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Protein

Pleckstrin-2

Gene

Plek2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. Overexpression of pleckstrin 2 causes large lamellipodia and peripheral ruffle formation.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin-2
Gene namesi
Name:Plek2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1351466. Plek2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Pleckstrin-2PRO_0000053863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei120 – 1201PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9WV52.
PaxDbiQ9WV52.
PeptideAtlasiQ9WV52.
PRIDEiQ9WV52.

PTM databases

PhosphoSiteiQ9WV52.

Expressioni

Tissue specificityi

Ubiquitous. Most abundant in the thymus, large bowel, small bowel, stomach, and prostate.

Gene expression databases

BgeeiQ9WV52.
CleanExiMM_PLEK2.
GenevisibleiQ9WV52. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021544.

Structurei

Secondary structure

1
353
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi129 – 1368Combined sources
Beta strandi139 – 1424Combined sources
Beta strandi150 – 1534Combined sources
Helixi161 – 17010Combined sources
Helixi177 – 19014Combined sources
Beta strandi192 – 1954Combined sources
Beta strandi197 – 2004Combined sources
Beta strandi216 – 2183Combined sources
Beta strandi220 – 2234Combined sources
Beta strandi225 – 2273Combined sources
Beta strandi233 – 2353Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V3FNMR-A129-235[»]
ProteinModelPortaliQ9WV52.
SMRiQ9WV52. Positions 4-95, 129-235, 241-353.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WV52.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 104101PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini139 – 22587DEPPROSITE-ProRule annotationAdd
BLAST
Domaini247 – 353107PH 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGI2. Eukaryota.
ENOG410ZHY3. LUCA.
GeneTreeiENSGT00390000006543.
HOGENOMiHOG000294078.
HOVERGENiHBG001361.
InParanoidiQ9WV52.
KOiK19993.
OMAiHNWKVRW.
OrthoDBiEOG74XS6R.
PhylomeDBiQ9WV52.
TreeFamiTF332246.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000591. DEP_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50186. DEP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDGVLKEGF LVKRGHIVHN WKARWFILRQ NTLLYYKLEG GRRVTPPKGR
60 70 80 90 100
IVLDGCTITC PCLEYENRPL LIKLKTRTST EYFLEACSRE ERDSWAFEIT
110 120 130 140 150
GAIHAGQPGK IQQLHILKNS FKLPPHISLH RIVDKMHDTS TGIRPSPNME
160 170 180 190 200
QGSTYKKTFL GSSLVDWLIS SNFAASRLEA VTLASMLMEE NFLRPVGVRS
210 220 230 240 250
MGAIRSGDLA EQFLDDSTAL YTFAESYKKK VSSKEEISLS TMELSGTVVK
260 270 280 290 300
QGYLSKQGHK RKNWKVRRFV LRKDPAFLHY YDPSKEENRP VGGFSLRGSL
310 320 330 340 350
VSALEDNGVP TGVKGNVQGN LFKVITKDDT HYYIQASSKA ERAEWIEAIK

KLT
Length:353
Mass (Da):40,018
Last modified:November 1, 1999 - v1
Checksum:i4593DC41B62E9A5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157600 mRNA. Translation: AAD42973.1.
AF170564 mRNA. Translation: AAD46924.1.
BC028902 mRNA. Translation: AAH28902.1.
CCDSiCCDS26004.1.
PIRiJC7128.
RefSeqiNP_038766.1. NM_013738.3.
UniGeneiMm.103380.

Genome annotation databases

EnsembliENSMUST00000021544; ENSMUSP00000021544; ENSMUSG00000021118.
GeneIDi27260.
KEGGimmu:27260.
UCSCiuc007nzl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157600 mRNA. Translation: AAD42973.1.
AF170564 mRNA. Translation: AAD46924.1.
BC028902 mRNA. Translation: AAH28902.1.
CCDSiCCDS26004.1.
PIRiJC7128.
RefSeqiNP_038766.1. NM_013738.3.
UniGeneiMm.103380.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V3FNMR-A129-235[»]
ProteinModelPortaliQ9WV52.
SMRiQ9WV52. Positions 4-95, 129-235, 241-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021544.

PTM databases

PhosphoSiteiQ9WV52.

Proteomic databases

MaxQBiQ9WV52.
PaxDbiQ9WV52.
PeptideAtlasiQ9WV52.
PRIDEiQ9WV52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021544; ENSMUSP00000021544; ENSMUSG00000021118.
GeneIDi27260.
KEGGimmu:27260.
UCSCiuc007nzl.2. mouse.

Organism-specific databases

CTDi26499.
MGIiMGI:1351466. Plek2.

Phylogenomic databases

eggNOGiENOG410IGI2. Eukaryota.
ENOG410ZHY3. LUCA.
GeneTreeiENSGT00390000006543.
HOGENOMiHOG000294078.
HOVERGENiHBG001361.
InParanoidiQ9WV52.
KOiK19993.
OMAiHNWKVRW.
OrthoDBiEOG74XS6R.
PhylomeDBiQ9WV52.
TreeFamiTF332246.

Miscellaneous databases

EvolutionaryTraceiQ9WV52.
PROiQ9WV52.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WV52.
CleanExiMM_PLEK2.
GenevisibleiQ9WV52. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000591. DEP_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50186. DEP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Pleckstrin 2, a widely expressed paralog of pleckstrin involved in actin rearrangement."
    Hu M., Bauman E.M., Roll R.L., Yeilding N., Abrams C.S.
    J. Biol. Chem. 274:21515-21518(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family."
    Inazu T., Yamada K., Miyamoto K.
    Biochem. Biophys. Res. Commun. 265:87-93(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  4. "Solution structure of the DEP domain of mouse pleckstrin2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 129-235.

Entry informationi

Entry nameiPLEK2_MOUSE
AccessioniPrimary (citable) accession number: Q9WV52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.