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Protein

Pro-FMRFamide-related neuropeptide FF

Gene

Npff

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF and SF potentiate and sensitize ASIC2 and ASIC3 channels.2 Publications

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD
  • neuropeptide hormone activity Source: RGD

GO - Biological processi

  • acute inflammatory response to antigenic stimulus Source: RGD
  • excitatory postsynaptic potential Source: RGD
  • maternal process involved in female pregnancy Source: RGD
  • negative regulation of appetite Source: RGD
  • negative regulation of heart rate Source: RGD
  • negative regulation of insulin secretion Source: RGD
  • neuropeptide signaling pathway Source: GO_Central
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • regulation of membrane depolarization Source: RGD
  • regulation of sensory perception of pain Source: RGD
  • response to drug Source: RGD
  • response to morphine Source: RGD
  • somatostatin secretion Source: RGD
  • spinal cord development Source: RGD
  • vasopressin secretion Source: RGD

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-FMRFamide-related neuropeptide FF
Alternative name(s):
FMRFamide-related peptides
Cleaved into the following 3 chains:
Neuropeptide SF
Short name:
NPSF
Neuropeptide FF
Short name:
NPFF
Neuropeptide AF-like
Short name:
NPAF
Gene namesi
Name:Npff
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi62033. Npff.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • dendrite Source: RGD
  • extracellular space Source: RGD
  • perikaryon Source: RGD
  • postsynapse Source: GOC
  • vesicle Source: RGD

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000000990822 – 69Add BLAST48
PeptideiPRO_000000990972 – 82Neuropeptide SFAdd BLAST11
PeptideiPRO_000000991075 – 82Neuropeptide FF8
PropeptideiPRO_000000991185 – 100Add BLAST16
PeptideiPRO_0000009912101 – 111Neuropeptide AF-likeAdd BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82Phenylalanine amideBy similarity1
Modified residuei111Phenylalanine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9WVA9.
PRIDEiQ9WVA9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000047739.
GenevisibleiQ9WVA9. RN.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD
  • neuropeptide hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065607.

Chemistry databases

BindingDBiQ9WVA9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2TH. Eukaryota.
ENOG410Z134. LUCA.
GeneTreeiENSGT00390000015021.
HOVERGENiHBG006519.
InParanoidiQ9WVA9.
KOiK05247.
OMAiGLNSQFW.
OrthoDBiEOG09040MOZ.
PhylomeDBiQ9WVA9.

Family and domain databases

InterProiView protein in InterPro
IPR008065. NPFF.
PfamiView protein in Pfam
PF15085. NPFF. 1 hit.
PIRSFiPIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTSiPR01682. FMRFAMIDEPEP.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKWAAVLL LLLLLRNWGH AEEAGSWGED QVFAEEDKGP HPSQYAHTPD
60 70 80 90 100
RIQTPGSLMR VLLQAMERPR RNPAFLFQPQ RFGRNAWGPW SKEQLSPQAR
110
EFWSLAAPQR FGKK
Length:114
Mass (Da):13,152
Last modified:November 1, 1999 - v1
Checksum:i482ABA87BA28F9E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148700 mRNA. Translation: AAD39828.1.
RefSeqiNP_072108.1. NM_022586.1.
UniGeneiRn.48705.

Genome annotation databases

EnsembliENSRNOT00000074497; ENSRNOP00000065607; ENSRNOG00000047739.
GeneIDi60337.
KEGGirno:60337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148700 mRNA. Translation: AAD39828.1.
RefSeqiNP_072108.1. NM_022586.1.
UniGeneiRn.48705.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065607.

Chemistry databases

BindingDBiQ9WVA9.

Proteomic databases

PaxDbiQ9WVA9.
PRIDEiQ9WVA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074497; ENSRNOP00000065607; ENSRNOG00000047739.
GeneIDi60337.
KEGGirno:60337.

Organism-specific databases

CTDi8620.
RGDi62033. Npff.

Phylogenomic databases

eggNOGiENOG410J2TH. Eukaryota.
ENOG410Z134. LUCA.
GeneTreeiENSGT00390000015021.
HOVERGENiHBG006519.
InParanoidiQ9WVA9.
KOiK05247.
OMAiGLNSQFW.
OrthoDBiEOG09040MOZ.
PhylomeDBiQ9WVA9.

Enzyme and pathway databases

ReactomeiR-RNO-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ9WVA9.

Gene expression databases

BgeeiENSRNOG00000047739.
GenevisibleiQ9WVA9. RN.

Family and domain databases

InterProiView protein in InterPro
IPR008065. NPFF.
PfamiView protein in Pfam
PF15085. NPFF. 1 hit.
PIRSFiPIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTSiPR01682. FMRFAMIDEPEP.
ProtoNetiSearch...

Entry informationi

Entry nameiNPFF_RAT
AccessioniPrimary (citable) accession number: Q9WVA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: February 15, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.