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Q9WV60

- GSK3B_MOUSE

UniProt

Q9WV60 - GSK3B_MOUSE

Protein

Glycogen synthase kinase-3 beta

Gene

Gsk3b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 2 (01 May 2000)
      Previous versions | rss
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    Functioni

    Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SFPQ at 'Thr-679' upon T-cell activation. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity.10 Publications

    Catalytic activityi

    ATP + [tau protein] = ADP + [tau protein] phosphate.
    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by phosphorylation at Tyr-216. In response to insulin, inhibited by phosphorylation at Ser-9 by PKB/AKT1 and RPS6KA3; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site. Inhibited by lithium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851ATPPROSITE-ProRule annotation
    Active sitei181 – 1811Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi62 – 709ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. beta-catenin binding Source: MGI
    3. kinase activity Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. protein kinase activity Source: MGI
    6. protein serine/threonine kinase activity Source: UniProtKB
    7. tau-protein kinase activity Source: MGI

    GO - Biological processi

    1. axonogenesis Source: MGI
    2. canonical Wnt signaling pathway Source: MGI
    3. canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: BHF-UCL
    4. cell migration Source: MGI
    5. cell proliferation Source: MGI
    6. cellular response to interleukin-3 Source: UniProtKB
    7. cellular response to mechanical stimulus Source: Ensembl
    8. circadian rhythm Source: UniProtKB
    9. cytoskeleton organization Source: UniProtKB
    10. epithelial to mesenchymal transition Source: UniProtKB
    11. ER overload response Source: MGI
    12. establishment of cell polarity Source: Ensembl
    13. extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
    14. fat cell differentiation Source: MGI
    15. glycogen metabolic process Source: UniProtKB-KW
    16. hippocampus development Source: Ensembl
    17. hypermethylation of CpG island Source: BHF-UCL
    18. intracellular signal transduction Source: MGI
    19. myoblast fusion Source: MGI
    20. myotube differentiation Source: MGI
    21. negative regulation of apoptotic process Source: MGI
    22. negative regulation of cardiac muscle hypertrophy Source: MGI
    23. negative regulation of dendrite morphogenesis Source: Ensembl
    24. negative regulation of MAP kinase activity Source: Ensembl
    25. negative regulation of neuron maturation Source: MGI
    26. negative regulation of neuron projection development Source: MGI
    27. negative regulation of NFAT protein import into nucleus Source: UniProtKB
    28. negative regulation of protein binding Source: Ensembl
    29. negative regulation of protein complex assembly Source: Ensembl
    30. organ morphogenesis Source: MGI
    31. peptidyl-serine phosphorylation Source: UniProtKB
    32. phosphorylation Source: UniProtKB
    33. positive regulation of cell-matrix adhesion Source: Ensembl
    34. positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
    35. positive regulation of peptidyl-serine phosphorylation Source: MGI
    36. positive regulation of peptidyl-threonine phosphorylation Source: MGI
    37. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
    38. positive regulation of protein binding Source: MGI
    39. positive regulation of protein complex assembly Source: Ensembl
    40. positive regulation of protein export from nucleus Source: Ensembl
    41. positive regulation of Rac GTPase activity Source: Ensembl
    42. positive regulation of stem cell differentiation Source: MGI
    43. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    44. protein export from nucleus Source: MGI
    45. protein localization to microtubule Source: MGI
    46. protein phosphorylation Source: UniProtKB
    47. re-entry into mitotic cell cycle Source: MGI
    48. regulation of gene expression by genetic imprinting Source: BHF-UCL
    49. regulation of microtubule-based process Source: UniProtKB
    50. regulation of neuronal synaptic plasticity Source: Ensembl
    51. response to drug Source: Ensembl
    52. response to lithium ion Source: Ensembl
    53. superior temporal gyrus development Source: Ensembl
    54. Wnt signaling pathway Source: MGI

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Signal transduction inhibitor, Transferase

