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Q9WVB1

- RAB6A_RAT

UniProt

Q9WVB1 - RAB6A_RAT

Protein

Ras-related protein Rab-6A

Gene

Rab6a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER) By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 289GTPBy similarity
    Nucleotide bindingi68 – 725GTPBy similarity
    Nucleotide bindingi126 – 1294GTPBy similarity
    Nucleotide bindingi156 – 1583GTPBy similarity

    GO - Molecular functioni

    1. ATPase activator activity Source: RGD
    2. ATPase binding Source: RGD
    3. GTPase activity Source: UniProtKB
    4. GTP binding Source: UniProtKB

    GO - Biological processi

    1. Golgi vesicle transport Source: RGD
    2. GTP catabolic process Source: GOC
    3. positive regulation of ATPase activity Source: GOC
    4. protein targeting to Golgi Source: UniProtKB
    5. Rab protein signal transduction Source: RGD

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-6A
    Short name:
    Rab-6
    Gene namesi
    Name:Rab6a
    Synonyms:Rab6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi619737. Rab6a.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. Golgi membrane Source: UniProtKB-SubCell
    3. membrane Source: RGD

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 208207Ras-related protein Rab-6APRO_0000121114Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Lipidationi206 – 2061S-geranylgeranyl cysteineBy similarity
    Modified residuei208 – 2081Cysteine methyl esterBy similarity
    Lipidationi208 – 2081S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ9WVB1.
    PRIDEiQ9WVB1.

    PTM databases

    PhosphoSiteiQ9WVB1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9WVB1.

    Interactioni

    Subunit structurei

    Interacts with CCDC64; leads to its accumulation in the pericentrosomal region. Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Interacts with RAB6KIFL. Interacts with BICD1. Interacts with BICD2. Interacts with TMF1. Interacts (GTP-bound) with DYNLRB1; the interaction is direct By similarity. Interacts with PIFO By similarity. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9WVB1. 5 interactions.
    MINTiMINT-4542658.
    STRINGi10116.ENSRNOP00000025104.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVB1.
    SMRiQ9WVB1. Positions 13-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 509Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00730000110423.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    KOiK07893.
    OMAiSTSKWID.
    OrthoDBiEOG77DJ7M.
    PhylomeDBiQ9WVB1.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WVB1-1 [UniParc]FASTAAdd to Basket

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    MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF    50
    LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS 100
    FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV 150
    MFIETSAKAG YNVKQLFRRV AAALPGMEST QDRSREDMID IKLEKPQEQP 200
    VNEGGCSC 208
    Length:208
    Mass (Da):23,590
    Last modified:November 30, 2010 - v2
    Checksum:iDD08CC2914668FD4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC145474 Genomic DNA. No translation available.
    AF148210 mRNA. Translation: AAD38018.1.
    RefSeqiXP_006229856.1. XM_006229794.1.
    UniGeneiRn.1695.

    Genome annotation databases

    EnsembliENSRNOT00000025104; ENSRNOP00000025104; ENSRNOG00000018176.
    GeneIDi84379.
    KEGGirno:84379.
    UCSCiRGD:619737. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC145474 Genomic DNA. No translation available.
    AF148210 mRNA. Translation: AAD38018.1 .
    RefSeqi XP_006229856.1. XM_006229794.1.
    UniGenei Rn.1695.

    3D structure databases

    ProteinModelPortali Q9WVB1.
    SMRi Q9WVB1. Positions 13-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9WVB1. 5 interactions.
    MINTi MINT-4542658.
    STRINGi 10116.ENSRNOP00000025104.

    PTM databases

    PhosphoSitei Q9WVB1.

    Proteomic databases

    PaxDbi Q9WVB1.
    PRIDEi Q9WVB1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025104 ; ENSRNOP00000025104 ; ENSRNOG00000018176 .
    GeneIDi 84379.
    KEGGi rno:84379.
    UCSCi RGD:619737. rat.

    Organism-specific databases

    CTDi 5870.
    RGDi 619737. Rab6a.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00730000110423.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    KOi K07893.
    OMAi STSKWID.
    OrthoDBi EOG77DJ7M.
    PhylomeDBi Q9WVB1.

    Miscellaneous databases

    PROi Q9WVB1.

    Gene expression databases

    Genevestigatori Q9WVB1.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "Identification of Rab6 as an N-ethylmaleimide-sensitive fusion protein-binding protein."
      Han S.Y., Park D.Y., Park S.D., Hong S.H.
      Biochem. J. 352:165-173(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-208.
      Strain: Sprague-Dawley.
      Tissue: Lung.

    Entry informationi

    Entry nameiRAB6A_RAT
    AccessioniPrimary (citable) accession number: Q9WVB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3