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Q9WVA8 (NPFF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pro-FMRFamide-related neuropeptide FF
Alternative name(s):
FMRFamide-related peptides

Cleaved into the following 3 chains:

  1. Neuropeptide SF
    Short name=NPSF
  2. Neuropeptide FF
    Short name=NPFF
  3. Neuropeptide AF-like
    Short name=NPAF
Gene names
Name:Npff
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. Ref.2

Subcellular location

Secreted.

Sequence similarities

Belongs to the FARP (FMRFamide related peptide) family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionNeuropeptide
   PTMAmidation
Cleavage on pair of basic residues
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacute inflammatory response to antigenic stimulus

Inferred from electronic annotation. Source: Ensembl

maternal process involved in female pregnancy

Inferred from electronic annotation. Source: Ensembl

negative regulation of appetite

Inferred from electronic annotation. Source: Ensembl

negative regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

negative regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

regulation of excitatory postsynaptic membrane potential

Inferred from electronic annotation. Source: Ensembl

regulation of membrane depolarization

Inferred from electronic annotation. Source: Ensembl

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to morphine

Inferred from electronic annotation. Source: Ensembl

somatostatin secretion

Inferred from electronic annotation. Source: Ensembl

spinal cord development

Inferred from electronic annotation. Source: Ensembl

vasopressin secretion

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentaxon terminus

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

perikaryon

Inferred from electronic annotation. Source: Ensembl

vesicle

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Propeptide22 – 6948
PRO_0000009903
Peptide72 – 8211Neuropeptide SF
PRO_0000009904
Peptide75 – 828Neuropeptide FF
PRO_0000009905
Propeptide85 – 10016
PRO_0000009906
Peptide101 – 11111Neuropeptide AF-like
PRO_0000009907

Amino acid modifications

Modified residue821Phenylalanine amide By similarity
Modified residue1111Phenylalanine amide By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WVA8 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 8743308C46561DDA

FASTA11413,012
        10         20         30         40         50         60 
MDSKWAALLL LLLLLLNWGH TEEAGSWGED QVFAGEDKGP HPPQYAHIPD RIQTPGSLFR 

        70         80         90        100        110 
VLLQAMDTPR RSPAFLFQPQ RFGRSAWGSW SKEQLNPQAR QFWSLAAPQR FGKK 

« Hide

References

[1]"Gene for pain modulatory neuropeptide NPFF: induction in spinal cord by noxious stimuli."
Vilim F.S., Aarnisalo A.A., Nieminen M.L., Lintunen M., Karlstedt K., Kontinen V.K., Kalso E., States B., Panula P., Ziff E.
Mol. Pharmacol. 55:804-811(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels."
Askwith C.C., Cheng C., Ikuma M., Benson C., Price M.P., Welsh M.J.
Neuron 26:133-141(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF148701 mRNA. Translation: AAD39829.1.
CCDSCCDS27887.1.
RefSeqNP_061257.1. NM_018787.1.
UniGeneMm.445915.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000023814.

Proteomic databases

PRIDEQ9WVA8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023814; ENSMUSP00000023814; ENSMUSG00000023052.
GeneID54615.
KEGGmmu:54615.
UCSCuc007xwj.1. mouse.

Organism-specific databases

CTD8620.
MGIMGI:1891708. Npff.

Phylogenomic databases

eggNOGNOG44970.
GeneTreeENSGT00390000015021.
HOGENOMHOG000113843.
HOVERGENHBG006519.
InParanoidQ9WVA8.
KOK05247.
OMAPGRSQGF.
OrthoDBEOG75B87K.
PhylomeDBQ9WVA8.
TreeFamTF330924.

Gene expression databases

BgeeQ9WVA8.
CleanExMM_NPFF.
GenevestigatorQ9WVA8.

Family and domain databases

InterProIPR008065. FMRFamid-related_peptide.
[Graphical view]
PANTHERPTHR15044. PTHR15044. 1 hit.
PfamPF15085. NPFF. 1 hit.
[Graphical view]
PIRSFPIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTSPR01682. FMRFAMIDEPEP.
ProtoNetSearch...

Other

NextBio311432.
PROQ9WVA8.
SOURCESearch...

Entry information

Entry nameNPFF_MOUSE
AccessionPrimary (citable) accession number: Q9WVA8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot