Band 4.1-like protein 3 - Mus musculus (Mouse)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Band 4.1-like protein 3

Alternative name(s):
4.1B
Differentially expressed in adenocarcinoma of the lung protein 1
Short name=DAL-1
Short name=DAL1P
Short name=mDAL-1

Gene names

Name:	Epb41l3
Synonyms:	Dal1, Epb4.1l3, Kiaa0987

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	929 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Isoform 2 (heart-specific) has the complete spectrin--actin-binding (SAB) domain and fully interacts with spectrin and actin.
Subunit structure	Interacts with CADM1 By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Tissue specificity	Highest expression in brain, lower in testis, adrenal gland, heart and kidney. Also present in muscle and epithelial cells. Isoform 1 is expressed in brain, isoform 2 is expressed in heart and isoform 3 is mostly expressed in kidney but also in heart and brain. Isoform 6 seems to be most abundant in kidney while isoform 4 and isoform 5 are predominantly expressed in heart and brain.
Miscellaneous	The complete SAB domain is present only in the heart-specific isoforms (isoform 2 and isoform 5).
Sequence similarities	Contains 1 FERM domain.
Sequence caution	The sequence AAD51365.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing
Ligand	Actin-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cortical actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro cortical cytoskeleton organization Traceable author statement PubMed 21966409. Source: BHF-UCL cytoskeletal anchoring at plasma membrane Traceable author statement PubMed 21966409. Source: BHF-UCL myelin maintenance Inferred from mutant phenotype PubMed 21966409. Source: BHF-UCL neuron projection morphogenesis Inferred from mutant phenotype PubMed 21966409. Source: BHF-UCL paranodal junction assembly Inferred from mutant phenotype PubMed 21966409. Source: BHF-UCL protein localization to juxtaparanode region of axon Inferred from mutant phenotype PubMed 21966409. Source: BHF-UCL protein localization to paranode region of axon Inferred from mutant phenotype PubMed 21966409. Source: BHF-UCL protein localization to plasma membrane Inferred from mutant phenotype PubMed 21966409. Source: BHF-UCL regulation of cell shape Inferred from mutant phenotype PubMed 21966409. Source: BHF-UCL
Cellular_component	cell-cell junction Inferred from sequence or structural similarity. Source: HGNC cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell extrinsic to membrane Inferred from electronic annotation. Source: InterPro juxtaparanode region of axon Inferred from direct assay PubMed 12975355 PubMed 16551741 PubMed 21966409. Source: BHF-UCL paranode region of axon Inferred from direct assay PubMed 12975355 PubMed 16551741 PubMed 21966409. Source: BHF-UCL
Molecular_function	structural constituent of cytoskeleton Traceable author statement PubMed 21966409. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select] Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9WV92-1) Also known as: 4.1B-brain; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9WV92-2) Also known as: 4.1B-heart; The sequence of this isoform differs from the canonical sequence as follows: 547-558: Missing. 559-559: D → NSLIKRIKGENVYVKHSNLMLED

Isoform 3 (identifier: Q9WV92-3) Also known as: 4.1B-kidney; The sequence of this isoform differs from the canonical sequence as follows: 547-558: Missing.

Isoform 4 (identifier: Q9WV92-4) Also known as: 4.1b-brain; The sequence of this isoform differs from the canonical sequence as follows: 894-929: ALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED → E

Isoform 5 (identifier: Q9WV92-5) Also known as: 4.1B-heart; The sequence of this isoform differs from the canonical sequence as follows: 547-558: Missing. 559-559: D → NSLIKRIKGENVYVKHSNLMLED 894-929: ALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED → E

Isoform 6 (identifier: Q9WV92-6) Also known as: 4.1B-kidney; The sequence of this isoform differs from the canonical sequence as follows: 547-558: Missing. 894-929: ALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED → E

Isoform 7 (identifier: Q9WV92-7) The sequence of this isoform differs from the canonical sequence as follows: 455-472: Missing. 547-558: Missing. 623-663: Missing. 894-929: ALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED → E
Note: Inferred from the cDNA sequence of Ref.2.

