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Q9WV60

- GSK3B_MOUSE

UniProt

Q9WV60 - GSK3B_MOUSE

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Protein
Glycogen synthase kinase-3 beta
Gene
Gsk3b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SFPQ at 'Thr-679' upon T-cell activation. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity.10 Publications

Catalytic activityi

ATP + [tau protein] = ADP + [tau protein] phosphate.
ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by phosphorylation at Tyr-216. In response to insulin, inhibited by phosphorylation at Ser-9 by PKB/AKT1 and RPS6KA3; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site. Inhibited by lithium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851ATP By similarity
Active sitei181 – 1811Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 709ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. beta-catenin binding Source: MGI
  3. kinase activity Source: UniProtKB
  4. protein binding Source: UniProtKB
  5. protein kinase activity Source: MGI
  6. protein serine/threonine kinase activity Source: UniProtKB
  7. tau-protein kinase activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. ER overload response Source: MGI
  2. Wnt signaling pathway Source: MGI
  3. axonogenesis Source: MGI
  4. canonical Wnt signaling pathway Source: MGI
  5. canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: BHF-UCL
  6. cell migration Source: MGI
  7. cell proliferation Source: MGI
  8. cellular response to interleukin-3 Source: UniProtKB
  9. cellular response to mechanical stimulus Source: Ensembl
  10. circadian rhythm Source: UniProtKB
  11. cytoskeleton organization Source: UniProtKB
  12. epithelial to mesenchymal transition Source: UniProtKB
  13. establishment of cell polarity Source: Ensembl
  14. extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
  15. fat cell differentiation Source: MGI
  16. glycogen metabolic process Source: UniProtKB-KW
  17. hippocampus development Source: Ensembl
  18. hypermethylation of CpG island Source: BHF-UCL
  19. intracellular signal transduction Source: MGI
  20. myoblast fusion Source: MGI
  21. myotube differentiation Source: MGI
  22. negative regulation of MAP kinase activity Source: Ensembl
  23. negative regulation of NFAT protein import into nucleus Source: UniProtKB
  24. negative regulation of apoptotic process Source: MGI
  25. negative regulation of cardiac muscle hypertrophy Source: MGI
  26. negative regulation of dendrite morphogenesis Source: Ensembl
  27. negative regulation of neuron maturation Source: MGI
  28. negative regulation of neuron projection development Source: MGI
  29. negative regulation of protein binding Source: Ensembl
  30. negative regulation of protein complex assembly Source: Ensembl
  31. organ morphogenesis Source: MGI
  32. peptidyl-serine phosphorylation Source: UniProtKB
  33. phosphorylation Source: UniProtKB
  34. positive regulation of Rac GTPase activity Source: Ensembl
  35. positive regulation of cell-matrix adhesion Source: Ensembl
  36. positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
  37. positive regulation of peptidyl-serine phosphorylation Source: MGI
  38. positive regulation of peptidyl-threonine phosphorylation Source: MGI
  39. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  40. positive regulation of protein binding Source: MGI
  41. positive regulation of protein complex assembly Source: Ensembl
  42. positive regulation of protein export from nucleus Source: Ensembl
  43. positive regulation of stem cell differentiation Source: MGI
  44. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  45. protein export from nucleus Source: MGI
  46. protein localization to microtubule Source: MGI
  47. protein phosphorylation Source: UniProtKB
  48. re-entry into mitotic cell cycle Source: MGI
  49. regulation of gene expression by genetic imprinting Source: BHF-UCL
  50. regulation of microtubule-based process Source: UniProtKB
  51. regulation of neuronal synaptic plasticity Source: Ensembl
  52. response to drug Source: Ensembl
  53. response to lithium ion Source: Ensembl
  54. superior temporal gyrus development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Signal transduction inhibitor, Transferase

Keywords - Biological processi

Biological rhythms, Carbohydrate metabolism, Differentiation, Glycogen metabolism, Neurogenesis, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_203336. Degradation of beta-catenin by the destruction complex.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_218396. Beta-catenin phosphorylation cascade.
REACT_220918. AKT phosphorylates targets in the cytosol.
REACT_222185. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen synthase kinase-3 beta (EC:2.7.11.26)
Short name:
GSK-3 beta
Alternative name(s):
Serine/threonine-protein kinase GSK3B (EC:2.7.11.1)
Gene namesi
Name:Gsk3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1861437. Gsk3b.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Cell membrane By similarity
Note: The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane By similarity.

