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Protein

Acid ceramidase

Gene

Asah1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.

Catalytic activityi

N-acylsphingosine + H2O = a carboxylate + sphingosine.

GO - Molecular functioni

  • ceramidase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.5.1.23. 3474.
ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
R-MMU-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiC89.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid ceramidase (EC:3.5.1.23)
Short name:
AC
Short name:
ACDase
Short name:
Acid CDase
Alternative name(s):
Acylsphingosine deacylase
N-acylsphingosine amidohydrolase
Cleaved into the following 2 chains:
Gene namesi
Name:Asah1
Synonyms:Asah
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1277124. Asah1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000231619 – 141Acid ceramidase subunit alphaAdd BLAST123
ChainiPRO_0000002317142 – 394Acid ceramidase subunit betaAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1
Glycosylationi258N-linked (GlcNAc...)1 Publication1
Glycosylationi341N-linked (GlcNAc...)Sequence analysis1
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9WV54.
MaxQBiQ9WV54.
PaxDbiQ9WV54.
PeptideAtlasiQ9WV54.
PRIDEiQ9WV54.

PTM databases

iPTMnetiQ9WV54.
PhosphoSitePlusiQ9WV54.
SwissPalmiQ9WV54.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031591.
CleanExiMM_ASAH1.
ExpressionAtlasiQ9WV54. baseline and differential.
GenevisibleiQ9WV54. MM.

Interactioni

Subunit structurei

Heterodimer of one alpha and one beta subunit.

Protein-protein interaction databases

IntActiQ9WV54. 1 interactor.
MINTiMINT-4088419.
STRINGi10090.ENSMUSP00000034000.

Structurei

3D structure databases

ProteinModelPortaliQ9WV54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acid ceramidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFSS. Eukaryota.
ENOG410XQ6Y. LUCA.
GeneTreeiENSGT00530000063548.
HOGENOMiHOG000007253.
HOVERGENiHBG050586.
InParanoidiQ9WV54.
KOiK12348.
OMAiWYTINLD.
OrthoDBiEOG091G08N9.
PhylomeDBiQ9WV54.
TreeFamiTF313219.

Family and domain databases

Gene3Di3.60.60.10. 1 hit.
InterProiIPR016699. Acid_ceramidase-like.
IPR029130. Acid_ceramidase_N.
IPR029132. CBAH/NAAA_C.
IPR003199. Chologlycine_hydro/PeptC59.
[Graphical view]
PfamiPF02275. CBAH. 1 hit.
PF15508. NAAA-beta. 1 hit.
[Graphical view]
PIRSFiPIRSF017632. Acid_ceramidase-like. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WV54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGQSLLTWV LAAAVTCAQA QDVPPWTEDC RKSTYPPSGP TYRGPVPWHT
60 70 80 90 100
INLDLPPYKR WHELLAQKAP ALRILVNSIT SLVNTFVPSG KLMKMVDQKL
110 120 130 140 150
PGMIGSLPDP FGEEMRGIAD VTGIPLGEII SFNIFYELFT MCTSIITEDE
160 170 180 190 200
KGHLLHGRNM DFGIFLGWNI NNNTWVVTEE LKPLTVNLDF QRNNKTVFKA
210 220 230 240 250
TSFVGYVGML TGFKPGLFSL SLNERFSING GYLGILEWMF GRKDAQWVGF
260 270 280 290 300
ITRSVLENTT SYEEAKNTLT KTKIMAPVYF ILGGKKSGEG CVITRERKES
310 320 330 340 350
LDVYELDPKH GRWYVVQTNY DRWKNTLFID DRRTPAKKCL NHTTQKNLSF
360 370 380 390
ATIYDVLSTK PVLNKLTVFT TLMDVTKGQF ESHLRDCPDP CIGW
Length:394
Mass (Da):44,670
Last modified:November 1, 1999 - v1
Checksum:iDA7BFBFDC45C9F65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157500 mRNA. Translation: AAD39551.1.
AK075666 mRNA. Translation: BAC35884.1.
BC003204 mRNA. Translation: AAH03204.1.
CCDSiCCDS22262.1.
RefSeqiNP_062708.1. NM_019734.3.
XP_017168016.1. XM_017312527.1.
XP_017168017.1. XM_017312528.1.
XP_017168018.1. XM_017312529.1.
XP_017168019.1. XM_017312530.1.
XP_017168020.1. XM_017312531.1.
XP_017168021.1. XM_017312532.1.
UniGeneiMm.22547.

Genome annotation databases

EnsembliENSMUST00000034000; ENSMUSP00000034000; ENSMUSG00000031591.
GeneIDi11886.
KEGGimmu:11886.
UCSCiuc009lnw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157500 mRNA. Translation: AAD39551.1.
AK075666 mRNA. Translation: BAC35884.1.
BC003204 mRNA. Translation: AAH03204.1.
CCDSiCCDS22262.1.
RefSeqiNP_062708.1. NM_019734.3.
XP_017168016.1. XM_017312527.1.
XP_017168017.1. XM_017312528.1.
XP_017168018.1. XM_017312529.1.
XP_017168019.1. XM_017312530.1.
XP_017168020.1. XM_017312531.1.
XP_017168021.1. XM_017312532.1.
UniGeneiMm.22547.

3D structure databases

ProteinModelPortaliQ9WV54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WV54. 1 interactor.
MINTiMINT-4088419.
STRINGi10090.ENSMUSP00000034000.

Protein family/group databases

MEROPSiC89.001.

PTM databases

iPTMnetiQ9WV54.
PhosphoSitePlusiQ9WV54.
SwissPalmiQ9WV54.

Proteomic databases

EPDiQ9WV54.
MaxQBiQ9WV54.
PaxDbiQ9WV54.
PeptideAtlasiQ9WV54.
PRIDEiQ9WV54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034000; ENSMUSP00000034000; ENSMUSG00000031591.
GeneIDi11886.
KEGGimmu:11886.
UCSCiuc009lnw.2. mouse.

Organism-specific databases

CTDi427.
MGIiMGI:1277124. Asah1.

Phylogenomic databases

eggNOGiENOG410IFSS. Eukaryota.
ENOG410XQ6Y. LUCA.
GeneTreeiENSGT00530000063548.
HOGENOMiHOG000007253.
HOVERGENiHBG050586.
InParanoidiQ9WV54.
KOiK12348.
OMAiWYTINLD.
OrthoDBiEOG091G08N9.
PhylomeDBiQ9WV54.
TreeFamiTF313219.

Enzyme and pathway databases

BRENDAi3.5.1.23. 3474.
ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiAsah1. mouse.
PROiQ9WV54.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031591.
CleanExiMM_ASAH1.
ExpressionAtlasiQ9WV54. baseline and differential.
GenevisibleiQ9WV54. MM.

Family and domain databases

Gene3Di3.60.60.10. 1 hit.
InterProiIPR016699. Acid_ceramidase-like.
IPR029130. Acid_ceramidase_N.
IPR029132. CBAH/NAAA_C.
IPR003199. Chologlycine_hydro/PeptC59.
[Graphical view]
PfamiPF02275. CBAH. 1 hit.
PF15508. NAAA-beta. 1 hit.
[Graphical view]
PIRSFiPIRSF017632. Acid_ceramidase-like. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiASAH1_MOUSE
AccessioniPrimary (citable) accession number: Q9WV54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.