Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9WV48

- SHAN1_RAT

UniProt

Q9WV48 - SHAN1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

SH3 and multiple ankyrin repeat domains protein 1

Gene

Shank1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.2 Publications

GO - Molecular functioni

  1. ankyrin repeat binding Source: BHF-UCL
  2. GKAP/Homer scaffold activity Source: BHF-UCL
  3. identical protein binding Source: BHF-UCL
  4. ionotropic glutamate receptor binding Source: RGD
  5. protein complex binding Source: RGD
  6. protein C-terminus binding Source: RGD
  7. receptor signaling complex scaffold activity Source: RGD
  8. scaffold protein binding Source: BHF-UCL
  9. SH3 domain binding Source: BHF-UCL
  10. somatostatin receptor binding Source: UniProtKB

GO - Biological processi

  1. adult behavior Source: Ensembl
  2. associative learning Source: BHF-UCL
  3. cytoskeletal anchoring at plasma membrane Source: UniProtKB
  4. dendritic spine morphogenesis Source: BHF-UCL
  5. determination of affect Source: Ensembl
  6. habituation Source: BHF-UCL
  7. long-term memory Source: BHF-UCL
  8. negative regulation of actin filament bundle assembly Source: BHF-UCL
  9. neuromuscular process controlling balance Source: BHF-UCL
  10. olfactory behavior Source: BHF-UCL
  11. positive regulation of dendritic spine development Source: UniProtKB
  12. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
  13. protein complex assembly Source: BHF-UCL
  14. protein localization to synapse Source: BHF-UCL
  15. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
  16. righting reflex Source: BHF-UCL
  17. social behavior Source: Ensembl
  18. synapse maturation Source: UniProtKB
  19. vocalization behavior Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and multiple ankyrin repeat domains protein 1
Short name:
Shank1
Alternative name(s):
GKAP/SAPAP-interacting protein
SPANK-1
Somatostatin receptor-interacting protein
Short name:
SSTR-interacting protein
Short name:
SSTRIP
Synamon
Gene namesi
Name:Shank1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi621011. Shank1.

Subcellular locationi

Cytoplasm 1 Publication. Cell junctionsynapse 1 Publication. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density 1 Publication
Note: Colocalizes with alpha-latrotoxin receptor 1.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. dendrite Source: UniProtKB
  4. dendritic spine Source: BHF-UCL
  5. excitatory synapse Source: BHF-UCL
  6. intracellular Source: UniProtKB
  7. ionotropic glutamate receptor complex Source: Ensembl
  8. neuronal postsynaptic density Source: BHF-UCL
  9. neuron projection Source: BHF-UCL
  10. plasma membrane Source: BHF-UCL
  11. postsynaptic membrane Source: RGD
  12. synapse Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21672167SH3 and multiple ankyrin repeat domains protein 1PRO_0000174672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei186 – 1861PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9WV48.
PRIDEiQ9WV48.

PTM databases

PhosphoSiteiQ9WV48.

Expressioni

Tissue specificityi

Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum).

Developmental stagei

Expression increases from low levels at birth to high levels at 3-4 weeks before dropping slightly in adulthood. Expressed in the cortex and the molecular layer of the cerebellum at postnatal day 7. Isoform 2 expression does not change during development of both cortex and cerebellum. Isoform 4 expression decreases significantly during development of cortex but not cerebellum.1 Publication

Gene expression databases

ExpressionAtlasiQ9WV48. baseline and differential.
GenevestigatoriQ9WV48.

Interactioni

Subunit structurei

May homomultimerize via its SAM domain. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2 (By similarity). Interacts with IGSF9.By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Arhgef7Q9ES28-26EBI-80909,EBI-8620514From a different organism.
Dlg4P310163EBI-80909,EBI-375655
Dlgap1P978366EBI-80909,EBI-80901
Dlgap1P97836-52EBI-80909,EBI-6269434
Homer1Q9Z214-24EBI-80909,EBI-2338999
SharpinQ9EQL97EBI-80909,EBI-1394695

Protein-protein interaction databases

BioGridi249365. 5 interactions.
IntActiQ9WV48. 17 interactions.
MINTiMINT-101286.

