Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleoside diphosphate kinase 3

Gene

Nme3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis (By similarity).By similarity

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29ATPBy similarity1
Binding sitei77ATPBy similarity1
Binding sitei105ATPBy similarity1
Binding sitei111ATPBy similarity1
Binding sitei122ATPBy similarity1
Binding sitei132ATPBy similarity1
Active sitei135Pros-phosphohistidine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase 3 (EC:2.7.4.6)
Short name:
NDK 3
Short name:
NDP kinase 3
Alternative name(s):
DR-nm23
Nucleoside diphosphate kinase C
Short name:
NDPKC
nm23-M3
Gene namesi
Name:Nme3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1930182 Nme3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001371241 – 169Nucleoside diphosphate kinase 3Add BLAST169

Proteomic databases

EPDiQ9WV85
MaxQBiQ9WV85
PaxDbiQ9WV85
PeptideAtlasiQ9WV85
PRIDEiQ9WV85

PTM databases

iPTMnetiQ9WV85
PhosphoSitePlusiQ9WV85
SwissPalmiQ9WV85

Expressioni

Gene expression databases

BgeeiENSMUSG00000073435
CleanExiMM_NME3
GenevisibleiQ9WV85 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024978

Structurei

3D structure databases

ProteinModelPortaliQ9WV85
SMRiQ9WV85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888 Eukaryota
COG0105 LUCA
GeneTreeiENSGT00760000119146
HOGENOMiHOG000224564
HOVERGENiHBG000423
InParanoidiQ9WV85
KOiK00940
OMAiRLVKYMG
OrthoDBiEOG091G0PLD
PhylomeDBiQ9WV85
TreeFamiTF106373

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WV85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICLVLTIFA NLFPSAYSGV NERTFLAVKP DGVQRRLVGE IVRRFERKGF
60 70 80 90 100
KLVALKLVQA SEELLREHYV ELREKPFYSR LVKYMSSGPV VAMVWQGLDV
110 120 130 140 150
VHASRALIGA TDPGDAMPGT IRGDFCMEVG KNVIHGSDSV ESAHREIALW
160
FREAELLCWE DSAGHWLYE
Length:169
Mass (Da):19,099
Last modified:November 9, 2004 - v3
Checksum:i53223C0601A6467C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97G → W in AAD38976 (Ref. 1) Curated1
Sequence conflicti127M → V in AAG02199 (PubMed:12383506).Curated1
Sequence conflicti127M → V in AAG02201 (PubMed:12383506).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153449 mRNA Translation: AAD38976.1
AF288689 mRNA Translation: AAG02199.1
AF288691 Genomic DNA Translation: AAG02201.1
AK007399 mRNA Translation: BAB25013.1
BC028503 mRNA Translation: AAH28503.1
CCDSiCCDS28503.1
RefSeqiNP_062704.2, NM_019730.2
UniGeneiMm.430765

Genome annotation databases

EnsembliENSMUST00000024978; ENSMUSP00000024978; ENSMUSG00000073435
GeneIDi79059
KEGGimmu:79059
UCSCiuc008ayz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNDK3_MOUSE
AccessioniPrimary (citable) accession number: Q9WV85
Secondary accession number(s): Q9D931, Q9EPA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 9, 2004
Last modified: May 23, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health