GO - Cellular componenti

  1. beta-catenin destruction complex Source: MGI
  2. cell body Source: MGI
  3. centrosome Source: Ensembl
  4. cytoplasm Source: UniProtKB
  5. cytosol Source: MGI
  6. dendritic shaft Source: MGI
  7. dendritic spine Source: Ensembl
  8. growth cone Source: MGI
  9. membrane Source: UniProtKB
  10. membrane raft Source: Ensembl
  11. membrane-bounded organelle Source: MGI
  12. neuronal cell body Source: MGI
  13. nucleoplasm Source: Reactome
  14. nucleus Source: UniProtKB
  15. perinuclear region of cytoplasm Source: BHF-UCL
  16. plasma membrane Source: UniProtKB
  17. ribonucleoprotein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality at E16 due to hepatocyte apoptosis.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi9 – 91S → A: Loss of phosphorylation; No inhibition of activity and constitutively active. 2 Publications
Mutagenesisi85 – 851K → R: Inhibits interaction with AXIN1 and ZBED3. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Glycogen synthase kinase-3 beta
PRO_0000085981Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Phosphoserine; by PKB/AKT1, RPS6KA3 and SGK32 Publications
Modified residuei216 – 2161Phosphotyrosine By similarity
Modified residuei389 – 3891Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by AKT1 and ILK1. Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3B, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-216. Phosphorylation of Ser-9 in the hippocampus peaks at CT0, whereas in the liver it peaks at CT12.2 Publications
Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity By similarity.

Keywords - PTMi

ADP-ribosylation, Phosphoprotein

Proteomic databases

MaxQBiQ9WV60.
PaxDbiQ9WV60.
PRIDEiQ9WV60.

PTM databases

PhosphoSiteiQ9WV60.

Miscellaneous databases

PMAP-CutDBQ9WV60.

Expressioni

Gene expression databases

ArrayExpressiQ9WV60.
BgeeiQ9WV60.
CleanExiMM_GSK3B.
GenevestigatoriQ9WV60.

Interactioni

Subunit structurei

Monomer. Interacts with DAB2IP (via C2 domain); the interaction stimulates GSK3B kinase activation. Interacts (via C2 domain) with PPP2CA By similarity. Interacts with CABYR, MMP2, MUC1, NIN and PRUNE By similarity. Interacts with AXIN1; the interaction mediates hyperphosphorylation of CTNNB1 leading to its ubiquitination and destruction. Interacts with and phosphorylates SNAI1. Interacts with DNM1L (via a C-terminal domain) By similarity. Interacts with ARRB2 and DISC1. Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B By similarity. Interacts with SGK3. Interacts with the CLOCK-ARNTL/BMAL1 heterodimer By similarity. Interacts with AXIN1 and ZBED3. Interacts with the ARNTL/BMAL1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Ctnnb1Q022482EBI-400793,EBI-397872
Epm2aQ9WUA52EBI-400793,EBI-1040928

Protein-protein interaction databases

BioGridi208115. 22 interactions.
IntActiQ9WV60. 19 interactions.
MINTiMINT-4096935.
STRINGi10090.ENSMUSP00000110398.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi38 – 4811
Beta strandi52 – 6413
Beta strandi69 – 757
Turni76 – 783
Beta strandi81 – 888
Helixi97 – 1015
Beta strandi112 – 1187
Beta strandi127 – 1337
Helixi139 – 14810
Helixi155 – 17319
Turni174 – 1763
Helixi184 – 1863
Beta strandi187 – 1904
Turni191 – 1944
Beta strandi195 – 1984
Helixi225 – 2284
Helixi237 – 25216
Helixi262 – 27312
Helixi278 – 2847
Helixi286 – 2883
Helixi301 – 3044
Helixi311 – 32010
Helixi325 – 3273
Helixi331 – 3355
Helixi338 – 3403
Helixi341 – 3444
Turni364 – 3674
Helixi371 – 3733
Helixi374 – 3774
Helixi380 – 3823

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NU1X-ray2.50A1-383[»]
ProteinModelPortaliQ9WV60.
SMRiQ9WV60. Positions 6-386.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 340285Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00520000055635.
HOGENOMiHOG000233017.
HOVERGENiHBG014652.
KOiK03083.
OrthoDBiEOG7TF78V.
PhylomeDBiQ9WV60.
TreeFamiTF101104.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV60-1 [UniParc]FASTAAdd to Basket

« Hide

MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR    50
PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI 100
MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK 150
QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD 200
FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL 250
LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300
WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL 350
PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAASP PANATAASDT 400
NAGDRGQTNN AASASASNST 420
Length:420
Mass (Da):46,710
Last modified:May 1, 2000 - v2
Checksum:i200C3FD1B38B4883
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF156099 mRNA. Translation: AAD39258.2.
BC006936 mRNA. Translation: AAH06936.1.
BC060743 mRNA. Translation: AAH60743.1.
CCDSiCCDS28163.1.
RefSeqiNP_062801.1. NM_019827.6.
UniGeneiMm.394930.

Genome annotation databases

EnsembliENSMUST00000023507; ENSMUSP00000023507; ENSMUSG00000022812.
GeneIDi56637.
KEGGimmu:56637.
UCSCiuc007zen.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF156099 mRNA. Translation: AAD39258.2 .
BC006936 mRNA. Translation: AAH06936.1 .
BC060743 mRNA. Translation: AAH60743.1 .
CCDSi CCDS28163.1.
RefSeqi NP_062801.1. NM_019827.6.
UniGenei Mm.394930.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4NU1 X-ray 2.50 A 1-383 [» ]
ProteinModelPortali Q9WV60.
SMRi Q9WV60. Positions 6-386.
ModBasei Search...