Structurei

Secondary structure

1
2167
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi657 – 66711Combined sources
Beta strandi670 – 6723Combined sources
Beta strandi675 – 6828Combined sources
Beta strandi694 – 6963Combined sources
Beta strandi698 – 7058Combined sources
Helixi710 – 7134Combined sources
Beta strandi721 – 7255Combined sources
Helixi735 – 74410Combined sources
Turni745 – 7473Combined sources
Beta strandi748 – 75710Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q3OX-ray1.80A/B654-762[»]
1Q3PX-ray2.25A/B654-762[»]
3L4FX-ray2.80D653-765[»]
3QJMX-ray2.31A/B654-768[»]
3QJNX-ray2.71A/B/C/D/E/F/G/H654-768[»]
ProteinModelPortaliQ9WV48.
SMRiQ9WV48. Positions 656-759, 2101-2162.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WV48.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati195 – 21016ANK 1Add
BLAST
Repeati212 – 24534ANK 2Add
BLAST
Repeati246 – 27833ANK 3Add
BLAST
Repeati279 – 31234ANK 4Add
BLAST
Repeati313 – 34533ANK 5Add
BLAST
Repeati346 – 37833ANK 6Add
BLAST
Repeati379 – 39517ANK 7Add
BLAST
Domaini554 – 61360SH3PROSITE-ProRule annotationAdd
BLAST
Domaini663 – 75795PDZPROSITE-ProRule annotationAdd
BLAST
Domaini2104 – 216764SAMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi929 – 9324Poly-Pro
Compositional biasi1010 – 10156Poly-His
Compositional biasi1022 – 10276Poly-His
Compositional biasi1194 – 11996Poly-Gly
Compositional biasi1850 – 186011Poly-ProAdd
BLAST

