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Protein

Transgelin-2

Gene

Tagln2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin-2
Alternative name(s):
SM22-beta
Gene namesi
Name:Tagln2
Synonyms:Kiaa0120
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1312985. Tagln2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002047872 – 199Transgelin-2Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei17N6-acetyllysineBy similarity1
Modified residuei20N6-acetyllysineBy similarity1
Modified residuei163PhosphoserineCombined sources1
Modified residuei180PhosphothreonineCombined sources1
Modified residuei182Omega-N-methylarginineCombined sources1
Modified residuei196Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9WVA4.
MaxQBiQ9WVA4.
PaxDbiQ9WVA4.
PeptideAtlasiQ9WVA4.
PRIDEiQ9WVA4.

PTM databases

iPTMnetiQ9WVA4.
PhosphoSitePlusiQ9WVA4.
SwissPalmiQ9WVA4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026547.
CleanExiMM_TAGLN2.
ExpressionAtlasiQ9WVA4. baseline and differential.
GenevisibleiQ9WVA4. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WVA4. 3 interactors.
MINTiMINT-1851835.
STRINGi10090.ENSMUSP00000106859.

Structurei

3D structure databases

ProteinModelPortaliQ9WVA4.
SMRiQ9WVA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 136CHPROSITE-ProRule annotationAdd BLAST113
Repeati174 – 199Calponin-likeAdd BLAST26

Sequence similaritiesi

Belongs to the calponin family.Curated

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ9WVA4.
KOiK20526.
OMAiFRMANRG.
OrthoDBiEOG09040IY2.
PhylomeDBiQ9WVA4.
TreeFamiTF313921.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
PfamiView protein in Pfam
PF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
PRINTSiPR00888. SM22CALPONIN.
SMARTiView protein in SMART
SM00033. CH. 1 hit.
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANRGPSYGL SREVQQKIEK QYDADLEQIL IQWITTQCRE DVGQPQPGRE
60 70 80 90 100
NFQKWLKDGT VLCKLINSLY PEGQAPVKKI QASSMAFKQM EQISQFLQAA
110 120 130 140 150
ERYGINTTDI FQTVDLWEGK NMACVQRTLM NLGGLAVARD DGLFSGDPNW
160 170 180 190
FPKKSKENPR NFSDNQLQEG KNVIGLQMGT NRGASQAGMT GYGMPRQIL
Length:199
Mass (Da):22,395
Last modified:December 16, 2008 - v4
Checksum:i3CA18C829CA2CC99
GO

Sequence cautioni

The sequence BAD32170 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46Q → K in BAE39928 (PubMed:16141072).Curated1
Sequence conflicti192 – 199YGMPRQIL → MGCHGDPLIILSLLPLPSMN G in AAD37787 (Ref. 2) Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465519 mRNA. Translation: AAM54133.1.
AF149291 mRNA. Translation: AAD37787.1.
AK172892 mRNA. Translation: BAD32170.1. Different initiation.
AK151576 mRNA. Translation: BAE30516.1.
AK167395 mRNA. Translation: BAE39484.1.
AK167922 mRNA. Translation: BAE39928.1.
AK171088 mRNA. Translation: BAE42241.1.
CH466520 Genomic DNA. Translation: EDL39010.1.
BC009076 mRNA. Translation: AAH09076.1.
BC049861 mRNA. Translation: AAH49861.1.
CCDSiCCDS35784.1.
RefSeqiNP_848713.1. NM_178598.2.
UniGeneiMm.271711.

Genome annotation databases

EnsembliENSMUST00000111228; ENSMUSP00000106859; ENSMUSG00000026547.
ENSMUST00000111230; ENSMUSP00000106861; ENSMUSG00000026547.
GeneIDi21346.
KEGGimmu:21346.
UCSCiuc007dqp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465519 mRNA. Translation: AAM54133.1.
AF149291 mRNA. Translation: AAD37787.1.
AK172892 mRNA. Translation: BAD32170.1. Different initiation.
AK151576 mRNA. Translation: BAE30516.1.
AK167395 mRNA. Translation: BAE39484.1.
AK167922 mRNA. Translation: BAE39928.1.
AK171088 mRNA. Translation: BAE42241.1.
CH466520 Genomic DNA. Translation: EDL39010.1.
BC009076 mRNA. Translation: AAH09076.1.
BC049861 mRNA. Translation: AAH49861.1.
CCDSiCCDS35784.1.
RefSeqiNP_848713.1. NM_178598.2.
UniGeneiMm.271711.

3D structure databases

ProteinModelPortaliQ9WVA4.
SMRiQ9WVA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVA4. 3 interactors.
MINTiMINT-1851835.
STRINGi10090.ENSMUSP00000106859.

PTM databases

iPTMnetiQ9WVA4.
PhosphoSitePlusiQ9WVA4.
SwissPalmiQ9WVA4.

Proteomic databases

EPDiQ9WVA4.
MaxQBiQ9WVA4.
PaxDbiQ9WVA4.
PeptideAtlasiQ9WVA4.
PRIDEiQ9WVA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111228; ENSMUSP00000106859; ENSMUSG00000026547.
ENSMUST00000111230; ENSMUSP00000106861; ENSMUSG00000026547.
GeneIDi21346.
KEGGimmu:21346.
UCSCiuc007dqp.1. mouse.

Organism-specific databases

CTDi8407.
MGIiMGI:1312985. Tagln2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ9WVA4.
KOiK20526.
OMAiFRMANRG.
OrthoDBiEOG09040IY2.
PhylomeDBiQ9WVA4.
TreeFamiTF313921.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiTagln2. mouse.
PROiQ9WVA4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026547.
CleanExiMM_TAGLN2.
ExpressionAtlasiQ9WVA4. baseline and differential.
GenevisibleiQ9WVA4. MM.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
PfamiView protein in Pfam
PF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
PRINTSiPR00888. SM22CALPONIN.
SMARTiView protein in SMART
SM00033. CH. 1 hit.
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAGL2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVA4
Secondary accession number(s): Q3TIB8
, Q6A0C6, Q78ZX2, Q91VU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 16, 2008
Last modified: February 15, 2017
This is version 129 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.