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Q9WV80

- SNX1_MOUSE

UniProt

Q9WV80 - SNX1_MOUSE

Protein

Sorting nexin-1

Gene

Snx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei186 – 1861Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei188 – 1881Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei214 – 2141Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei238 – 2381Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol binding Source: UniProtKB

    GO - Biological processi

    1. intracellular protein transport Source: RefGenome
    2. retrograde transport, endosome to Golgi Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-1
    Gene namesi
    Name:Snx1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1928395. Snx1.

    Subcellular locationi

    Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Golgi apparatustrans-Golgi network membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Early endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: RefGenome
    2. early endosome membrane Source: UniProtKB-SubCell
    3. endosome Source: MGI
    4. endosome membrane Source: UniProtKB
    5. Golgi apparatus Source: UniProtKB-SubCell
    6. retromer complex Source: InterPro

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype. Mice are born at the expected Mendelian ratio and are fertile. Mice lacking both Snx1 and Snx2 die during embryonic development, around 9.5 and 11.5 dpc.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Sorting nexin-1PRO_0000213836Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei32 – 321PhosphoserineBy similarity
    Modified residuei39 – 391PhosphoserineBy similarity
    Modified residuei188 – 1881Phosphoserine1 Publication
    Modified residuei237 – 2371N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9WV80.
    PaxDbiQ9WV80.
    PRIDEiQ9WV80.

    PTM databases

    PhosphoSiteiQ9WV80.

    Expressioni

    Gene expression databases

    CleanExiMM_SNX1.
    GenevestigatoriQ9WV80.

    Interactioni

    Subunit structurei

    Self-assembles into a complex of approximately 300 kDa. Interacts with HGS. Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with SNX6 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi207981. 1 interaction.
    IntActiQ9WV80. 2 interactions.
    MINTiMINT-1864956.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WV80.
    SMRiQ9WV80. Positions 142-269, 305-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini143 – 272130PXPROSITE-ProRule annotationAdd
    BLAST
    Domaini302 – 522221BARAdd
    BLAST

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 BAR domain.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5391.
    HOGENOMiHOG000293327.
    HOVERGENiHBG000618.
    InParanoidiQ9WV80.
    KOiK17917.
    PhylomeDBiQ9WV80.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    IPR028660. SNX1.
    IPR005329. Sorting_nexin_N.
    IPR015404. Vps5_C.
    [Graphical view]
    PANTHERiPTHR10555:SF129. PTHR10555:SF129. 1 hit.
    PfamiPF00787. PX. 1 hit.
    PF03700. Sorting_nexin. 1 hit.
    PF09325. Vps5. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WV80-1 [UniParc]FASTAAdd to Basket

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    MASGGGGCSA SERLPPPFPG MDPESEGAAG ASEPEAGDSD TEGEDIFTGA    50
    AAATKPQSPK KTTSLFPIKN GSKENGIHED QDQEPQDLFA DATVELSLDS 100
    TQNNQKTMPG KTLTSHSPQE ATNSPKPQPS YEELEEEEQE DQFDLTVGIT 150
    DPEKIGDGMN AYVAYKVTTQ TSLPMFRSRQ FAVKRRFSDF LGLYEKLSEK 200
    HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA ALERYLQRIV 250
    NHPTMLQDPD VREFLEKEEL PRAVGTQALS GAGLLKMFNK ATDAVSKMTI 300
    KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTALFAKS 350
    LAMLGSSEDN TALSRALSQL AEVEEKIEQL HQEQANNDSF LLAELLSDYI 400
    RLLAIVRAAF DQRMKTWQRW QDAQATLQKK RESEARLLWA NKPDKLQQAK 450
    DEITEWESRV TQYERDFERI STVVRKEVTR FEKEKSKDFK NHVMKYLETL 500
    LHSQQQLAKY WEAFLPEAKA IS 522
    Length:522
    Mass (Da):58,952
    Last modified:November 1, 1999 - v1
    Checksum:i1EFC06B3EA551311
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311A → G in BAB20283. (PubMed:11726276)Curated
    Sequence conflicti117 – 1171S → P in BAB20283. (PubMed:11726276)Curated
    Sequence conflicti124 – 1241S → C in BAB20283. (PubMed:11726276)Curated
    Sequence conflicti138 – 1381Missing in BAB20283. (PubMed:11726276)Curated
    Sequence conflicti389 – 3891S → F in BAB20283. (PubMed:11726276)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154120 mRNA. Translation: AAD38805.1.
    AB019214 mRNA. Translation: BAB20283.1.
    RefSeqiNP_062701.2. NM_019727.2.
    UniGeneiMm.271891.

    Genome annotation databases

    GeneIDi56440.
    KEGGimmu:56440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154120 mRNA. Translation: AAD38805.1 .
    AB019214 mRNA. Translation: BAB20283.1 .
    RefSeqi NP_062701.2. NM_019727.2.
    UniGenei Mm.271891.

    3D structure databases

    ProteinModelPortali Q9WV80.
    SMRi Q9WV80. Positions 142-269, 305-513.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207981. 1 interaction.
    IntActi Q9WV80. 2 interactions.
    MINTi MINT-1864956.

    PTM databases

    PhosphoSitei Q9WV80.

    Proteomic databases

    MaxQBi Q9WV80.
    PaxDbi Q9WV80.
    PRIDEi Q9WV80.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 56440.
    KEGGi mmu:56440.

    Organism-specific databases

    CTDi 6642.
    MGIi MGI:1928395. Snx1.

    Phylogenomic databases

    eggNOGi COG5391.
    HOGENOMi HOG000293327.
    HOVERGENi HBG000618.
    InParanoidi Q9WV80.
    KOi K17917.
    PhylomeDBi Q9WV80.

    Miscellaneous databases

    ChiTaRSi SNX1. mouse.
    NextBioi 312630.
    PROi Q9WV80.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_SNX1.
    Genevestigatori Q9WV80.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    IPR028660. SNX1.
    IPR005329. Sorting_nexin_N.
    IPR015404. Vps5_C.
    [Graphical view ]
    PANTHERi PTHR10555:SF129. PTHR10555:SF129. 1 hit.
    Pfami PF00787. PX. 1 hit.
    PF03700. Sorting_nexin. 1 hit.
    PF09325. Vps5. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of mouse sorting nexin 1 (Snx1) cDNA."
      Takahara K., Omatsu Y., Maeda Y., Shimoyama S., Inaba K.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thymus.
    2. "Association of mouse sorting nexin 1 with early endosomes."
      Nakamura N., Sun-Wada G.H., Yamamoto A., Wada Y., Futai M.
      J. Biochem. 130:765-771(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT.
      Strain: C57BL/6.
    3. "Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice."
      Schwarz D.G., Griffin C.T., Schneider E.A., Yee D., Magnuson T.
      Mol. Biol. Cell 13:3588-3600(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiSNX1_MOUSE
    AccessioniPrimary (citable) accession number: Q9WV80
    Secondary accession number(s): Q9EQZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Binds phosphatidylinositol 3-phosphate (PtdIns-3P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2) in liposome-based assays. Can bind PtdIns(3,4,5)P3 in protein:lipid overlay assays, but not in liposome-based assays By similarity.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3