SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9WVB9

- DVL1_RAT

UniProt

Q9WVB9 - DVL1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Segment polarity protein dishevelled homolog DVL-1
Gene
Dvl1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) By similarity.

GO - Molecular functioni

  1. Rac GTPase binding Source: RGD
  2. frizzled binding Source: RefGenome
  3. protein kinase binding Source: RGD
  4. signal transducer activity Source: InterPro

GO - Biological processi

  1. Wnt signaling pathway Source: RGD
  2. axon extension Source: RefGenome
  3. axon guidance Source: RefGenome
  4. canonical Wnt signaling pathway Source: RefGenome
  5. cochlea morphogenesis Source: RefGenome
  6. collateral sprouting Source: RefGenome
  7. convergent extension Source: RefGenome
  8. convergent extension involved in neural plate elongation Source: Ensembl
  9. cytoplasmic microtubule organization Source: Ensembl
  10. dendrite morphogenesis Source: RefGenome
  11. intracellular signal transduction Source: InterPro
  12. negative regulation of protein binding Source: Ensembl
  13. negative regulation of protein kinase activity Source: Ensembl
  14. neural tube development Source: Ensembl
  15. neurotransmitter secretion Source: Ensembl
  16. planar cell polarity pathway involved in neural tube closure Source: RefGenome
  17. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  18. positive regulation of neuron projection development Source: Ensembl
  19. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  20. positive regulation of transcription, DNA-templated Source: RefGenome
  21. prepulse inhibition Source: Ensembl
  22. protein localization to microtubule Source: Ensembl
  23. protein localization to nucleus Source: Ensembl
  24. regulation of signaling Source: RefGenome
  25. skeletal muscle acetylcholine-gated channel clustering Source: RefGenome
  26. social behavior Source: Ensembl
  27. transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_205007. WNT mediated activation of DVL.
REACT_206488. degradation of DVL.
REACT_212065. TCF dependent signaling in response to WNT.
REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-1
Short name:
Dishevelled-1
Alternative name(s):
DSH homolog 1
Gene namesi
Name:Dvl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi620632. Dvl1.

Subcellular locationi

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmcytosol By similarity. Cytoplasmic vesicle By similarity
Note: Localizes at the cell membrane upon interaction with frizzled family members By similarity.

GO - Cellular componenti

  1. axon Source: RGD
  2. cell cortex Source: RefGenome
  3. clathrin-coated vesicle Source: RefGenome
  4. cytosol Source: UniProtKB-SubCell
  5. dendrite Source: RGD
  6. growth cone Source: RGD
  7. lateral plasma membrane Source: Ensembl
  8. microtubule cytoskeleton Source: MGI
  9. neuronal cell body Source: RGD
  10. synapse Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Segment polarity protein dishevelled homolog DVL-1
PRO_0000145745Add
BLAST

Post-translational modificationi

Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains By similarity.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9WVB9.
PRIDEiQ9WVB9.

Expressioni

Gene expression databases

GenevestigatoriQ9WVB9.

Interactioni

Subunit structurei

Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts (via PDZ domain) with NXN. Interacts with CXXC4. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD. Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site. Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering. Interacts (via PDZ domain) with TMEM88 By similarity.1 Publication

Protein-protein interaction databases

BioGridi249815. 5 interactions.
IntActiQ9WVB9. 1 interaction.
STRINGi10116.ENSRNOP00000026439.

Structurei

3D structure databases

ProteinModelPortaliQ9WVB9.
SMRiQ9WVB9. Positions 251-345, 406-499.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8585DIX
Add
BLAST
Domaini251 – 32373PDZ
Add
BLAST
Domaini425 – 49975DEP
Add
BLAST

Domaini

The DIX domain promotes homooligomerization By similarity.
The DEP domain mediates interaction with the cell membrane By similarity.

Sequence similaritiesi

Belongs to the DSH family.
Contains 1 DEP domain.
Contains 1 DIX domain.
Contains 1 PDZ (DHR) domain.

