Reviewed,
UniProtKB/Swiss-Prot Q9WV80 (SNX1_MOUSE)
Last modified
November 24, 2009.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Sorting nexin-1 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 522 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with PtdIns(3,4,5)P3 and, with weaker affinity, with PtdIns(3,5)P2 By similarity. |
| Subunit structure | Self-assembles into a complex of approximately 300 kDa. Interacts with HGS. Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2 By similarity. |
| Subcellular location | Endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Golgi apparatus › trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side By similarity. |
| Sequence similarities | Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein transport Transport |
| Cellular component | Endosome Golgi apparatus Membrane |
| PTM | Acetylation Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | cell communication Inferred from electronic annotation. Source: InterPro intracellular protein transportInferred from electronic annotation. Source: InterPro |
| Cellular component | Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | phosphoinositide binding Inferred from electronic annotation. Source: InterPro protein bindingInferred from physical interaction. Source: IntAct protein transporter activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 522 | 522 | Sorting nexin-1 | PRO_0000213836 | |||||
Regions | |||||||||
| Domain | 143 – 272 | 130 | PX | ||||||
Amino acid modifications | |||||||||
| Modified residue | 32 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 39 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 41 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 188 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 237 | 1 | N6-acetyllysine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 31 | 1 | A → G in BAB20283. Ref.2 | ||||||
| Sequence conflict | 117 | 1 | S → P in BAB20283. Ref.2 | ||||||
| Sequence conflict | 124 | 1 | S → C in BAB20283. Ref.2 | ||||||
| Sequence conflict | 138 | 1 | Missing in BAB20283. Ref.2 | ||||||
| Sequence conflict | 389 | 1 | S → F in BAB20283. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete sequence of mouse sorting nexin 1 (Snx1) cDNA." Takahara K., Omatsu Y., Maeda Y., Shimoyama S., Inaba K. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thymus. |
| [2] | "Association of mouse sorting nexin 1 with early endosomes." Nakamura N., Sun-Wada G.H., Yamamoto A., Wada Y., Futai M. J. Biochem. 130:765-771(2001) [PubMed: 11726276] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT. Strain: C57BL/6. |
| [3] | "Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF154120 mRNA. Translation: AAD38805.1. AB019214 mRNA. Translation: BAB20283.1. | |
| IPI | IPI00622364. |
| RefSeq | NP_062701.2. |
| UniGene | Mm.271891 |
3D structure databases | |
| SMR | Q9WV80. Positions 142-269. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9WV80. 1 interaction. |
| STRING | Q9WV80. |
PTM databases | |
| PhosphoSite | Q9WV80. |
Proteomic databases | |
| PRIDE | Q9WV80. |
Genome annotation databases | |
| Ensembl | ENSMUST00000034946; ENSMUSP00000034946; ENSMUSG00000032382; Mus musculus. [Genome view] |
| GeneID | 56440. |
| KEGG | mmu:56440. |
Organism-specific databases | |
| CTD | 56440. |
| MGI | MGI:1928395. Snx1. |
Phylogenomic databases | |
| HOGENOM | Q9WV80. |
| HOVERGEN | Q9WV80. |
Gene expression databases | |
| ArrayExpress | Q9WV80. |
| Bgee | Q9WV80. |
| CleanEx | MM_SNX1. |
| Genevestigator | Q9WV80. |
| GermOnline | ENSMUSG00000032382. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001683. PX. IPR005329. Sorting_nexin_N. IPR015404. Vps5_C. [Graphical view] |
| Gene3D | G3DSA:3.30.1520.10. PX. 1 hit. |
| Pfam | PF00787. PX. 1 hit. PF03700. Sorting_nexin. 1 hit. PF09325. Vps5. 1 hit. [Graphical view] |
| SMART | SM00312. PX. 1 hit. [Graphical view] |
| PROSITE | PS50195. PX. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 312630. |
| SOURCE | Search... |
Entry information
| Entry name | SNX1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9WV80 Secondary accession number(s): Q9EQZ9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


