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Protein

E3 ubiquitin-protein ligase TRIM17

Gene

Trim17

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a ubiquitin E3 ligase.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6651RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri94 – 13542B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM17 (EC:6.3.2.-)
Alternative name(s):
Testis RING finger protein
Tripartite motif-containing protein 17
Gene namesi
Name:Trim17
Synonyms:Terf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi69290. Trim17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477E3 ubiquitin-protein ligase TRIM17PRO_0000056226Add
BLAST

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9WV59.
PRIDEiQ9WV59.

PTM databases

PhosphoSiteiQ9WV59.

Expressioni

Tissue specificityi

Expressed almost exclusively in the testis.

Gene expression databases

ExpressionAtlasiQ9WV59. baseline.
GenevisibleiQ9WV59. RN.

Interactioni

Subunit structurei

Interacts (via coiled coil) with TRIM44 (via coiled coil).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003885.

Structurei

3D structure databases

ProteinModelPortaliQ9WV59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini276 – 475200B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili135 – 22591Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6651RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri94 – 13542B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ9WV59.
KOiK12007.
OMAiCAVGQKS.
OrthoDBiEOG7V49Z8.
PhylomeDBiQ9WV59.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR032918. TRIM17.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR24103:SF397. PTHR24103:SF397. 1 hit.
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAVELARRL QEEATCSICL DYFTDPVMTA CGHNFCRECI QMSWEKGKGK
60 70 80 90 100
KGKKKQKGSF PCPECREMSP QRNLRPNRLL TKVAEMARQH PGLHKRDLCQ
110 120 130 140 150
IHQEPLKLFC QDDQTPICVV CREAQEHRMH RVLPLDEAAR EYKLRLEEDI
160 170 180 190 200
KYLREEMMKT ETLQAKEEQT LTEWQERVKE RRERILEEFQ KVVLFLVEEE
210 220 230 240 250
RRLLQILKKE EDDTLGKLQD SKASLDHQSR SLDLILLQLE EQTQQEPLQM
260 270 280 290 300
LQDVKDTLTR KESLSMQYPE VVLPVAIKTV CRVPGQIEVL KSFQEDVVPD
310 320 330 340 350
PSTAYPYLLL YESRQRRYLS PPPEGSAPYS KDRFLAYPCA VGQKSFSSGR
360 370 380 390 400
HYWEVGMNLT GDALWALGVC RDNVSRKDRV LKSPENGFWV VQLSKGKKHL
410 420 430 440 450
PLLPNSIPVT LTEPPSHMGI FLDFQAGEVS FYSVNDGSHL HSFSQVAFPG
460 470
PLLPFFCLGS PKSGQMVIST VTMWVKG
Length:477
Mass (Da):54,954
Last modified:November 1, 1999 - v1
Checksum:i1AAB42BB02615ADF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156272 mRNA. Translation: AAD40287.1.
BC078819 mRNA. Translation: AAH78819.1.
PIRiJE0343.
RefSeqiNP_073635.1. NM_022798.2.
UniGeneiRn.48706.

Genome annotation databases

EnsembliENSRNOT00000003885; ENSRNOP00000003885; ENSRNOG00000022983.
GeneIDi64702.
KEGGirno:64702.
UCSCiRGD:69290. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156272 mRNA. Translation: AAD40287.1.
BC078819 mRNA. Translation: AAH78819.1.
PIRiJE0343.
RefSeqiNP_073635.1. NM_022798.2.
UniGeneiRn.48706.

3D structure databases

ProteinModelPortaliQ9WV59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003885.

PTM databases

PhosphoSiteiQ9WV59.

Proteomic databases

PaxDbiQ9WV59.
PRIDEiQ9WV59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003885; ENSRNOP00000003885; ENSRNOG00000022983.
GeneIDi64702.
KEGGirno:64702.
UCSCiRGD:69290. rat.

Organism-specific databases

CTDi51127.
RGDi69290. Trim17.

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ9WV59.
KOiK12007.
OMAiCAVGQKS.
OrthoDBiEOG7V49Z8.
PhylomeDBiQ9WV59.
TreeFamiTF338674.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi613706.
PROiQ9WV59.

Gene expression databases

ExpressionAtlasiQ9WV59. baseline.
GenevisibleiQ9WV59. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR032918. TRIM17.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR24103:SF397. PTHR24103:SF397. 1 hit.
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis."
    Ogawa S., Goto W., Orimo A., Hosoi T., Ouchi Y., Muramatsu M., Inoue S.
    Biochem. Biophys. Res. Commun. 251:515-519(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTRI17_RAT
AccessioniPrimary (citable) accession number: Q9WV59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.