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Q9WVB9

- DVL1_RAT

UniProt

Q9WVB9 - DVL1_RAT

Protein

Segment polarity protein dishevelled homolog DVL-1

Gene

Dvl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. protein kinase binding Source: RGD
    3. Rac GTPase binding Source: RGD
    4. signal transducer activity Source: InterPro

    GO - Biological processi

    1. axon extension Source: RefGenome
    2. axon guidance Source: RefGenome
    3. canonical Wnt signaling pathway Source: RefGenome
    4. cochlea morphogenesis Source: RefGenome
    5. collateral sprouting Source: RefGenome
    6. convergent extension Source: RefGenome
    7. convergent extension involved in neural plate elongation Source: Ensembl
    8. cytoplasmic microtubule organization Source: Ensembl
    9. dendrite morphogenesis Source: RefGenome
    10. intracellular signal transduction Source: InterPro
    11. negative regulation of protein binding Source: Ensembl
    12. negative regulation of protein kinase activity Source: Ensembl
    13. neural tube development Source: Ensembl
    14. neurotransmitter secretion Source: Ensembl
    15. planar cell polarity pathway involved in neural tube closure Source: RefGenome
    16. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    17. positive regulation of neuron projection development Source: Ensembl
    18. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
    19. positive regulation of transcription, DNA-templated Source: RefGenome
    20. prepulse inhibition Source: Ensembl
    21. protein localization to microtubule Source: Ensembl
    22. protein localization to nucleus Source: Ensembl
    23. regulation of signaling Source: RefGenome
    24. skeletal muscle acetylcholine-gated channel clustering Source: RefGenome
    25. social behavior Source: Ensembl
    26. transcription from RNA polymerase II promoter Source: Ensembl
    27. Wnt signaling pathway Source: RGD

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_205007. WNT mediated activation of DVL.
    REACT_206488. degradation of DVL.
    REACT_212065. TCF dependent signaling in response to WNT.
    REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Segment polarity protein dishevelled homolog DVL-1
    Short name:
    Dishevelled-1
    Alternative name(s):
    DSH homolog 1
    Gene namesi
    Name:Dvl1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi620632. Dvl1.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytosol By similarity. Cytoplasmic vesicle By similarity
    Note: Localizes at the cell membrane upon interaction with frizzled family members.By similarity

    GO - Cellular componenti

    1. axon Source: RGD
    2. cell cortex Source: RefGenome
    3. clathrin-coated vesicle Source: RefGenome
    4. cytosol Source: UniProtKB-SubCell
    5. dendrite Source: RGD
    6. growth cone Source: RGD
    7. lateral plasma membrane Source: Ensembl
    8. microtubule cytoskeleton Source: MGI
    9. neuronal cell body Source: RGD
    10. synapse Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 695695Segment polarity protein dishevelled homolog DVL-1PRO_0000145745Add
    BLAST

    Post-translational modificationi

    Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ9WVB9.
    PRIDEiQ9WVB9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9WVB9.

    Interactioni

    Subunit structurei

    Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts (via PDZ domain) with NXN. Interacts with CXXC4. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD. Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site. Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering. Interacts (via PDZ domain) with TMEM88 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi249815. 5 interactions.
    IntActiQ9WVB9. 1 interaction.
    STRINGi10116.ENSRNOP00000026439.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVB9.
    SMRiQ9WVB9. Positions 251-345, 406-499.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8585DIXPROSITE-ProRule annotationAdd
    BLAST
    Domaini251 – 32373PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini425 – 49975DEPPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The DIX domain promotes homooligomerization.By similarity
    The DEP domain mediates interaction with the cell membrane.By similarity