    Keywords - Biological processi

    Biological rhythms, Carbohydrate metabolism, Differentiation, Glycogen metabolism, Neurogenesis, Wnt signaling pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_203336. Degradation of beta-catenin by the destruction complex.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_218396. Beta-catenin phosphorylation cascade.
    REACT_220918. AKT phosphorylates targets in the cytosol.
    REACT_222185. Regulation of HSF1-mediated heat shock response.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycogen synthase kinase-3 beta (EC:2.7.11.26)
    Short name:
    GSK-3 beta
    Alternative name(s):
    Serine/threonine-protein kinase GSK3B (EC:2.7.11.1)
    Gene namesi
    Name:Gsk3b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1861437. Gsk3b.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Cell membrane By similarity
    Note: The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane By similarity.By similarity

    GO - Cellular componenti

    1. beta-catenin destruction complex Source: MGI
    2. cell body Source: MGI
    3. centrosome Source: Ensembl
    4. cytoplasm Source: UniProtKB
    5. cytosol Source: MGI
    6. dendritic shaft Source: MGI
    7. dendritic spine Source: Ensembl
    8. growth cone Source: MGI
    9. membrane Source: UniProtKB
    10. membrane-bounded organelle Source: MGI
    11. membrane raft Source: Ensembl
    12. neuronal cell body Source: MGI
    13. nucleoplasm Source: Reactome
    14. nucleus Source: UniProtKB
    15. perinuclear region of cytoplasm Source: BHF-UCL
    16. plasma membrane Source: UniProtKB
    17. ribonucleoprotein complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Embryonic lethality at E16 due to hepatocyte apoptosis.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi9 – 91S → A: Loss of phosphorylation; No inhibition of activity and constitutively active. 2 Publications
    Mutagenesisi85 – 851K → R: Inhibits interaction with AXIN1 and ZBED3. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420Glycogen synthase kinase-3 betaPRO_0000085981Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91Phosphoserine; by PKB/AKT1, RPS6KA3 and SGK32 Publications
    Modified residuei216 – 2161PhosphotyrosineBy similarity
    Modified residuei389 – 3891Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated by AKT1 and ILK1. Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3B, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-216. Phosphorylation of Ser-9 in the hippocampus peaks at CT0, whereas in the liver it peaks at CT12.3 Publications
    Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity.By similarity

    Keywords - PTMi

    ADP-ribosylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9WV60.
    PaxDbiQ9WV60.
    PRIDEiQ9WV60.

    PTM databases

    PhosphoSiteiQ9WV60.

    Miscellaneous databases

    PMAP-CutDBQ9WV60.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9WV60.
    BgeeiQ9WV60.
    CleanExiMM_GSK3B.
    GenevestigatoriQ9WV60.

    Interactioni

    Subunit structurei

    Monomer. Interacts with DAB2IP (via C2 domain); the interaction stimulates GSK3B kinase activation. Interacts (via C2 domain) with PPP2CA By similarity. Interacts with CABYR, MMP2, MUC1, NIN and PRUNE By similarity. Interacts with AXIN1; the interaction mediates hyperphosphorylation of CTNNB1 leading to its ubiquitination and destruction. Interacts with and phosphorylates SNAI1. Interacts with DNM1L (via a C-terminal domain) By similarity. Interacts with ARRB2 and DISC1. Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B By similarity. Interacts with SGK3. Interacts with the CLOCK-ARNTL/BMAL1 heterodimer By similarity. Interacts with AXIN1 and ZBED3. Interacts with the ARNTL/BMAL1.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Ctnnb1Q022482EBI-400793,EBI-397872
    Epm2aQ9WUA52EBI-400793,EBI-1040928

    Protein-protein interaction databases

    BioGridi208115. 22 interactions.
    IntActiQ9WV60. 19 interactions.
    MINTiMINT-4096935.
    STRINGi10090.ENSMUSP00000110398.