Isoform 8 (identifier: Q9WV92-8) The sequence of this isoform differs from the canonical sequence as follows: 455-472: Missing. 528-528: K → KSPPGHGAAD...NDPSDSSEEE 894-929: ALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED → E

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 929

929

Band 4.1-like protein 3

PRO_0000219400

Regions

Domain

118 – 399

282

FERM

Region

402 – 528

127

Hydrophilic

Region

559 – 602

44

Spectrin--actin-binding

Region

777 – 929

153

C-terminal (CTD)

Amino acid modifications

Modified residue

96

1

Phosphoserine Ref.6 Ref.7 Ref.8 Ref.11 Ref.12

Modified residue

428

1

Phosphoserine Ref.11

Modified residue

451

1

Phosphoserine Ref.8 Ref.11

Modified residue

470

1

Phosphoserine Ref.5

Modified residue

486

1

Phosphoserine Ref.5 Ref.6 Ref.8 Ref.9 Ref.12

Modified residue

488

1

Phosphothreonine Ref.8

Modified residue

495

1

Phosphothreonine Ref.5 Ref.6 Ref.8 Ref.9

Modified residue

542

1

Phosphothreonine Ref.8

Modified residue

543

1

Phosphoserine Ref.5 Ref.6 Ref.9

Modified residue

547

1

Phosphoserine Ref.5 Ref.6 Ref.8

Modified residue

599

1

Phosphoserine Ref.11

Modified residue

623

1

Phosphothreonine Ref.6

Modified residue

626

1

Phosphoserine Ref.6

Modified residue

627

1

Phosphoserine Ref.6

Modified residue

797

1

Phosphoserine Ref.10

Modified residue

798

1

Phosphothreonine Ref.8 Ref.10

Modified residue

804

1

Phosphoserine Ref.5 Ref.8

Modified residue

923

1

Phosphothreonine Ref.7

Natural variations

Alternative sequence

455 – 472

18

Missing in isoform 7 and isoform 8.

VSP_000487

Alternative sequence

528

1

K → KSPPGHGAADSCPPSPPSAH PDPPPPTELRRRCKEKERAE PSSLESEAQGKAYLGDQDVA FSYRQPAGKGTTLFSFSLQL PESFPSLLDEDGYLSFPNLS ETNLLPQSWQHFLPIRSPSL LPCFLFIFFFLLSASFSVPY ALTLSFPLALCLCYLEPKAA SLSASLDNDPSDSSEEE in isoform 8.

VSP_023063

Alternative sequence

547 – 558

12

Missing in isoform 2, isoform 3, isoform 5, isoform 6 and isoform 7.

VSP_000490

Alternative sequence

559

1

D → NSLIKRIKGENVYVKHSNLM LED in isoform 2 and isoform 5.

VSP_000489

Alternative sequence

623 – 663

41

Missing in isoform 7.

VSP_000488

Alternative sequence

894 – 929

36

ALAQA…EDGED → E in isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8.

