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Protein

Pleckstrin-2

Gene

Plek2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. Overexpression of pleckstrin 2 causes large lamellipodia and peripheral ruffle formation.

GO - Molecular functioni

  • phosphatidylinositol-3,4-bisphosphate binding Source: MGI
  • phosphatidylinositol-3,5-bisphosphate binding Source: MGI

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • intracellular signal transduction Source: InterPro
  • positive regulation of cell projection organization Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin-2
Gene namesi
Name:Plek2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1351466 Plek2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538631 – 353Pleckstrin-2Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei120PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9WV52
PaxDbiQ9WV52
PeptideAtlasiQ9WV52
PRIDEiQ9WV52

PTM databases

iPTMnetiQ9WV52
PhosphoSitePlusiQ9WV52

Expressioni

Tissue specificityi

Ubiquitous. Most abundant in the thymus, large bowel, small bowel, stomach, and prostate.

Gene expression databases

BgeeiENSMUSG00000021118
CleanExiMM_PLEK2
GenevisibleiQ9WV52 MM

Structurei

Secondary structure

1353
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi129 – 136Combined sources8
Beta strandi139 – 142Combined sources4
Beta strandi150 – 153Combined sources4
Helixi161 – 170Combined sources10
Helixi177 – 190Combined sources14
Beta strandi192 – 195Combined sources4
Beta strandi197 – 200Combined sources4
Beta strandi216 – 218Combined sources3
Beta strandi220 – 223Combined sources4
Beta strandi225 – 227Combined sources3
Beta strandi233 – 235Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V3FNMR-A129-235[»]
ProteinModelPortaliQ9WV52
SMRiQ9WV52
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WV52

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 104PH 1PROSITE-ProRule annotationAdd BLAST101
Domaini139 – 225DEPPROSITE-ProRule annotationAdd BLAST87
Domaini247 – 353PH 2PROSITE-ProRule annotationAdd BLAST107

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGI2 Eukaryota
ENOG410ZHY3 LUCA
GeneTreeiENSGT00390000006543
HOGENOMiHOG000294078
HOVERGENiHBG001361
InParanoidiQ9WV52
KOiK19993
OMAiHNWKVRW
OrthoDBiEOG091G09EY
PhylomeDBiQ9WV52
TreeFamiTF332246

Family and domain databases

CDDicd04444 DEP_PLEK2, 1 hit
Gene3Di1.10.10.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037370 Pleckstrin
IPR037369 PLEK2_DEP
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12092 PTHR12092, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00169 PH, 2 hits
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50003 PH_DOMAIN, 2 hits

Sequencei

Sequence statusi: Complete.

Q9WV52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDGVLKEGF LVKRGHIVHN WKARWFILRQ NTLLYYKLEG GRRVTPPKGR
60 70 80 90 100
IVLDGCTITC PCLEYENRPL LIKLKTRTST EYFLEACSRE ERDSWAFEIT
110 120 130 140 150
GAIHAGQPGK IQQLHILKNS FKLPPHISLH RIVDKMHDTS TGIRPSPNME
160 170 180 190 200
QGSTYKKTFL GSSLVDWLIS SNFAASRLEA VTLASMLMEE NFLRPVGVRS
210 220 230 240 250
MGAIRSGDLA EQFLDDSTAL YTFAESYKKK VSSKEEISLS TMELSGTVVK
260 270 280 290 300
QGYLSKQGHK RKNWKVRRFV LRKDPAFLHY YDPSKEENRP VGGFSLRGSL
310 320 330 340 350
VSALEDNGVP TGVKGNVQGN LFKVITKDDT HYYIQASSKA ERAEWIEAIK

KLT
Length:353
Mass (Da):40,018
Last modified:November 1, 1999 - v1
Checksum:i4593DC41B62E9A5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157600 mRNA Translation: AAD42973.1
AF170564 mRNA Translation: AAD46924.1
BC028902 mRNA Translation: AAH28902.1
CCDSiCCDS26004.1
PIRiJC7128
RefSeqiNP_038766.1, NM_013738.3
UniGeneiMm.103380

Genome annotation databases

EnsembliENSMUST00000021544; ENSMUSP00000021544; ENSMUSG00000021118
GeneIDi27260
KEGGimmu:27260
UCSCiuc007nzl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPLEK2_MOUSE
AccessioniPrimary (citable) accession number: Q9WV52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health