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Q9WV48

- SHAN1_RAT

UniProt

Q9WV48 - SHAN1_RAT

Protein

SH3 and multiple ankyrin repeat domains protein 1

Gene

Shank1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.2 Publications

    GO - Molecular functioni

    1. ankyrin repeat binding Source: BHF-UCL
    2. GKAP/Homer scaffold activity Source: BHF-UCL
    3. identical protein binding Source: BHF-UCL
    4. ionotropic glutamate receptor binding Source: RGD
    5. protein binding Source: IntAct
    6. protein complex binding Source: RGD
    7. protein C-terminus binding Source: RGD
    8. receptor signaling complex scaffold activity Source: RGD
    9. scaffold protein binding Source: BHF-UCL
    10. SH3 domain binding Source: BHF-UCL
    11. somatostatin receptor binding Source: UniProtKB

    GO - Biological processi

    1. adult behavior Source: Ensembl
    2. associative learning Source: BHF-UCL
    3. cytoskeletal anchoring at plasma membrane Source: UniProtKB
    4. dendritic spine morphogenesis Source: BHF-UCL
    5. determination of affect Source: Ensembl
    6. habituation Source: BHF-UCL
    7. long-term memory Source: BHF-UCL
    8. negative regulation of actin filament bundle assembly Source: BHF-UCL
    9. neuromuscular process controlling balance Source: BHF-UCL
    10. olfactory behavior Source: BHF-UCL
    11. positive regulation of dendritic spine development Source: UniProtKB
    12. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
    13. protein complex assembly Source: BHF-UCL
    14. protein localization to synapse Source: BHF-UCL
    15. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
    16. righting reflex Source: BHF-UCL
    17. social behavior Source: Ensembl
    18. synapse maturation Source: UniProtKB
    19. vocalization behavior Source: Ensembl

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH3 and multiple ankyrin repeat domains protein 1
    Short name:
    Shank1
    Alternative name(s):
    GKAP/SAPAP-interacting protein
    SPANK-1
    Somatostatin receptor-interacting protein
    Short name:
    SSTR-interacting protein
    Short name:
    SSTRIP
    Synamon
    Gene namesi
    Name:Shank1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi621011. Shank1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell junctionsynapse 1 Publication. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density 1 Publication
    Note: Colocalizes with alpha-latrotoxin receptor 1.

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasm Source: UniProtKB-SubCell
    3. dendrite Source: UniProtKB
    4. dendritic spine Source: BHF-UCL
    5. excitatory synapse Source: BHF-UCL
    6. intracellular Source: UniProtKB
    7. ionotropic glutamate receptor complex Source: Ensembl
    8. neuronal postsynaptic density Source: BHF-UCL
    9. neuron projection Source: BHF-UCL
    10. plasma membrane Source: BHF-UCL
    11. postsynaptic membrane Source: RGD
    12. synapse Source: BHF-UCL

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21672167SH3 and multiple ankyrin repeat domains protein 1PRO_0000174672Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei186 – 1861PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9WV48.
    PRIDEiQ9WV48.

    PTM databases

    PhosphoSiteiQ9WV48.

    Expressioni

    Tissue specificityi

    Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum).

    Developmental stagei

    Expression increases from low levels at birth to high levels at 3-4 weeks before dropping slightly in adulthood. Expressed in the cortex and the molecular layer of the cerebellum at postnatal day 7. Isoform 2 expression does not change during development of both cortex and cerebellum. Isoform 4 expression decreases significantly during development of cortex but not cerebellum.1 Publication

    Gene expression databases

    GenevestigatoriQ9WV48.

    Interactioni

    Subunit structurei

    May homomultimerize via its SAM domain. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2 By similarity. Interacts with IGSF9.By similarity7 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Arhgef7Q9ES28-26EBI-80909,EBI-8620514From a different organism.
    Dlg4P310163EBI-80909,EBI-375655
    Dlgap1P978366EBI-80909,EBI-80901
    Dlgap1P97836-52EBI-80909,EBI-6269434
    Homer1Q9Z214-24EBI-80909,EBI-2338999
    SharpinQ9EQL97EBI-80909,EBI-1394695

    Protein-protein interaction databases

    BioGridi249365. 5 interactions.
    IntActiQ9WV48. 17 interactions.
    MINTiMINT-101286.

