Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat and SOCS box protein 1

Gene

Asb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in testis development. Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • intracellular signal transduction Source: InterPro
  • male genitalia development Source: MGI
  • protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 1
Short name:
ASB-1
Gene namesi
Name:Asb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1929735. Asb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Decreased spermatogenesis with less complete filling of seminiferous tubules but fertility does not appear to be affected.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Ankyrin repeat and SOCS box protein 1PRO_0000066924Add
BLAST

Proteomic databases

MaxQBiQ9WV74.
PaxDbiQ9WV74.
PRIDEiQ9WV74.

PTM databases

PhosphoSiteiQ9WV74.

Expressioni

Tissue specificityi

Highest expression in testis, spleen, bone marrow and salivary gland.2 Publications

Gene expression databases

BgeeiENSMUSG00000026311.
CleanExiMM_ASB1.
ExpressionAtlasiQ9WV74. baseline and differential.
GenevisibleiQ9WV74. MM.

Interactioni

Subunit structurei

Interacts with CUL5 and RNF7.By similarity

Protein-protein interaction databases

BioGridi211142. 2 interactions.
STRINGi10090.ENSMUSP00000027538.

Structurei

3D structure databases

ProteinModelPortaliQ9WV74.
SMRiQ9WV74. Positions 1-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati37 – 6933ANK 1Add
BLAST
Repeati78 – 10730ANK 2Add
BLAST
Repeati111 – 14030ANK 3Add
BLAST
Repeati144 – 17330ANK 4Add
BLAST
Repeati192 – 22130ANK 5Add
BLAST
Repeati236 – 26631ANK 6Add
BLAST
Domaini287 – 33650SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOVERGENiHBG107089.
InParanoidiQ9WV74.
KOiK10323.
OMAiPVNTQEF.
OrthoDBiEOG091G090M.
PhylomeDBiQ9WV74.
TreeFamiTF331945.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGTGPDG RAGPGPAGPN LKEWLREQFC DHPLEHCDDT RLHDAAYVGD
60 70 80 90 100
LQTLRNLLQE ESYRSRINEK SVWCCGWLPC TPLRIAATAG HGNCVDFLIR
110 120 130 140 150
KGAEVDLVDV KGQTALYVAV VNGHLESTEI LLEAGADPNG SRHHRSTPVY
160 170 180 190 200
HASRVGRDDI LKALIRYGAD VDVNHHLTPD TRPPFSRRLT SLVVCPLYIS
210 220 230 240 250
AAYHNLQCFR LLLQAGANPD FNCNGPVNTQ EFYRGSPGCV MDAVLRHGCE
260 270 280 290 300
AAFVSLLVEF GANLNLVKWE SLGPEARGRR KMDPEALQVF KEARSIPRTL
310 320 330
LSLCRVAVRR ALGKYRLHLV PSLPLPDPIK KFLLYE
Length:336
Mass (Da):37,232
Last modified:November 1, 1999 - v1
Checksum:i966119E1B21A5E4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155352 mRNA. Translation: AAD38808.1.
CCDSiCCDS35665.1.
RefSeqiNP_001034215.1. NM_001039126.2.
UniGeneiMm.234152.

Genome annotation databases

EnsembliENSMUST00000086843; ENSMUSP00000084054; ENSMUSG00000026311.
GeneIDi65247.
KEGGimmu:65247.
UCSCiuc007caz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155352 mRNA. Translation: AAD38808.1.
CCDSiCCDS35665.1.
RefSeqiNP_001034215.1. NM_001039126.2.
UniGeneiMm.234152.

3D structure databases

ProteinModelPortaliQ9WV74.
SMRiQ9WV74. Positions 1-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211142. 2 interactions.
STRINGi10090.ENSMUSP00000027538.

PTM databases

PhosphoSiteiQ9WV74.

Proteomic databases

MaxQBiQ9WV74.
PaxDbiQ9WV74.
PRIDEiQ9WV74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086843; ENSMUSP00000084054; ENSMUSG00000026311.
GeneIDi65247.
KEGGimmu:65247.
UCSCiuc007caz.1. mouse.

Organism-specific databases

CTDi51665.
MGIiMGI:1929735. Asb1.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOVERGENiHBG107089.
InParanoidiQ9WV74.
KOiK10323.
OMAiPVNTQEF.
OrthoDBiEOG091G090M.
PhylomeDBiQ9WV74.
TreeFamiTF331945.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ9WV74.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026311.
CleanExiMM_ASB1.
ExpressionAtlasiQ9WV74. baseline and differential.
GenevisibleiQ9WV74. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASB1_MOUSE
AccessioniPrimary (citable) accession number: Q9WV74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.