Sequence similaritiesi

Belongs to the SHANK family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
HOVERGENiHBG079186.
InParanoidiQ9WV48.
KOiK15009.
OMAiWEEGPGP.
OrthoDBiEOG7X6KZ7.
PhylomeDBiQ9WV48.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9WV48-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN
60 70 80 90 100
LASTRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK
110 120 130 140 150
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP
160 170 180 190 200
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD
210 220 230 240 250
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA
260 270 280 290 300
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL
310 320 330 340 350
LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA
360 370 380 390 400
LHICALYNKE TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR
410 420 430 440 450
NHREQDVVPF QESPKYAARR RGPPGAGLTV PPALLRANSD TSMALPDWMV
460 470 480 490 500
FSAPGASSSG TPGPTSGPQG QSQPSAPSTK LSSGTLRSAS SPRGARARSP
510 520 530 540 550
SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS LGSRGRRRKL
560 570 580 590 600
YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV
610 620 630 640 650
GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG
660 670 680 690 700
IDSGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ
710 720 730 740 750
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM
760 770 780 790 800
VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP AISLRSKSMT SELEEMVSPW
810 820 830 840 850
KKKIEYEQQP AAVPSMEKKR TVYQMALNKL DEILAAAQQT ISASESPGPG
860 870 880 890 900
GLASLGKHRP KGFFATESSF DPHHRSQPSY DRPSFLPPGP GLMLRQKSIG
910 920 930 940 950
AAEDDRPYLA PPAMKFSRSL SVPGSEDIPP PPTTSPPEPP YSTPPAPSSS
960 970 980 990 1000
GRLTPSPRGG PFNPSSGGPL PASSPSSFDG PSPPDTRGGG REKSLYHSAA
1010 1020 1030 1040 1050
LPPAHHHPPH HHHHHAPPPQ PHHHHAHPPH PPEMETGGSP DDPPPRLALG
1060 1070 1080 1090 1100
PQPSLRGWRG GGPSPTSGAP SPSHHSSSGG SSGPTQAPAL RYFQLPPRAA
1110 1120 1130 1140 1150
SAAMYVPARS GRGRKGPLVK QTKVEGEPQK GSIPSASSPT SPALPRSEPP
1160 1170 1180 1190 1200
PAGPSEKNSI PIPTIIIKAP STSSSGRSSQ GSSTEAEPPT QPDGAGGGGS
1210 1220 1230 1240 1250
SPSPAPATSP VPPSPSPVPT PASPSGPATL DFTSQFGAAL VGAARREGGW
1260 1270 1280 1290 1300
QNEARRRSTL FLSTDAGDED GGDSGLGPGG PPGPRLRHSK SIDEGMFSAE
1310 1320 1330 1340 1350
PYLRLESGGS SGGYGAYAAG SRAYGGSGSS SAFTSFLPPR PLVHPLTGKA
1360 1370 1380 1390 1400
LDPASPLGLA LAARERALKE SSEGGGTPQP PPRPPSPRYD APPPTLHHHS
1410 1420 1430 1440 1450
PHSPHSPHAR HEPVLRLWGD PARRELGYRA GLGSQEKALT ASPPAARRSL
1460 1470 1480 1490 1500
LHRLPPTAPG VGPLLLQLGP EPPTPHPGVS KAWRTAAPEE PERLPLHVRF
1510 1520 1530 1540 1550
LENCQARPPP AGTRGSSTED GPGVPPPSPR RVLPTSPTSP RGNEENGLPL
1560 1570 1580 1590 1600
LVLPPPAPSV DVDDGEFLFA EPLPPPLEFS NSFEKPESPL TPGPPHPLPD
1610 1620 1630 1640 1650
PPSPATPLPA APPPAVAAAP PTLDSTASSL TSYDSEVATL TQGAPAAPGD
1660 1670 1680 1690 1700
PPAPGPPAPA APAPPAPQPG PDPPPGTDSG IEEVDSRSSS DHPLETISSA
1710 1720 1730 1740 1750
STLSSLSAEG GGNTGGVAGG GAGVASGTEL LDTYVAYLDG QAFGGSGTPG
1760 1770 1780 1790 1800
PPYPPQLMTP SKLRGRALGT SGNLRPGPSG GLRDPVTPTS PTVSVTGAGT
1810 1820 1830 1840 1850
DGLLALSACP GPSTAGVAGG PVAVEPEVPP VPLPAASSLP RKLLPWEEGP
1860 1870 1880 1890 1900
GPPPPPLPGP LSQPQASALA TVKASIISEL SSKLQQFGGS STAGGALPWA
1910 1920 1930 1940 1950
RGGSGGSTDS HHGGASYIPE RTSSLQRQRL SEDSQTSLLS KPSSSIFQNW
1960 1970 1980 1990 2000
PKPPLPPLPT GSGVSSSTAA APGATSPSAS SASASTRHLQ GVEFEMRPPL
2010 2020 2030 2040 2050
LRRAPSPSLL PASDHKVSPA PRPSSLPILP SGPIYPGLFD IRSSPTGGAG
2060 2070 2080 2090 2100
GSTDPFAPVF VPPHPGISGG LGGALSGASR SLSPTRLLSL PPDKPFGAKP
2110 2120 2130 2140 2150
LGFWTKFDVA DWLEWLGLSE HRAQFLDHEI DGSHLPALTK EDYVDLGVTR
2160
VGHRMNIDRA LKFFLER
Length:2,167
Mass (Da):226,335
Last modified:November 1, 1999 - v1
Checksum:i3F478B5A7B18BA86
GO
Isoform 2 (identifier: Q9WV48-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-614: Missing.
     615-654: SQEGRQESRS...PSLIDGIDSG → MALSAVGGGP...PRRRSVWYIY

Show »
Length:1,553
Mass (Da):159,899
Checksum:iB9B7E6A33E26DE48
GO
Isoform 3 (identifier: Q9WV48-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-654: Missing.

Show »
Length:2,158
Mass (Da):225,477
Checksum:iBF18578E26D6578C
GO
Isoform 4 (identifier: Q9WV48-4) [UniParc]FASTAAdd to Basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     797-804: Missing.

Show »
Length:2,159
Mass (Da):225,368
Checksum:i912C1737EC330CB1
GO
Isoform 5 (identifier: Q9WV48-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1930-1943: LSEDSQTSLLSKPS → QYRIVVKSSDFGDF
     1944-2167: Missing.