VSP_000491

Experimental info

Sequence conflict

6 – 10

5

GSDSE → RIRLR in AAD51365. Ref.2

Sequence conflict

28

1

Q → R in AAD51365. Ref.2

Sequence conflict

288

1

A → V in AAD51365. Ref.2

Sequence conflict

306

1

V → G in AAD51365. Ref.2

Sequences

Sequence		Length	Mass (Da)
Isoform 1 (4.1B-brain) [UniParc]. Last modified November 1, 1999. Version 1. Checksum: F4975FF405DA44AE Show »	FASTA	929	103,338
10 20 30 40 50 60 MTTESGSDSE SKPDQEAEPQ EAAGPQGQAG AQPGPEPAGG NGSLNGEKQQ PALEQFPEAA 70 80 90 100 110 120 AHSTPVKREI GDKDRDFAAA AAKQLEYQQF EDDKLSQRSS SSKLSRSPLK IVKRPKSMQC 130 140 150 160 170 180 KVTLLDGSEY GCDVDKRSRG QVLFDKVCEH LNLLEKDYFG LTYRDAENQK NWLDPAKEIK 190 200 210 220 230 240 KQIRSGAWHF SFNVKFYPPD PAQLSEDITR YYLCLQLRDD IVSGRLPCSF VTLALLGSYT 250 260 270 280 290 300 VQSELGDYDP DECGNDYISE FRFAPNHTKE LEDKVIELHK SHRGMTPAEA EMHFLENAKK 310 320 330 340 350 360 LSMYGVDLHH AKDSEGVEIM LGVCASGLLI YRDRLRINRF AWPKVLKISY KRNNFYIKIR 370 380 390 400 410 420 PGEFEQFEST IGFKLPNHRA AKRLWKVCVE HHTFFRLLLP EAPPKKFLTL GSKFRYSGRT 430 440 450 460 470 480 QAQTRRASAL IDRPAPYFER SSSKRYTMSR SLDGASVSEN HEIYMKDSVS AAEVGTGQYA 490 500 510 520 530 540 TTKGISQTNL ITTVTPEKKA EEERVEEEDR RKKAEEATPV TALRHEGKTD SERTDTAADG 550 560 570 580 590 600 ETSATESDQE EDAEIKAQDL DKTQDELMKH QTNISELKRT FLETSTETAL TNEWEKRLST 610 620 630 640 650 660 SPVRLAARQE DAPMIEPLVP EETKQSSGEK LMDGSEILSL LESARKPTEF IGGVSSTTQS 670 680 690 700 710 720 WVQKLETKTE PVEAEVESTP HPQPLSTEKV LQETILVEER HVMSVHASGD ASHTARDEVD 730 740 750 760 770 780 AAESTPTDRR HTGKGKEGSS VTEAAKEQRG EEVDQSAPEQ EQPATVSHEE EQASTIRTSE 790 800 810 820 830 840 GLEQKSHFES STVRVESTSV GSISPGGAKL EISTKEVPVV HTETKTITYE SSQVDPGADL 850 860 870 880 890 900 EPGVLMSAQT ITSETTSTTT TTHITKTVKG GISETRIEKR IVITGDADID HDQALAQAIK 910 920 EAKEQHPDMS VTKVVVHKET EITPEDGED « Hide
Isoform 2 (4.1B-heart) [UniParc]. Checksum: 389443CDEF2CC2A5 Show »	FASTA	939	104,561
10 20 30 40 50 60 MTTESGSDSE SKPDQEAEPQ EAAGPQGQAG AQPGPEPAGG NGSLNGEKQQ PALEQFPEAA 70 80 90 100 110 120 AHSTPVKREI GDKDRDFAAA AAKQLEYQQF EDDKLSQRSS SSKLSRSPLK IVKRPKSMQC 130 140 150 160 170 180 KVTLLDGSEY GCDVDKRSRG QVLFDKVCEH LNLLEKDYFG LTYRDAENQK NWLDPAKEIK 190 200 210 220 230 240 KQIRSGAWHF SFNVKFYPPD PAQLSEDITR YYLCLQLRDD IVSGRLPCSF VTLALLGSYT 250 260 270 280 290 300 VQSELGDYDP DECGNDYISE FRFAPNHTKE LEDKVIELHK SHRGMTPAEA EMHFLENAKK 310 320 330 340 350 360 LSMYGVDLHH AKDSEGVEIM LGVCASGLLI