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Protein

Ankyrin repeat and SOCS box protein 3

Gene

Asb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 3
Short name:
ASB-3
Gene namesi
Name:Asb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1929749. Asb3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Ankyrin repeat and SOCS box protein 3PRO_0000066927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9WV72.
MaxQBiQ9WV72.
PaxDbiQ9WV72.
PRIDEiQ9WV72.

PTM databases

iPTMnetiQ9WV72.
PhosphoSiteiQ9WV72.

Expressioni

Tissue specificityi

Widely expressed; highest expression in testis and spleen.1 Publication

Gene expression databases

BgeeiQ9WV72.
CleanExiMM_ASB3.
ExpressionAtlasiQ9WV72. baseline and differential.
GenevisibleiQ9WV72. MM.

Interactioni

Subunit structurei

Interacts with TCEB2 and TNFRSF1B.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211146. 2 interactions.
STRINGi10090.ENSMUSP00000020551.

Structurei

3D structure databases

ProteinModelPortaliQ9WV72.
SMRiQ9WV72. Positions 12-345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati9 – 3830ANK 1Add
BLAST
Repeati42 – 7130ANK 2Add
BLAST
Repeati78 – 10730ANK 3Add
BLAST
Repeati111 – 14030ANK 4Add
BLAST
Repeati145 – 17430ANK 5Add
BLAST
Repeati178 – 20730ANK 6Add
BLAST
Repeati211 – 24030ANK 7Add
BLAST
Repeati246 – 27530ANK 8Add
BLAST
Repeati279 – 30830ANK 9Add
BLAST
Repeati315 – 34632ANK 10Add
BLAST
Domaini442 – 50564SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 10 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063050.
HOGENOMiHOG000022587.
HOVERGENiHBG024356.
InParanoidiQ9WV72.
KOiK10325.
OMAiRASNTWI.
OrthoDBiEOG70W3D7.
TreeFamiTF315127.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF13606. Ank_3. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFTEAYSDT CSTVGLAARE GNVKILRKLL KKGRSVDVAD NRGWMPIHEA
60 70 80 90 100
AYHNAVECLQ MLIHTDSSEN YIKAKTFEGF CALHLAVSQG HWKITQILLE
110 120 130 140 150
AGADPNETTL EETTPLFLAV ESGRIDVLKL LLQHGANVNG SHSMSGWNSL
160 170 180 190 200
HQASFQGNAE TIRLLLKQGA DRECQDDFGI TPLFVAAQYG KLESMSILIS
210 220 230 240 250
SGANVNCQAL DKATPLFIAA QEGHTKCVEL LLSSGADPDL YCNEDNWQLP
260 270 280 290 300
IHAAAQMGHT ETLDLLIPRT NRACDTGPDK VSPVYSAVFG GREECLEMLL
310 320 330 340 350
QNGYSPDAQM CLVFGFSSPL CMAFQKDCDF SGIVNILLKY GAQLNELHLA
360 370 380 390 400
YCLKYEKFSM FCSFLKKGSL MVPWNHTSEF ISYAVKAQTK YKAWLPHLLL
410 420 430 440 450
AGFDPLILLC SSSWVDSASD DILIFTLEFS NWKRLPSAVE KMLSVRANSS
460 470 480 490 500
WALQQHLASV PSLTHLCRLE IRASLKAEHL HSDIFIHQLP LPRSLQNYLL
510 520
YEEVLRMNEI LEPAANQDGE TSKAT
Length:525
Mass (Da):58,283
Last modified:July 27, 2011 - v2
Checksum:iDEFCAC73EE2AF5E7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631R → K in AAD38810 (PubMed:11111040).Curated
Sequence conflicti277 – 2771G → E in AAD38810 (PubMed:11111040).Curated
Sequence conflicti418 – 4181A → V in AAD38810 (PubMed:11111040).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155354 mRNA. Translation: AAD38810.1.
AK143580 mRNA. Translation: BAE25448.1.
AL646095, AL662891, AL732621 Genomic DNA. Translation: CAI24293.1.
AL662891, AL646095, AL732621 Genomic DNA. Translation: CAI24539.1.
AL732621, AL646095, AL662891 Genomic DNA. Translation: CAI25026.1.
CCDSiCCDS24511.1.
RefSeqiNP_076395.2. NM_023906.3.
XP_006514834.1. XM_006514771.2.
UniGeneiMm.440539.

Genome annotation databases

EnsembliENSMUST00000020551; ENSMUSP00000020551; ENSMUSG00000020305.
GeneIDi65257.
KEGGimmu:65257.
UCSCiuc007iif.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155354 mRNA. Translation: AAD38810.1.
AK143580 mRNA. Translation: BAE25448.1.
AL646095, AL662891, AL732621 Genomic DNA. Translation: CAI24293.1.
AL662891, AL646095, AL732621 Genomic DNA. Translation: CAI24539.1.
AL732621, AL646095, AL662891 Genomic DNA. Translation: CAI25026.1.
CCDSiCCDS24511.1.
RefSeqiNP_076395.2. NM_023906.3.
XP_006514834.1. XM_006514771.2.
UniGeneiMm.440539.

3D structure databases

ProteinModelPortaliQ9WV72.
SMRiQ9WV72. Positions 12-345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211146. 2 interactions.
STRINGi10090.ENSMUSP00000020551.

PTM databases

iPTMnetiQ9WV72.
PhosphoSiteiQ9WV72.

Proteomic databases

EPDiQ9WV72.
MaxQBiQ9WV72.
PaxDbiQ9WV72.
PRIDEiQ9WV72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020551; ENSMUSP00000020551; ENSMUSG00000020305.
GeneIDi65257.
KEGGimmu:65257.
UCSCiuc007iif.1. mouse.

Organism-specific databases

CTDi51130.
MGIiMGI:1929749. Asb3.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063050.
HOGENOMiHOG000022587.
HOVERGENiHBG024356.
InParanoidiQ9WV72.
KOiK10325.
OMAiRASNTWI.
OrthoDBiEOG70W3D7.
TreeFamiTF315127.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiAsb3. mouse.
PROiQ9WV72.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WV72.
CleanExiMM_ASB3.
ExpressionAtlasiQ9WV72. baseline and differential.
GenevisibleiQ9WV72. MM.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF13606. Ank_3. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4."
    Kile B.T., Viney E.M., Willson T.A., Brodnicki T.C., Cancilla M.R., Herlihy A.S., Croker B.A., Baca M., Nicola N.A., Hilton D.J., Alexander W.S.
    Gene 258:31-41(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spleen.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiASB3_MOUSE
AccessioniPrimary (citable) accession number: Q9WV72
Secondary accession number(s): Q5SSV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.