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Protein

Pleckstrin-2

Gene

Plek2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. Overexpression of pleckstrin 2 causes large lamellipodia and peripheral ruffle formation.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin-2
Gene namesi
Name:Plek2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1351466. Plek2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538631 – 353Pleckstrin-2Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei120PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9WV52.
PaxDbiQ9WV52.
PeptideAtlasiQ9WV52.
PRIDEiQ9WV52.

PTM databases

PhosphoSitePlusiQ9WV52.

Expressioni

Tissue specificityi

Ubiquitous. Most abundant in the thymus, large bowel, small bowel, stomach, and prostate.

Gene expression databases

BgeeiENSMUSG00000021118.
CleanExiMM_PLEK2.
GenevisibleiQ9WV52. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021544.

Structurei

Secondary structure

1353
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi129 – 136Combined sources8
Beta strandi139 – 142Combined sources4
Beta strandi150 – 153Combined sources4
Helixi161 – 170Combined sources10
Helixi177 – 190Combined sources14
Beta strandi192 – 195Combined sources4
Beta strandi197 – 200Combined sources4
Beta strandi216 – 218Combined sources3
Beta strandi220 – 223Combined sources4
Beta strandi225 – 227Combined sources3
Beta strandi233 – 235Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V3FNMR-A129-235[»]
ProteinModelPortaliQ9WV52.
SMRiQ9WV52.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WV52.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 104PH 1PROSITE-ProRule annotationAdd BLAST101
Domaini139 – 225DEPPROSITE-ProRule annotationAdd BLAST87
Domaini247 – 353PH 2PROSITE-ProRule annotationAdd BLAST107

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGI2. Eukaryota.
ENOG410ZHY3. LUCA.
GeneTreeiENSGT00390000006543.
HOGENOMiHOG000294078.
HOVERGENiHBG001361.
InParanoidiQ9WV52.
KOiK19993.
OMAiHNWKVRW.
OrthoDBiEOG091G09EY.
PhylomeDBiQ9WV52.
TreeFamiTF332246.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000591. DEP_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50186. DEP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDGVLKEGF LVKRGHIVHN WKARWFILRQ NTLLYYKLEG GRRVTPPKGR
60 70 80 90 100
IVLDGCTITC PCLEYENRPL LIKLKTRTST EYFLEACSRE ERDSWAFEIT
110 120 130 140 150
GAIHAGQPGK IQQLHILKNS FKLPPHISLH RIVDKMHDTS TGIRPSPNME
160 170 180 190 200
QGSTYKKTFL GSSLVDWLIS SNFAASRLEA VTLASMLMEE NFLRPVGVRS
210 220 230 240 250
MGAIRSGDLA EQFLDDSTAL YTFAESYKKK VSSKEEISLS TMELSGTVVK
260 270 280 290 300
QGYLSKQGHK RKNWKVRRFV LRKDPAFLHY YDPSKEENRP VGGFSLRGSL
310 320 330 340 350
VSALEDNGVP TGVKGNVQGN LFKVITKDDT HYYIQASSKA ERAEWIEAIK

KLT
Length:353
Mass (Da):40,018
Last modified:November 1, 1999 - v1
Checksum:i4593DC41B62E9A5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157600 mRNA. Translation: AAD42973.1.
AF170564 mRNA. Translation: AAD46924.1.
BC028902 mRNA. Translation: AAH28902.1.
CCDSiCCDS26004.1.
PIRiJC7128.
RefSeqiNP_038766.1. NM_013738.3.
UniGeneiMm.103380.

Genome annotation databases

EnsembliENSMUST00000021544; ENSMUSP00000021544; ENSMUSG00000021118.
GeneIDi27260.
KEGGimmu:27260.
UCSCiuc007nzl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157600 mRNA. Translation: AAD42973.1.
AF170564 mRNA. Translation: AAD46924.1.
BC028902 mRNA. Translation: AAH28902.1.
CCDSiCCDS26004.1.
PIRiJC7128.
RefSeqiNP_038766.1. NM_013738.3.
UniGeneiMm.103380.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V3FNMR-A129-235[»]
ProteinModelPortaliQ9WV52.
SMRiQ9WV52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021544.

PTM databases

PhosphoSitePlusiQ9WV52.

Proteomic databases

MaxQBiQ9WV52.
PaxDbiQ9WV52.
PeptideAtlasiQ9WV52.
PRIDEiQ9WV52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021544; ENSMUSP00000021544; ENSMUSG00000021118.
GeneIDi27260.
KEGGimmu:27260.
UCSCiuc007nzl.2. mouse.

Organism-specific databases

CTDi26499.
MGIiMGI:1351466. Plek2.

Phylogenomic databases

eggNOGiENOG410IGI2. Eukaryota.
ENOG410ZHY3. LUCA.
GeneTreeiENSGT00390000006543.
HOGENOMiHOG000294078.
HOVERGENiHBG001361.
InParanoidiQ9WV52.
KOiK19993.
OMAiHNWKVRW.
OrthoDBiEOG091G09EY.
PhylomeDBiQ9WV52.
TreeFamiTF332246.

Miscellaneous databases

EvolutionaryTraceiQ9WV52.
PROiQ9WV52.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021118.
CleanExiMM_PLEK2.
GenevisibleiQ9WV52. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000591. DEP_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50186. DEP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLEK2_MOUSE
AccessioniPrimary (citable) accession number: Q9WV52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.