YRDRLRINRF AWPKVLKISY KRNNFYIKIR 370 380 390 400 410 420 PGEFEQFEST IGFKLPNHRA AKRLWKVCVE HHTFFRLLLP EAPPKKFLTL GSKFRYSGRT 430 440 450 460 470 480 QAQTRRASAL IDRPAPYFER SSSKRYTMSR SLDGASVSEN HEIYMKDSVS AAEVGTGQYA 490 500 510 520 530 540 TTKGISQTNL ITTVTPEKKA EEERVEEEDR RKKAEEATPV TALRHEGKTD SERTDTAADG 550 560 570 580 590 600 ETSATENSLI KRIKGENVYV KHSNLMLEDL DKTQDELMKH QTNISELKRT FLETSTETAL 610 620 630 640 650 660 TNEWEKRLST SPVRLAARQE DAPMIEPLVP EETKQSSGEK LMDGSEILSL LESARKPTEF 670 680 690 700 710 720 IGGVSSTTQS WVQKLETKTE PVEAEVESTP HPQPLSTEKV LQETILVEER HVMSVHASGD 730 740 750 760 770 780 ASHTARDEVD AAESTPTDRR HTGKGKEGSS VTEAAKEQRG EEVDQSAPEQ EQPATVSHEE 790 800 810 820 830 840 EQASTIRTSE GLEQKSHFES STVRVESTSV GSISPGGAKL EISTKEVPVV HTETKTITYE 850 860 870 880 890 900 SSQVDPGADL EPGVLMSAQT ITSETTSTTT TTHITKTVKG GISETRIEKR IVITGDADID 910 920 930 HDQALAQAIK EAKEQHPDMS VTKVVVHKET EITPEDGED « Hide
Isoform 3 (4.1B-kidney) [UniParc]. Checksum: D0EF7EA95EDA3C24 Show »	FASTA	917	101,993
10 20 30 40 50 60 MTTESGSDSE SKPDQEAEPQ EAAGPQGQAG AQPGPEPAGG NGSLNGEKQQ PALEQFPEAA 70 80 90 100 110 120 AHSTPVKREI GDKDRDFAAA AAKQLEYQQF EDDKLSQRSS SSKLSRSPLK IVKRPKSMQC 130 140 150 160 170 180 KVTLLDGSEY GCDVDKRSRG QVLFDKVCEH LNLLEKDYFG LTYRDAENQK NWLDPAKEIK 190 200 210 220 230 240 KQIRSGAWHF SFNVKFYPPD PAQLSEDITR YYLCLQLRDD IVSGRLPCSF VTLALLGSYT 250 260 270 280 290 300 VQSELGDYDP DECGNDYISE FRFAPNHTKE LEDKVIELHK SHRGMTPAEA EMHFLENAKK 310 320 330 340 350 360 LSMYGVDLHH AKDSEGVEIM LGVCASGLLI YRDRLRINRF AWPKVLKISY KRNNFYIKIR 370 380 390 400 410 420 PGEFEQFEST IGFKLPNHRA AKRLWKVCVE HHTFFRLLLP EAPPKKFLTL GSKFRYSGRT 430 440 450 460 470 480 QAQTRRASAL IDRPAPYFER SSSKRYTMSR SLDGASVSEN HEIYMKDSVS AAEVGTGQYA 490 500 510 520 530 540 TTKGISQTNL ITTVTPEKKA EEERVEEEDR RKKAEEATPV TALRHEGKTD SERTDTAADG 550 560 570 580 590 600 ETSATEDLDK TQDELMKHQT NISELKRTFL ETSTETALTN EWEKRLSTSP VRLAARQEDA 610 620 630 640 650 660 PMIEPLVPEE TKQSSGEKLM DGSEILSLLE SARKPTEFIG GVSSTTQSWV QKLETKTEPV 670 680 690 700 710 720 EAEVESTPHP QPLSTEKVLQ ETILVEERHV MSVHASGDAS HTARDEVDAA ESTPTDRRHT 730 740 750 760 770 780 GKGKEGSSVT EAAKEQRGEE VDQSAPEQEQ PATVSHEEEQ ASTIRTSEGL EQKSHFESST 790 800 810 820 830 840 VRVESTSVGS ISPGGAKLEI STKEVPVVHT ETKTITYESS QVDPGADLEP GVLMSAQTIT 850 860 870 880 890 900 SETTSTTTTT HITKTVKGGI SETRIEKRIV ITGDADIDHD QALAQAIKEA KEQHPDMSVT 910 KVVVHKETEI TPEDGED « Hide
