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Protein

Ras-related protein Rab-6A

Gene

Rab6a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 28GTPBy similarity9
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4
Nucleotide bindingi156 – 158GTPBy similarity3

GO - Molecular functioni

  • ATPase activator activity Source: RGD
  • GTPase activity Source: UniProtKB
  • GTP binding Source: RGD

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-6798695 Neutrophil degranulation
R-RNO-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-RNO-6811440 Retrograde transport at the Trans-Golgi-Network
R-RNO-8854214 TBC/RABGAPs
R-RNO-8873719 RAB geranylgeranylation
R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-6A
Short name:
Rab-6
Gene namesi
Name:Rab6a
Synonyms:Rab6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi619737 Rab6a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001211142 – 208Ras-related protein Rab-6AAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei184PhosphoserineCombined sources1
Lipidationi206S-geranylgeranyl cysteineBy similarity1
Modified residuei208Cysteine methyl esterBy similarity1
Lipidationi208S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Prenylated.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ9WVB1
PRIDEiQ9WVB1

PTM databases

iPTMnetiQ9WVB1
PhosphoSitePlusiQ9WVB1

Expressioni

Gene expression databases

BgeeiENSRNOG00000018176
ExpressionAtlasiQ9WVB1 baseline and differential
GenevisibleiQ9WVB1 RN

Interactioni

Subunit structurei

Interacts with BICDL1; leads to its accumulation in the pericentrosomal region. Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Interacts with RAB6KIFL. Interacts with BICD1. Interacts with BICD2. Interacts with TMF1. Interacts (GTP-bound) with DYNLRB1; the interaction is direct (By similarity). Interacts with PIFO (By similarity). Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826. Interacts with RIC1 and RGP1; the interactions are direct with a preference for RAB6A-GDP.By similarity

Protein-protein interaction databases

BioGridi249922, 2 interactors
IntActiQ9WVB1, 4 interactors
MINTiQ9WVB1
STRINGi10116.ENSRNOP00000025104

Structurei

3D structure databases

ProteinModelPortaliQ9WVB1
SMRiQ9WVB1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094 Eukaryota
ENOG410XPBI LUCA
GeneTreeiENSGT00910000144073
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9WVB1
OMAiMYQATIG
PhylomeDBiQ9WVB1

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF
60 70 80 90 100
LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS
110 120 130 140 150
FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV
160 170 180 190 200
MFIETSAKAG YNVKQLFRRV AAALPGMEST QDRSREDMID IKLEKPQEQP

VNEGGCSC
Length:208
Mass (Da):23,590
Last modified:November 30, 2010 - v2
Checksum:iDD08CC2914668FD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145474 Genomic DNA No translation available.
AF148210 mRNA Translation: AAD38018.1
RefSeqiXP_006229856.1, XM_006229794.2
UniGeneiRn.1695

Genome annotation databases

EnsembliENSRNOT00000087534; ENSRNOP00000073670; ENSRNOG00000018176
GeneIDi84379
UCSCiRGD:619737 rat

Similar proteinsi

Entry informationi

Entry nameiRAB6A_RAT
AccessioniPrimary (citable) accession number: Q9WVB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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