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Q9WVB9

- DVL1_RAT

UniProt

Q9WVB9 - DVL1_RAT

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Protein

Segment polarity protein dishevelled homolog DVL-1

Gene

Dvl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity).By similarity

GO - Molecular functioni

  1. frizzled binding Source: RefGenome
  2. protein kinase binding Source: RGD
  3. Rac GTPase binding Source: RGD

GO - Biological processi

  1. axon extension Source: RefGenome
  2. axon guidance Source: RefGenome
  3. canonical Wnt signaling pathway Source: RefGenome
  4. cochlea morphogenesis Source: RefGenome
  5. collateral sprouting Source: RefGenome
  6. convergent extension Source: RefGenome
  7. convergent extension involved in neural plate elongation Source: Ensembl
  8. cytoplasmic microtubule organization Source: Ensembl
  9. dendrite morphogenesis Source: RefGenome
  10. intracellular signal transduction Source: InterPro
  11. negative regulation of protein binding Source: Ensembl
  12. negative regulation of protein kinase activity Source: Ensembl
  13. neural tube development Source: Ensembl
  14. neurotransmitter secretion Source: Ensembl
  15. planar cell polarity pathway involved in neural tube closure Source: RefGenome
  16. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  17. positive regulation of neuron projection development Source: Ensembl
  18. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  19. positive regulation of transcription, DNA-templated Source: RefGenome
  20. prepulse inhibition Source: Ensembl
  21. protein localization to microtubule Source: Ensembl
  22. protein localization to nucleus Source: Ensembl
  23. regulation of signaling Source: RefGenome
  24. skeletal muscle acetylcholine-gated channel clustering Source: RefGenome
  25. social behavior Source: Ensembl
  26. transcription from RNA polymerase II promoter Source: Ensembl
  27. Wnt signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_205007. WNT mediated activation of DVL.
REACT_206488. degradation of DVL.
REACT_212065. TCF dependent signaling in response to WNT.
REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-1
Short name:
Dishevelled-1
Alternative name(s):
DSH homolog 1
Gene namesi
Name:Dvl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi620632. Dvl1.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytosol By similarity. Cytoplasmic vesicle By similarity
Note: Localizes at the cell membrane upon interaction with frizzled family members.By similarity

GO - Cellular componenti

  1. axon Source: RGD
  2. cell cortex Source: RefGenome
  3. clathrin-coated vesicle Source: RefGenome
  4. dendrite Source: RGD
  5. growth cone Source: RGD
  6. lateral plasma membrane Source: Ensembl
  7. microtubule cytoskeleton Source: MGI
  8. neuronal cell body Source: RGD
  9. synapse Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Segment polarity protein dishevelled homolog DVL-1PRO_0000145745Add
BLAST

Post-translational modificationi

Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9WVB9.
PRIDEiQ9WVB9.

Expressioni

Gene expression databases

GenevestigatoriQ9WVB9.

Interactioni

Subunit structurei

Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts (via PDZ domain) with NXN. Interacts with CXXC4. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD. Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site. Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering. Interacts (via PDZ domain) with TMEM88 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249815. 5 interactions.
IntActiQ9WVB9. 1 interaction.
STRINGi10116.ENSRNOP00000026439.

Structurei

3D structure databases

ProteinModelPortaliQ9WVB9.
SMRiQ9WVB9. Positions 251-345, 406-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8585DIXPROSITE-ProRule annotationAdd
BLAST
Domaini251 – 32373PDZPROSITE-ProRule annotationAdd
BLAST
Domaini425 – 49975DEPPROSITE-ProRule annotationAdd
BLAST

Domaini

The DIX domain promotes homooligomerization.By similarity
The DEP domain mediates interaction with the cell membrane.By similarity