    Structurei

    Secondary structure

    1
    420
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi38 – 4811
    Beta strandi52 – 6413
    Beta strandi69 – 757
    Turni76 – 783
    Beta strandi81 – 888
    Helixi97 – 1015
    Beta strandi112 – 1187
    Beta strandi127 – 1337
    Helixi139 – 14810
    Helixi155 – 17319
    Turni174 – 1763
    Helixi184 – 1863
    Beta strandi187 – 1904
    Turni191 – 1944
    Beta strandi195 – 1984
    Helixi225 – 2284
    Helixi237 – 25216
    Helixi262 – 27312
    Helixi278 – 2847
    Helixi286 – 2883
    Helixi301 – 3044
    Helixi311 – 32010
    Helixi325 – 3273
    Helixi331 – 3355
    Helixi338 – 3403
    Helixi341 – 3444
    Turni364 – 3674
    Helixi371 – 3733
    Helixi374 – 3774
    Helixi380 – 3823

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4NU1X-ray2.50A1-383[»]
    ProteinModelPortaliQ9WV60.
    SMRiQ9WV60. Positions 6-386.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 340285Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00520000055635.
    HOGENOMiHOG000233017.
    HOVERGENiHBG014652.
    KOiK03083.
    OrthoDBiEOG7TF78V.
    PhylomeDBiQ9WV60.
    TreeFamiTF101104.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WV60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR    50
    PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI 100
    MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK 150
    QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD 200
    FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL 250
    LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300
    WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL 350
    PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAASP PANATAASDT 400
    NAGDRGQTNN AASASASNST 420
    Length:420
    Mass (Da):46,710
    Last modified:May 1, 2000 - v2
    Checksum:i200C3FD1B38B4883
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF156099 mRNA. Translation: AAD39258.2.
    BC006936 mRNA. Translation: AAH06936.1.
    BC060743 mRNA. Translation: AAH60743.1.
    CCDSiCCDS28163.1.
    RefSeqiNP_062801.1. NM_019827.6.
    UniGeneiMm.394930.

    Genome annotation databases

    EnsembliENSMUST00000023507; ENSMUSP00000023507; ENSMUSG00000022812.
    GeneIDi56637.
    KEGGimmu:56637.
    UCSCiuc007zen.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF156099 mRNA. Translation: AAD39258.2 .
    BC006936 mRNA. Translation: AAH06936.1 .
    BC060743 mRNA. Translation: AAH60743.1 .
    CCDSi CCDS28163.1.
    RefSeqi NP_062801.1. NM_019827.6.
    UniGenei Mm.394930.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4NU1 X-ray 2.50 A 1-383 [» ]
    ProteinModelPortali Q9WV60.
    SMRi Q9WV60. Positions 6-386.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208115. 22 interactions.
    IntActi Q9WV60. 19 interactions.
    MINTi MINT-4096935.
    STRINGi 10090.ENSMUSP00000110398.

    Chemistry

    BindingDBi Q9WV60.
    ChEMBLi CHEMBL1075321.

    PTM databases

    PhosphoSitei Q9WV60.

    Proteomic databases

    MaxQBi Q9WV60.
    PaxDbi Q9WV60.
    PRIDEi Q9WV60.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023507 ; ENSMUSP00000023507 ; ENSMUSG00000022812 .
    GeneIDi 56637.
    KEGGi mmu:56637.
    UCSCi uc007zen.1. mouse.

    Organism-specific databases

    CTDi 2932.
    MGIi MGI:1861437. Gsk3b.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00520000055635.
    HOGENOMi HOG000233017.
    HOVERGENi HBG014652.
    KOi K03083.
    OrthoDBi EOG7TF78V.
    PhylomeDBi Q9WV60.
    TreeFami TF101104.

    Enzyme and pathway databases

    Reactomei REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_203336. Degradation of beta-catenin by the destruction complex.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_218396. Beta-catenin phosphorylation cascade.
    REACT_220918. AKT phosphorylates targets in the cytosol.
    REACT_222185. Regulation of HSF1-mediated heat shock response.

    Miscellaneous databases

    ChiTaRSi GSK3B. mouse.
    NextBioi 313081.
    PMAP-CutDB Q9WV60.
    PROi Q9WV60.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WV60.
    Bgeei Q9WV60.
    CleanExi MM_GSK3B.
    Genevestigatori Q9WV60.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Testicular expression and hormonal control of glycogen synthase kinase 3, a homologue of yeast RIM11."
      Salameh W.A., Guo T.B., Chan K.C., Mitchell A.P.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II and FVB/N.
      Tissue: Mammary gland.
    3. "Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation."
      Hoeflich K.P., Luo J., Rubie E.A., Tsao M.S., Jin O., Woodgett J.R.
      Nature 406:86-90(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    5. "An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior."
      Beaulieu J.-M., Sotnikova T.D., Marion S., Lefkowitz R.J., Gainetdinov R.R., Caron M.G.
      Cell 122:261-273(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARRB2.
    6. "Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis."
      McManus E.J., Sakamoto K., Armit L.J., Ronaldson L., Shpiro N., Marquez R., Alessi D.R.
      EMBO J. 24:1571-1583(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF SER-9.
    7. "Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1."
      Maurer U., Charvet C., Wagman A.S., Dejardin E., Green D.R.
      Mol. Cell 21:749-760(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN MCL1 PHOSPHORYLATION.
    8. "GSK3 alpha and GSK3 beta are necessary for axon formation."
      Garrido J.J., Simon D., Varea O., Wandosell F.
      FEBS Lett. 581:1579-1586(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN AXON FORMATION.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    10. "Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance."
      Tanabe K., Liu Z., Patel S., Doble B.W., Li L., Cras-Meneur C., Martinez S.C., Welling C.M., White M.F., Bernal-Mizrachi E., Woodgett J.R., Permutt M.A.
      PLoS Biol. 6:E37-E37(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF PANCREATIC BETA-CELLS.
    11. "Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling."
      Mao Y., Ge X., Frank C.L., Madison J.M., Koehler A.N., Doud M.K., Tassa C., Berry E.M., Soda T., Singh K.K., Biechele T., Petryshen T.L., Moon R.T., Haggarty S.J., Tsai L.H.
      Cell 136:1017-1031(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DISC1.
    12. "Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling."
      Chen T., Li M., Ding Y., Zhang L.S., Xi Y., Pan W.J., Tao D.L., Wang J.Y., Li L.
      J. Biol. Chem. 284:6683-6689(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AXIN1 AND ZBED3, MUTAGENESIS OF LYS-85.
    13. "DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping."
      Kurabayashi N., Hirota T., Sakai M., Sanada K., Fukada Y.
      Mol. Cell. Biol. 30:1757-1768(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation."
      Sahar S., Zocchi L., Kinoshita C., Borrelli E., Sassone-Corsi P.
      PLoS ONE 5:E8561-E8561(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ARNTL/BMAL1.
    15. "Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3beta."
      Wu X., Shen Q.T., Oristian D.S., Lu C.P., Zheng Q., Wang H.W., Fuchs E.
      Cell 144:341-352(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    16. "ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation."
      Wakatsuki S., Saitoh F., Araki T.
      Nat. Cell Biol. 13:1415-1423(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF DPYSL2, PHOSPHORYLATION AT SER-9, MUTAGENESIS OF SER-9.
    17. "Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock."
      Kaasik K., Kivimae S., Allen J.J., Chalkley R.J., Huang Y., Baer K., Kissel H., Burlingame A.L., Shokat K.M., Ptacek L.J., Fu Y.H.
      Cell Metab. 17:291-302(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT SER-9.

    Entry informationi

    Entry nameiGSK3B_MOUSE
    AccessioniPrimary (citable) accession number: Q9WV60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 152 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3