Isoform 4 (4.1b-brain) [UniParc]. Checksum: 2E5E5915A9568B81 Show »	FASTA	894	99,510
10 20 30 40 50 60 MTTESGSDSE SKPDQEAEPQ EAAGPQGQAG AQPGPEPAGG NGSLNGEKQQ PALEQFPEAA 70 80 90 100 110 120 AHSTPVKREI GDKDRDFAAA AAKQLEYQQF EDDKLSQRSS SSKLSRSPLK IVKRPKSMQC 130 140 150 160 170 180 KVTLLDGSEY GCDVDKRSRG QVLFDKVCEH LNLLEKDYFG LTYRDAENQK NWLDPAKEIK 190 200 210 220 230 240 KQIRSGAWHF SFNVKFYPPD PAQLSEDITR YYLCLQLRDD IVSGRLPCSF VTLALLGSYT 250 260 270 280 290 300 VQSELGDYDP DECGNDYISE FRFAPNHTKE LEDKVIELHK SHRGMTPAEA EMHFLENAKK 310 320 330 340 350 360 LSMYGVDLHH AKDSEGVEIM LGVCASGLLI YRDRLRINRF AWPKVLKISY KRNNFYIKIR 370 380 390 400 410 420 PGEFEQFEST IGFKLPNHRA AKRLWKVCVE HHTFFRLLLP EAPPKKFLTL GSKFRYSGRT 430 440 450 460 470 480 QAQTRRASAL IDRPAPYFER SSSKRYTMSR SLDGASVSEN HEIYMKDSVS AAEVGTGQYA 490 500 510 520 530 540 TTKGISQTNL ITTVTPEKKA EEERVEEEDR RKKAEEATPV TALRHEGKTD SERTDTAADG 550 560 570 580 590 600 ETSATESDQE EDAEIKAQDL DKTQDELMKH QTNISELKRT FLETSTETAL TNEWEKRLST 610 620 630 640 650 660 SPVRLAARQE DAPMIEPLVP EETKQSSGEK LMDGSEILSL LESARKPTEF IGGVSSTTQS 670 680 690 700 710 720 WVQKLETKTE PVEAEVESTP HPQPLSTEKV LQETILVEER HVMSVHASGD ASHTARDEVD 730 740 750 760 770 780 AAESTPTDRR HTGKGKEGSS VTEAAKEQRG EEVDQSAPEQ EQPATVSHEE EQASTIRTSE 790 800 810 820 830 840 GLEQKSHFES STVRVESTSV GSISPGGAKL EISTKEVPVV HTETKTITYE SSQVDPGADL 850 860 870 880 890 EPGVLMSAQT ITSETTSTTT TTHITKTVKG GISETRIEKR IVITGDADID HDQE « Hide
Isoform 5 (4.1B-heart) [UniParc]. Checksum: 12419E015BB8DD08 Show »	FASTA	904	100,734
10 20 30 40 50 60 MTTESGSDSE SKPDQEAEPQ EAAGPQGQAG AQPGPEPAGG NGSLNGEKQQ PALEQFPEAA 70 80 90 100 110 120 AHSTPVKREI GDKDRDFAAA AAKQLEYQQF EDDKLSQRSS SSKLSRSPLK IVKRPKSMQC 130 140 150 160 170 180 KVTLLDGSEY GCDVDKRSRG QVLFDKVCEH LNLLEKDYFG LTYRDAENQK NWLDPAKEIK 190 200 210 220 230 240 KQIRSGAWHF SFNVKFYPPD PAQLSEDITR YYLCLQLRDD IVSGRLPCSF VTLALLGSYT 250 260 270 280 290 300 VQSELGDYDP DECGNDYISE FRFAPNHTKE LEDKVIELHK SHRGMTPAEA EMHFLENAKK 310 320 330 340 350 360 LSMYGVDLHH AKDSEGVEIM LGVCASGLLI YRDRLRINRF AWPKVLKISY KRNNFYIKIR 370 380 390 400 410 420 PGEFEQFEST IGFKLPNHRA AKRLWKVCVE HHTFFRLLLP EAPPKKFLTL GSKFRYSGRT 430 440 450 460 470 480 QAQTRRASAL IDRPAPYFER SSSKRYTMSR SLDGASVSEN HEIYMKDSVS AAEVGTGQYA 490 500 510 520 530 540 TTKGISQTNL ITTVTPEKKA EEERVEEEDR RKKAEEATPV TALRHEGKTD SERTDTAADG 550 560 570 580 590 600 ETSATENSLI KRIKGENVYV KHSNLMLEDL DKTQDELMKH QTNISELKRT FLETSTETAL 610 620 630 640 650 660 TNEWEKRLST