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Protein

Ankyrin repeat and SOCS box protein 3

Gene

Asb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 3
Short name:
ASB-3
Gene namesi
Name:Asb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1929749. Asb3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669271 – 525Ankyrin repeat and SOCS box protein 3Add BLAST525

Proteomic databases

MaxQBiQ9WV72.
PaxDbiQ9WV72.
PRIDEiQ9WV72.

PTM databases

iPTMnetiQ9WV72.
PhosphoSitePlusiQ9WV72.

Expressioni

Tissue specificityi

Widely expressed; highest expression in testis and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000020305.
CleanExiMM_ASB3.
ExpressionAtlasiQ9WV72. baseline and differential.
GenevisibleiQ9WV72. MM.

Interactioni

Subunit structurei

Interacts with TCEB2 and TNFRSF1B.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211146. 2 interactors.
STRINGi10090.ENSMUSP00000020551.

Structurei

3D structure databases

ProteinModelPortaliQ9WV72.
SMRiQ9WV72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 38ANK 1Add BLAST30
Repeati42 – 71ANK 2Add BLAST30
Repeati78 – 107ANK 3Add BLAST30
Repeati111 – 140ANK 4Add BLAST30
Repeati145 – 174ANK 5Add BLAST30
Repeati178 – 207ANK 6Add BLAST30
Repeati211 – 240ANK 7Add BLAST30
Repeati246 – 275ANK 8Add BLAST30
Repeati279 – 308ANK 9Add BLAST30
Repeati315 – 346ANK 10Add BLAST32
Domaini442 – 505SOCS boxPROSITE-ProRule annotationAdd BLAST64

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 10 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063050.
HOGENOMiHOG000022587.
HOVERGENiHBG024356.
InParanoidiQ9WV72.
KOiK10325.
OrthoDBiEOG091G03ZR.
TreeFamiTF315127.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF13606. Ank_3. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFTEAYSDT CSTVGLAARE GNVKILRKLL KKGRSVDVAD NRGWMPIHEA
60 70 80 90 100
AYHNAVECLQ MLIHTDSSEN YIKAKTFEGF CALHLAVSQG HWKITQILLE
110 120 130 140 150
AGADPNETTL EETTPLFLAV ESGRIDVLKL LLQHGANVNG SHSMSGWNSL
160 170 180 190 200
HQASFQGNAE TIRLLLKQGA DRECQDDFGI TPLFVAAQYG KLESMSILIS
210 220 230 240 250
SGANVNCQAL DKATPLFIAA QEGHTKCVEL LLSSGADPDL YCNEDNWQLP
260 270 280 290 300
IHAAAQMGHT ETLDLLIPRT NRACDTGPDK VSPVYSAVFG GREECLEMLL
310 320 330 340 350
QNGYSPDAQM CLVFGFSSPL CMAFQKDCDF SGIVNILLKY GAQLNELHLA
360 370 380 390 400
YCLKYEKFSM FCSFLKKGSL MVPWNHTSEF ISYAVKAQTK YKAWLPHLLL
410 420 430 440 450
AGFDPLILLC SSSWVDSASD DILIFTLEFS NWKRLPSAVE KMLSVRANSS
460 470 480 490 500
WALQQHLASV PSLTHLCRLE IRASLKAEHL HSDIFIHQLP LPRSLQNYLL
510 520
YEEVLRMNEI LEPAANQDGE TSKAT
Length:525
Mass (Da):58,283
Last modified:July 27, 2011 - v2
Checksum:iDEFCAC73EE2AF5E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163R → K in AAD38810 (PubMed:11111040).Curated1
Sequence conflicti277G → E in AAD38810 (PubMed:11111040).Curated1
Sequence conflicti418A → V in AAD38810 (PubMed:11111040).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155354 mRNA. Translation: AAD38810.1.
AK143580 mRNA. Translation: BAE25448.1.
AL646095, AL662891, AL732621 Genomic DNA. Translation: CAI24293.1.
AL662891, AL646095, AL732621 Genomic DNA. Translation: CAI24539.1.
AL732621, AL646095, AL662891 Genomic DNA. Translation: CAI25026.1.
CCDSiCCDS24511.1.
RefSeqiNP_076395.2. NM_023906.3.
XP_006514834.1. XM_006514771.3.
UniGeneiMm.440539.

Genome annotation databases

EnsembliENSMUST00000020551; ENSMUSP00000020551; ENSMUSG00000020305.
GeneIDi65257.
KEGGimmu:65257.
UCSCiuc007iif.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155354 mRNA. Translation: AAD38810.1.
AK143580 mRNA. Translation: BAE25448.1.
AL646095, AL662891, AL732621 Genomic DNA. Translation: CAI24293.1.
AL662891, AL646095, AL732621 Genomic DNA. Translation: CAI24539.1.
AL732621, AL646095, AL662891 Genomic DNA. Translation: CAI25026.1.
CCDSiCCDS24511.1.
RefSeqiNP_076395.2. NM_023906.3.
XP_006514834.1. XM_006514771.3.
UniGeneiMm.440539.

3D structure databases

ProteinModelPortaliQ9WV72.
SMRiQ9WV72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211146. 2 interactors.
STRINGi10090.ENSMUSP00000020551.

PTM databases

iPTMnetiQ9WV72.
PhosphoSitePlusiQ9WV72.

Proteomic databases

MaxQBiQ9WV72.
PaxDbiQ9WV72.
PRIDEiQ9WV72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020551; ENSMUSP00000020551; ENSMUSG00000020305.
GeneIDi65257.
KEGGimmu:65257.
UCSCiuc007iif.1. mouse.

Organism-specific databases

CTDi51130.
MGIiMGI:1929749. Asb3.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063050.
HOGENOMiHOG000022587.
HOVERGENiHBG024356.
InParanoidiQ9WV72.
KOiK10325.
OrthoDBiEOG091G03ZR.
TreeFamiTF315127.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiAsb3. mouse.
PROiQ9WV72.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020305.
CleanExiMM_ASB3.
ExpressionAtlasiQ9WV72. baseline and differential.
GenevisibleiQ9WV72. MM.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF13606. Ank_3. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASB3_MOUSE
AccessioniPrimary (citable) accession number: Q9WV72
Secondary accession number(s): Q5SSV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.