Protein-protein interaction databases

BioGridi 208115. 22 interactions.
IntActi Q9WV60. 19 interactions.
MINTi MINT-4096935.
STRINGi 10090.ENSMUSP00000110398.

Chemistry

BindingDBi Q9WV60.
ChEMBLi CHEMBL1075321.

PTM databases

PhosphoSitei Q9WV60.

Proteomic databases

MaxQBi Q9WV60.
PaxDbi Q9WV60.
PRIDEi Q9WV60.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023507 ; ENSMUSP00000023507 ; ENSMUSG00000022812 .
GeneIDi 56637.
KEGGi mmu:56637.
UCSCi uc007zen.1. mouse.

Organism-specific databases

CTDi 2932.
MGIi MGI:1861437. Gsk3b.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00520000055635.
HOGENOMi HOG000233017.
HOVERGENi HBG014652.
KOi K03083.
OrthoDBi EOG7TF78V.
PhylomeDBi Q9WV60.
TreeFami TF101104.

Enzyme and pathway databases

Reactomei REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_203336. Degradation of beta-catenin by the destruction complex.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_218396. Beta-catenin phosphorylation cascade.
REACT_220918. AKT phosphorylates targets in the cytosol.
REACT_222185. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

ChiTaRSi GSK3B. mouse.
NextBioi 313081.
PMAP-CutDB Q9WV60.
PROi Q9WV60.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9WV60.
Bgeei Q9WV60.
CleanExi MM_GSK3B.
Genevestigatori Q9WV60.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Testicular expression and hormonal control of glycogen synthase kinase 3, a homologue of yeast RIM11."
    Salameh W.A., Guo T.B., Chan K.C., Mitchell A.P.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary gland.
  3. "Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation."
    Hoeflich K.P., Luo J., Rubie E.A., Tsao M.S., Jin O., Woodgett J.R.
    Nature 406:86-90(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. "An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior."
    Beaulieu J.-M., Sotnikova T.D., Marion S., Lefkowitz R.J., Gainetdinov R.R., Caron M.G.
    Cell 122:261-273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARRB2.
  6. "Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis."
    McManus E.J., Sakamoto K., Armit L.J., Ronaldson L., Shpiro N., Marquez R., Alessi D.R.
    EMBO J. 24:1571-1583(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF SER-9.
  7. "Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1."
    Maurer U., Charvet C., Wagman A.S., Dejardin E., Green D.R.
    Mol. Cell 21:749-760(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MCL1 PHOSPHORYLATION.
  8. "GSK3 alpha and GSK3 beta are necessary for axon formation."
    Garrido J.J., Simon D., Varea O., Wandosell F.
    FEBS Lett. 581:1579-1586(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN AXON FORMATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance."
    Tanabe K., Liu Z., Patel S., Doble B.W., Li L., Cras-Meneur C., Martinez S.C., Welling C.M., White M.F., Bernal-Mizrachi E., Woodgett J.R., Permutt M.A.
    PLoS Biol. 6:E37-E37(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF PANCREATIC BETA-CELLS.
  11. "Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling."
    Mao Y., Ge X., Frank C.L., Madison J.M., Koehler A.N., Doud M.K., Tassa C., Berry E.M., Soda T., Singh K.K., Biechele T., Petryshen T.L., Moon R.T., Haggarty S.J., Tsai L.H.
    Cell 136:1017-1031(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DISC1.
  12. "Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling."
    Chen T., Li M., Ding Y., Zhang L.S., Xi Y., Pan W.J., Tao D.L., Wang J.Y., Li L.
    J. Biol. Chem. 284:6683-6689(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AXIN1 AND ZBED3, MUTAGENESIS OF LYS-85.
  13. "DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping."
    Kurabayashi N., Hirota T., Sakai M., Sanada K., Fukada Y.
    Mol. Cell. Biol. 30:1757-1768(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation."
    Sahar S., Zocchi L., Kinoshita C., Borrelli E., Sassone-Corsi P.
    PLoS ONE 5:E8561-E8561(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ARNTL/BMAL1.
  15. "Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3beta."
    Wu X., Shen Q.T., Oristian D.S., Lu C.P., Zheng Q., Wang H.W., Fuchs E.
    Cell 144:341-352(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  16. "ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation."
    Wakatsuki S., Saitoh F., Araki T.
    Nat. Cell Biol. 13:1415-1423(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF DPYSL2, PHOSPHORYLATION AT SER-9, MUTAGENESIS OF SER-9.
  17. "Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock."
    Kaasik K., Kivimae S., Allen J.J., Chalkley R.J., Huang Y., Baer K., Kissel H., Burlingame A.L., Shokat K.M., Ptacek L.J., Fu Y.H.
    Cell Metab. 17:291-302(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT SER-9.

Entry informationi

Entry nameiGSK3B_MOUSE
AccessioniPrimary (citable) accession number: Q9WV60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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