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Protein

Pro-FMRFamide-related neuropeptide FF

Gene

Npff

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF and SF potentiate and sensitize ASIC2 and ASIC3 channels.2 Publications

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD
  • neuropeptide hormone activity Source: RGD

GO - Biological processi

  • acute inflammatory response to antigenic stimulus Source: RGD
  • excitatory postsynaptic potential Source: RGD
  • maternal process involved in female pregnancy Source: RGD
  • negative regulation of appetite Source: RGD
  • negative regulation of heart rate Source: RGD
  • negative regulation of insulin secretion Source: RGD
  • neuropeptide signaling pathway Source: GO_Central
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • regulation of membrane depolarization Source: RGD
  • regulation of sensory perception of pain Source: RGD
  • response to drug Source: RGD
  • response to morphine Source: RGD
  • somatostatin secretion Source: RGD
  • spinal cord development Source: RGD
  • vasopressin secretion Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-FMRFamide-related neuropeptide FF
Alternative name(s):
FMRFamide-related peptides
Cleaved into the following 3 chains:
Neuropeptide SF
Short name:
NPSF
Neuropeptide FF
Short name:
NPFF
Neuropeptide AF-like
Short name:
NPAF
Gene namesi
Name:Npff
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi62033. Npff.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • dendrite Source: RGD
  • extracellular space Source: RGD
  • perikaryon Source: RGD
  • postsynapse Source: GOC
  • vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 6948PRO_0000009908Add
BLAST
Peptidei72 – 8211Neuropeptide SFPRO_0000009909Add
BLAST
Peptidei75 – 828Neuropeptide FFPRO_0000009910
Propeptidei85 – 10016PRO_0000009911Add
BLAST
Peptidei101 – 11111Neuropeptide AF-likePRO_0000009912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821Phenylalanine amideBy similarity
Modified residuei111 – 1111Phenylalanine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9WVA9.
PRIDEiQ9WVA9.

Expressioni

Gene expression databases

GenevisibleiQ9WVA9. RN.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD
  • neuropeptide hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065607.

Chemistry

BindingDBiQ9WVA9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2TH. Eukaryota.
ENOG410Z134. LUCA.
GeneTreeiENSGT00390000015021.
HOVERGENiHBG006519.
InParanoidiQ9WVA9.
KOiK05247.
OMAiGLNSQFW.
OrthoDBiEOG75B87K.
PhylomeDBiQ9WVA9.

Family and domain databases

InterProiIPR008065. NPFF.
[Graphical view]
PANTHERiPTHR15044:SF0. PTHR15044:SF0. 1 hit.
PfamiPF15085. NPFF. 1 hit.
[Graphical view]
PIRSFiPIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTSiPR01682. FMRFAMIDEPEP.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKWAAVLL LLLLLRNWGH AEEAGSWGED QVFAEEDKGP HPSQYAHTPD
60 70 80 90 100
RIQTPGSLMR VLLQAMERPR RNPAFLFQPQ RFGRNAWGPW SKEQLSPQAR
110
EFWSLAAPQR FGKK
Length:114
Mass (Da):13,152
Last modified:November 1, 1999 - v1
Checksum:i482ABA87BA28F9E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148700 mRNA. Translation: AAD39828.1.
RefSeqiNP_072108.1. NM_022586.1.
UniGeneiRn.48705.

Genome annotation databases

EnsembliENSRNOT00000074497; ENSRNOP00000065607; ENSRNOG00000047739.
GeneIDi60337.
KEGGirno:60337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148700 mRNA. Translation: AAD39828.1.
RefSeqiNP_072108.1. NM_022586.1.
UniGeneiRn.48705.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065607.

Chemistry

BindingDBiQ9WVA9.

Proteomic databases

PaxDbiQ9WVA9.
PRIDEiQ9WVA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074497; ENSRNOP00000065607; ENSRNOG00000047739.
GeneIDi60337.
KEGGirno:60337.

Organism-specific databases

CTDi8620.
RGDi62033. Npff.

Phylogenomic databases

eggNOGiENOG410J2TH. Eukaryota.
ENOG410Z134. LUCA.
GeneTreeiENSGT00390000015021.
HOVERGENiHBG006519.
InParanoidiQ9WVA9.
KOiK05247.
OMAiGLNSQFW.
OrthoDBiEOG75B87K.
PhylomeDBiQ9WVA9.

Enzyme and pathway databases

ReactomeiR-RNO-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ9WVA9.

Gene expression databases

GenevisibleiQ9WVA9. RN.

Family and domain databases

InterProiIPR008065. NPFF.
[Graphical view]
PANTHERiPTHR15044:SF0. PTHR15044:SF0. 1 hit.
PfamiPF15085. NPFF. 1 hit.
[Graphical view]
PIRSFiPIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTSiPR01682. FMRFAMIDEPEP.
ProtoNetiSearch...

Publicationsi

  1. "Gene for pain modulatory neuropeptide NPFF: induction in spinal cord by noxious stimuli."
    Vilim F.S., Aarnisalo A.A., Nieminen M.L., Lintunen M., Karlstedt K., Kontinen V.K., Kalso E., States B., Panula P., Ziff E.
    Mol. Pharmacol. 55:804-811(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF."
    Catarsi S., Babinski K., Seguela P.
    Neuropharmacology 41:592-600(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability."
    Deval E., Baron A., Lingueglia E., Mazarguil H., Zajac J.-M., Lazdunski M.
    Neuropharmacology 44:662-671(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNPFF_RAT
AccessioniPrimary (citable) accession number: Q9WVA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.