Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Plasmalemma vesicle-associated protein

Gene

Plvap

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Plasmalemma vesicle-associated protein
Alternative name(s):
Plasmalemma vesicle protein 1
Short name:
PV-1
gp68
Gene namesi
Name:Plvap
Synonyms:Pv1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi619971 Plvap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini48 – 438ExtracellularSequence analysisAdd BLAST391

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584641 – 438Plasmalemma vesicle-associated proteinAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9WV78
PRIDEiQ9WV78

PTM databases

iPTMnetiQ9WV78
PhosphoSitePlusiQ9WV78

Expressioni

Tissue specificityi

Expressed in lung (alveolar endothelial and bronchial epithelial cells), kidney (endothelium of peritubular capillaries), spleen, liver, adrenal (endothelial cells of the zona reticularis of the cortex and chromaffin cells in the medulla), pancreas (islets of Langerhans), testis (germ cells, interstitial cells in neonatal testis and spermatids), ovary (stromal endothelial, thecal layer of developing follicles, luteal cells within the corpus luteum), intestine (endothelium of capillaries of the intestinal villi) and pituitary (pituicyte cells in the neural lobe) (at protein level). Expressed in lung, kidney, spleen, liver, adrenal, testis, heart, muscle, pituitary, thyroid and ovary.4 Publications

Developmental stagei

Expressed in endothelial cells of the lung at 12 dpc.1 Publication

Gene expression databases

BgeeiENSRNOG00000017676
ExpressionAtlasiQ9WV78 baseline and differential
GenevisibleiQ9WV78 RN

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

BioGridi248574, 1 interactor
IntActiQ9WV78, 1 interactor
STRINGi10116.ENSRNOP00000023927

Structurei

3D structure databases

ProteinModelPortaliQ9WV78
SMRiQ9WV78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili289 – 383Sequence analysisAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi191 – 233Gln-richAdd BLAST43
Compositional biasi393 – 436Pro-richAdd BLAST44

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJNT Eukaryota
ENOG410Y4AG LUCA
GeneTreeiENSGT00390000006166
HOGENOMiHOG000115581
HOVERGENiHBG082152
InParanoidiQ9WV78
KOiK17309
OMAiRNLWRDS
PhylomeDBiQ9WV78
TreeFamiTF337332

Family and domain databases

InterProiView protein in InterPro
IPR009538 PV-1
PANTHERiPTHR21687 PTHR21687, 1 hit
PfamiView protein in Pfam
PF06637 PV-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WV78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSMDRSPY SRTGDRDRGC WYYLRYFFLF VSLIQFLIIL GLVLFMIYGN
60 70 80 90 100
VHATTESSLR ATEIRADNLY SQVVGLSAAQ ANLSKQLNIS TLVKDTVMQQ
110 120 130 140 150
LLTTRREVER INASFRQCQG DLITYINYNR FIAAIILSEK QCQEQLKEGN
160 170 180 190 200
KTCEALLFKL GEKVKTLEME VVKEKAVCSK DKDSLLAGKR QAEMQQEACG
210 220 230 240 250
KAREQQKQDQ QVTEEQLRKV QSLCLPLDQE KFQADVLNVW RDSLVYRSLD
260 270 280 290 300
NIGYHYSLMP EFSSLRRTCE SLPGIMTTKV EELARGLRAG IERVTRENGE
310 320 330 340 350
LRRQKLELER AIQGEREART RAGTEAQARE TQLRTECARQ TQLALEEKAA
360 370 380 390 400
LRTQRDDLER QLEARKRELE QLRTEVDVRI SALDTCVKAK SLPAIQPRLP
410 420 430
GPPPNPPPID PASLEEFKKR ILESQRPPLV NPAVPPSG
Length:438
Mass (Da):50,033
Last modified:November 1, 1999 - v1
Checksum:i99A016CDD12568C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154831 mRNA Translation: AAD41524.1
BC070900 mRNA Translation: AAH70900.1
RefSeqiNP_064471.1, NM_020086.1
UniGeneiRn.53915

Genome annotation databases

EnsembliENSRNOT00000023926; ENSRNOP00000023927; ENSRNOG00000017676
GeneIDi56765
KEGGirno:56765
UCSCiRGD:619971 rat

Similar proteinsi

Entry informationi

Entry nameiPLVAP_RAT
AccessioniPrimary (citable) accession number: Q9WV78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health