Phylogenomic databases

eggNOGiNOG322275.
GeneTreeiENSGT00390000013552.
HOGENOMiHOG000017084.
HOVERGENiHBG005542.
InParanoidiQ9WVB9.
KOiK02353.
OMAiYPRYGMS.
OrthoDBiEOG7BP82N.
PhylomeDBiQ9WVB9.
TreeFamiTF318198.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR008340. Dishevelled_1.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF5. PTHR10878:SF5. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVB9-1 [UniParc]FASTAAdd to Basket

« Hide

MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK    50
SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT 100
DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR 150
RNRDEAARTN GHPRGDRRRE LGLPPDSAST VLSSELESSS FIDSDEEDNT 200
SRLSSSTEQS TSSRLIRKHK CRRRKQRLRQ TDRASSFSSI TDSTMSLNII 250
TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 300
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTIP 350
RADPVRPIDP AAWLSHTAAL TGALPRYGTS PCSSAITRTS SSSLTSSVPG 400
APQLEEAPLT VKSDMSAIVR VMQLPDSGLE IRDRMWLKIT IANAVIGADV 450
VDWLYTHVEG FKERREARKY ASSMLKHGFL RHTVNKITFS EQCYYVFGDL 500
CSNLASLNLN SGSSGASDQD TLAPLPHPSV PWPLGQGYPY QYPGPPPCFP 550
PAYQDPGFSY GSGSAGSQQS EGSKSSGSTR SSHRTPGREE RRATGAGGSG 600
SESDHTVPSG SGSTGWWERP VSQLSRGSSP RSQASAVAPG LPPLHPLTKA 650
YAVVGGPPGG PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM 695
Length:695
Mass (Da):75,447
Last modified:March 27, 2002 - v3
Checksum:iEEC4AA99A117D22A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF143545 mRNA. Translation: AAD33896.2.
AF143546 mRNA. Translation: AAD33897.2.
AF143548, AF143547 Genomic DNA. Translation: AAD41492.2.
AF143550, AF143549 Genomic DNA. Translation: AAD41493.1.
RefSeqiNP_114008.1. NM_031820.1.
UniGeneiRn.144610.

Genome annotation databases

EnsembliENSRNOT00000026439; ENSRNOP00000026439; ENSRNOG00000019423.
GeneIDi83721.
KEGGirno:83721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF143545 mRNA. Translation: AAD33896.2 .
AF143546 mRNA. Translation: AAD33897.2 .
AF143548 , AF143547 Genomic DNA. Translation: AAD41492.2 .
AF143550 , AF143549 Genomic DNA. Translation: AAD41493.1 .
RefSeqi NP_114008.1. NM_031820.1.
UniGenei Rn.144610.

3D structure databases

ProteinModelPortali Q9WVB9.
SMRi Q9WVB9. Positions 251-345, 406-499.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249815. 5 interactions.
IntActi Q9WVB9. 1 interaction.
STRINGi 10116.ENSRNOP00000026439.

Proteomic databases

PaxDbi Q9WVB9.
PRIDEi Q9WVB9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026439 ; ENSRNOP00000026439 ; ENSRNOG00000019423 .
GeneIDi 83721.
KEGGi rno:83721.

Organism-specific databases

CTDi 1855.
RGDi 620632. Dvl1.

Phylogenomic databases

eggNOGi NOG322275.
GeneTreei ENSGT00390000013552.
HOGENOMi HOG000017084.
HOVERGENi HBG005542.
InParanoidi Q9WVB9.
KOi K02353.
OMAi YPRYGMS.
OrthoDBi EOG7BP82N.
PhylomeDBi Q9WVB9.
TreeFami TF318198.

Enzyme and pathway databases

Reactomei REACT_205007. WNT mediated activation of DVL.
REACT_206488. degradation of DVL.
REACT_212065. TCF dependent signaling in response to WNT.
REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Miscellaneous databases

NextBioi 616297.
PROi Q9WVB9.

Gene expression databases

Genevestigatori Q9WVB9.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR008340. Dishevelled_1.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10878. PTHR10878. 1 hit.
PTHR10878:SF5. PTHR10878:SF5. 1 hit.
Pfami PF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
PRINTSi PR01760. DISHEVELLED.
SMARTi SM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mapping and sequencing rat dishevelled-1: a candidate gene for cerebral ischaemic insult in a rat model of stroke."
    de Lange R.P.J., Burr K., Clark J.S., Negrin C.D., Brosnan M.J., St Clair D.M., Dominiczak A.F., Shaw D.J.
    Neurogenetics 3:99-106(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Wistar Kyoto.
  2. "Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein."
    Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A.
    Mol. Cell. Biol. 21:330-342(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CXXC4.

Entry informationi

Entry nameiDVL1_RAT
AccessioniPrimary (citable) accession number: Q9WVB9
Secondary accession number(s): Q9QUG5, Q9WVB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 27, 2002
Last modified: September 3, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi