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Protein

Prostaglandin F2 receptor negative regulator

Gene

Ptgfrn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).By similarity

GO - Biological processi

  • lipid particle organization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin F2 receptor negative regulator
Alternative name(s):
Prostaglandin F2-alpha receptor regulatory protein
Prostaglandin F2-alpha receptor-associated protein
CD_antigen: CD315
Gene namesi
Name:Ptgfrn
Synonyms:Fprp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1277114. Ptgfrn.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 832ExtracellularSequence analysisAdd BLAST811
Transmembranei833 – 853HelicalSequence analysisAdd BLAST21
Topological domaini854 – 879CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001476322 – 879Prostaglandin F2 receptor negative regulatorAdd BLAST858

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 119PROSITE-ProRule annotation
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi169 ↔ 247PROSITE-ProRule annotation
Modified residuei271PhosphothreonineBy similarity1
Disulfide bondi299 ↔ 373PROSITE-ProRule annotation
Glycosylationi300N-linked (GlcNAc...)1 Publication1
Glycosylationi383N-linked (GlcNAc...)Sequence analysis1
Glycosylationi413N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi429 ↔ 515PROSITE-ProRule annotation
Glycosylationi525N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi571 ↔ 655PROSITE-ProRule annotation
Glycosylationi600N-linked (GlcNAc...)2 Publications1
Glycosylationi618N-linked (GlcNAc...)2 Publications1
Glycosylationi691N-linked (GlcNAc...)1 Publication1
Disulfide bondi711 ↔ 793PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9WV91.
PaxDbiQ9WV91.
PRIDEiQ9WV91.

PTM databases

iPTMnetiQ9WV91.
PhosphoSitePlusiQ9WV91.
SwissPalmiQ9WV91.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027864.
CleanExiMM_PTGFRN.
GenevisibleiQ9WV91. MM.

Interactioni

Subunit structurei

Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9WV91. 1 interactor.
MINTiMINT-4095317.
STRINGi10090.ENSMUSP00000099755.

Structurei

3D structure databases

ProteinModelPortaliQ9WV91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 137Ig-like C2-type 1Add BLAST116
Domaini149 – 263Ig-like C2-type 2Add BLAST115
Domaini276 – 389Ig-like C2-type 3Add BLAST114
Domaini406 – 536Ig-like C2-type 4Add BLAST131
Domaini544 – 662Ig-like C2-type 5Add BLAST119
Domaini688 – 813Ig-like C2-type 6Add BLAST126

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi89 – 91Cell attachment siteSequence analysis3
Motifi424 – 427Endoplasmic reticulum retention signal4
Motifi703 – 705Cell attachment siteSequence analysis3

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHZG. Eukaryota.
ENOG4111FCJ. LUCA.
GeneTreeiENSGT00390000010278.
HOGENOMiHOG000112641.
HOVERGENiHBG031554.
InParanoidiQ9WV91.
KOiK06729.
OMAiQTSGPIF.
OrthoDBiEOG091G01C5.
TreeFamiTF332702.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 6 hits.
SM00406. IGv. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WV91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRPAPRPLL LALLSLAVCR GRVVRVPAGT LVRVVGTELV IPCNVSDYDG
60 70 80 90 100
PSEQNFDWSF SSSGSSFVEL ASTWEVGFPA QLYRERLQRG DILLRRTAND
110 120 130 140 150
AVELHIKNVQ PSDQGHYKCS TPSTDATVQG NYEDTVQVKV LADALVVGPS
160 170 180 190 200
SRPPPGLSLR EGEPFELRCI ASTTSPLHTH LALRWELHRG PVHRSILALS
210 220 230 240 250
HEGRFHPGPG YEQRYHSGDV RLDTVGSDAY RLSVARALSA DQGSYRCVVS
260 270 280 290 300
EWITEQGSWQ EIQEKAVEVA TVVIQPTALQ LAVPRTVSVT EGKDLDLSCN
310 320 330 340 350
ITTDRVDDVR PEVTWYFKKT PDTSLLASHM LARLDRDSLV HSSPHVALSH
360 370 380 390 400
VDTRSYHLLV RDVSKENSGY YLCLVALWAP GHNRSWHKVA EAMSAPSGVS
410 420 430 440 450
VTWLEPEYQV YLNASKVPGF SDDPTELQCR VIDTKRLEAG VRLTVSWYYR
460 470 480 490 500
MTRRNDDVVA SELLAVMDGD WTLRYGERSK QRAQDGEFIF SKEHTDTFNF
510 520 530 540 550
RIQRTTEEDR GNYYCVVSAW TRQRNNSWVK SKDVFSKPVN IFWASEDSVL
560 570 580 590 600
VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLITAE KPVGDLSSPN
610 620 630 640 650
ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA
660 670 680 690 700
GLYRCMVTAW SPIGGSLWRE AATSLSNPIE IDFQTSGPTF NASVHSDTPS
710 720 730 740 750
VTRGDLIKLF CIVTVEGAVL DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD
760 770 780 790 800
RKGVVTTGQR DWKSTVSLER VSVLEFLLQV HGSEDQDFGN YYCSVTPWVR
810 820 830 840 850
SPTGSWQREA EIHSRPIFIT VKMDVLNAFK YPLLIGVGLS TVIGLLSCLI
860 870
GYCSSHWCCK KEVRETRRER RRLMSMEMD
Length:879
Mass (Da):98,722
Last modified:July 27, 2011 - v2
Checksum:i0E7037B9625B56A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128V → A in AAD38383 (PubMed:10893677).Curated1
Sequence conflicti136V → M in AAD38383 (PubMed:10893677).Curated1
Sequence conflicti267V → E in AAD38383 (PubMed:10893677).Curated1
Sequence conflicti500F → L in AAD38383 (PubMed:10893677).Curated1
Sequence conflicti521T → A in AAD38383 (PubMed:10893677).Curated1
Sequence conflicti647V → D in AAD38383 (PubMed:10893677).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152344 mRNA. Translation: AAD38383.1.
AL672281, AL669937 Genomic DNA. Translation: CAI26220.1.
AL669937, AL672281 Genomic DNA. Translation: CAI26224.1.
AL669872, AL645930 Genomic DNA. Translation: CAM22064.1.
BC145713 mRNA. Translation: AAI45714.1.
BC145715 mRNA. Translation: AAI45716.1.
CCDSiCCDS17680.1.
RefSeqiNP_035327.2. NM_011197.3.
UniGeneiMm.24807.

Genome annotation databases

EnsembliENSMUST00000102694; ENSMUSP00000099755; ENSMUSG00000027864.
GeneIDi19221.
KEGGimmu:19221.
UCSCiuc008qre.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152344 mRNA. Translation: AAD38383.1.
AL672281, AL669937 Genomic DNA. Translation: CAI26220.1.
AL669937, AL672281 Genomic DNA. Translation: CAI26224.1.
AL669872, AL645930 Genomic DNA. Translation: CAM22064.1.
BC145713 mRNA. Translation: AAI45714.1.
BC145715 mRNA. Translation: AAI45716.1.
CCDSiCCDS17680.1.
RefSeqiNP_035327.2. NM_011197.3.
UniGeneiMm.24807.

3D structure databases

ProteinModelPortaliQ9WV91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WV91. 1 interactor.
MINTiMINT-4095317.
STRINGi10090.ENSMUSP00000099755.

PTM databases

iPTMnetiQ9WV91.
PhosphoSitePlusiQ9WV91.
SwissPalmiQ9WV91.

Proteomic databases

MaxQBiQ9WV91.
PaxDbiQ9WV91.
PRIDEiQ9WV91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102694; ENSMUSP00000099755; ENSMUSG00000027864.
GeneIDi19221.
KEGGimmu:19221.
UCSCiuc008qre.1. mouse.

Organism-specific databases

CTDi5738.
MGIiMGI:1277114. Ptgfrn.

Phylogenomic databases

eggNOGiENOG410IHZG. Eukaryota.
ENOG4111FCJ. LUCA.
GeneTreeiENSGT00390000010278.
HOGENOMiHOG000112641.
HOVERGENiHBG031554.
InParanoidiQ9WV91.
KOiK06729.
OMAiQTSGPIF.
OrthoDBiEOG091G01C5.
TreeFamiTF332702.

Miscellaneous databases

ChiTaRSiPtgfrn. mouse.
PROiQ9WV91.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027864.
CleanExiMM_PTGFRN.
GenevisibleiQ9WV91. MM.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 6 hits.
SM00406. IGv. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPRP_MOUSE
AccessioniPrimary (citable) accession number: Q9WV91
Secondary accession number(s): Q5SRA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.