    4. membrane Source: RGD
    5. midbody Source: UniProtKB-SubCell
    6. septin complex Source: InterPro
    7. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Centromere, Chromosome, Cilium, Cytoplasm, Cytoskeleton, Kinetochore

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 436435Septin-7PRO_0000173532Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei29 – 291PhosphotyrosineBy similarity
    Modified residuei333 – 3331PhosphoserineBy similarity
    Modified residuei372 – 3721N6-acetyllysineBy similarity
    Modified residuei423 – 4231PhosphoserineBy similarity
    Modified residuei425 – 4251PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ9WVC0.
    PRIDEiQ9WVC0.

    PTM databases

    PhosphoSiteiQ9WVC0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9WVC0.

    Interactioni

    Subunit structurei

    Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT6, while interaction with SEPT2 seems indirect. In the absence of SEPT6, forms homodimers. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPT2, SEPT6 and SEPT7. Interacts with SEPT5, SEPT8, SEPT9 and SEPT11 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi249132. 3 interactions.
    IntActiQ9WVC0. 3 interactions.
    MINTiMINT-4569549.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVC0.
    SMRiQ9WVC0. Positions 33-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 315270Septin-type GAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili331 – 436106Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5019.
    HOVERGENiHBG065093.
    InParanoidiQ9WVC0.
    KOiK16944.
    PhylomeDBiQ9WVC0.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR000038. Cell_div_GTP-bd.
    IPR027417. P-loop_NTPase.
    IPR016491. Septin.
    IPR008115. Septin7.
    [Graphical view]
    PANTHERiPTHR18884. PTHR18884. 1 hit.
    PfamiPF00735. Septin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006698. Septin. 1 hit.
    PRINTSiPR01742. SEPTIN7.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51719. G_SEPTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WVC0-1 [UniParc]FASTAAdd to Basket

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    MSVSARSAAA EERSVNCSTM AQPKNLEGYV GFANLPNQVY RKSVKRGFEF    50
    TLMVVGESGL GKSTLINSLF LTDLYSPEYP GPSHRIKKTV QVEQSKVLIK 100
    EGGVQLLLTI VDTPGFGDAV DNSNCWQPVI DYIDSKFEDY LNAESRVNRR 150
    QMPDNRVQCC LYFIAPSGHG LKPLDIEFMK RLHEKVNIIP LIAKADTLTP 200
    EECQQFKKQI MKEIQGHKIK IYEFPETDDE EENKLVKKIK DRLPLAVVGS 250
    NTIIEVNGKR VRGRQYPWGV AEVENGEHCD FTILRNMLIR THMQDLKDVT 300
    NNVHYENYRS RKLAAVTYNG VDNNKNKGQL TKSPLAQMEE ERREHVAKMK 350
    KMEMEMEQVF EMKVKEKVQK LKDSEAELQR RHEQMKKNLE AQHKELEEKR 400
    RQFEEEKANW EAQQRILEQQ NSSRTLEKNK KKGKIF 436
    Length:436
    Mass (Da):50,508
    Last modified:November 1, 1999 - v1
    Checksum:i666DC3C1F0880404
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF142759 mRNA. Translation: AAD37861.1.
    RefSeqiNP_072138.2. NM_022616.2.
    UniGeneiRn.48701.

    Genome annotation databases

    GeneIDi64551.
    KEGGirno:64551.
    UCSCiRGD:620469. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF142759 mRNA. Translation: AAD37861.1 .
    RefSeqi NP_072138.2. NM_022616.2.
    UniGenei Rn.48701.

    3D structure databases

    ProteinModelPortali Q9WVC0.
    SMRi Q9WVC0. Positions 33-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249132. 3 interactions.
    IntActi Q9WVC0. 3 interactions.
    MINTi MINT-4569549.

    PTM databases

    PhosphoSitei Q9WVC0.

    Proteomic databases

    PaxDbi Q9WVC0.
    PRIDEi Q9WVC0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 64551.
    KEGGi rno:64551.
    UCSCi RGD:620469. rat.

    Organism-specific databases

    CTDi 989.
    RGDi 620469. Sept7.

    Phylogenomic databases

    eggNOGi COG5019.
    HOVERGENi HBG065093.
    InParanoidi Q9WVC0.
    KOi K16944.
    PhylomeDBi Q9WVC0.

    Miscellaneous databases

    NextBioi 613444.
    PROi Q9WVC0.

    Gene expression databases

    Genevestigatori Q9WVC0.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR000038. Cell_div_GTP-bd.
    IPR027417. P-loop_NTPase.
    IPR016491. Septin.
    IPR008115. Septin7.
    [Graphical view ]
    PANTHERi PTHR18884. PTHR18884. 1 hit.
    Pfami PF00735. Septin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006698. Septin. 1 hit.
    PRINTSi PR01742. SEPTIN7.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51719. G_SEPTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of postsynaptic density proteins by MALDI-TOF mass spectrometry (Abstract #713.1)."
      Walikonis R.S., Jensen O., Mann M., Kennedy M.B.
      Abstr. - Soc. Neurosci. 24:1801-1801(1998)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. Lubec G., Kang S.U.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 137-146 AND 186-194, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    3. "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11."
      Nagata K., Asano T., Nozawa Y., Inagaki M.
      J. Biol. Chem. 279:55895-55904(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SEPT2; SEPT7; SEPT8; SEPT9 AND SEPT11.

    Entry informationi

    Entry nameiSEPT7_RAT
    AccessioniPrimary (citable) accession number: Q9WVC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Coordinated expression with SEPT2 and SEPT6.By similarity

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3