Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acid ceramidase

Gene

Asah1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.

Catalytic activityi

N-acylsphingosine + H2O = a carboxylate + sphingosine.

GO - Molecular functioni

  • ceramidase activity Source: UniProtKB-EC
  • N-acylsphingosine amidohydrolase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDAi3.5.1.23 3474
ReactomeiR-MMU-1660662 Glycosphingolipid metabolism
R-MMU-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiC89.001

Names & Taxonomyi

Protein namesi
Recommended name:
Acid ceramidase (EC:3.5.1.23)
Short name:
AC
Short name:
ACDase
Short name:
Acid CDase
Alternative name(s):
Acylsphingosine deacylase
N-acylsphingosine amidohydrolase
Cleaved into the following 2 chains:
Gene namesi
Name:Asah1
Synonyms:Asah
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1277124 Asah1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000231619 – 141Acid ceramidase subunit alphaAdd BLAST123
ChainiPRO_0000002317142 – 394Acid ceramidase subunit betaAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9WV54
MaxQBiQ9WV54
PaxDbiQ9WV54
PeptideAtlasiQ9WV54
PRIDEiQ9WV54

PTM databases

iPTMnetiQ9WV54
PhosphoSitePlusiQ9WV54
SwissPalmiQ9WV54

Expressioni

Gene expression databases

BgeeiENSMUSG00000031591
CleanExiMM_ASAH1
ExpressionAtlasiQ9WV54 baseline and differential
GenevisibleiQ9WV54 MM

Interactioni

Subunit structurei

Heterodimer of one alpha and one beta subunit.

Protein-protein interaction databases

IntActiQ9WV54, 1 interactor
MINTiQ9WV54
STRINGi10090.ENSMUSP00000034000

Structurei

3D structure databases

ProteinModelPortaliQ9WV54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acid ceramidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFSS Eukaryota
ENOG410XQ6Y LUCA
GeneTreeiENSGT00530000063548
HOGENOMiHOG000007253
HOVERGENiHBG050586
InParanoidiQ9WV54
KOiK12348
OMAiDAMWIGF
OrthoDBiEOG091G08N9
PhylomeDBiQ9WV54
TreeFamiTF313219

Family and domain databases

InterProiView protein in InterPro
IPR016699 Acid_ceramidase-like
IPR029130 Acid_ceramidase_N
IPR029132 CBAH/NAAA_C
PfamiView protein in Pfam
PF02275 CBAH, 1 hit
PF15508 NAAA-beta, 1 hit
PIRSFiPIRSF017632 Acid_ceramidase-like, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WV54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGQSLLTWV LAAAVTCAQA QDVPPWTEDC RKSTYPPSGP TYRGPVPWHT
60 70 80 90 100
INLDLPPYKR WHELLAQKAP ALRILVNSIT SLVNTFVPSG KLMKMVDQKL
110 120 130 140 150
PGMIGSLPDP FGEEMRGIAD VTGIPLGEII SFNIFYELFT MCTSIITEDE
160 170 180 190 200
KGHLLHGRNM DFGIFLGWNI NNNTWVVTEE LKPLTVNLDF QRNNKTVFKA
210 220 230 240 250
TSFVGYVGML TGFKPGLFSL SLNERFSING GYLGILEWMF GRKDAQWVGF
260 270 280 290 300
ITRSVLENTT SYEEAKNTLT KTKIMAPVYF ILGGKKSGEG CVITRERKES
310 320 330 340 350
LDVYELDPKH GRWYVVQTNY DRWKNTLFID DRRTPAKKCL NHTTQKNLSF
360 370 380 390
ATIYDVLSTK PVLNKLTVFT TLMDVTKGQF ESHLRDCPDP CIGW
Length:394
Mass (Da):44,670
Last modified:November 1, 1999 - v1
Checksum:iDA7BFBFDC45C9F65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157500 mRNA Translation: AAD39551.1
AK075666 mRNA Translation: BAC35884.1
BC003204 mRNA Translation: AAH03204.1
CCDSiCCDS22262.1
RefSeqiNP_062708.1, NM_019734.3
XP_017168016.1, XM_017312527.1
XP_017168017.1, XM_017312528.1
XP_017168018.1, XM_017312529.1
XP_017168019.1, XM_017312530.1
XP_017168020.1, XM_017312531.1
XP_017168021.1, XM_017312532.1
UniGeneiMm.22547

Genome annotation databases

EnsembliENSMUST00000034000; ENSMUSP00000034000; ENSMUSG00000031591
GeneIDi11886
KEGGimmu:11886
UCSCiuc009lnw.2 mouse

Similar proteinsi

Entry informationi

Entry nameiASAH1_MOUSE
AccessioniPrimary (citable) accession number: Q9WV54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health