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Q9WV91

- FPRP_MOUSE

UniProt

Q9WV91 - FPRP_MOUSE

Protein

Prostaglandin F2 receptor negative regulator

Gene

Ptgfrn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur By similarity.By similarity

    GO - Biological processi

    1. lipid particle organization Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin F2 receptor negative regulator
    Alternative name(s):
    Prostaglandin F2-alpha receptor regulatory protein
    Prostaglandin F2-alpha receptor-associated protein
    CD_antigen: CD315
    Gene namesi
    Name:Ptgfrn
    Synonyms:Fprp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1277114. Ptgfrn.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 879858Prostaglandin F2 receptor negative regulatorPRO_0000014763Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 119PROSITE-ProRule annotation
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi169 ↔ 247PROSITE-ProRule annotation
    Modified residuei271 – 2711PhosphothreonineBy similarity
    Disulfide bondi299 ↔ 373PROSITE-ProRule annotation
    Glycosylationi300 – 3001N-linked (GlcNAc...)1 Publication
    Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi429 ↔ 515PROSITE-ProRule annotation
    Glycosylationi525 – 5251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi571 ↔ 655PROSITE-ProRule annotation
    Glycosylationi600 – 6001N-linked (GlcNAc...)2 Publications
    Glycosylationi618 – 6181N-linked (GlcNAc...)2 Publications
    Glycosylationi691 – 6911N-linked (GlcNAc...)1 Publication
    Disulfide bondi711 ↔ 793PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9WV91.
    PRIDEiQ9WV91.

    PTM databases

    PhosphoSiteiQ9WV91.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9WV91.
    BgeeiQ9WV91.
    CleanExiMM_PTGFRN.
    GenevestigatoriQ9WV91.

    Interactioni

    Subunit structurei

    Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9WV91. 1 interaction.
    MINTiMINT-4095317.
    STRINGi10090.ENSMUSP00000099755.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WV91.
    SMRiQ9WV91. Positions 101-126.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 832811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini854 – 87926CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei833 – 85321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 137116Ig-like C2-type 1Add
    BLAST
    Domaini149 – 263115Ig-like C2-type 2Add
    BLAST
    Domaini276 – 389114Ig-like C2-type 3Add
    BLAST
    Domaini406 – 536131Ig-like C2-type 4Add
    BLAST
    Domaini544 – 662119Ig-like C2-type 5Add
    BLAST
    Domaini688 – 813126Ig-like C2-type 6Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi89 – 913Cell attachment siteSequence Analysis
    Motifi424 – 4274Endoplasmic reticulum retention signal
    Motifi703 – 7053Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39204.
    GeneTreeiENSGT00390000010278.
    HOGENOMiHOG000112641.
    HOVERGENiHBG031554.
    InParanoidiQ5SRA8.
    KOiK06729.
    OMAiWKSDLSL.
    OrthoDBiEOG7RNJZG.
    TreeFamiTF332702.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 3 hits.
    [Graphical view]
    SMARTiSM00409. IG. 5 hits.
    SM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WV91-1 [UniParc]FASTAAdd to Basket

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    MGRPAPRPLL LALLSLAVCR GRVVRVPAGT LVRVVGTELV IPCNVSDYDG    50
    PSEQNFDWSF SSSGSSFVEL ASTWEVGFPA QLYRERLQRG DILLRRTAND 100
    AVELHIKNVQ PSDQGHYKCS TPSTDATVQG NYEDTVQVKV LADALVVGPS 150
    SRPPPGLSLR EGEPFELRCI ASTTSPLHTH LALRWELHRG PVHRSILALS 200
    HEGRFHPGPG YEQRYHSGDV RLDTVGSDAY RLSVARALSA DQGSYRCVVS 250
    EWITEQGSWQ EIQEKAVEVA TVVIQPTALQ LAVPRTVSVT EGKDLDLSCN 300
    ITTDRVDDVR PEVTWYFKKT PDTSLLASHM LARLDRDSLV HSSPHVALSH 350
    VDTRSYHLLV RDVSKENSGY YLCLVALWAP GHNRSWHKVA EAMSAPSGVS 400
    VTWLEPEYQV YLNASKVPGF SDDPTELQCR VIDTKRLEAG VRLTVSWYYR 450
    MTRRNDDVVA SELLAVMDGD WTLRYGERSK QRAQDGEFIF SKEHTDTFNF 500
    RIQRTTEEDR GNYYCVVSAW TRQRNNSWVK SKDVFSKPVN IFWASEDSVL 550
    VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLITAE KPVGDLSSPN 600
    ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA 650
    GLYRCMVTAW SPIGGSLWRE AATSLSNPIE IDFQTSGPTF NASVHSDTPS 700
    VTRGDLIKLF CIVTVEGAVL DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD 750
    RKGVVTTGQR DWKSTVSLER VSVLEFLLQV HGSEDQDFGN YYCSVTPWVR 800
    SPTGSWQREA EIHSRPIFIT VKMDVLNAFK YPLLIGVGLS TVIGLLSCLI 850
    GYCSSHWCCK KEVRETRRER RRLMSMEMD 879
    Length:879
    Mass (Da):98,722
    Last modified:July 27, 2011 - v2
    Checksum:i0E7037B9625B56A3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti128 – 1281V → A in AAD38383. (PubMed:10893677)Curated
    Sequence conflicti136 – 1361V → M in AAD38383. (PubMed:10893677)Curated
    Sequence conflicti267 – 2671V → E in AAD38383. (PubMed:10893677)Curated
    Sequence conflicti500 – 5001F → L in AAD38383. (PubMed:10893677)Curated
    Sequence conflicti521 – 5211T → A in AAD38383. (PubMed:10893677)Curated
    Sequence conflicti647 – 6471V → D in AAD38383. (PubMed:10893677)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152344 mRNA. Translation: AAD38383.1.
    AL672281, AL669937 Genomic DNA. Translation: CAI26220.1.
    AL669937, AL672281 Genomic DNA. Translation: CAI26224.1.
    AL669872, AL645930 Genomic DNA. Translation: CAM22064.1.
    BC145713 mRNA. Translation: AAI45714.1.
    BC145715 mRNA. Translation: AAI45716.1.
    CCDSiCCDS17680.1.
    RefSeqiNP_035327.2. NM_011197.3.
    UniGeneiMm.24807.

    Genome annotation databases

    EnsembliENSMUST00000102694; ENSMUSP00000099755; ENSMUSG00000027864.
    GeneIDi19221.
    KEGGimmu:19221.
    UCSCiuc008qre.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152344 mRNA. Translation: AAD38383.1 .
    AL672281 , AL669937 Genomic DNA. Translation: CAI26220.1 .
    AL669937 , AL672281 Genomic DNA. Translation: CAI26224.1 .
    AL669872 , AL645930 Genomic DNA. Translation: CAM22064.1 .
    BC145713 mRNA. Translation: AAI45714.1 .
    BC145715 mRNA. Translation: AAI45716.1 .
    CCDSi CCDS17680.1.
    RefSeqi NP_035327.2. NM_011197.3.
    UniGenei Mm.24807.

    3D structure databases

    ProteinModelPortali Q9WV91.
    SMRi Q9WV91. Positions 101-126.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9WV91. 1 interaction.
    MINTi MINT-4095317.
    STRINGi 10090.ENSMUSP00000099755.

    PTM databases

    PhosphoSitei Q9WV91.

    Proteomic databases

    PaxDbi Q9WV91.
    PRIDEi Q9WV91.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102694 ; ENSMUSP00000099755 ; ENSMUSG00000027864 .
    GeneIDi 19221.
    KEGGi mmu:19221.
    UCSCi uc008qre.1. mouse.

    Organism-specific databases

    CTDi 5738.
    MGIi MGI:1277114. Ptgfrn.

    Phylogenomic databases

    eggNOGi NOG39204.
    GeneTreei ENSGT00390000010278.
    HOGENOMi HOG000112641.
    HOVERGENi HBG031554.
    InParanoidi Q5SRA8.
    KOi K06729.
    OMAi WKSDLSL.
    OrthoDBi EOG7RNJZG.
    TreeFami TF332702.

    Miscellaneous databases

    NextBioi 295996.
    PROi Q9WV91.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WV91.
    Bgeei Q9WV91.
    CleanExi MM_PTGFRN.
    Genevestigatori Q9WV91.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 3 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 5 hits.
    SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The monoclonal antibodies 18d7/91f2 recognize a receptor regulatory protein on mouse bone marrow stromal cells."
      Weng L., Falla N., Van den Heuvel R., Raymackers J., Karperien M., Van Bezooijen R., Van Vlasselaer P., Lowik C., Merregaert J.
      J. Bone Miner. Res. 15:1286-1300(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-600 AND ASN-618.
      Tissue: Myoblast.
    5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-300; ASN-600; ASN-618 AND ASN-691.

    Entry informationi

    Entry nameiFPRP_MOUSE
    AccessioniPrimary (citable) accession number: Q9WV91
    Secondary accession number(s): Q5SRA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3