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Q9WVA8

- NPFF_MOUSE

UniProt

Q9WVA8 - NPFF_MOUSE

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Protein

Pro-FMRFamide-related neuropeptide FF

Gene

Npff

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.1 Publication

GO - Biological processi

  1. acute inflammatory response to antigenic stimulus Source: Ensembl
  2. maternal process involved in female pregnancy Source: Ensembl
  3. negative regulation of appetite Source: Ensembl
  4. negative regulation of heart rate Source: Ensembl
  5. negative regulation of insulin secretion Source: Ensembl
  6. neuropeptide signaling pathway Source: UniProtKB-KW
  7. positive regulation of blood pressure Source: Ensembl
  8. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  9. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  10. regulation of membrane depolarization Source: Ensembl
  11. regulation of sensory perception of pain Source: Ensembl
  12. response to drug Source: Ensembl
  13. response to morphine Source: Ensembl
  14. somatostatin secretion Source: Ensembl
  15. spinal cord development Source: Ensembl
  16. vasopressin secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-FMRFamide-related neuropeptide FF
Alternative name(s):
FMRFamide-related peptides
Cleaved into the following 3 chains:
Neuropeptide SF
Short name:
NPSF
Neuropeptide FF
Short name:
NPFF
Neuropeptide AF-like
Short name:
NPAF
Gene namesi
Name:Npff
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1891708. Npff.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. dendrite Source: Ensembl
  3. extracellular space Source: Ensembl
  4. perikaryon Source: Ensembl
  5. vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 6948PRO_0000009903Add
BLAST
Peptidei72 – 8211Neuropeptide SFPRO_0000009904Add
BLAST
Peptidei75 – 828Neuropeptide FFPRO_0000009905
Propeptidei85 – 10016PRO_0000009906Add
BLAST
Peptidei101 – 11111Neuropeptide AF-likePRO_0000009907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821Phenylalanine amideBy similarity
Modified residuei111 – 1111Phenylalanine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiQ9WVA8.

Expressioni

Gene expression databases

BgeeiQ9WVA8.
CleanExiMM_NPFF.
GenevestigatoriQ9WVA8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023814.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44970.
GeneTreeiENSGT00390000015021.
HOGENOMiHOG000113843.
HOVERGENiHBG006519.
InParanoidiQ9WVA8.
KOiK05247.
OMAiPGRSQGF.
OrthoDBiEOG75B87K.
PhylomeDBiQ9WVA8.
TreeFamiTF330924.

Family and domain databases

InterProiIPR008065. FMRFamid-related_peptide.
[Graphical view]
PANTHERiPTHR15044. PTHR15044. 1 hit.
PfamiPF15085. NPFF. 1 hit.
[Graphical view]
PIRSFiPIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTSiPR01682. FMRFAMIDEPEP.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVA8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSKWAALLL LLLLLLNWGH TEEAGSWGED QVFAGEDKGP HPPQYAHIPD
60 70 80 90 100
RIQTPGSLFR VLLQAMDTPR RSPAFLFQPQ RFGRSAWGSW SKEQLNPQAR
110
QFWSLAAPQR FGKK
Length:114
Mass (Da):13,012
Last modified:November 1, 1999 - v1
Checksum:i8743308C46561DDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF148701 mRNA. Translation: AAD39829.1.
CCDSiCCDS27887.1.
RefSeqiNP_061257.1. NM_018787.1.
UniGeneiMm.445915.

Genome annotation databases

EnsembliENSMUST00000023814; ENSMUSP00000023814; ENSMUSG00000023052.
GeneIDi54615.
KEGGimmu:54615.
UCSCiuc007xwj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF148701 mRNA. Translation: AAD39829.1 .
CCDSi CCDS27887.1.
RefSeqi NP_061257.1. NM_018787.1.
UniGenei Mm.445915.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000023814.

Proteomic databases

PRIDEi Q9WVA8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023814 ; ENSMUSP00000023814 ; ENSMUSG00000023052 .
GeneIDi 54615.
KEGGi mmu:54615.
UCSCi uc007xwj.1. mouse.

Organism-specific databases

CTDi 8620.
MGIi MGI:1891708. Npff.

Phylogenomic databases

eggNOGi NOG44970.
GeneTreei ENSGT00390000015021.
HOGENOMi HOG000113843.
HOVERGENi HBG006519.
InParanoidi Q9WVA8.
KOi K05247.
OMAi PGRSQGF.
OrthoDBi EOG75B87K.
PhylomeDBi Q9WVA8.
TreeFami TF330924.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 311432.
PROi Q9WVA8.
SOURCEi Search...

Gene expression databases

Bgeei Q9WVA8.
CleanExi MM_NPFF.
Genevestigatori Q9WVA8.

Family and domain databases

InterProi IPR008065. FMRFamid-related_peptide.
[Graphical view ]
PANTHERi PTHR15044. PTHR15044. 1 hit.
Pfami PF15085. NPFF. 1 hit.
[Graphical view ]
PIRSFi PIRSF038092. FMRFamid-rel_pep_precur. 1 hit.
PRINTSi PR01682. FMRFAMIDEPEP.
ProtoNeti Search...

Publicationsi

  1. "Gene for pain modulatory neuropeptide NPFF: induction in spinal cord by noxious stimuli."
    Vilim F.S., Aarnisalo A.A., Nieminen M.L., Lintunen M., Karlstedt K., Kontinen V.K., Kalso E., States B., Panula P., Ziff E.
    Mol. Pharmacol. 55:804-811(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels."
    Askwith C.C., Cheng C., Ikuma M., Benson C., Price M.P., Welsh M.J.
    Neuron 26:133-141(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNPFF_MOUSE
AccessioniPrimary (citable) accession number: Q9WVA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: October 1, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3