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Q9WV56

- GDF2_MOUSE

UniProt

Q9WV56 - GDF2_MOUSE

Protein

Growth/differentiation factor 2

Gene

Gdf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.1 Publication

    GO - Molecular functioni

    1. protein binding Source: DFLAT

    GO - Biological processi

    1. activin receptor signaling pathway Source: Ensembl
    2. angiogenesis Source: UniProtKB
    3. BMP signaling pathway Source: Ensembl
    4. cellular iron ion homeostasis Source: DFLAT
    5. glucose metabolic process Source: DFLAT
    6. growth Source: InterPro
    7. negative regulation of cell growth Source: Ensembl
    8. negative regulation of DNA biosynthetic process Source: Ensembl
    9. negative regulation of endothelial cell migration Source: Ensembl
    10. negative regulation of endothelial cell proliferation Source: Ensembl
    11. neuron differentiation Source: DFLAT
    12. osteoblast differentiation Source: MGI
    13. pathway-restricted SMAD protein phosphorylation Source: Ensembl
    14. patterning of blood vessels Source: DFLAT
    15. positive regulation of angiogenesis Source: DFLAT
    16. positive regulation of BMP signaling pathway Source: DFLAT
    17. positive regulation of endothelial cell differentiation Source: DFLAT
    18. positive regulation of endothelial cell proliferation Source: DFLAT
    19. positive regulation of gene expression Source: MGI
    20. positive regulation of interleukin-8 production Source: Ensembl
    21. positive regulation of osteoblast differentiation Source: MGI
    22. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    23. positive regulation of transcription, DNA-templated Source: DFLAT
    24. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    25. vasculogenesis Source: DFLAT

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Keywords - Biological processi

    Angiogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth/differentiation factor 2
    Short name:
    GDF-2
    Alternative name(s):
    Bone morphogenetic protein 9
    Short name:
    BMP-9
    Gene namesi
    Name:Gdf2
    Synonyms:Bmp9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1321394. Gdf2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 318296By similarityPRO_0000033904Add
    BLAST
    Chaini319 – 428110Growth/differentiation factor 2PRO_0000033905Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi326 ↔ 392By similarity
    Disulfide bondi355 ↔ 425By similarity
    Disulfide bondi359 ↔ 427By similarity
    Disulfide bondi391 – 391InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9WV56.

    PTM databases

    PhosphoSiteiQ9WV56.

    Expressioni

    Gene expression databases

    BgeeiQ9WV56.
    CleanExiMM_GDF2.
    GenevestigatoriQ9WV56.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with ENG By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WV56.
    SMRiQ9WV56. Positions 324-428.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG280573.
    GeneTreeiENSGT00740000115456.
    HOGENOMiHOG000249477.
    HOVERGENiHBG106648.
    InParanoidiQ3ZAS6.
    KOiK05503.
    OMAiENMKVDF.
    OrthoDBiEOG7ZD1V3.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WV56-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPGAFRVAL LPLFLLVCVT QQKPLQNWEQ ASPGENAHSS LGLSGAGEEG    50
    VFDLQMFLEN MKVDFLRSLN LSGIPSQDKT RAEPPQYMID LYNRYTTDKS 100
    STPASNIVRS FSVEDAISTA ATEDFPFQKH ILIFNISIPR HEQITRAELR 150
    LYVSCQNDVD STHGLEGSMV VYDVLEDSET WDQATGTKTF LVSQDIRDEG 200
    WETLEVSSAV KRWVRADSTT NKNKLEVTVQ SHRESCDTLD ISVPPGSKNL 250
    PFFVVFSNDR SNGTKETRLE LKEMIGHEQE TMLVKTAKNA YQVAGESQEE 300
    EGLDGYTAVG PLLARRKRST GASSHCQKTS LRVNFEDIGW DSWIIAPKEY 350
    DAYECKGGCF FPLADDVTPT KHAIVQTLVH LKFPTKVGKA CCVPTKLSPI 400
    SILYKDDMGV PTLKYHYEGM SVAECGCR 428
    Length:428
    Mass (Da):47,703
    Last modified:July 27, 2011 - v2
    Checksum:i82E4475FF8B27F36
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti293 – 2931V → G in AAD40308. 1 PublicationCurated
    Sequence conflicti382 – 3821K → E in AAD56961. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF156890 mRNA. Translation: AAD40308.1.
    AF188286 mRNA. Translation: AAD56961.1.
    AK147029 mRNA. Translation: BAE27621.1.
    CH466573 Genomic DNA. Translation: EDL24862.1.
    BC103625 mRNA. Translation: AAI03626.1.
    BC103679 mRNA. Translation: AAI03680.1.
    BC103680 mRNA. Translation: AAI03681.1.
    BC103681 mRNA. Translation: AAI03682.1.
    CCDSiCCDS26928.1.
    RefSeqiNP_062379.3. NM_019506.4.
    UniGeneiMm.422844.

    Genome annotation databases

    EnsembliENSMUST00000100720; ENSMUSP00000098286; ENSMUSG00000072625.
    GeneIDi12165.
    KEGGimmu:12165.
    UCSCiuc007tac.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF156890 mRNA. Translation: AAD40308.1 .
    AF188286 mRNA. Translation: AAD56961.1 .
    AK147029 mRNA. Translation: BAE27621.1 .
    CH466573 Genomic DNA. Translation: EDL24862.1 .
    BC103625 mRNA. Translation: AAI03626.1 .
    BC103679 mRNA. Translation: AAI03680.1 .
    BC103680 mRNA. Translation: AAI03681.1 .
    BC103681 mRNA. Translation: AAI03682.1 .
    CCDSi CCDS26928.1.
    RefSeqi NP_062379.3. NM_019506.4.
    UniGenei Mm.422844.

    3D structure databases

    ProteinModelPortali Q9WV56.
    SMRi Q9WV56. Positions 324-428.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9WV56.

    Proteomic databases

    PRIDEi Q9WV56.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000100720 ; ENSMUSP00000098286 ; ENSMUSG00000072625 .
    GeneIDi 12165.
    KEGGi mmu:12165.
    UCSCi uc007tac.1. mouse.

    Organism-specific databases

    CTDi 2658.
    MGIi MGI:1321394. Gdf2.

    Phylogenomic databases

    eggNOGi NOG280573.
    GeneTreei ENSGT00740000115456.
    HOGENOMi HOG000249477.
    HOVERGENi HBG106648.
    InParanoidi Q3ZAS6.
    KOi K05503.
    OMAi ENMKVDF.
    OrthoDBi EOG7ZD1V3.
    TreeFami TF316134.

    Miscellaneous databases

    NextBioi 280527.
    PROi Q9WV56.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WV56.
    CleanExi MM_GDF2.
    Genevestigatori Q9WV56.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Growth/differentiation factor-2, a new TGF-beta family member with bone promoting activities."
      Zimmers T.A., Koniaris L.G., Sitzmann J.V., Lee S.-J.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Liver.
    2. Celeste A.J.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies."
      Nolan-Stevaux O., Zhong W., Culp S., Shaffer K., Hoover J., Wickramasinghe D., Ruefli-Brasse A.
      PLoS ONE 7:E50920-E50920(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiGDF2_MOUSE
    AccessioniPrimary (citable) accession number: Q9WV56
    Secondary accession number(s): Q3ZAS6, Q9QZE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3