Show »
Length:1,943
Mass (Da):202,919
Checksum:iD290DD45558B73AF
GO

Sequence cautioni

The sequence AAD29417.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAF02498.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1141 – 11411S → T in AAD04569. (PubMed:10488079)Curated
Sequence conflicti1174 – 11741S → N in AAD29417. (PubMed:10433268)Curated
Sequence conflicti1246 – 12461R → K in AAD04569. (PubMed:10488079)Curated
Sequence conflicti1323 – 13231A → T in AAD04569. (PubMed:10488079)Curated
Sequence conflicti1331 – 13311S → D in AAD04569. (PubMed:10488079)Curated
Sequence conflicti1726 – 17261S → N in AAD29417. (PubMed:10433268)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 614614Missing in isoform 2. CuratedVSP_006072Add
BLAST
Alternative sequencei615 – 65440SQEGR…GIDSG → MALSAVGGGPGGGALPQPPP ALSSSWPALGPRRRSVWYIY in isoform 2. CuratedVSP_006073Add
BLAST
Alternative sequencei646 – 6549Missing in isoform 3. 1 PublicationVSP_006074
Alternative sequencei797 – 8048Missing in isoform 4. 1 PublicationVSP_006075
Alternative sequencei1930 – 194314LSEDS…LSKPS → QYRIVVKSSDFGDF in isoform 5. CuratedVSP_006076Add
BLAST
Alternative sequencei1944 – 2167224Missing in isoform 5. CuratedVSP_006077Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102855 mRNA. Translation: AAD04569.2.
AF131951 mRNA. Translation: AAD29417.1. Different initiation.
AF159046 mRNA. Translation: AAD42975.1.
AF141904 mRNA. Translation: AAF02498.1. Different initiation.
RefSeqiNP_113939.2. NM_031751.2. [Q9WV48-1]
XP_008757636.1. XM_008759414.1. [Q9WV48-4]
XP_008757637.1. XM_008759415.1. [Q9WV48-3]
XP_008757639.1. XM_008759417.1. [Q9WV48-5]
UniGeneiRn.225968.

Genome annotation databases

EnsembliENSRNOT00000026100; ENSRNOP00000026100; ENSRNOG00000019207. [Q9WV48-1]
ENSRNOT00000044257; ENSRNOP00000039860; ENSRNOG00000019207. [Q9WV48-3]
ENSRNOT00000048805; ENSRNOP00000042890; ENSRNOG00000019207. [Q9WV48-4]
ENSRNOT00000049346; ENSRNOP00000044509; ENSRNOG00000019207. [Q9WV48-5]
GeneIDi78957.
KEGGirno:78957.
UCSCiRGD:621011. rat. [Q9WV48-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102855 mRNA. Translation: AAD04569.2 .
AF131951 mRNA. Translation: AAD29417.1 . Different initiation.
AF159046 mRNA. Translation: AAD42975.1 .
AF141904 mRNA. Translation: AAF02498.1 . Different initiation.
RefSeqi NP_113939.2. NM_031751.2. [Q9WV48-1 ]
XP_008757636.1. XM_008759414.1. [Q9WV48-4 ]
XP_008757637.1. XM_008759415.1. [Q9WV48-3 ]
XP_008757639.1. XM_008759417.1. [Q9WV48-5 ]
UniGenei Rn.225968.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Q3O X-ray 1.80 A/B 654-762 [» ]
1Q3P X-ray 2.25 A/B 654-762 [» ]
3L4F X-ray 2.80 D 653-765 [» ]
3QJM X-ray 2.31 A/B 654-768 [» ]
3QJN X-ray 2.71 A/B/C/D/E/F/G/H 654-768 [» ]
ProteinModelPortali Q9WV48.
SMRi Q9WV48. Positions 656-759, 2101-2162.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249365. 5 interactions.
IntActi Q9WV48. 17 interactions.
MINTi MINT-101286.

PTM databases

PhosphoSitei Q9WV48.