    Sequence similaritiesi

    Belongs to the DSH family.Curated
    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG322275.
    GeneTreeiENSGT00390000013552.
    HOGENOMiHOG000017084.
    HOVERGENiHBG005542.
    InParanoidiQ9WVB9.
    KOiK02353.
    OMAiYPRYGMS.
    OrthoDBiEOG7BP82N.
    PhylomeDBiQ9WVB9.
    TreeFamiTF318198.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR008340. Dishevelled_1.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF5. PTHR10878:SF5. 1 hit.
    PfamiPF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    PRINTSiPR01760. DISHEVELLED.
    SMARTiSM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WVB9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK    50
    SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT 100
    DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR 150
    RNRDEAARTN GHPRGDRRRE LGLPPDSAST VLSSELESSS FIDSDEEDNT 200
    SRLSSSTEQS TSSRLIRKHK CRRRKQRLRQ TDRASSFSSI TDSTMSLNII 250
    TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 300
    LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTIP 350
    RADPVRPIDP AAWLSHTAAL TGALPRYGTS PCSSAITRTS SSSLTSSVPG 400
    APQLEEAPLT VKSDMSAIVR VMQLPDSGLE IRDRMWLKIT IANAVIGADV 450
    VDWLYTHVEG FKERREARKY ASSMLKHGFL RHTVNKITFS EQCYYVFGDL 500
    CSNLASLNLN SGSSGASDQD TLAPLPHPSV PWPLGQGYPY QYPGPPPCFP 550
    PAYQDPGFSY GSGSAGSQQS EGSKSSGSTR SSHRTPGREE RRATGAGGSG 600
    SESDHTVPSG SGSTGWWERP VSQLSRGSSP RSQASAVAPG LPPLHPLTKA 650
    YAVVGGPPGG PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM 695
    Length:695
    Mass (Da):75,447
    Last modified:March 27, 2002 - v3
    Checksum:iEEC4AA99A117D22A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF143545 mRNA. Translation: AAD33896.2.
    AF143546 mRNA. Translation: AAD33897.2.
    AF143548, AF143547 Genomic DNA. Translation: AAD41492.2.
    AF143550, AF143549 Genomic DNA. Translation: AAD41493.1.
    RefSeqiNP_114008.1. NM_031820.1.
    UniGeneiRn.144610.

    Genome annotation databases

    EnsembliENSRNOT00000026439; ENSRNOP00000026439; ENSRNOG00000019423.
    GeneIDi83721.
    KEGGirno:83721.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF143545 mRNA. Translation: AAD33896.2 .
    AF143546 mRNA. Translation: AAD33897.2 .
    AF143548 , AF143547 Genomic DNA. Translation: AAD41492.2 .
    AF143550 , AF143549 Genomic DNA. Translation: AAD41493.1 .
    RefSeqi NP_114008.1. NM_031820.1.
    UniGenei Rn.144610.

    3D structure databases

    ProteinModelPortali Q9WVB9.
    SMRi Q9WVB9. Positions 251-345, 406-499.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249815. 5 interactions.
    IntActi Q9WVB9. 1 interaction.
    STRINGi 10116.ENSRNOP00000026439.

    Proteomic databases

    PaxDbi Q9WVB9.
    PRIDEi Q9WVB9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026439 ; ENSRNOP00000026439 ; ENSRNOG00000019423 .
    GeneIDi 83721.
    KEGGi rno:83721.

    Organism-specific databases

    CTDi 1855.
    RGDi 620632. Dvl1.

    Phylogenomic databases

    eggNOGi NOG322275.
    GeneTreei ENSGT00390000013552.
    HOGENOMi HOG000017084.
    HOVERGENi HBG005542.
    InParanoidi Q9WVB9.
    KOi K02353.
    OMAi YPRYGMS.
    OrthoDBi EOG7BP82N.
    PhylomeDBi Q9WVB9.
    TreeFami TF318198.

    Enzyme and pathway databases

    Reactomei REACT_205007. WNT mediated activation of DVL.
    REACT_206488. degradation of DVL.
    REACT_212065. TCF dependent signaling in response to WNT.
    REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Miscellaneous databases

    NextBioi 616297.
    PROi Q9WVB9.

    Gene expression databases

    Genevestigatori Q9WVB9.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR008340. Dishevelled_1.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF5. PTHR10878:SF5. 1 hit.
    Pfami PF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    PRINTSi PR01760. DISHEVELLED.
    SMARTi SM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping and sequencing rat dishevelled-1: a candidate gene for cerebral ischaemic insult in a rat model of stroke."
      de Lange R.P.J., Burr K., Clark J.S., Negrin C.D., Brosnan M.J., St Clair D.M., Dominiczak A.F., Shaw D.J.
      Neurogenetics 3:99-106(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: Wistar Kyoto.
    2. "Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein."
      Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A.
      Mol. Cell. Biol. 21:330-342(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CXXC4.

    Entry informationi

    Entry nameiDVL1_RAT
    AccessioniPrimary (citable) accession number: Q9WVB9
    Secondary accession number(s): Q9QUG5, Q9WVB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3