SPVRLAARQE DAPMIEPLVP EETKQSSGEK LMDGSEILSL LESARKPTEF 670 680 690 700 710 720 IGGVSSTTQS WVQKLETKTE PVEAEVESTP HPQPLSTEKV LQETILVEER HVMSVHASGD 730 740 750 760 770 780 ASHTARDEVD AAESTPTDRR HTGKGKEGSS VTEAAKEQRG EEVDQSAPEQ EQPATVSHEE 790 800 810 820 830 840 EQASTIRTSE GLEQKSHFES STVRVESTSV GSISPGGAKL EISTKEVPVV HTETKTITYE 850 860 870 880 890 900 SSQVDPGADL EPGVLMSAQT ITSETTSTTT TTHITKTVKG GISETRIEKR IVITGDADID HDQE « Hide
Isoform 6 (4.1B-kidney) [UniParc]. Checksum: 94CC9620418FDF2C Show »	FASTA	882	98,166
10 20 30 40 50 60 MTTESGSDSE SKPDQEAEPQ EAAGPQGQAG AQPGPEPAGG NGSLNGEKQQ PALEQFPEAA 70 80 90 100 110 120 AHSTPVKREI GDKDRDFAAA AAKQLEYQQF EDDKLSQRSS SSKLSRSPLK IVKRPKSMQC 130 140 150 160 170 180 KVTLLDGSEY GCDVDKRSRG QVLFDKVCEH LNLLEKDYFG LTYRDAENQK NWLDPAKEIK 190 200 210 220 230 240 KQIRSGAWHF SFNVKFYPPD PAQLSEDITR YYLCLQLRDD IVSGRLPCSF VTLALLGSYT 250 260 270 280 290 300 VQSELGDYDP DECGNDYISE FRFAPNHTKE LEDKVIELHK SHRGMTPAEA EMHFLENAKK 310 320 330 340 350 360 LSMYGVDLHH AKDSEGVEIM LGVCASGLLI YRDRLRINRF AWPKVLKISY KRNNFYIKIR 370 380 390 400 410 420 PGEFEQFEST IGFKLPNHRA AKRLWKVCVE HHTFFRLLLP EAPPKKFLTL GSKFRYSGRT 430 440 450 460 470 480 QAQTRRASAL IDRPAPYFER SSSKRYTMSR SLDGASVSEN HEIYMKDSVS AAEVGTGQYA 490 500 510 520 530 540 TTKGISQTNL ITTVTPEKKA EEERVEEEDR RKKAEEATPV TALRHEGKTD SERTDTAADG 550 560 570 580 590 600 ETSATEDLDK TQDELMKHQT NISELKRTFL ETSTETALTN EWEKRLSTSP VRLAARQEDA 610 620 630 640 650 660 PMIEPLVPEE TKQSSGEKLM DGSEILSLLE SARKPTEFIG GVSSTTQSWV QKLETKTEPV 670 680 690 700 710 720 EAEVESTPHP QPLSTEKVLQ ETILVEERHV MSVHASGDAS HTARDEVDAA ESTPTDRRHT 730 740 750 760 770 780 GKGKEGSSVT EAAKEQRGEE VDQSAPEQEQ PATVSHEEEQ ASTIRTSEGL EQKSHFESST 790 800 810 820 830 840 VRVESTSVGS ISPGGAKLEI STKEVPVVHT ETKTITYESS QVDPGADLEP GVLMSAQTIT 850 860 870 880 SETTSTTTTT HITKTVKGGI SETRIEKRIV ITGDADIDHD QE « Hide
Isoform 7 [UniParc]. Checksum: 2F78D9ADA3DC0674 Show »	FASTA	823	91,850
10 20 30 40 50 60 MTTESGSDSE SKPDQEAEPQ EAAGPQGQAG AQPGPEPAGG NGSLNGEKQQ PALEQFPEAA 70 80 90 100 110 120 AHSTPVKREI GDKDRDFAAA AAKQLEYQQF EDDKLSQRSS SSKLSRSPLK IVKRPKSMQC 130 140 150 160 170 180 KVTLLDGSEY GCDVDKRSRG QVLFDKVCEH LNLLEKDYFG LTYRDAENQK NWLDPAKEIK 190 200 210 220 230 240 KQIRSGAWHF SFNVKFYPPD PAQLSEDITR YYLCLQLRDD IVSGRLPCSF VTLALLGSYT 250 260 270 280 290 300 VQSELGDYDP DECGNDYISE FRFAPNHTKE LEDKVIELHK SHRGMTPAEA EMHFLENAKK 310 320 330 340 350 360 LSMYGVDLHH AKDSEGVEIM LGVCASGLLI