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Protein

Transducin-like enhancer protein 2

Gene

Tle2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-201722. Formation of the beta-catenin:TCF transactivating complex.
R-MMU-3769402. Deactivation of the beta-catenin transactivating complex.
R-MMU-4641265. Repression of WNT target genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Transducin-like enhancer protein 2
Gene namesi
Name:Tle2
Synonyms:Grg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:104635. Tle2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 767767Transducin-like enhancer protein 2PRO_0000051279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei253 – 2531Phosphoserine; by CK2Sequence analysis
Modified residuei274 – 2741Phosphoserine; by CDK1Sequence analysis
Modified residuei278 – 2781Phosphothreonine; by CDK1Sequence analysis
Modified residuei306 – 3061PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated by XIAP/BIRC4.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9WVB2.
PaxDbiQ9WVB2.
PRIDEiQ9WVB2.

PTM databases

iPTMnetiQ9WVB2.
PhosphoSiteiQ9WVB2.

Expressioni

Gene expression databases

BgeeiQ9WVB2.
ExpressionAtlasiQ9WVB2. baseline and differential.
GenevisibleiQ9WVB2. MM.

Interactioni

Subunit structurei

Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121125.

Structurei

3D structure databases

ProteinModelPortaliQ9WVB2.
SMRiQ9WVB2. Positions 23-148, 439-767.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati479 – 51739WD 1Add
BLAST
Repeati525 – 56440WD 2Add
BLAST
Repeati569 – 60840WD 3Add
BLAST
Repeati611 – 65040WD 4Add
BLAST
Repeati693 – 73240WD 5Add
BLAST
Repeati734 – 76633WD 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 152152Q domainBy similarityAdd
BLAST
Regioni153 – 21563GP domainBy similarityAdd
BLAST
Regioni216 – 27964CcN domainBy similarityAdd
BLAST
Regioni280 – 447168SP domainBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi238 – 2425Nuclear localization signalSequence analysis

Domaini

WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.1 Publication

Sequence similaritiesi

Belongs to the WD repeat Groucho/TLE family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0639. Eukaryota.
ENOG410XPX3. LUCA.
GeneTreeiENSGT00550000074465.
HOGENOMiHOG000293211.
HOVERGENiHBG004689.
InParanoidiQ9WVB2.
OMAiICAQIVP.
PhylomeDBiQ9WVB2.
TreeFamiTF314167.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR005617. Groucho/TLE_N.
IPR009146. Groucho_enhance.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03920. TLE_N. 2 hits.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR01850. GROUCHOFAMLY.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPQGRHPTP LQSGQPFKFS VLEICDRIKE EFQFLQAQYH SLKLECEKLA
60 70 80 90 100
SEKTEMQRHY VMAAPHQCPQ GGTSYPHWPR LSPLQYYEMS YGLNIEMHKQ
110 120 130 140 150
AEIVKRLSAI CAQMVPFLTQ EHQQQVLQAV DRAKQVTVGE LNSLLGQQNQ
160 170 180 190 200
LQPLSHAPPV PLTPRPAGLV GAGATGLLAL SGALAAQAQL VAAVKEDRVG
210 220 230 240 250
VDAEGSRVDR AASRSSSPSP PESLVEEDHP SSRGGSGKQQ RAEDKDLSGP
260 270 280 290 300
YDSEEDKSDY NLVVDEDQPS EPPSPVTTPC GKAPLCIPAR RDLTDSPASL
310 320 330 340 350
ASSLGSPLPR SKDIALNDLP TGTPASRSCG TSPPQDSSTP GPSSASHLCQ
360 370 380 390 400
LAAQPAAPTD SIALRSPLTL SSPFTSSFSL GSHSTLNGDL SMPGSYVGLH
410 420 430 440 450
LSPQVSSSVV YGRSPLQMAF ESHPHLRGSS VSLPGIPVAK PAYSFHVSAD
460 470 480 490 500
GQMQPVPFPS DALVGTGIPR HARQLHTLAH GEVVCAVTIS SSTQHVYTGG
510 520 530 540 550
KGCVKVWDVG QPGSKTPVAQ LDCLNRDNYI RSCKLLPDGQ SLIVGGEAST
560 570 580 590 600
LSIWDLAAPT PRIKAELTSS APACYALAVS PDAKVCFSCC SDGNIVVWDL
610 620 630 640 650
QNQAMVRQFQ GHTDGASCID ISDYGTRLWT GGLDNTVRCW DLREGRQLQQ
660 670 680 690 700
HDFSSQIFSL GHCPNQDWLA VGMESSHVEV LHVRKPEKYQ LRLHESCVLS
710 720 730 740 750
LKFASCGRWF VSTGKDNLLN AWRTPYGASI FQSKESSSVL SCDISRNNKY
760
IVTGSGDKKA TVYEVVY
Length:767
Mass (Da):82,623
Last modified:November 1, 1999 - v1
Checksum:i2BECE931EE993C44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145958 mRNA. Translation: AAD37694.1.
CCDSiCCDS24063.1.
RefSeqiNP_062699.1. NM_019725.2.
XP_006513647.1. XM_006513584.2.
UniGeneiMm.38608.

Genome annotation databases

EnsembliENSMUST00000146358; ENSMUSP00000121125; ENSMUSG00000034771.
GeneIDi21886.
KEGGimmu:21886.
UCSCiuc007gis.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145958 mRNA. Translation: AAD37694.1.
CCDSiCCDS24063.1.
RefSeqiNP_062699.1. NM_019725.2.
XP_006513647.1. XM_006513584.2.
UniGeneiMm.38608.

3D structure databases

ProteinModelPortaliQ9WVB2.
SMRiQ9WVB2. Positions 23-148, 439-767.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121125.

PTM databases

iPTMnetiQ9WVB2.
PhosphoSiteiQ9WVB2.

Proteomic databases

EPDiQ9WVB2.
PaxDbiQ9WVB2.
PRIDEiQ9WVB2.

Protocols and materials databases

DNASUi21886.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000146358; ENSMUSP00000121125; ENSMUSG00000034771.
GeneIDi21886.
KEGGimmu:21886.
UCSCiuc007gis.2. mouse.

Organism-specific databases

CTDi7089.
MGIiMGI:104635. Tle2.

Phylogenomic databases

eggNOGiKOG0639. Eukaryota.
ENOG410XPX3. LUCA.
GeneTreeiENSGT00550000074465.
HOGENOMiHOG000293211.
HOVERGENiHBG004689.
InParanoidiQ9WVB2.
OMAiICAQIVP.
PhylomeDBiQ9WVB2.
TreeFamiTF314167.

Enzyme and pathway databases

ReactomeiR-MMU-201722. Formation of the beta-catenin:TCF transactivating complex.
R-MMU-3769402. Deactivation of the beta-catenin transactivating complex.
R-MMU-4641265. Repression of WNT target genes.

Miscellaneous databases

PROiQ9WVB2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WVB2.
ExpressionAtlasiQ9WVB2. baseline and differential.
GenevisibleiQ9WVB2. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR005617. Groucho/TLE_N.
IPR009146. Groucho_enhance.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03920. TLE_N. 2 hits.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR01850. GROUCHOFAMLY.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1."
    Dang J., Inukai T., Kurosawa H., Goi K., Inaba T., Lenny N.T., Downing J.R., Stifani S., Look A.T.
    Mol. Cell. Biol. 21:5935-5945(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The Groucho/TLE/Grg family of transcriptional co-repressors."
    Jennings B.H., Ish-Horowicz D.
    Genome Biol. 9:R205.1-R205.7(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTLE2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.