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Reviewed, UniProtKB/Swiss-Prot Q9WV80 (SNX1_MOUSE)

Last modified November 24, 2009. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Sorting nexin-1
Gene names
Name: Snx1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with PtdIns(3,4,5)P3 and, with weaker affinity, with PtdIns(3,5)P2 By similarity.

Subunit structure

Self-assembles into a complex of approximately 300 kDa. Interacts with HGS. Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2 By similarity.

Subcellular location

Endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Golgi apparatus › trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 PX (phox homology) domain.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

IkbkbO883512EBI-646356,EBI-447960

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Sorting nexin-1
PRO_0000213836

Regions

Domain143 – 272130PX

Amino acid modifications

Modified residue321Phosphoserine By similarity
Modified residue391Phosphoserine By similarity
Modified residue411Phosphothreonine By similarity
Modified residue1881Phosphoserine Ref.3
Modified residue2371N6-acetyllysine By similarity

Experimental info

Sequence conflict311A → G in BAB20283. Ref.2
Sequence conflict1171S → P in BAB20283. Ref.2
Sequence conflict1241S → C in BAB20283. Ref.2
Sequence conflict1381Missing in BAB20283. Ref.2
Sequence conflict3891S → F in BAB20283. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q9WV80-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 1EFC06B3EA551311

FASTA52258,952
        10         20         30         40         50         60 
MASGGGGCSA SERLPPPFPG MDPESEGAAG ASEPEAGDSD TEGEDIFTGA AAATKPQSPK 

        70         80         90        100        110        120 
KTTSLFPIKN GSKENGIHED QDQEPQDLFA DATVELSLDS TQNNQKTMPG KTLTSHSPQE 

       130        140        150        160        170        180 
ATNSPKPQPS YEELEEEEQE DQFDLTVGIT DPEKIGDGMN AYVAYKVTTQ TSLPMFRSRQ 

       190        200        210        220        230        240 
FAVKRRFSDF LGLYEKLSEK HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA 

       250        260        270        280        290        300 
ALERYLQRIV NHPTMLQDPD VREFLEKEEL PRAVGTQALS GAGLLKMFNK ATDAVSKMTI 

       310        320        330        340        350        360 
KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTALFAKS LAMLGSSEDN 

       370        380        390        400        410        420 
TALSRALSQL AEVEEKIEQL HQEQANNDSF LLAELLSDYI RLLAIVRAAF DQRMKTWQRW 

       430        440        450        460        470        480 
QDAQATLQKK RESEARLLWA NKPDKLQQAK DEITEWESRV TQYERDFERI STVVRKEVTR 

       490        500        510        520 
FEKEKSKDFK NHVMKYLETL LHSQQQLAKY WEAFLPEAKA IS

« Hide

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References

« Hide 'large scale' references
[1]"Complete sequence of mouse sorting nexin 1 (Snx1) cDNA."
Takahara K., Omatsu Y., Maeda Y., Shimoyama S., Inaba K.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Thymus.
[2]"Association of mouse sorting nexin 1 with early endosomes."
Nakamura N., Sun-Wada G.H., Yamamoto A., Wada Y., Futai M.
J. Biochem. 130:765-771(2001) [PubMed: 11726276] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT.
Strain: C57BL/6.
[3]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF154120 mRNA. Translation: AAD38805.1.
AB019214 mRNA. Translation: BAB20283.1.
IPIIPI00622364.
RefSeqNP_062701.2.
UniGeneMm.271891

3D structure databases

SMRQ9WV80. Positions 142-269.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9WV80. 1 interaction.
STRINGQ9WV80.

PTM databases

PhosphoSiteQ9WV80.

Proteomic databases

PRIDEQ9WV80.

Genome annotation databases

EnsemblENSMUST00000034946; ENSMUSP00000034946; ENSMUSG00000032382; Mus musculus. [Genome view]
GeneID56440.
KEGGmmu:56440.

Organism-specific databases

CTD56440.
MGIMGI:1928395. Snx1.

Phylogenomic databases

HOGENOMQ9WV80.
HOVERGENQ9WV80.

Gene expression databases

ArrayExpressQ9WV80.
BgeeQ9WV80.
CleanExMM_SNX1.
GenevestigatorQ9WV80.
GermOnlineENSMUSG00000032382. Mus musculus.

Family and domain databases

InterProIPR001683. PX.
IPR005329. Sorting_nexin_N.
IPR015404. Vps5_C.
[Graphical view]
Gene3DG3DSA:3.30.1520.10. PX. 1 hit.
PfamPF00787. PX. 1 hit.
PF03700. Sorting_nexin. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view]
SMARTSM00312. PX. 1 hit.
[Graphical view]
PROSITEPS50195. PX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio312630.
SOURCESearch...

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Entry information

Entry nameSNX1_MOUSE
AccessionPrimary (citable) accession number: Q9WV80
Secondary accession number(s): Q9EQZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: November 24, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents