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Protein

Spondin-2

Gene

Spon2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Divalent metal cationSequence analysis1
Metal bindingi140Divalent metal cationBy similarity1
Sitei140Important for metal ion-dependent interaction with integrinBy similarity1
Metal bindingi159CalciumBy similarity1
Metal bindingi187CalciumBy similarity1
Metal bindingi191Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • signaling receptor binding Source: RGD

GO - Biological processi

  • cell adhesion Source: RGD
  • innate immune response Source: UniProtKB-KW

Keywordsi

Biological processCell adhesion, Immunity, Innate immunity
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-5173214 O-glycosylation of TSR domain-containing proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Spondin-2
Alternative name(s):
Mindin
Gene namesi
Name:Spon2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi708584 Spon2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003587226 – 330Spondin-2Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 170PROSITE-ProRule annotation
Glycosylationi282C-linked (Man) tryptophanBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WV75
PRIDEiQ9WV75

Expressioni

Tissue specificityi

Abundantly expressed in the developing hippocampus.1 Publication

Gene expression databases

BgeeiENSRNOG00000006033
GenevisibleiQ9WV75 RN

Interactioni

Subunit structurei

Monomer. Interacts with integrin (By similarity).By similarity

GO - Molecular functioni

  • signaling receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008262

Structurei

3D structure databases

ProteinModelPortaliQ9WV75
SMRiQ9WV75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 220SpondinPROSITE-ProRule annotationAdd BLAST191
Domaini276 – 330TSP type-1PROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IR0P Eukaryota
ENOG410XX1S LUCA
GeneTreeiENSGT00890000139423
HOGENOMiHOG000114626
HOVERGENiHBG052919
InParanoidiQ9WV75
OMAiHSRHSLV
OrthoDBiEOG091G0BT5
PhylomeDBiQ9WV75

Family and domain databases

Gene3Di2.20.100.10, 1 hit
2.60.40.2130, 1 hit
InterProiView protein in InterPro
IPR009465 Spondin_N
IPR038678 Spondin_N_sf
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF06468 Spond_N, 1 hit
PF00090 TSP_1, 1 hit
SMARTiView protein in SMART
SM00209 TSP1, 1 hit
SUPFAMiSSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS51020 SPONDIN, 1 hit
PS50092 TSP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WV75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENVSFSLDR TLWVFLLAML GSTAGQPLGG ESVCTARPLA RYSITFTGKW
60 70 80 90 100
SQTAFPKQYP LFRPPAQWSS LLGAAHSSDY SMWRKNEYVS NGLRDFAERG
110 120 130 140 150
EAWALMKEIE AAGEKLQSVH AVFSAPAVPS GTGQTSAELE VHPRHSLVSF
160 170 180 190 200
VVRIVPSPDW FVGIDSLDLC EGGRWKEQVV LDLYPHDAGT DSGFTFSSPN
210 220 230 240 250
FATIPQDTVT EITASSPSHP ANSFYYPRLK SLPPIAKVTF VRLRQSPRAF
260 270 280 290 300
APPSLDLASR GNEIVDSLSV PETPLDCEVS LWSSWGLCGG PCGKLGAKSR
310 320 330
TRYVRVQPAN NGTPCPELEE EAECAPDNCV
Length:330
Mass (Da):36,015
Last modified:November 1, 1999 - v1
Checksum:iECBCF07A0345A83A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155196 mRNA Translation: AAD38195.1
BC078734 mRNA Translation: AAH78734.1
RefSeqiNP_612542.1, NM_138533.3
XP_017454551.1, XM_017599062.1
XP_017454552.1, XM_017599063.1
XP_017460311.1, XM_017604822.1
XP_017460312.1, XM_017604823.1
UniGeneiRn.6699

Genome annotation databases

EnsembliENSRNOT00000008262; ENSRNOP00000008262; ENSRNOG00000006033
GeneIDi100910790
171569
KEGGirno:100910790
rno:171569

Similar proteinsi

Entry informationi

Entry nameiSPON2_RAT
AccessioniPrimary (citable) accession number: Q9WV75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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