Sequence similaritiesi

Belongs to the DSH family.Curated
Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG322275.
GeneTreeiENSGT00390000013552.
HOGENOMiHOG000017084.
HOVERGENiHBG005542.
InParanoidiQ9WVB9.
KOiK02353.
OMAiYPRYGMS.
OrthoDBiEOG7BP82N.
PhylomeDBiQ9WVB9.
TreeFamiTF318198.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008340. DVL-1.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF5. PTHR10878:SF5. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVB9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK
60 70 80 90 100
SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT
110 120 130 140 150
DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR
160 170 180 190 200
RNRDEAARTN GHPRGDRRRE LGLPPDSAST VLSSELESSS FIDSDEEDNT
210 220 230 240 250
SRLSSSTEQS TSSRLIRKHK CRRRKQRLRQ TDRASSFSSI TDSTMSLNII
260 270 280 290 300
TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM
310 320 330 340 350
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTIP
360 370 380 390 400
RADPVRPIDP AAWLSHTAAL TGALPRYGTS PCSSAITRTS SSSLTSSVPG
410 420 430 440 450
APQLEEAPLT VKSDMSAIVR VMQLPDSGLE IRDRMWLKIT IANAVIGADV
460 470 480 490 500
VDWLYTHVEG FKERREARKY ASSMLKHGFL RHTVNKITFS EQCYYVFGDL
510 520 530 540 550
CSNLASLNLN SGSSGASDQD TLAPLPHPSV PWPLGQGYPY QYPGPPPCFP
560 570 580 590 600
PAYQDPGFSY GSGSAGSQQS EGSKSSGSTR SSHRTPGREE RRATGAGGSG
610 620 630 640 650
SESDHTVPSG SGSTGWWERP VSQLSRGSSP RSQASAVAPG LPPLHPLTKA
660 670 680 690
YAVVGGPPGG PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM
Length:695
Mass (Da):75,447
Last modified:March 27, 2002 - v3
Checksum:iEEC4AA99A117D22A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143545 mRNA. Translation: AAD33896.2.
AF143546 mRNA. Translation: AAD33897.2.
AF143548, AF143547 Genomic DNA. Translation: AAD41492.2.
AF143550, AF143549 Genomic DNA. Translation: AAD41493.1.
RefSeqiNP_114008.1. NM_031820.1.
UniGeneiRn.144610.

Genome annotation databases

EnsembliENSRNOT00000026439; ENSRNOP00000026439; ENSRNOG00000019423.
GeneIDi83721.
KEGGirno:83721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143545 mRNA. Translation: AAD33896.2 .
AF143546 mRNA. Translation: AAD33897.2 .
AF143548 , AF143547 Genomic DNA. Translation: AAD41492.2 .
AF143550 , AF143549 Genomic DNA. Translation: AAD41493.1 .
RefSeqi NP_114008.1. NM_031820.1.
UniGenei Rn.144610.

3D structure databases

ProteinModelPortali Q9WVB9.
SMRi Q9WVB9. Positions 251-345, 406-499.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249815. 5 interactions.
IntActi Q9WVB9. 1 interaction.
STRINGi 10116.ENSRNOP00000026439.

Proteomic databases

PaxDbi Q9WVB9.
PRIDEi Q9WVB9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026439 ; ENSRNOP00000026439 ; ENSRNOG00000019423 .
GeneIDi 83721.
KEGGi rno:83721.

Organism-specific databases

CTDi 1855.
RGDi 620632. Dvl1.

Phylogenomic databases

eggNOGi NOG322275.
GeneTreei ENSGT00390000013552.
HOGENOMi HOG000017084.
HOVERGENi HBG005542.
InParanoidi Q9WVB9.
KOi K02353.
OMAi YPRYGMS.
OrthoDBi EOG7BP82N.
PhylomeDBi Q9WVB9.
TreeFami TF318198.

Enzyme and pathway databases

Reactomei REACT_205007. WNT mediated activation of DVL.
REACT_206488. degradation of DVL.
REACT_212065. TCF dependent signaling in response to WNT.
REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Miscellaneous databases

NextBioi 616297.
PROi Q9WVB9.

Gene expression databases

Genevestigatori Q9WVB9.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008340. DVL-1.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10878. PTHR10878. 1 hit.
PTHR10878:SF5. PTHR10878:SF5. 1 hit.
Pfami PF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
PRINTSi PR01760. DISHEVELLED.
SMARTi SM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mapping and sequencing rat dishevelled-1: a candidate gene for cerebral ischaemic insult in a rat model of stroke."
    de Lange R.P.J., Burr K., Clark J.S., Negrin C.D., Brosnan M.J., St Clair D.M., Dominiczak A.F., Shaw D.J.
    Neurogenetics 3:99-106(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Wistar Kyoto.
  2. "Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein."
    Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A.
    Mol. Cell. Biol. 21:330-342(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CXXC4.

Entry informationi

Entry nameiDVL1_RAT
AccessioniPrimary (citable) accession number: Q9WVB9
Secondary accession number(s): Q9QUG5, Q9WVB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 27, 2002
Last modified: October 29, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3