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Protein

Spondin-2

Gene

Spon2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411Divalent metal cationSequence analysis
Metal bindingi140 – 1401Divalent metal cationBy similarity
Sitei140 – 1401Important for metal ion-dependent interaction with integrinBy similarity
Metal bindingi159 – 1591CalciumBy similarity
Metal bindingi187 – 1871CalciumBy similarity
Metal bindingi191 – 1911Calcium; via carbonyl oxygenBy similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • receptor binding Source: RGD

GO - Biological processi

  • cell adhesion Source: RGD
  • innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Immunity, Innate immunity

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spondin-2
Alternative name(s):
Mindin
Gene namesi
Name:Spon2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi708584. Spon2.

Subcellular locationi

GO - Cellular componenti

  • extracellular matrix Source: RGD
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 330305Spondin-2PRO_0000035872Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 170PROSITE-ProRule annotation
Glycosylationi282 – 2821C-linked (Man)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WV75.
PRIDEiQ9WV75.

Expressioni

Tissue specificityi

Abundantly expressed in the developing hippocampus.1 Publication

Gene expression databases

GenevisibleiQ9WV75. RN.

Interactioni

Subunit structurei

Monomer. Interacts with integrin (By similarity).By similarity

GO - Molecular functioni

  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008262.

Structurei

3D structure databases

ProteinModelPortaliQ9WV75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 220191SpondinPROSITE-ProRule annotationAdd
BLAST
Domaini276 – 33055TSP type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 spondin domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IR0P. Eukaryota.
ENOG410XX1S. LUCA.
GeneTreeiENSGT00810000125397.
HOGENOMiHOG000114626.
HOVERGENiHBG052919.
InParanoidiQ9WV75.
OMAiHSRHSLV.
OrthoDBiEOG71CFK9.
PhylomeDBiQ9WV75.

Family and domain databases

InterProiIPR009465. Spondin_N.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF06468. Spond_N. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
SMARTiSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS51020. SPONDIN. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WV75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENVSFSLDR TLWVFLLAML GSTAGQPLGG ESVCTARPLA RYSITFTGKW
60 70 80 90 100
SQTAFPKQYP LFRPPAQWSS LLGAAHSSDY SMWRKNEYVS NGLRDFAERG
110 120 130 140 150
EAWALMKEIE AAGEKLQSVH AVFSAPAVPS GTGQTSAELE VHPRHSLVSF
160 170 180 190 200
VVRIVPSPDW FVGIDSLDLC EGGRWKEQVV LDLYPHDAGT DSGFTFSSPN
210 220 230 240 250
FATIPQDTVT EITASSPSHP ANSFYYPRLK SLPPIAKVTF VRLRQSPRAF
260 270 280 290 300
APPSLDLASR GNEIVDSLSV PETPLDCEVS LWSSWGLCGG PCGKLGAKSR
310 320 330
TRYVRVQPAN NGTPCPELEE EAECAPDNCV
Length:330
Mass (Da):36,015
Last modified:November 1, 1999 - v1
Checksum:iECBCF07A0345A83A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155196 mRNA. Translation: AAD38195.1.
BC078734 mRNA. Translation: AAH78734.1.
RefSeqiNP_612542.1. NM_138533.3.
UniGeneiRn.6699.

Genome annotation databases

EnsembliENSRNOT00000008262; ENSRNOP00000008262; ENSRNOG00000006033.
GeneIDi171569.
KEGGirno:171569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155196 mRNA. Translation: AAD38195.1.
BC078734 mRNA. Translation: AAH78734.1.
RefSeqiNP_612542.1. NM_138533.3.
UniGeneiRn.6699.

3D structure databases

ProteinModelPortaliQ9WV75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008262.

Proteomic databases

PaxDbiQ9WV75.
PRIDEiQ9WV75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008262; ENSRNOP00000008262; ENSRNOG00000006033.
GeneIDi171569.
KEGGirno:171569.

Organism-specific databases

CTDi10417.
RGDi708584. Spon2.

Phylogenomic databases

eggNOGiENOG410IR0P. Eukaryota.
ENOG410XX1S. LUCA.
GeneTreeiENSGT00810000125397.
HOGENOMiHOG000114626.
HOVERGENiHBG052919.
InParanoidiQ9WV75.
OMAiHSRHSLV.
OrthoDBiEOG71CFK9.
PhylomeDBiQ9WV75.

Miscellaneous databases

PROiQ9WV75.

Gene expression databases

GenevisibleiQ9WV75. RN.

Family and domain databases

InterProiIPR009465. Spondin_N.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF06468. Spond_N. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
SMARTiSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS51020. SPONDIN. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "F-spondin and mindin: two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons."
    Feinstein Y., Borrell V., Garcia C., Burstyn-Cohen T., Tzarfaty V., Frumkin A., Nose A., Okamoto H., Higashijima S., Soriano A., Klar A.
    Development 126:3637-3648(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSPON2_RAT
AccessioniPrimary (citable) accession number: Q9WV75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.