YRDRLRINRF AWPKVLKISY KRNNFYIKIR 370 380 390 400 410 420 PGEFEQFEST IGFKLPNHRA AKRLWKVCVE HHTFFRLLLP EAPPKKFLTL GSKFRYSGRT 430 440 450 460 470 480 QAQTRRASAL IDRPAPYFER SSSKRYTMSR SLDGEVGTGQ YATTKGISQT NLITTVTPEK 490 500 510 520 530 540 KAEEERVEEE DRRKKAEEAT PVTALRHEGK TDSERTDTAA DGETSATEDL DKTQDELMKH 550 560 570 580 590 600 QTNISELKRT FLETSTETAL TNEWEKRLST SPVRLAARQE DAPMIEPLVP EEKLETKTEP 610 620 630 640 650 660 VEAEVESTPH PQPLSTEKVL QETILVEERH VMSVHASGDA SHTARDEVDA AESTPTDRRH 670 680 690 700 710 720 TGKGKEGSSV TEAAKEQRGE EVDQSAPEQE QPATVSHEEE QASTIRTSEG LEQKSHFESS 730 740 750 760 770 780 TVRVESTSVG SISPGGAKLE ISTKEVPVVH TETKTITYES SQVDPGADLE PGVLMSAQTI 790 800 810 820 TSETTSTTTT THITKTVKGG ISETRIEKRI VITGDADIDH DQE « Hide
Isoform 8 [UniParc]. Checksum: 3D9A917D79B9E7F5 Show »	FASTA	1,052	116,785
10 20 30 40 50 60 MTTESGSDSE SKPDQEAEPQ EAAGPQGQAG AQPGPEPAGG NGSLNGEKQQ PALEQFPEAA 70 80 90 100 110 120 AHSTPVKREI GDKDRDFAAA AAKQLEYQQF EDDKLSQRSS SSKLSRSPLK IVKRPKSMQC 130 140 150 160 170 180 KVTLLDGSEY GCDVDKRSRG QVLFDKVCEH LNLLEKDYFG LTYRDAENQK NWLDPAKEIK 190 200 210 220 230 240 KQIRSGAWHF SFNVKFYPPD PAQLSEDITR YYLCLQLRDD IVSGRLPCSF VTLALLGSYT 250 260 270 280 290 300 VQSELGDYDP DECGNDYISE FRFAPNHTKE LEDKVIELHK SHRGMTPAEA EMHFLENAKK 310 320 330 340 350 360 LSMYGVDLHH AKDSEGVEIM LGVCASGLLI YRDRLRINRF AWPKVLKISY KRNNFYIKIR 370 380 390 400 410 420 PGEFEQFEST IGFKLPNHRA AKRLWKVCVE HHTFFRLLLP EAPPKKFLTL GSKFRYSGRT 430 440 450 460 470 480 QAQTRRASAL IDRPAPYFER SSSKRYTMSR SLDGEVGTGQ YATTKGISQT NLITTVTPEK 490 500 510 520 530 540 KAEEERVEEE DRRKKAEEAT PVTALRHEGK SPPGHGAADS CPPSPPSAHP DPPPPTELRR 550 560 570 580 590 600 RCKEKERAEP SSLESEAQGK AYLGDQDVAF SYRQPAGKGT TLFSFSLQLP ESFPSLLDED 610 620 630 640 650 660 GYLSFPNLSE TNLLPQSWQH FLPIRSPSLL PCFLFIFFFL LSASFSVPYA LTLSFPLALC 670 680 690 700 710 720 LCYLEPKAAS LSASLDNDPS DSSEEETDSE RTDTAADGET SATESDQEED AEIKAQDLDK 730 740 750 760 770 780 TQDELMKHQT NISELKRTFL ETSTETALTN EWEKRLSTSP VRLAARQEDA PMIEPLVPEE 790 800 810 820 830 840 TKQSSGEKLM DGSEILSLLE SARKPTEFIG GVSSTTQSWV QKLETKTEPV EAEVESTPHP 850 860 870 880 890 900 QPLSTEKVLQ ETILVEERHV MSVHASGDAS HTARDEVDAA ESTPTDRRHT GKGKEGSSVT 910 920 930 940 950 960 EAAKEQRGEE VDQSAPEQEQ PATVSHEEEQ ASTIRTSEGL EQKSHFESST VRVESTSVGS 970 980 990 1000 1010 1020 ISPGGAKLEI STKEVPVVHT ETKTITYESS QVDPGADLEP GVLMSAQTIT SETTSTTTTT 1030 1040 1050 HITKTVKGGI SETRIEKRIV ITGDADIDHD QE « Hide

