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Protein

Pro-FMRFamide-related neuropeptide FF

Gene

Npff

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_329572. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-FMRFamide-related neuropeptide FF
Alternative name(s):
FMRFamide-related peptides
Cleaved into the following 3 chains:
Neuropeptide SF
Short name:
NPSF
Neuropeptide FF
Short name:
NPFF
Neuropeptide AF-like
Short name:
NPAF
Gene namesi
Name:Npff
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1891708. Npff.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 6948PRO_0000009903Add
BLAST
Peptidei72 – 8211Neuropeptide SFPRO_0000009904Add
BLAST
Peptidei75 – 828Neuropeptide FFPRO_0000009905
Propeptidei85 – 10016PRO_0000009906Add
BLAST
Peptidei101 – 11111Neuropeptide AF-likePRO_0000009907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821Phenylalanine amideBy similarity
Modified residuei111 – 1111Phenylalanine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiQ9WVA8.

Expressioni

Gene expression databases

BgeeiQ9WVA8.
CleanExiMM_NPFF.
GenevisibleiQ9WVA8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023814.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44970.
GeneTreeiENSGT00390000015021.
HOGENOMiHOG000113843.
HOVERGENiHBG006519.
InParanoidiQ9WVA8.
KOiK05247.
OMAiPGRSQGF.
OrthoDBiEOG75B87K.
PhylomeDBiQ9WVA8.
TreeFamiTF330924.

Family and domain databases

InterProiIPR008065. NPFF.
[Graphical view]
PANTHERiPTHR15044:SF0. PTHR15044:SF0. 1 hit.
PfamiPF15085. NPFF. 1 hit.
[Graphical view]
PIRSFiPIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTSiPR01682. FMRFAMIDEPEP.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKWAALLL LLLLLLNWGH TEEAGSWGED QVFAGEDKGP HPPQYAHIPD
60 70 80 90 100
RIQTPGSLFR VLLQAMDTPR RSPAFLFQPQ RFGRSAWGSW SKEQLNPQAR
110
QFWSLAAPQR FGKK
Length:114
Mass (Da):13,012
Last modified:November 1, 1999 - v1
Checksum:i8743308C46561DDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148701 mRNA. Translation: AAD39829.1.
CCDSiCCDS27887.1.
RefSeqiNP_061257.1. NM_018787.1.
UniGeneiMm.445915.

Genome annotation databases

EnsembliENSMUST00000023814; ENSMUSP00000023814; ENSMUSG00000023052.
GeneIDi54615.
KEGGimmu:54615.
UCSCiuc007xwj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148701 mRNA. Translation: AAD39829.1.
CCDSiCCDS27887.1.
RefSeqiNP_061257.1. NM_018787.1.
UniGeneiMm.445915.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023814.

Proteomic databases

PRIDEiQ9WVA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023814; ENSMUSP00000023814; ENSMUSG00000023052.
GeneIDi54615.
KEGGimmu:54615.
UCSCiuc007xwj.1. mouse.

Organism-specific databases

CTDi8620.
MGIiMGI:1891708. Npff.

Phylogenomic databases

eggNOGiNOG44970.
GeneTreeiENSGT00390000015021.
HOGENOMiHOG000113843.
HOVERGENiHBG006519.
InParanoidiQ9WVA8.
KOiK05247.
OMAiPGRSQGF.
OrthoDBiEOG75B87K.
PhylomeDBiQ9WVA8.
TreeFamiTF330924.

Enzyme and pathway databases

ReactomeiREACT_329572. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi311432.
PROiQ9WVA8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WVA8.
CleanExiMM_NPFF.
GenevisibleiQ9WVA8. MM.

Family and domain databases

InterProiIPR008065. NPFF.
[Graphical view]
PANTHERiPTHR15044:SF0. PTHR15044:SF0. 1 hit.
PfamiPF15085. NPFF. 1 hit.
[Graphical view]
PIRSFiPIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTSiPR01682. FMRFAMIDEPEP.
ProtoNetiSearch...

Publicationsi

  1. "Gene for pain modulatory neuropeptide NPFF: induction in spinal cord by noxious stimuli."
    Vilim F.S., Aarnisalo A.A., Nieminen M.L., Lintunen M., Karlstedt K., Kontinen V.K., Kalso E., States B., Panula P., Ziff E.
    Mol. Pharmacol. 55:804-811(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels."
    Askwith C.C., Cheng C., Ikuma M., Benson C., Price M.P., Welsh M.J.
    Neuron 26:133-141(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNPFF_MOUSE
AccessioniPrimary (citable) accession number: Q9WVA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: June 24, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.