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Q9WVC0

- SEPT7_RAT

UniProt

Q9WVC0 - SEPT7_RAT

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Protein

Septin-7

Gene

Sept7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891GTPBy similarity
Binding sitei115 – 1151GTP; via amide nitrogenBy similarity
Binding sitei249 – 2491GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei264 – 2641GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 638GTPBy similarity
Nucleotide bindingi194 – 2029GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. cilium morphogenesis Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB-KW
  3. regulation of embryonic cell shape Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-7
Alternative name(s):
CDC10 protein homolog
Gene namesi
Name:Sept7
Synonyms:Cdc10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620469. Sept7.

Subcellular locationi

Cytoplasm 1 Publication. Chromosomecentromerekinetochore By similarity. Cytoplasmcytoskeletonspindle By similarity. Cleavage furrow By similarity. Midbody By similarity. Cytoplasmcytoskeletoncilium axoneme By similarity
Note: Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase (By similarity). Associated with actin stress fibers. According to PubMed:15485874, also found in the nucleus.By similarity

GO - Cellular componenti

  1. axoneme Source: UniProtKB
  2. kinetochore Source: UniProtKB-KW
  3. membrane Source: RGD
  4. septin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Centromere, Chromosome, Cilium, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 436435Septin-7PRO_0000173532Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei29 – 291PhosphotyrosineBy similarity
Modified residuei333 – 3331PhosphoserineBy similarity
Modified residuei372 – 3721N6-acetyllysineBy similarity
Modified residuei423 – 4231PhosphoserineBy similarity
Modified residuei425 – 4251PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9WVC0.
PRIDEiQ9WVC0.

PTM databases

PhosphoSiteiQ9WVC0.

Expressioni

Gene expression databases

GenevestigatoriQ9WVC0.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT6, while interaction with SEPT2 seems indirect. In the absence of SEPT6, forms homodimers. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPT2, SEPT6 and SEPT7. Interacts with SEPT5, SEPT8, SEPT9 and SEPT11 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249132. 3 interactions.
IntActiQ9WVC0. 3 interactions.
MINTiMINT-4569549.

Structurei

3D structure databases

ProteinModelPortaliQ9WVC0.
SMRiQ9WVC0. Positions 33-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 315270Septin-type GAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili331 – 436106Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5019.
HOVERGENiHBG065093.
InParanoidiQ9WVC0.
KOiK16944.
PhylomeDBiQ9WVC0.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008115. Septin7.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
PRINTSiPR01742. SEPTIN7.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVC0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVSARSAAA EERSVNCSTM AQPKNLEGYV GFANLPNQVY RKSVKRGFEF
60 70 80 90 100
TLMVVGESGL GKSTLINSLF LTDLYSPEYP GPSHRIKKTV QVEQSKVLIK
110 120 130 140 150
EGGVQLLLTI VDTPGFGDAV DNSNCWQPVI DYIDSKFEDY LNAESRVNRR
160 170 180 190 200
QMPDNRVQCC LYFIAPSGHG LKPLDIEFMK RLHEKVNIIP LIAKADTLTP
210 220 230 240 250
EECQQFKKQI MKEIQGHKIK IYEFPETDDE EENKLVKKIK DRLPLAVVGS
260 270 280 290 300
NTIIEVNGKR VRGRQYPWGV AEVENGEHCD FTILRNMLIR THMQDLKDVT
310 320 330 340 350
NNVHYENYRS RKLAAVTYNG VDNNKNKGQL TKSPLAQMEE ERREHVAKMK
360 370 380 390 400
KMEMEMEQVF EMKVKEKVQK LKDSEAELQR RHEQMKKNLE AQHKELEEKR
410 420 430
RQFEEEKANW EAQQRILEQQ NSSRTLEKNK KKGKIF
Length:436
Mass (Da):50,508
Last modified:November 1, 1999 - v1
Checksum:i666DC3C1F0880404
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142759 mRNA. Translation: AAD37861.1.
RefSeqiNP_072138.2. NM_022616.2.
UniGeneiRn.48701.

Genome annotation databases

GeneIDi64551.
KEGGirno:64551.
UCSCiRGD:620469. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142759 mRNA. Translation: AAD37861.1 .
RefSeqi NP_072138.2. NM_022616.2.
UniGenei Rn.48701.

3D structure databases

ProteinModelPortali Q9WVC0.
SMRi Q9WVC0. Positions 33-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249132. 3 interactions.
IntActi Q9WVC0. 3 interactions.
MINTi MINT-4569549.

PTM databases

PhosphoSitei Q9WVC0.

Proteomic databases

PaxDbi Q9WVC0.
PRIDEi Q9WVC0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 64551.
KEGGi rno:64551.
UCSCi RGD:620469. rat.

Organism-specific databases

CTDi 989.
RGDi 620469. Sept7.

Phylogenomic databases

eggNOGi COG5019.
HOVERGENi HBG065093.
InParanoidi Q9WVC0.
KOi K16944.
PhylomeDBi Q9WVC0.

Miscellaneous databases

NextBioi 613444.
PROi Q9WVC0.

Gene expression databases

Genevestigatori Q9WVC0.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008115. Septin7.
[Graphical view ]
PANTHERi PTHR18884. PTHR18884. 1 hit.
Pfami PF00735. Septin. 1 hit.
[Graphical view ]
PIRSFi PIRSF006698. Septin. 1 hit.
PRINTSi PR01742. SEPTIN7.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51719. G_SEPTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of postsynaptic density proteins by MALDI-TOF mass spectrometry (Abstract #713.1)."
    Walikonis R.S., Jensen O., Mann M., Kennedy M.B.
    Abstr. - Soc. Neurosci. 24:1801-1801(1998)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 137-146 AND 186-194, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  3. "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11."
    Nagata K., Asano T., Nozawa Y., Inagaki M.
    J. Biol. Chem. 279:55895-55904(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SEPT2; SEPT7; SEPT8; SEPT9 AND SEPT11.

Entry informationi

Entry nameiSEPT7_RAT
AccessioniPrimary (citable) accession number: Q9WVC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Coordinated expression with SEPT2 and SEPT6.By similarity

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3