References

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[1]	"Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain." Parra M., Gascard P., Walensky L.D., Gimm J.A., Blackshaw S., Chan N., Takakuwa Y., Berger T., Lee G., Chasis J.A., Snyder S.H., Mohandas N., Conboy J.G. J. Biol. Chem. 275:3247-3255(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6). Tissue: Brain.
[2]	"Mouse DAL-1 (mDAL-1) cDNA sequence." Azam M., Andrabi S., Lin L., Newsham I., Chishti A.H. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-929 (ISOFORM 7). Strain: BALB/c. Tissue: Brain.
[3]	"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H. DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 202-929 (ISOFORM 8). Tissue: Fetal brain.
[4]	Marra M., Hillier L., Kucaba T., Martin J., Beck C., Wylie T., Underwood K., Steptoe M., Theising B., Allen M., Bowers Y., Person B., Swaller T., Gibbons M., Pape D., Harvey N., Schurk R., Ritter E. Wilson R. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 719-929 (ISOFORMS 4/5/6/7).
[5]	"Phosphoproteomic analysis of the developing mouse brain." Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P. Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-470; SER-486; THR-495; SER-543; SER-547 AND SER-804, MASS SPECTROMETRY. Tissue: Embryonic brain.
[6]	"Proteomic analysis of in vivo phosphorylated synaptic proteins." Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I., Blackstock W.P., Choudhary J.S., Grant S.G. J. Biol. Chem. 280:5972-5982(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96; SER-486; THR-495; SER-543; SER-547; THR-623; SER-626 AND SER-627, MASS SPECTROMETRY. Tissue: Forebrain.
[7]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96 AND THR-923, MASS SPECTROMETRY. Tissue: Brain.
[8]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96; SER-451; SER-486; THR-488; THR-495; THR-542; SER-547; THR-798 AND SER-804, MASS SPECTROMETRY. Tissue: Brain cortex.
[9]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-486; THR-495 AND SER-543, MASS SPECTROMETRY. Tissue: Liver.
[10]	Lubec G., Kang S. Submitted (APR-2007) to UniProtKB Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-797 AND THR-798, MASS SPECTROMETRY. Tissue: Brain.
[11]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96; SER-428; SER-451 AND SER-599, MASS SPECTROMETRY. Tissue: Melanoma.
[12]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96 AND SER-486, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF152247 mRNA. Translation: AAD38048.1. AF177146 mRNA. Translation: AAD51365.1. Different initiation. AK173080 mRNA. Translation: BAD32358.1.
IPI	IPI00125501. IPI00229294. IPI00229295. IPI00229298. IPI00229299. IPI00229300. IPI00406263. IPI00464296.
RefSeq	NP_038841.1. NM_013813.1.
UniGene	Mm.131135.
3D structure databases
ProteinModelPortal	Q9WV92.
SMR	Q9WV92. Positions 116-398.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9WV92. 6 interactions.
PTM databases
PhosphoSite	Q9WV92.
Proteomic databases
PaxDb	Q9WV92.
PRIDE	Q9WV92.
Protocols and materials databases
DNASU	13823.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000080208; ENSMUSP00000079098; ENSMUSG00000024044. ENSMUST00000112680; ENSMUSP00000108300; ENSMUSG00000024044.
GeneID	13823.
KEGG	mmu:13823.
UCSC	uc008dkp.1. mouse. uc008dkq.1. mouse. uc008dkr.1. mouse.
Organism-specific databases
CTD	13823.
MGI	MGI:103008. Epb4.1l3.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG242913.
GeneTree	ENSGT00690000101906.
HOGENOM	HOG000228840.
HOVERGEN	HBG007777.
KO	K06107.
OMA	AITNEWE.
OrthoDB	EOG4Z8XVQ.
Gene expression databases
ArrayExpress	Q9WV92.
Bgee	Q9WV92.
CleanEx	MM_EPB4.1L3.
Genevestigator	Q9WV92.
GermOnline	ENSMUSG00000024044. Mus musculus.
Family and domain databases
Gene3D	1.20.80.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR008379. Band_4.1_C. IPR019749. Band_41_domain. IPR019750. Band_41_fam. IPR021187. Band_41_protein. IPR000798. Ez/rad/moesin_like. IPR014847. FERM-adjacent. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR019748. FERM_central. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR018979. FERM_N. IPR018980. FERM_PH-like_C. IPR011993. PH_like_dom. IPR007477. SAB_dom. [Graphical view]
Pfam	PF05902. 4_1_CTD. 1 hit. PF08736. FA. 1 hit. PF09380. FERM_C. 1 hit. PF00373. FERM_M. 1 hit. PF09379. FERM_N. 1 hit. PF04382. SAB. 1 hit. [Graphical view]
PIRSF	PIRSF002304. Membrane_skeletal_4_1. 1 hit.
PRINTS	PR00935. BAND41. PR00661. ERMFAMILY.
SMART	SM00295. B41. 1 hit. [Graphical view]
SUPFAM	SSF47031. FERM_3-hlx. 1 hit.
PROSITE	PS00660. FERM_1. 1 hit. PS00661. FERM_2. 1 hit. PS50057. FERM_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	284624.
SOURCE	Search...

Entry information

Entry name

E41L3_MOUSE

Accession

Primary (citable) accession number: Q9WV92
Secondary accession number(s): Q69ZT8, Q9R102

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents