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Protein

Transgelin-2

Gene

Tagln2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin-2
Alternative name(s):
SM22-beta
Gene namesi
Name:Tagln2
Synonyms:Kiaa0120
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1312985. Tagln2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 199198Transgelin-2PRO_0000204787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei11 – 111PhosphoserineBy similarity
Modified residuei17 – 171N6-acetyllysineBy similarity
Modified residuei20 – 201N6-acetyllysineBy similarity
Modified residuei163 – 1631PhosphoserineCombined sources
Modified residuei180 – 1801PhosphothreonineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9WVA4.
MaxQBiQ9WVA4.
PaxDbiQ9WVA4.
PeptideAtlasiQ9WVA4.
PRIDEiQ9WVA4.

PTM databases

iPTMnetiQ9WVA4.
PhosphoSiteiQ9WVA4.
SwissPalmiQ9WVA4.

Expressioni

Gene expression databases

BgeeiQ9WVA4.
CleanExiMM_TAGLN2.
ExpressionAtlasiQ9WVA4. baseline and differential.
GenevisibleiQ9WVA4. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9WVA4. 3 interactions.
MINTiMINT-1851835.
STRINGi10090.ENSMUSP00000106859.

Structurei

3D structure databases

ProteinModelPortaliQ9WVA4.
SMRiQ9WVA4. Positions 9-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 136113CHPROSITE-ProRule annotationAdd
BLAST
Repeati174 – 19926Calponin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 1 calponin-like repeat.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ9WVA4.
OMAiFRMANRG.
OrthoDBiEOG718KD9.
PhylomeDBiQ9WVA4.
TreeFamiTF313921.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANRGPSYGL SREVQQKIEK QYDADLEQIL IQWITTQCRE DVGQPQPGRE
60 70 80 90 100
NFQKWLKDGT VLCKLINSLY PEGQAPVKKI QASSMAFKQM EQISQFLQAA
110 120 130 140 150
ERYGINTTDI FQTVDLWEGK NMACVQRTLM NLGGLAVARD DGLFSGDPNW
160 170 180 190
FPKKSKENPR NFSDNQLQEG KNVIGLQMGT NRGASQAGMT GYGMPRQIL
Length:199
Mass (Da):22,395
Last modified:December 16, 2008 - v4
Checksum:i3CA18C829CA2CC99
GO

Sequence cautioni

The sequence BAD32170.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461Q → K in BAE39928 (PubMed:16141072).Curated
Sequence conflicti192 – 1998YGMPRQIL → MGCHGDPLIILSLLPLPSMN G in AAD37787 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465519 mRNA. Translation: AAM54133.1.
AF149291 mRNA. Translation: AAD37787.1.
AK172892 mRNA. Translation: BAD32170.1. Different initiation.
AK151576 mRNA. Translation: BAE30516.1.
AK167395 mRNA. Translation: BAE39484.1.
AK167922 mRNA. Translation: BAE39928.1.
AK171088 mRNA. Translation: BAE42241.1.
CH466520 Genomic DNA. Translation: EDL39010.1.
BC009076 mRNA. Translation: AAH09076.1.
BC049861 mRNA. Translation: AAH49861.1.
CCDSiCCDS35784.1.
RefSeqiNP_848713.1. NM_178598.2.
UniGeneiMm.271711.

Genome annotation databases

EnsembliENSMUST00000111228; ENSMUSP00000106859; ENSMUSG00000026547.
ENSMUST00000111230; ENSMUSP00000106861; ENSMUSG00000026547.
GeneIDi21346.
KEGGimmu:21346.
UCSCiuc007dqp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465519 mRNA. Translation: AAM54133.1.
AF149291 mRNA. Translation: AAD37787.1.
AK172892 mRNA. Translation: BAD32170.1. Different initiation.
AK151576 mRNA. Translation: BAE30516.1.
AK167395 mRNA. Translation: BAE39484.1.
AK167922 mRNA. Translation: BAE39928.1.
AK171088 mRNA. Translation: BAE42241.1.
CH466520 Genomic DNA. Translation: EDL39010.1.
BC009076 mRNA. Translation: AAH09076.1.
BC049861 mRNA. Translation: AAH49861.1.
CCDSiCCDS35784.1.
RefSeqiNP_848713.1. NM_178598.2.
UniGeneiMm.271711.

3D structure databases

ProteinModelPortaliQ9WVA4.
SMRiQ9WVA4. Positions 9-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVA4. 3 interactions.
MINTiMINT-1851835.
STRINGi10090.ENSMUSP00000106859.

PTM databases

iPTMnetiQ9WVA4.
PhosphoSiteiQ9WVA4.
SwissPalmiQ9WVA4.

Proteomic databases

EPDiQ9WVA4.
MaxQBiQ9WVA4.
PaxDbiQ9WVA4.
PeptideAtlasiQ9WVA4.
PRIDEiQ9WVA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111228; ENSMUSP00000106859; ENSMUSG00000026547.
ENSMUST00000111230; ENSMUSP00000106861; ENSMUSG00000026547.
GeneIDi21346.
KEGGimmu:21346.
UCSCiuc007dqp.1. mouse.

Organism-specific databases

CTDi8407.
MGIiMGI:1312985. Tagln2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ9WVA4.
OMAiFRMANRG.
OrthoDBiEOG718KD9.
PhylomeDBiQ9WVA4.
TreeFamiTF313921.

Miscellaneous databases

ChiTaRSiTagln2. mouse.
PROiQ9WVA4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WVA4.
CleanExiMM_TAGLN2.
ExpressionAtlasiQ9WVA4. baseline and differential.
GenevisibleiQ9WVA4. MM.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SM22beta encodes a lineage-restricted cytoskeletal protein with a unique developmentally regulated pattern of expression."
    Zhang J.C.L., Helmke B.P., Shum A., Du K., Yu W.W., Lu M.M., Davies P.F., Parmacek M.S.
    Mech. Dev. 115:161-166(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Heart.
  2. "Molecular cloning of mouse transgelin gene."
    Jin C.G., Chen W.F., Li Y., Zhang J., Qian X.P.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Thymus.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreatic islet.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/cJ, C57BL/6J and NOD.
    Tissue: Bone marrow and Placenta.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N and NMRI.
    Tissue: Colon and Mammary tumor.
  7. Lubec G., Yang J.W., Zigmond M.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 140-153.
    Tissue: Brain.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163 AND THR-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTAGL2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVA4
Secondary accession number(s): Q3TIB8
, Q6A0C6, Q78ZX2, Q91VU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 16, 2008
Last modified: July 6, 2016
This is version 124 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.