Septin-7 - Rattus norvegicus (Rat)

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Q9WVC0 (SEPT7_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 95. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Septin-7

Alternative name(s):
CDC10 protein homolog

Gene names

Name:	Sept7
Synonyms:	Cdc10

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements By similarity.
Subunit structure	Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT6, while interaction with SEPT2 seems indirect. In the absence of SEPT6, forms homodimers. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPT2, SEPT6 and SEPT7. Interacts with SEPT5, SEPT8, SEPT9 and SEPT11 By similarity. Ref.3
Subcellular location	Cytoplasm. Chromosome › centromere › kinetochore By similarity. Cytoplasm › cytoskeleton › spindle By similarity. Cleavage furrow By similarity. Midbody By similarity. Cytoplasm › cytoskeleton › cilium axoneme By similarity. Note: Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase By similarity. Associated with actin stress fibers. According to Ref.3, also found in the nucleus. Ref.3
Miscellaneous	Coordinated expression with SEPT2 and SEPT6 By similarity.
Sequence similarities	Belongs to the septin family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cell projection Centromere Chromosome Cilium Cytoplasm Cytoskeleton Kinetochore
Domain	Coiled coil
Ligand	GTP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW cilium morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB mitosis Inferred from electronic annotation. Source: UniProtKB-KW regulation of embryonic cell shape Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cilium axoneme Inferred from sequence or structural similarity. Source: UniProtKB cleavage furrow Inferred from electronic annotation. Source: UniProtKB-SubCell condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from direct assay PubMed 10818142. Source: RGD midbody Inferred from electronic annotation. Source: UniProtKB-SubCell septin complex Inferred from electronic annotation. Source: InterPro spindle Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 436

436

Septin-7

PRO_0000173532

Regions

Nucleotide binding

56 – 63

GTP By similarity

Nucleotide binding

194 – 202

GTP By similarity

Coiled coil

331 – 436

106

Potential

Sites

Binding site

GTP By similarity

Binding site

115

GTP; via amide nitrogen By similarity

Binding site

249

GTP; via amide nitrogen and carbonyl oxygen By similarity

Binding site

264

GTP By similarity

Amino acid modifications

Modified residue

Phosphotyrosine By similarity

Modified residue

227

Phosphothreonine By similarity

Modified residue

333

Phosphoserine By similarity

Modified residue

423

Phosphoserine By similarity

Modified residue

425

Phosphothreonine Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

Q9WVC0 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 666DC3C1F0880404
Show »

FASTA

436

50,508

        10         20         30         40         50         60 
MSVSARSAAA EERSVNCSTM AQPKNLEGYV GFANLPNQVY RKSVKRGFEF TLMVVGESGL 

        70         80         90        100        110        120 
GKSTLINSLF LTDLYSPEYP GPSHRIKKTV QVEQSKVLIK EGGVQLLLTI VDTPGFGDAV 

       130        140        150        160        170        180 
DNSNCWQPVI DYIDSKFEDY LNAESRVNRR QMPDNRVQCC LYFIAPSGHG LKPLDIEFMK 

       190        200        210        220        230        240 
RLHEKVNIIP LIAKADTLTP EECQQFKKQI MKEIQGHKIK IYEFPETDDE EENKLVKKIK 

       250        260        270        280        290        300 
DRLPLAVVGS NTIIEVNGKR VRGRQYPWGV AEVENGEHCD FTILRNMLIR THMQDLKDVT 

       310        320        330        340        350        360 
NNVHYENYRS RKLAAVTYNG VDNNKNKGQL TKSPLAQMEE ERREHVAKMK KMEMEMEQVF 

       370        380        390        400        410        420 
EMKVKEKVQK LKDSEAELQR RHEQMKKNLE AQHKELEEKR RQFEEEKANW EAQQRILEQQ 

       430 
NSSRTLEKNK KKGKIF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of postsynaptic density proteins by MALDI-TOF mass spectrometry (Abstract #713.1)." Walikonis R.S., Jensen O., Mann M., Kennedy M.B. Abstr. - Soc. Neurosci. 24:1801-1801(1998) Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.
[2]	Lubec G., Kang S.U. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 137-146 AND 186-194, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Brain.
[3]	"Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11." Nagata K., Asano T., Nozawa Y., Inagaki M. J. Biol. Chem. 279:55895-55904(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SEPT2; SEPT7; SEPT8; SEPT9 AND SEPT11.
[4]	"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites." Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A. Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-425, MASS SPECTROMETRY. Tissue: Renal collecting duct.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF142759 mRNA. Translation: AAD37861.1.
IPI	IPI00884567.
RefSeq	NP_072138.2. NM_022616.2.
UniGene	Rn.48701.
3D structure databases
ProteinModelPortal	Q9WVC0.
SMR	Q9WVC0. Positions 33-314.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9WVC0. 2 interactions.
PTM databases
PhosphoSite	Q9WVC0.
Proteomic databases
PaxDb	Q9WVC0.
PRIDE	Q9WVC0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	64551.
KEGG	rno:64551.
UCSC	RGD:620469. rat.
Organism-specific databases
CTD	989.
RGD	620469. Sept7.
Phylogenomic databases
eggNOG	COG5019.
HOVERGEN	HBG065093.
InParanoid	Q9WVC0.
Gene expression databases
ArrayExpress	Q9WVC0.
Genevestigator	Q9WVC0.
GermOnline	ENSRNOG00000006545. Rattus norvegicus.
Family and domain databases
InterPro	IPR000038. Cell_div_GTP-bd. IPR016491. Septin. IPR008115. Septin7. [Graphical view]
PANTHER	PTHR18884. PTHR18884. 1 hit.
Pfam	PF00735. Septin. 1 hit. [Graphical view]
PIRSF	PIRSF006698. Septin. 1 hit.
PRINTS	PR01742. SEPTIN7.
ProtoNet	Search...
Other
NextBio	613444.

Entry information

Entry name

SEPT7_RAT

Accession

Primary (citable) accession number: Q9WVC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents