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Q9WV84

- NDKM_MOUSE

UniProt

Q9WV84 - NDKM_MOUSE

Protein

Nucleoside diphosphate kinase, mitochondrial

Gene

Nme4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

    Catalytic activityi

    ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441ATPBy similarity
    Binding sitei92 – 921ATPBy similarity
    Binding sitei120 – 1201ATPBy similarity
    Binding sitei126 – 1261ATPBy similarity
    Binding sitei137 – 1371ATPBy similarity
    Binding sitei147 – 1471ATPBy similarity
    Active sitei150 – 1501Pros-phosphohistidine intermediateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. nucleoside diphosphate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. CTP biosynthetic process Source: InterPro
    2. GTP biosynthetic process Source: InterPro
    3. UTP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoside diphosphate kinase, mitochondrial (EC:2.7.4.6)
    Short name:
    NDK
    Short name:
    NDP kinase, mitochondrial
    Alternative name(s):
    Nucleoside diphosphate kinase D
    Short name:
    NDPKD
    nm23-M4
    Gene namesi
    Name:Nme4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1931148. Nme4.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: UniProtKB-SubCell
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3232MitochondrionSequence AnalysisAdd
    BLAST
    Chaini33 – 186154Nucleoside diphosphate kinase, mitochondrialPRO_0000019433Add
    BLAST

    Proteomic databases

    PaxDbiQ9WV84.
    PRIDEiQ9WV84.

    PTM databases

    PhosphoSiteiQ9WV84.

    Expressioni

    Tissue specificityi

    Expressed in the base region of the oxyntic and pyloric mucosae.1 Publication

    Gene expression databases

    BgeeiQ9WV84.
    CleanExiMM_NME4.
    GenevestigatoriQ9WV84.

    Interactioni

    Subunit structurei

    Homohexamer By similarity. Interacts with CAPN8.By similarity1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WV84.
    SMRiQ9WV84. Positions 36-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NDK family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0105.
    GeneTreeiENSGT00700000104244.
    HOVERGENiHBG000423.
    InParanoidiQ9WV84.
    KOiK00940.
    OMAiEHERALC.
    OrthoDBiEOG7GJ6FG.
    PhylomeDBiQ9WV84.
    TreeFamiTF106373.

    Family and domain databases

    Gene3Di3.30.70.141. 1 hit.
    HAMAPiMF_00451. NDP_kinase.
    InterProiIPR001564. Nucleoside_diP_kinase.
    IPR023005. Nucleoside_diP_kinase_AS.
    [Graphical view]
    PfamiPF00334. NDK. 1 hit.
    [Graphical view]
    PRINTSiPR01243. NUCDPKINASE.
    SMARTiSM00562. NDK. 1 hit.
    [Graphical view]
    SUPFAMiSSF54919. SSF54919. 1 hit.
    PROSITEiPS00469. NDP_KINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WV84-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLFGRVAA LRALLCGPRF QCLLVRPSSG GPPWPQERTL VAVKPDGVQR    50
    RLVGTVIQRF ERRGFKLVGM KMLQAPESIL AEHYRDLQRK PFYPALISYM 100
    SSGPVVAMVW EGPNVVHISR AMIGHTDSTE AAPGTIRGDF SVHISRNVIH 150
    ASDSVDGAQR EIELWFQSSE LLNWADGGHH SSCYPA 186
    Length:186
    Mass (Da):20,549
    Last modified:November 1, 1999 - v1
    Checksum:i472A32D65C0B25A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153451 mRNA. Translation: AAD38977.1.
    AF288690 mRNA. Translation: AAG02200.1.
    AF288692 Genomic DNA. Translation: AAG02202.1.
    BC027277 mRNA. Translation: AAH27277.1.
    CCDSiCCDS28544.1.
    RefSeqiNP_062705.1. NM_019731.1.
    UniGeneiMm.41787.

    Genome annotation databases

    EnsembliENSMUST00000025007; ENSMUSP00000025007; ENSMUSG00000024177.
    GeneIDi56520.
    KEGGimmu:56520.
    UCSCiuc008bdh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153451 mRNA. Translation: AAD38977.1 .
    AF288690 mRNA. Translation: AAG02200.1 .
    AF288692 Genomic DNA. Translation: AAG02202.1 .
    BC027277 mRNA. Translation: AAH27277.1 .
    CCDSi CCDS28544.1.
    RefSeqi NP_062705.1. NM_019731.1.
    UniGenei Mm.41787.

    3D structure databases

    ProteinModelPortali Q9WV84.
    SMRi Q9WV84. Positions 36-174.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9WV84.

    Proteomic databases

    PaxDbi Q9WV84.
    PRIDEi Q9WV84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025007 ; ENSMUSP00000025007 ; ENSMUSG00000024177 .
    GeneIDi 56520.
    KEGGi mmu:56520.
    UCSCi uc008bdh.1. mouse.

    Organism-specific databases

    CTDi 4833.
    MGIi MGI:1931148. Nme4.

    Phylogenomic databases

    eggNOGi COG0105.
    GeneTreei ENSGT00700000104244.
    HOVERGENi HBG000423.
    InParanoidi Q9WV84.
    KOi K00940.
    OMAi EHERALC.
    OrthoDBi EOG7GJ6FG.
    PhylomeDBi Q9WV84.
    TreeFami TF106373.

    Miscellaneous databases

    NextBioi 312846.
    PROi Q9WV84.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WV84.
    CleanExi MM_NME4.
    Genevestigatori Q9WV84.

    Family and domain databases

    Gene3Di 3.30.70.141. 1 hit.
    HAMAPi MF_00451. NDP_kinase.
    InterProi IPR001564. Nucleoside_diP_kinase.
    IPR023005. Nucleoside_diP_kinase_AS.
    [Graphical view ]
    Pfami PF00334. NDK. 1 hit.
    [Graphical view ]
    PRINTSi PR01243. NUCDPKINASE.
    SMARTi SM00562. NDK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54919. SSF54919. 1 hit.
    PROSITEi PS00469. NDP_KINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mehus J.G., Lambeth D.O.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of the nm23-M2, nm23-M3 and nm23-M4 mouse genes: comparison with their human orthologs."
      Masse K., Dabernat S., Bourbon P.-M., Larou M., Amrein L., Barraud P., Perel Y., Camara M., Landry M., Lacombe M.L., Daniel J.-Y.
      Gene 296:87-97(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.
    4. "Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP."
      Hata S., Koyama S., Kawahara H., Doi N., Maeda T., Toyama-Sorimachi N., Abe K., Suzuki K., Sorimachi H.
      J. Biol. Chem. 281:11214-11224(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CAPN8, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNDKM_MOUSE
    AccessioniPrimary (citable) accession number: Q9WV84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3