Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hairy/enhancer-of-split related with YRPW motif protein 1

Gene

Hey1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.8 Publications

GO - Molecular functioni

  • DNA binding transcription factor activity Source: MGI
  • microsatellite binding Source: UniProtKB
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI
  • sequence-specific DNA binding Source: MGI
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
  • transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
  • transcription factor activity, transcription factor binding Source: UniProtKB

GO - Biological processi

  • anterior/posterior axis specification Source: MGI
  • arterial endothelial cell differentiation Source: BHF-UCL
  • artery development Source: MGI
  • atrioventricular valve formation Source: BHF-UCL
  • atrioventricular valve morphogenesis Source: BHF-UCL
  • blood vessel development Source: MGI
  • cardiac epithelial to mesenchymal transition Source: BHF-UCL
  • cardiac septum morphogenesis Source: BHF-UCL
  • cardiac ventricle morphogenesis Source: BHF-UCL
  • comma-shaped body morphogenesis Source: UniProtKB
  • dorsal aorta morphogenesis Source: BHF-UCL
  • endocardial cushion morphogenesis Source: BHF-UCL
  • endocardial cushion to mesenchymal transition involved in heart valve formation Source: MGI
  • epithelial to mesenchymal transition involved in endocardial cushion formation Source: MGI
  • establishment of epithelial cell polarity Source: MGI
  • inner ear receptor cell stereocilium organization Source: MGI
  • labyrinthine layer blood vessel development Source: BHF-UCL
  • mesenchymal cell development Source: BHF-UCL
  • negative regulation of gene expression Source: BHF-UCL
  • negative regulation of neuron differentiation Source: UniProtKB
  • negative regulation of Notch signaling pathway Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: MGI
  • negative regulation of transcription regulatory region DNA binding Source: MGI
  • Notch signaling involved in heart development Source: BHF-UCL
  • Notch signaling pathway Source: UniProtKB
  • osteoblast development Source: MGI
  • outflow tract morphogenesis Source: BHF-UCL
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • pulmonary valve morphogenesis Source: BHF-UCL
  • regulation of epithelial cell proliferation Source: MGI
  • regulation of inner ear auditory receptor cell differentiation Source: MGI
  • regulation of vasculogenesis Source: BHF-UCL
  • renal vesicle development Source: UniProtKB
  • S-shaped body morphogenesis Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
  • umbilical cord morphogenesis Source: BHF-UCL
  • ureteric bud morphogenesis Source: UniProtKB
  • vasculogenesis Source: MGI
  • ventricular septum morphogenesis Source: BHF-UCL
  • ventricular trabecula myocardium morphogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processNotch signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hairy/enhancer-of-split related with YRPW motif protein 1
Alternative name(s):
Hairy and enhancer of split-related protein 1
Short name:
HESR-1
Hairy-related transcription factor 1
Short name:
HRT-1
Short name:
mHRT1
Gene namesi
Name:Hey1
Synonyms:Herp2, Hesr1, Hrt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1341800 Hey1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272181 – 299Hairy/enhancer-of-split related with YRPW motif protein 1Add BLAST299

Proteomic databases

PaxDbiQ9WV93
PRIDEiQ9WV93

PTM databases

iPTMnetiQ9WV93
PhosphoSitePlusiQ9WV93

Expressioni

Tissue specificityi

Expressed in somitic mesoderm, brain, central nervous system, kidney, heart, nasal epithelium, limbs, lung, muscle, ovary and testis.2 Publications

Developmental stagei

Expressed in the developing nervous system, the somites, heart and craniofacial region. Expressed in the myocardium of the atrium at E9.5 and in the atrioventricular cushions from E9.5 to E12.5. Also expressed in developing and adult retina. Expressed in the ventricular zone of the ventral spinal cord at E12 and in the ventricular zone of the telencephalon at E12 and E15. Weakly expressed in the cortical plate at E15.5 Publications

Inductioni

By activation of the Notch signaling pathway.4 Publications

Gene expression databases

CleanExiMM_HEY1

Interactioni

Subunit structurei

May self-associate (By similarity). Interacts with HES1, NCOR1 and SIN3A (By similarity). Interacts with GATA4, GATA6 and HDAC1 and HEYL. Interacts with CCDC89/BOIP.By similarity4 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

ELMiQ9WV93
IntActiQ9WV93, 1 interactor
STRINGi10090.ENSMUSP00000038014

Structurei

3D structure databases

ProteinModelPortaliQ9WV93
SMRiQ9WV93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 104bHLHPROSITE-ProRule annotationAdd BLAST56
Domaini122 – 158OrangePROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 117Transcriptional repression and interaction with NCOR1 and SIN3ABy similarityAdd BLAST70

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi289 – 292YRPW motif4

Sequence similaritiesi

Belongs to the HEY family.Curated

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
HOGENOMiHOG000286035
HOVERGENiHBG003275
InParanoidiQ9WV93
PhylomeDBiQ9WV93

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WV93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAHPDYSS SDSELDETIE VEKESADENG NLSSALCSMS PTTSSQVLAR
60 70 80 90 100
KRRRGIIEKR RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH
110 120 130 140 150
LKMLHTAGGK GYFDAHALAM DYRSLGFREC LAEVARYLSI IEGLDASDPL
160 170 180 190 200
LVRLVSHLNN YASQREAASG AHGGLGHIPW GSAFGHHPHI AHPLLLPQNG
210 220 230 240 250
HGNAGTAASP TEPHHQGRLA SAHPEAPALR APPSGGLGPV LPVVTSASKL
260 270 280 290
SPPLLSSVAS LSAFPFSFSS FHLLSPSTPT QAANLGKPYR PWGTEIGAF
Length:299
Mass (Da):32,063
Last modified:November 1, 1999 - v1
Checksum:i99111DD24ACEE819
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151521 mRNA Translation: AAD38966.1
CCDSiCCDS17232.1
UniGeneiMm.29581

Similar proteinsi

Entry informationi

Entry nameiHEY1_MOUSE
AccessioniPrimary (citable) accession number: Q9WV93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health