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Protein

Nucleoside diphosphate kinase 3

Gene

Nme3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis (By similarity).By similarity

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291ATPBy similarity
Binding sitei77 – 771ATPBy similarity
Binding sitei105 – 1051ATPBy similarity
Binding sitei111 – 1111ATPBy similarity
Binding sitei122 – 1221ATPBy similarity
Binding sitei132 – 1321ATPBy similarity
Active sitei135 – 1351Pros-phosphohistidine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase 3 (EC:2.7.4.6)
Short name:
NDK 3
Short name:
NDP kinase 3
Alternative name(s):
DR-nm23
Nucleoside diphosphate kinase C
Short name:
NDPKC
nm23-M3
Gene namesi
Name:Nme3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1930182. Nme3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169Nucleoside diphosphate kinase 3PRO_0000137124Add
BLAST

Proteomic databases

EPDiQ9WV85.
MaxQBiQ9WV85.
PaxDbiQ9WV85.
PeptideAtlasiQ9WV85.
PRIDEiQ9WV85.

PTM databases

iPTMnetiQ9WV85.
PhosphoSiteiQ9WV85.

Expressioni

Gene expression databases

BgeeiQ9WV85.
CleanExiMM_NME3.
GenevisibleiQ9WV85. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024978.

Structurei

3D structure databases

ProteinModelPortaliQ9WV85.
SMRiQ9WV85. Positions 18-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224564.
HOVERGENiHBG000423.
InParanoidiQ9WV85.
KOiK00940.
OMAiELPCWED.
OrthoDBiEOG7GJ6FG.
PhylomeDBiQ9WV85.
TreeFamiTF106373.

Family and domain databases

HAMAPiMF_00451. NDP_kinase.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICLVLTIFA NLFPSAYSGV NERTFLAVKP DGVQRRLVGE IVRRFERKGF
60 70 80 90 100
KLVALKLVQA SEELLREHYV ELREKPFYSR LVKYMSSGPV VAMVWQGLDV
110 120 130 140 150
VHASRALIGA TDPGDAMPGT IRGDFCMEVG KNVIHGSDSV ESAHREIALW
160
FREAELLCWE DSAGHWLYE
Length:169
Mass (Da):19,099
Last modified:November 9, 2004 - v3
Checksum:i53223C0601A6467C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971G → W in AAD38976 (Ref. 1) Curated
Sequence conflicti127 – 1271M → V in AAG02199 (PubMed:12383506).Curated
Sequence conflicti127 – 1271M → V in AAG02201 (PubMed:12383506).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153449 mRNA. Translation: AAD38976.1.
AF288689 mRNA. Translation: AAG02199.1.
AF288691 Genomic DNA. Translation: AAG02201.1.
AK007399 mRNA. Translation: BAB25013.1.
BC028503 mRNA. Translation: AAH28503.1.
CCDSiCCDS28503.1.
RefSeqiNP_062704.2. NM_019730.2.
UniGeneiMm.430765.

Genome annotation databases

EnsembliENSMUST00000024978; ENSMUSP00000024978; ENSMUSG00000073435.
GeneIDi79059.
KEGGimmu:79059.
UCSCiuc008ayz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153449 mRNA. Translation: AAD38976.1.
AF288689 mRNA. Translation: AAG02199.1.
AF288691 Genomic DNA. Translation: AAG02201.1.
AK007399 mRNA. Translation: BAB25013.1.
BC028503 mRNA. Translation: AAH28503.1.
CCDSiCCDS28503.1.
RefSeqiNP_062704.2. NM_019730.2.
UniGeneiMm.430765.

3D structure databases

ProteinModelPortaliQ9WV85.
SMRiQ9WV85. Positions 18-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024978.

PTM databases

iPTMnetiQ9WV85.
PhosphoSiteiQ9WV85.

Proteomic databases

EPDiQ9WV85.
MaxQBiQ9WV85.
PaxDbiQ9WV85.
PeptideAtlasiQ9WV85.
PRIDEiQ9WV85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024978; ENSMUSP00000024978; ENSMUSG00000073435.
GeneIDi79059.
KEGGimmu:79059.
UCSCiuc008ayz.2. mouse.

Organism-specific databases

CTDi4832.
MGIiMGI:1930182. Nme3.

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224564.
HOVERGENiHBG000423.
InParanoidiQ9WV85.
KOiK00940.
OMAiELPCWED.
OrthoDBiEOG7GJ6FG.
PhylomeDBiQ9WV85.
TreeFamiTF106373.

Miscellaneous databases

PROiQ9WV85.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WV85.
CleanExiMM_NME3.
GenevisibleiQ9WV85. MM.

Family and domain databases

HAMAPiMF_00451. NDP_kinase.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mehus J.G., Lambeth D.O.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of the nm23-M2, nm23-M3 and nm23-M4 mouse genes: comparison with their human orthologs."
    Masse K., Dabernat S., Bourbon P.-M., Larou M., Amrein L., Barraud P., Perel Y., Camara M., Landry M., Lacombe M.L., Daniel J.-Y.
    Gene 296:87-97(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNDK3_MOUSE
AccessioniPrimary (citable) accession number: Q9WV85
Secondary accession number(s): Q9D931, Q9EPA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 9, 2004
Last modified: July 6, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.