Reviewed, UniProtKB/Swiss-Prot Q9WVB9 (DVL1_RAT)

Names and origin

Protein names

Recommended name:
    Segment polarity protein dishevelled homolog DVL-1
      Short name=Dishevelled-1
Alternative name(s):
    DSH homolog 1

Gene names

Name:

Dvl1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	695 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in the signal transduction pathway mediated by multiple Wnt genes.
Subunit structure	Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts (via PDZ domain) with NXN By similarity. Interacts with CXXC4.
Subcellular location	Cytoplasm Potential.
Post-translational modification	Ubiquitinated, leading to its subsequent degradation by the ubiquitin-proteasome. The interaction with INVS is required for ubiquitination By similarity.
Sequence similarities	Belongs to the DSH family. Contains 1 DEP domain. Contains 1 DIX domain. Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm
Molecular function	Developmental protein
PTM	Phosphoprotein Ubl conjugation
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Ref.1 Traceable author statement. Source: RGD intracellular signaling cascade Inferred from electronic annotation. Source: InterPro
Cellular component	axon Inferred from direct assay. Source: RGD cell soma Inferred from direct assay. Source: RGD dendrite Inferred from direct assay. Source: RGD growth cone Inferred from direct assay. Source: RGD microtubule cytoskeleton Inferred from direct assay. Source: MGI
Molecular function	Rac GTPase binding Inferred from physical interaction. Source: RGD protein kinase binding Inferred from physical interaction. Source: RGD signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 695	695	Segment polarity protein dishevelled homolog DVL-1		PRO_0000145745
Regions
	Domain	1 – 85	85	DIX
	Domain	251 – 323	73	PDZ
	Domain	425 – 499	75	DEP
Amino acid modifications
	Modified residue	559	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9WVB9-1 [UniParc]. Last modified March 27, 2002. Version 3. Checksum: EEC4AA99A117D22A	FASTA	695	75,447
	10 20 30 40 50 60 MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK SMDQDFGVVK 70 80 90 100 110 120 EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT DLPPPLERTG GIGDSRPPSF 130 140 150 160 170 180 HPNVASSRDG MDNETGTESM VSHRRERARR RNRDEAARTN GHPRGDRRRE LGLPPDSAST 190 200 210 220 230 240 VLSSELESSS FIDSDEEDNT SRLSSSTEQS TSSRLIRKHK CRRRKQRLRQ TDRASSFSSI 250 260 270 280 290 300 TDSTMSLNII TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 310 320 330 340 350 360 LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTIP RADPVRPIDP 370 380 390 400 410 420 AAWLSHTAAL TGALPRYGTS PCSSAITRTS SSSLTSSVPG APQLEEAPLT VKSDMSAIVR 430 440 450 460 470 480 VMQLPDSGLE IRDRMWLKIT IANAVIGADV VDWLYTHVEG FKERREARKY ASSMLKHGFL 490 500 510 520 530 540 RHTVNKITFS EQCYYVFGDL CSNLASLNLN SGSSGASDQD TLAPLPHPSV PWPLGQGYPY 550 560 570 580 590 600 QYPGPPPCFP PAYQDPGFSY GSGSAGSQQS EGSKSSGSTR SSHRTPGREE RRATGAGGSG 610 620 630 640 650 660 SESDHTVPSG SGSTGWWERP VSQLSRGSSP RSQASAVAPG LPPLHPLTKA YAVVGGPPGG 670 680 690 PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM

References

[1]	"Mapping and sequencing rat dishevelled-1: a candidate gene for cerebral ischaemic insult in a rat model of stroke." de Lange R.P.J., Burr K., Clark J.S., Negrin C.D., Brosnan M.J., St Clair D.M., Dominiczak A.F., Shaw D.J. Neurogenetics 3:99-106(2001) [PubMed: 11354832] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: Wistar Kyoto.
[2]	"Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein." Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A. Mol. Cell. Biol. 21:330-342(2001) [PubMed: 11113207] [Abstract] Cited for: INTERACTION WITH CXXC4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF143545 mRNA. Translation: AAD33896.2. AF143546 mRNA. Translation: AAD33897.2. AF143548, AF143547 Genomic DNA. Translation: AAD41492.2. AF143550, AF143549 Genomic DNA. Translation: AAD41493.1.
IPI	IPI00204871.
RefSeq	NP_114008.1.
UniGene	Rn.144610
3D structure databases
HSSP	HSSP built from PDB template 1FSH based on UniProtKB P51141.
SMR	Q9WVB9. Positions 249-337.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9WVB9.
Proteomic databases
PRIDE	Q9WVB9.
Genome annotation databases
Ensembl	ENSRNOT00000026439; ENSRNOP00000026439; ENSRNOG00000019423; Rattus norvegicus. [Genome view]
GeneID	83721.
KEGG	rno:83721.
UCSC	NM_031820. rat.
Organism-specific databases
CTD	83721.
RGD	620632. Dvl1.
Phylogenomic databases
HOVERGEN	Q9WVB9.
OMA	SMLKHGF.
Gene expression databases
ArrayExpress	Q9WVB9.
Genevestigator	Q9WVB9.
GermOnline	ENSRNOG00000019423. Rattus norvegicus.
Family and domain databases
InterPro	IPR008339. Dishevell. IPR003351. Dishevelled. IPR008340. Dishevelled_1. IPR001158. DIX. IPR015506. Dsh. IPR001478. PDZ/DHR/GLGF. IPR000591. Pleckstrin/G-protein_interact. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PANTHER	PTHR10878:SF5. Dishevelled_1. 1 hit. PTHR10878. Dsh. 1 hit.
Pfam	PF00610. DEP. 1 hit. PF02377. Dishevelled. 1 hit. PF00778. DIX. 1 hit. PF00595. PDZ. 1 hit. [Graphical view]
PRINTS	PR01760. DISHEVELLED. PR01761. DISHEVELLED1.
ProDom	PD003639. DIX. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00021. DAX. 1 hit. SM00049. DEP. 1 hit. SM00228. PDZ. 1 hit. [Graphical view]
PROSITE	PS50186. DEP. 1 hit. PS50841. DIX. 1 hit. PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	616297.

Entry information

Entry name

DVL1_RAT

Accession

Primary (citable) accession number: Q9WVB9
Secondary accession number(s): Q9QUG5, Q9WVB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	March 27, 2002
Last modified:	November 3, 2009
This is version 80 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)