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Q9WV80

- SNX1_MOUSE

UniProt

Q9WV80 - SNX1_MOUSE

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Protein

Sorting nexin-1

Gene

Snx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei186 – 1861Phosphatidylinositol 3-phosphateBy similarity
Binding sitei188 – 1881Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei214 – 2141Phosphatidylinositol 3-phosphateBy similarity
Binding sitei238 – 2381Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  1. intracellular protein transport Source: RefGenome
  2. retrograde transport, endosome to Golgi Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-1
Gene namesi
Name:Snx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1928395. Snx1.

Subcellular locationi

Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Golgi apparatustrans-Golgi network membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Early endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) By similarity.By similarity

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: RefGenome
  2. endosome Source: MGI
  3. endosome membrane Source: UniProtKB
  4. Golgi apparatus Source: UniProtKB-KW
  5. membrane Source: UniProtKB
  6. retromer complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mice are born at the expected Mendelian ratio and are fertile. Mice lacking both Snx1 and Snx2 die during embryonic development, around 9.5 and 11.5 dpc.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Sorting nexin-1PRO_0000213836Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321PhosphoserineBy similarity
Modified residuei39 – 391PhosphoserineBy similarity
Modified residuei188 – 1881Phosphoserine1 Publication
Modified residuei237 – 2371N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9WV80.
PaxDbiQ9WV80.
PRIDEiQ9WV80.

PTM databases

PhosphoSiteiQ9WV80.

Expressioni

Gene expression databases

CleanExiMM_SNX1.
GenevestigatoriQ9WV80.

Interactioni

Subunit structurei

Self-assembles into a complex of approximately 300 kDa. Interacts with HGS. Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with SNX6 By similarity.By similarity

Protein-protein interaction databases

BioGridi207981. 1 interaction.
IntActiQ9WV80. 2 interactions.
MINTiMINT-1864956.

Structurei

3D structure databases

ProteinModelPortaliQ9WV80.
SMRiQ9WV80. Positions 142-269, 305-513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 272130PXPROSITE-ProRule annotationAdd
BLAST
Domaini302 – 522221BARAdd
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 BAR domain.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5391.
HOGENOMiHOG000293327.
HOVERGENiHBG000618.
InParanoidiQ9WV80.
KOiK17917.
PhylomeDBiQ9WV80.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028660. SNX1.
IPR005329. Sorting_nexin_N.
IPR015404. Vps5_C.
[Graphical view]
PANTHERiPTHR10555:SF129. PTHR10555:SF129. 1 hit.
PfamiPF00787. PX. 1 hit.
PF03700. Sorting_nexin. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV80-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASGGGGCSA SERLPPPFPG MDPESEGAAG ASEPEAGDSD TEGEDIFTGA
60 70 80 90 100
AAATKPQSPK KTTSLFPIKN GSKENGIHED QDQEPQDLFA DATVELSLDS
110 120 130 140 150
TQNNQKTMPG KTLTSHSPQE ATNSPKPQPS YEELEEEEQE DQFDLTVGIT
160 170 180 190 200
DPEKIGDGMN AYVAYKVTTQ TSLPMFRSRQ FAVKRRFSDF LGLYEKLSEK
210 220 230 240 250
HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA ALERYLQRIV
260 270 280 290 300
NHPTMLQDPD VREFLEKEEL PRAVGTQALS GAGLLKMFNK ATDAVSKMTI
310 320 330 340 350
KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTALFAKS
360 370 380 390 400
LAMLGSSEDN TALSRALSQL AEVEEKIEQL HQEQANNDSF LLAELLSDYI
410 420 430 440 450
RLLAIVRAAF DQRMKTWQRW QDAQATLQKK RESEARLLWA NKPDKLQQAK
460 470 480 490 500
DEITEWESRV TQYERDFERI STVVRKEVTR FEKEKSKDFK NHVMKYLETL
510 520
LHSQQQLAKY WEAFLPEAKA IS
Length:522
Mass (Da):58,952
Last modified:November 1, 1999 - v1
Checksum:i1EFC06B3EA551311
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311A → G in BAB20283. (PubMed:11726276)Curated
Sequence conflicti117 – 1171S → P in BAB20283. (PubMed:11726276)Curated
Sequence conflicti124 – 1241S → C in BAB20283. (PubMed:11726276)Curated
Sequence conflicti138 – 1381Missing in BAB20283. (PubMed:11726276)Curated
Sequence conflicti389 – 3891S → F in BAB20283. (PubMed:11726276)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF154120 mRNA. Translation: AAD38805.1.
AB019214 mRNA. Translation: BAB20283.1.
RefSeqiNP_062701.2. NM_019727.2.
UniGeneiMm.271891.

Genome annotation databases

GeneIDi56440.
KEGGimmu:56440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF154120 mRNA. Translation: AAD38805.1 .
AB019214 mRNA. Translation: BAB20283.1 .
RefSeqi NP_062701.2. NM_019727.2.
UniGenei Mm.271891.

3D structure databases

ProteinModelPortali Q9WV80.
SMRi Q9WV80. Positions 142-269, 305-513.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207981. 1 interaction.
IntActi Q9WV80. 2 interactions.
MINTi MINT-1864956.

PTM databases

PhosphoSitei Q9WV80.

Proteomic databases

MaxQBi Q9WV80.
PaxDbi Q9WV80.
PRIDEi Q9WV80.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 56440.
KEGGi mmu:56440.

Organism-specific databases

CTDi 6642.
MGIi MGI:1928395. Snx1.

Phylogenomic databases

eggNOGi COG5391.
HOGENOMi HOG000293327.
HOVERGENi HBG000618.
InParanoidi Q9WV80.
KOi K17917.
PhylomeDBi Q9WV80.

Miscellaneous databases

ChiTaRSi SNX1. mouse.
NextBioi 312630.
PROi Q9WV80.
SOURCEi Search...

Gene expression databases

CleanExi MM_SNX1.
Genevestigatori Q9WV80.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
IPR028660. SNX1.
IPR005329. Sorting_nexin_N.
IPR015404. Vps5_C.
[Graphical view ]
PANTHERi PTHR10555:SF129. PTHR10555:SF129. 1 hit.
Pfami PF00787. PX. 1 hit.
PF03700. Sorting_nexin. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of mouse sorting nexin 1 (Snx1) cDNA."
    Takahara K., Omatsu Y., Maeda Y., Shimoyama S., Inaba K.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "Association of mouse sorting nexin 1 with early endosomes."
    Nakamura N., Sun-Wada G.H., Yamamoto A., Wada Y., Futai M.
    J. Biochem. 130:765-771(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT.
    Strain: C57BL/6.
  3. "Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice."
    Schwarz D.G., Griffin C.T., Schneider E.A., Yee D., Magnuson T.
    Mol. Biol. Cell 13:3588-3600(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSNX1_MOUSE
AccessioniPrimary (citable) accession number: Q9WV80
Secondary accession number(s): Q9EQZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds phosphatidylinositol 3-phosphate (PtdIns-3P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2) in liposome-based assays. Can bind PtdIns(3,4,5)P3 in protein:lipid overlay assays, but not in liposome-based assays By similarity.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3