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Q9WVA8

- NPFF_MOUSE

UniProt

Q9WVA8 - NPFF_MOUSE

Protein

Pro-FMRFamide-related neuropeptide FF

Gene

Npff

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.1 Publication

    GO - Biological processi

    1. acute inflammatory response to antigenic stimulus Source: Ensembl
    2. maternal process involved in female pregnancy Source: Ensembl
    3. negative regulation of appetite Source: Ensembl
    4. negative regulation of heart rate Source: Ensembl
    5. negative regulation of insulin secretion Source: Ensembl
    6. neuropeptide signaling pathway Source: UniProtKB-KW
    7. positive regulation of blood pressure Source: Ensembl
    8. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    9. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    10. regulation of membrane depolarization Source: Ensembl
    11. regulation of sensory perception of pain Source: Ensembl
    12. response to drug Source: Ensembl
    13. response to morphine Source: Ensembl
    14. somatostatin secretion Source: Ensembl
    15. spinal cord development Source: Ensembl
    16. vasopressin secretion Source: Ensembl

    Keywords - Molecular functioni

    Neuropeptide

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pro-FMRFamide-related neuropeptide FF
    Alternative name(s):
    FMRFamide-related peptides
    Cleaved into the following 3 chains:
    Neuropeptide SF
    Short name:
    NPSF
    Neuropeptide FF
    Short name:
    NPFF
    Neuropeptide AF-like
    Short name:
    NPAF
    Gene namesi
    Name:Npff
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1891708. Npff.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: Ensembl
    2. dendrite Source: Ensembl
    3. extracellular space Source: Ensembl
    4. perikaryon Source: Ensembl
    5. vesicle Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 6948PRO_0000009903Add
    BLAST
    Peptidei72 – 8211Neuropeptide SFPRO_0000009904Add
    BLAST
    Peptidei75 – 828Neuropeptide FFPRO_0000009905
    Propeptidei85 – 10016PRO_0000009906Add
    BLAST
    Peptidei101 – 11111Neuropeptide AF-likePRO_0000009907Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei82 – 821Phenylalanine amideBy similarity
    Modified residuei111 – 1111Phenylalanine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PRIDEiQ9WVA8.

    Expressioni

    Gene expression databases

    BgeeiQ9WVA8.
    CleanExiMM_NPFF.
    GenevestigatoriQ9WVA8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000023814.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44970.
    GeneTreeiENSGT00390000015021.
    HOGENOMiHOG000113843.
    HOVERGENiHBG006519.
    InParanoidiQ9WVA8.
    KOiK05247.
    OMAiPGRSQGF.
    OrthoDBiEOG75B87K.
    PhylomeDBiQ9WVA8.
    TreeFamiTF330924.

    Family and domain databases

    InterProiIPR008065. FMRFamid-related_peptide.
    [Graphical view]
    PANTHERiPTHR15044. PTHR15044. 1 hit.
    PfamiPF15085. NPFF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
    PRINTSiPR01682. FMRFAMIDEPEP.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WVA8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSKWAALLL LLLLLLNWGH TEEAGSWGED QVFAGEDKGP HPPQYAHIPD    50
    RIQTPGSLFR VLLQAMDTPR RSPAFLFQPQ RFGRSAWGSW SKEQLNPQAR 100
    QFWSLAAPQR FGKK 114
    Length:114
    Mass (Da):13,012
    Last modified:November 1, 1999 - v1
    Checksum:i8743308C46561DDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF148701 mRNA. Translation: AAD39829.1.
    CCDSiCCDS27887.1.
    RefSeqiNP_061257.1. NM_018787.1.
    UniGeneiMm.445915.

    Genome annotation databases

    EnsembliENSMUST00000023814; ENSMUSP00000023814; ENSMUSG00000023052.
    GeneIDi54615.
    KEGGimmu:54615.
    UCSCiuc007xwj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF148701 mRNA. Translation: AAD39829.1 .
    CCDSi CCDS27887.1.
    RefSeqi NP_061257.1. NM_018787.1.
    UniGenei Mm.445915.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000023814.

    Proteomic databases

    PRIDEi Q9WVA8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023814 ; ENSMUSP00000023814 ; ENSMUSG00000023052 .
    GeneIDi 54615.
    KEGGi mmu:54615.
    UCSCi uc007xwj.1. mouse.

    Organism-specific databases

    CTDi 8620.
    MGIi MGI:1891708. Npff.

    Phylogenomic databases

    eggNOGi NOG44970.
    GeneTreei ENSGT00390000015021.
    HOGENOMi HOG000113843.
    HOVERGENi HBG006519.
    InParanoidi Q9WVA8.
    KOi K05247.
    OMAi PGRSQGF.
    OrthoDBi EOG75B87K.
    PhylomeDBi Q9WVA8.
    TreeFami TF330924.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 311432.
    PROi Q9WVA8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WVA8.
    CleanExi MM_NPFF.
    Genevestigatori Q9WVA8.

    Family and domain databases

    InterProi IPR008065. FMRFamid-related_peptide.
    [Graphical view ]
    PANTHERi PTHR15044. PTHR15044. 1 hit.
    Pfami PF15085. NPFF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
    PRINTSi PR01682. FMRFAMIDEPEP.
    ProtoNeti Search...

    Publicationsi

    1. "Gene for pain modulatory neuropeptide NPFF: induction in spinal cord by noxious stimuli."
      Vilim F.S., Aarnisalo A.A., Nieminen M.L., Lintunen M., Karlstedt K., Kontinen V.K., Kalso E., States B., Panula P., Ziff E.
      Mol. Pharmacol. 55:804-811(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels."
      Askwith C.C., Cheng C., Ikuma M., Benson C., Price M.P., Welsh M.J.
      Neuron 26:133-141(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiNPFF_MOUSE
    AccessioniPrimary (citable) accession number: Q9WVA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3