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Protein

Plasmalemma vesicle-associated protein

Gene

Plvap

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Plasmalemma vesicle-associated protein
Alternative name(s):
Plasmalemma vesicle protein 1
Short name:
PV-1
gp68
Gene namesi
Name:Plvap
Synonyms:Pv1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi619971. Plvap.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626CytoplasmicSequence analysisAdd
BLAST
Transmembranei27 – 4721Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini48 – 438391ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • caveola Source: RGD
  • cell surface Source: Ensembl
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: RGD
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Plasmalemma vesicle-associated proteinPRO_0000058464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9WV78.
PRIDEiQ9WV78.

Expressioni

Tissue specificityi

Expressed in lung (alveolar endothelial and bronchial epithelial cells), kidney (endothelium of peritubular capillaries), spleen, liver, adrenal (endothelial cells of the zona reticularis of the cortex and chromaffin cells in the medulla), pancreas (islets of Langerhans), testis (germ cells, interstitial cells in neonatal testis and spermatids), ovary (stromal endothelial, thecal layer of developing follicles, luteal cells within the corpus luteum), intestine (endothelium of capillaries of the intestinal villi) and pituitary (pituicyte cells in the neural lobe) (at protein level). Expressed in lung, kidney, spleen, liver, adrenal, testis, heart, muscle, pituitary, thyroid and ovary.4 Publications

Developmental stagei

Expressed in endothelial cells of the lung at 12 dpc.1 Publication

Gene expression databases

ExpressionAtlasiQ9WV78. baseline and differential.
GenevisibleiQ9WV78. RN.

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

BioGridi248574. 1 interaction.
IntActiQ9WV78. 1 interaction.
STRINGi10116.ENSRNOP00000023927.

Structurei

3D structure databases

ProteinModelPortaliQ9WV78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili289 – 38395Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi191 – 23343Gln-richAdd
BLAST
Compositional biasi393 – 43644Pro-richAdd
BLAST

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJNT. Eukaryota.
ENOG410Y4AG. LUCA.
GeneTreeiENSGT00390000006166.
HOGENOMiHOG000115581.
HOVERGENiHBG082152.
InParanoidiQ9WV78.
KOiK17309.
OMAiMGLAMEH.
OrthoDBiEOG7PCJH0.
PhylomeDBiQ9WV78.
TreeFamiTF337332.

Family and domain databases

InterProiIPR009538. PV-1.
[Graphical view]
PfamiPF06637. PV-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSMDRSPY SRTGDRDRGC WYYLRYFFLF VSLIQFLIIL GLVLFMIYGN
60 70 80 90 100
VHATTESSLR ATEIRADNLY SQVVGLSAAQ ANLSKQLNIS TLVKDTVMQQ
110 120 130 140 150
LLTTRREVER INASFRQCQG DLITYINYNR FIAAIILSEK QCQEQLKEGN
160 170 180 190 200
KTCEALLFKL GEKVKTLEME VVKEKAVCSK DKDSLLAGKR QAEMQQEACG
210 220 230 240 250
KAREQQKQDQ QVTEEQLRKV QSLCLPLDQE KFQADVLNVW RDSLVYRSLD
260 270 280 290 300
NIGYHYSLMP EFSSLRRTCE SLPGIMTTKV EELARGLRAG IERVTRENGE
310 320 330 340 350
LRRQKLELER AIQGEREART RAGTEAQARE TQLRTECARQ TQLALEEKAA
360 370 380 390 400
LRTQRDDLER QLEARKRELE QLRTEVDVRI SALDTCVKAK SLPAIQPRLP
410 420 430
GPPPNPPPID PASLEEFKKR ILESQRPPLV NPAVPPSG
Length:438
Mass (Da):50,033
Last modified:November 1, 1999 - v1
Checksum:i99A016CDD12568C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154831 mRNA. Translation: AAD41524.1.
BC070900 mRNA. Translation: AAH70900.1.
RefSeqiNP_064471.1. NM_020086.1.
UniGeneiRn.53915.

Genome annotation databases

EnsembliENSRNOT00000023926; ENSRNOP00000023927; ENSRNOG00000017676.
GeneIDi56765.
KEGGirno:56765.
UCSCiRGD:619971. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154831 mRNA. Translation: AAD41524.1.
BC070900 mRNA. Translation: AAH70900.1.
RefSeqiNP_064471.1. NM_020086.1.
UniGeneiRn.53915.

3D structure databases

ProteinModelPortaliQ9WV78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248574. 1 interaction.
IntActiQ9WV78. 1 interaction.
STRINGi10116.ENSRNOP00000023927.

Proteomic databases

PaxDbiQ9WV78.
PRIDEiQ9WV78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023926; ENSRNOP00000023927; ENSRNOG00000017676.
GeneIDi56765.
KEGGirno:56765.
UCSCiRGD:619971. rat.

Organism-specific databases

CTDi83483.
RGDi619971. Plvap.

Phylogenomic databases

eggNOGiENOG410IJNT. Eukaryota.
ENOG410Y4AG. LUCA.
GeneTreeiENSGT00390000006166.
HOGENOMiHOG000115581.
HOVERGENiHBG082152.
InParanoidiQ9WV78.
KOiK17309.
OMAiMGLAMEH.
OrthoDBiEOG7PCJH0.
PhylomeDBiQ9WV78.
TreeFamiTF337332.

Miscellaneous databases

NextBioi611153.
PROiQ9WV78.

Gene expression databases

ExpressionAtlasiQ9WV78. baseline and differential.
GenevisibleiQ9WV78. RN.

Family and domain databases

InterProiIPR009538. PV-1.
[Graphical view]
PfamiPF06637. PV-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, cloning, and localization of rat PV-1, a novel endothelial caveolar protein."
    Stan R.-V., Ghitescu L., Jacobson B.S., Palade G.E.
    J. Cell Biol. 145:1189-1198(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-16; 232-241 AND 248-264, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Lung endothelial cell.
  2. "PV-1 is a component of the fenestral and stomatal diaphragms in fenestrated endothelia."
    Stan R.-V., Kubitza M., Palade G.E.
    Proc. Natl. Acad. Sci. U.S.A. 96:13203-13207(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Lung endothelial cell.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. "Distribution and characterization of plasmalemma vesicle protein-1 in rat endocrine glands."
    Hnasko R., McFarland M., Ben-Jonathan N.
    J. Endocrinol. 175:649-661(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Multiple PV1 dimers reside in the same stomatal or fenestral diaphragm."
    Stan R.-V.
    Am. J. Physiol. 286:H1347-H1353(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  6. "Developmental regulation of PV-1 in rat lung: association with the nuclear envelope and limited colocalization with Cav-1."
    Hnasko R., Ben-Jonathan N.
    Am. J. Physiol. 288:L275-L284(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPLVAP_RAT
AccessioniPrimary (citable) accession number: Q9WV78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 1, 1999
Last modified: February 17, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.