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Q9WV91

- FPRP_MOUSE

UniProt

Q9WV91 - FPRP_MOUSE

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Protein

Prostaglandin F2 receptor negative regulator

Gene

Ptgfrn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).By similarity

GO - Biological processi

  1. lipid particle organization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin F2 receptor negative regulator
Alternative name(s):
Prostaglandin F2-alpha receptor regulatory protein
Prostaglandin F2-alpha receptor-associated protein
CD_antigen: CD315
Gene namesi
Name:Ptgfrn
Synonyms:Fprp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1277114. Ptgfrn.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 832811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei833 – 85321HelicalSequence AnalysisAdd
BLAST
Topological domaini854 – 87926CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. Golgi apparatus Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 879858Prostaglandin F2 receptor negative regulatorPRO_0000014763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 119PROSITE-ProRule annotation
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi169 ↔ 247PROSITE-ProRule annotation
Modified residuei271 – 2711PhosphothreonineBy similarity
Disulfide bondi299 ↔ 373PROSITE-ProRule annotation
Glycosylationi300 – 3001N-linked (GlcNAc...)1 Publication
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi429 ↔ 515PROSITE-ProRule annotation
Glycosylationi525 – 5251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi571 ↔ 655PROSITE-ProRule annotation
Glycosylationi600 – 6001N-linked (GlcNAc...)2 Publications
Glycosylationi618 – 6181N-linked (GlcNAc...)2 Publications
Glycosylationi691 – 6911N-linked (GlcNAc...)1 Publication
Disulfide bondi711 ↔ 793PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9WV91.
PaxDbiQ9WV91.
PRIDEiQ9WV91.

PTM databases

PhosphoSiteiQ9WV91.

Expressioni

Gene expression databases

BgeeiQ9WV91.
CleanExiMM_PTGFRN.
ExpressionAtlasiQ9WV91. baseline and differential.
GenevestigatoriQ9WV91.

Interactioni

Subunit structurei

Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9WV91. 1 interaction.
MINTiMINT-4095317.
STRINGi10090.ENSMUSP00000099755.

Structurei

3D structure databases

ProteinModelPortaliQ9WV91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 137116Ig-like C2-type 1Add
BLAST
Domaini149 – 263115Ig-like C2-type 2Add
BLAST
Domaini276 – 389114Ig-like C2-type 3Add
BLAST
Domaini406 – 536131Ig-like C2-type 4Add
BLAST
Domaini544 – 662119Ig-like C2-type 5Add
BLAST
Domaini688 – 813126Ig-like C2-type 6Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi89 – 913Cell attachment siteSequence Analysis
Motifi424 – 4274Endoplasmic reticulum retention signal
Motifi703 – 7053Cell attachment siteSequence Analysis

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39204.
GeneTreeiENSGT00390000010278.
HOGENOMiHOG000112641.
HOVERGENiHBG031554.
InParanoidiQ9WV91.
KOiK06729.
OMAiWKSDLSL.
OrthoDBiEOG7RNJZG.
TreeFamiTF332702.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WV91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRPAPRPLL LALLSLAVCR GRVVRVPAGT LVRVVGTELV IPCNVSDYDG
60 70 80 90 100
PSEQNFDWSF SSSGSSFVEL ASTWEVGFPA QLYRERLQRG DILLRRTAND
110 120 130 140 150
AVELHIKNVQ PSDQGHYKCS TPSTDATVQG NYEDTVQVKV LADALVVGPS
160 170 180 190 200
SRPPPGLSLR EGEPFELRCI ASTTSPLHTH LALRWELHRG PVHRSILALS
210 220 230 240 250
HEGRFHPGPG YEQRYHSGDV RLDTVGSDAY RLSVARALSA DQGSYRCVVS
260 270 280 290 300
EWITEQGSWQ EIQEKAVEVA TVVIQPTALQ LAVPRTVSVT EGKDLDLSCN
310 320 330 340 350
ITTDRVDDVR PEVTWYFKKT PDTSLLASHM LARLDRDSLV HSSPHVALSH
360 370 380 390 400
VDTRSYHLLV RDVSKENSGY YLCLVALWAP GHNRSWHKVA EAMSAPSGVS
410 420 430 440 450
VTWLEPEYQV YLNASKVPGF SDDPTELQCR VIDTKRLEAG VRLTVSWYYR
460 470 480 490 500
MTRRNDDVVA SELLAVMDGD WTLRYGERSK QRAQDGEFIF SKEHTDTFNF
510 520 530 540 550
RIQRTTEEDR GNYYCVVSAW TRQRNNSWVK SKDVFSKPVN IFWASEDSVL
560 570 580 590 600
VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLITAE KPVGDLSSPN
610 620 630 640 650
ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA
660 670 680 690 700
GLYRCMVTAW SPIGGSLWRE AATSLSNPIE IDFQTSGPTF NASVHSDTPS
710 720 730 740 750
VTRGDLIKLF CIVTVEGAVL DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD
760 770 780 790 800
RKGVVTTGQR DWKSTVSLER VSVLEFLLQV HGSEDQDFGN YYCSVTPWVR
810 820 830 840 850
SPTGSWQREA EIHSRPIFIT VKMDVLNAFK YPLLIGVGLS TVIGLLSCLI
860 870
GYCSSHWCCK KEVRETRRER RRLMSMEMD
Length:879
Mass (Da):98,722
Last modified:July 27, 2011 - v2
Checksum:i0E7037B9625B56A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281V → A in AAD38383. (PubMed:10893677)Curated
Sequence conflicti136 – 1361V → M in AAD38383. (PubMed:10893677)Curated
Sequence conflicti267 – 2671V → E in AAD38383. (PubMed:10893677)Curated
Sequence conflicti500 – 5001F → L in AAD38383. (PubMed:10893677)Curated
Sequence conflicti521 – 5211T → A in AAD38383. (PubMed:10893677)Curated
Sequence conflicti647 – 6471V → D in AAD38383. (PubMed:10893677)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152344 mRNA. Translation: AAD38383.1.
AL672281, AL669937 Genomic DNA. Translation: CAI26220.1.
AL669937, AL672281 Genomic DNA. Translation: CAI26224.1.
AL669872, AL645930 Genomic DNA. Translation: CAM22064.1.
BC145713 mRNA. Translation: AAI45714.1.
BC145715 mRNA. Translation: AAI45716.1.
CCDSiCCDS17680.1.
RefSeqiNP_035327.2. NM_011197.3.
UniGeneiMm.24807.

Genome annotation databases

EnsembliENSMUST00000102694; ENSMUSP00000099755; ENSMUSG00000027864.
GeneIDi19221.
KEGGimmu:19221.
UCSCiuc008qre.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152344 mRNA. Translation: AAD38383.1 .
AL672281 , AL669937 Genomic DNA. Translation: CAI26220.1 .
AL669937 , AL672281 Genomic DNA. Translation: CAI26224.1 .
AL669872 , AL645930 Genomic DNA. Translation: CAM22064.1 .
BC145713 mRNA. Translation: AAI45714.1 .
BC145715 mRNA. Translation: AAI45716.1 .
CCDSi CCDS17680.1.
RefSeqi NP_035327.2. NM_011197.3.
UniGenei Mm.24807.

3D structure databases

ProteinModelPortali Q9WV91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9WV91. 1 interaction.
MINTi MINT-4095317.
STRINGi 10090.ENSMUSP00000099755.

PTM databases

PhosphoSitei Q9WV91.

Proteomic databases

MaxQBi Q9WV91.
PaxDbi Q9WV91.
PRIDEi Q9WV91.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102694 ; ENSMUSP00000099755 ; ENSMUSG00000027864 .
GeneIDi 19221.
KEGGi mmu:19221.
UCSCi uc008qre.1. mouse.

Organism-specific databases

CTDi 5738.
MGIi MGI:1277114. Ptgfrn.

Phylogenomic databases

eggNOGi NOG39204.
GeneTreei ENSGT00390000010278.
HOGENOMi HOG000112641.
HOVERGENi HBG031554.
InParanoidi Q9WV91.
KOi K06729.
OMAi WKSDLSL.
OrthoDBi EOG7RNJZG.
TreeFami TF332702.

Miscellaneous databases

ChiTaRSi Ptgfrn. mouse.
NextBioi 295996.
PROi Q9WV91.
SOURCEi Search...

Gene expression databases

Bgeei Q9WV91.
CleanExi MM_PTGFRN.
ExpressionAtlasi Q9WV91. baseline and differential.
Genevestigatori Q9WV91.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 3 hits.
[Graphical view ]
SMARTi SM00409. IG. 5 hits.
SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The monoclonal antibodies 18d7/91f2 recognize a receptor regulatory protein on mouse bone marrow stromal cells."
    Weng L., Falla N., Van den Heuvel R., Raymackers J., Karperien M., Van Bezooijen R., Van Vlasselaer P., Lowik C., Merregaert J.
    J. Bone Miner. Res. 15:1286-1300(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-600 AND ASN-618.
    Tissue: Myoblast.
  5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-300; ASN-600; ASN-618 AND ASN-691.

Entry informationi

Entry nameiFPRP_MOUSE
AccessioniPrimary (citable) accession number: Q9WV91
Secondary accession number(s): Q5SRA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3