Proteomic databases

PaxDbi Q9WV48.
PRIDEi Q9WV48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026100 ; ENSRNOP00000026100 ; ENSRNOG00000019207 . [Q9WV48-1 ]
ENSRNOT00000044257 ; ENSRNOP00000039860 ; ENSRNOG00000019207 . [Q9WV48-3 ]
ENSRNOT00000048805 ; ENSRNOP00000042890 ; ENSRNOG00000019207 . [Q9WV48-4 ]
ENSRNOT00000049346 ; ENSRNOP00000044509 ; ENSRNOG00000019207 . [Q9WV48-5 ]
GeneIDi 78957.
KEGGi rno:78957.
UCSCi RGD:621011. rat. [Q9WV48-1 ]

Organism-specific databases

CTDi 50944.
RGDi 621011. Shank1.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00510000046474.
HOGENOMi HOG000293276.
HOVERGENi HBG079186.
InParanoidi Q9WV48.
KOi K15009.
OMAi WEEGPGP.
OrthoDBi EOG7X6KZ7.
PhylomeDBi Q9WV48.

Miscellaneous databases

EvolutionaryTracei Q9WV48.
NextBioi 614372.
PROi Q9WV48.

Gene expression databases

ExpressionAtlasi Q9WV48. baseline and differential.
Genevestigatori Q9WV48.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein."
    Yao I., Hata Y., Hirao K., Deguchi M., Ide N., Takeuchi M., Takai Y.
    J. Biol. Chem. 274:27463-27466(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), INTERACTION WITH DLGAP1 AND DLG4.
    Tissue: Brain.
  2. "Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin."
    Naisbitt S., Kim E., Tu J.C., Xiao B., Sala C., Valtschanoff J., Weinberg R.J., Worley P.F., Sheng M.
    Neuron 23:569-582(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), INTERACTION WITH DLGAP1.
    Strain: Sprague-Dawley.
  3. "The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family."
    Tobaben S., Suedhof T.C., Stahl B.
    J. Biol. Chem. 275:36204-36210(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Characterization of the shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development."
    Lim S., Naisbitt S., Yoon J., Hwang J.-I., Suh P.-G., Sheng M., Kim E.
    J. Biol. Chem. 274:29510-29518(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORMS 1; 2; 3; 4 AND 5), DEVELOPMENTAL STAGE.
    Tissue: Brain.
  5. "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain."
    Zitzer H., Hoenck H.-H., Baechner D., Richter D., Kreienkamp H.-J.
    J. Biol. Chem. 274:32997-33001(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 4).
    Tissue: Brain.
  6. "Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins."
    Tu J.C., Xiao B., Naisbitt S., Yuan J.P., Petralia R.S., Brakeman P., Doan A., Aakalu V.K., Lanahan A.A., Sheng M., Worley P.F.
    Neuron 23:583-592(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOMER1, SUBCELLULAR LOCATION.
  7. "Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin."
    Bockers T.M., Mameza M.G., Kreutz M.R., Bockmann J., Weise C., Buck F., Richter D., Gundelfinger E.D., Kreienkamp H.-J.
    J. Biol. Chem. 276:40104-40112(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SPTAN1.
  8. "Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins."
    Lim S., Sala C., Yoon J., Park S., Kuroda S., Sheng M., Kim E.
    Mol. Cell. Neurosci. 17:385-397(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SHARPIN.
  9. "Regulation of dendritic spine morphology and synaptic function by Shank and Homer."
    Sala C., Piech V., Wilson N.R., Passafaro M., Liu G., Sheng M.
    Neuron 31:115-130(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "The Shank family of scaffold proteins."
    Sheng M., Kim E.
    J. Cell Sci. 113:1851-1856(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. "The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation."
    Shi S.-H., Cheng T., Jan L.Y., Jan Y.-N.
    Proc. Natl. Acad. Sci. U.S.A. 101:13346-13351(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IGSF9.
  12. Cited for: FUNCTION.
  13. "Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization."
    Im Y.J., Lee J.H., Park S.H., Park S.J., Rho S.-H., Kang G.B., Kim E., Eom S.H.
    J. Biol. Chem. 278:48099-48104(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 654-762 IN COMPLEX WITH DLGAP1, SUBUNIT.

Entry informationi

Entry nameiSHAN1_RAT
AccessioniPrimary (citable) accession number: Q9WV48
Secondary accession number(s): Q9QZZ8, Q9WU13, Q9WUE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3