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Protein

Pro-FMRFamide-related neuropeptide FF

Gene

Npff

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-FMRFamide-related neuropeptide FF
Alternative name(s):
FMRFamide-related peptides
Cleaved into the following 3 chains:
Neuropeptide SF
Short name:
NPSF
Neuropeptide FF
Short name:
NPFF
Neuropeptide AF-like
Short name:
NPAF
Gene namesi
Name:Npff
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1891708. Npff.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000000990322 – 69Add BLAST48
PeptideiPRO_000000990472 – 82Neuropeptide SFAdd BLAST11
PeptideiPRO_000000990575 – 82Neuropeptide FF8
PropeptideiPRO_000000990685 – 100Add BLAST16
PeptideiPRO_0000009907101 – 111Neuropeptide AF-likeAdd BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82Phenylalanine amideBy similarity1
Modified residuei111Phenylalanine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9WVA8.
PRIDEiQ9WVA8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023052.
CleanExiMM_NPFF.
GenevisibleiQ9WVA8. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023814.

Structurei

3D structure databases

ProteinModelPortaliQ9WVA8.
SMRiQ9WVA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2TH. Eukaryota.
ENOG410Z134. LUCA.
GeneTreeiENSGT00390000015021.
HOGENOMiHOG000113843.
HOVERGENiHBG006519.
InParanoidiQ9WVA8.
KOiK05247.
OMAiGLNSQFW.
OrthoDBiEOG09040MOZ.
PhylomeDBiQ9WVA8.
TreeFamiTF330924.

Family and domain databases

InterProiView protein in InterPro
IPR008065. NPFF.
PfamiView protein in Pfam
PF15085. NPFF. 1 hit.
PIRSFiPIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTSiPR01682. FMRFAMIDEPEP.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKWAALLL LLLLLLNWGH TEEAGSWGED QVFAGEDKGP HPPQYAHIPD
60 70 80 90 100
RIQTPGSLFR VLLQAMDTPR RSPAFLFQPQ RFGRSAWGSW SKEQLNPQAR
110
QFWSLAAPQR FGKK
Length:114
Mass (Da):13,012
Last modified:November 1, 1999 - v1
Checksum:i8743308C46561DDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148701 mRNA. Translation: AAD39829.1.
CCDSiCCDS27887.1.
RefSeqiNP_061257.1. NM_018787.1.
UniGeneiMm.445915.

Genome annotation databases

EnsembliENSMUST00000023814; ENSMUSP00000023814; ENSMUSG00000023052.
GeneIDi54615.
KEGGimmu:54615.
UCSCiuc007xwj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148701 mRNA. Translation: AAD39829.1.
CCDSiCCDS27887.1.
RefSeqiNP_061257.1. NM_018787.1.
UniGeneiMm.445915.

3D structure databases

ProteinModelPortaliQ9WVA8.
SMRiQ9WVA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023814.

Proteomic databases

PaxDbiQ9WVA8.
PRIDEiQ9WVA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023814; ENSMUSP00000023814; ENSMUSG00000023052.
GeneIDi54615.
KEGGimmu:54615.
UCSCiuc007xwj.1. mouse.

Organism-specific databases

CTDi8620.
MGIiMGI:1891708. Npff.

Phylogenomic databases

eggNOGiENOG410J2TH. Eukaryota.
ENOG410Z134. LUCA.
GeneTreeiENSGT00390000015021.
HOGENOMiHOG000113843.
HOVERGENiHBG006519.
InParanoidiQ9WVA8.
KOiK05247.
OMAiGLNSQFW.
OrthoDBiEOG09040MOZ.
PhylomeDBiQ9WVA8.
TreeFamiTF330924.

Enzyme and pathway databases

ReactomeiR-MMU-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ9WVA8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023052.
CleanExiMM_NPFF.
GenevisibleiQ9WVA8. MM.

Family and domain databases

InterProiView protein in InterPro
IPR008065. NPFF.
PfamiView protein in Pfam
PF15085. NPFF. 1 hit.
PIRSFiPIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTSiPR01682. FMRFAMIDEPEP.
ProtoNetiSearch...

Entry informationi

Entry nameiNPFF_MOUSE
AccessioniPrimary (citable) accession number: Q9WVA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: February 15, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.