    Structurei

    Secondary structure

    1
    2167
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi657 – 66711
    Beta strandi670 – 6723
    Beta strandi675 – 6828
    Beta strandi694 – 6963
    Beta strandi698 – 7058
    Helixi710 – 7134
    Beta strandi721 – 7255
    Helixi735 – 74410
    Turni745 – 7473
    Beta strandi748 – 75710

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Q3OX-ray1.80A/B654-762[»]
    1Q3PX-ray2.25A/B654-762[»]
    3L4FX-ray2.80D653-765[»]
    3QJMX-ray2.31A/B654-768[»]
    3QJNX-ray2.71A/B/C/D/E/F/G/H654-768[»]
    ProteinModelPortaliQ9WV48.
    SMRiQ9WV48. Positions 656-759, 2101-2162.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9WV48.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati195 – 21016ANK 1Add
    BLAST
    Repeati212 – 24534ANK 2Add
    BLAST
    Repeati246 – 27833ANK 3Add
    BLAST
    Repeati279 – 31234ANK 4Add
    BLAST
    Repeati313 – 34533ANK 5Add
    BLAST
    Repeati346 – 37833ANK 6Add
    BLAST
    Repeati379 – 39517ANK 7Add
    BLAST
    Domaini554 – 61360SH3PROSITE-ProRule annotationsAdd
    BLAST
    Domaini663 – 75795PDZPROSITE-ProRule annotationsAdd
    BLAST
    Domaini2104 – 216764SAMPROSITE-ProRule annotationsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi929 – 9324Poly-Pro
    Compositional biasi1010 – 10156Poly-His
    Compositional biasi1022 – 10276Poly-His
    Compositional biasi1194 – 11996Poly-Gly
    Compositional biasi1850 – 186011Poly-ProAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SHANK family.Curated
    Contains 7 ANK repeats.PROSITE-ProRule annotations
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotations
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotations
    Contains 1 SH3 domain.PROSITE-ProRule annotations

    Keywords - Domaini

    ANK repeat, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00510000046474.
    HOGENOMiHOG000293276.
    HOVERGENiHBG079186.
    InParanoidiQ9WV48.
    KOiK15009.
    OMAiWEEGPGP.
    OrthoDBiEOG7X6KZ7.
    PhylomeDBiQ9WV48.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    1.25.40.20. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001478. PDZ.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    PF00595. PDZ. 1 hit.
    PF00536. SAM_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 6 hits.
    SM00228. PDZ. 1 hit.
    SM00454. SAM. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF48403. SSF48403. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    PS50106. PDZ. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q9WV48-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN     50
    LASTRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK 100
    QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP 150
    YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD 200
    KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA 250
    LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 300
    LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA 350
    LHICALYNKE TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR 400
    NHREQDVVPF QESPKYAARR RGPPGAGLTV PPALLRANSD TSMALPDWMV 450
    FSAPGASSSG TPGPTSGPQG QSQPSAPSTK LSSGTLRSAS SPRGARARSP 500
    SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS LGSRGRRRKL 550
    YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 600
    GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG 650
    IDSGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ 700
    YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM 750
    VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP AISLRSKSMT SELEEMVSPW 800
    KKKIEYEQQP AAVPSMEKKR TVYQMALNKL DEILAAAQQT ISASESPGPG 850
    GLASLGKHRP KGFFATESSF DPHHRSQPSY DRPSFLPPGP GLMLRQKSIG 900
    AAEDDRPYLA PPAMKFSRSL SVPGSEDIPP PPTTSPPEPP YSTPPAPSSS 950
    GRLTPSPRGG PFNPSSGGPL PASSPSSFDG PSPPDTRGGG REKSLYHSAA 1000
    LPPAHHHPPH HHHHHAPPPQ PHHHHAHPPH PPEMETGGSP DDPPPRLALG 1050
    PQPSLRGWRG GGPSPTSGAP SPSHHSSSGG SSGPTQAPAL RYFQLPPRAA 1100
    SAAMYVPARS GRGRKGPLVK QTKVEGEPQK GSIPSASSPT SPALPRSEPP 1150
    PAGPSEKNSI PIPTIIIKAP STSSSGRSSQ GSSTEAEPPT QPDGAGGGGS 1200
    SPSPAPATSP VPPSPSPVPT PASPSGPATL DFTSQFGAAL VGAARREGGW 1250
    QNEARRRSTL FLSTDAGDED GGDSGLGPGG PPGPRLRHSK SIDEGMFSAE 1300
    PYLRLESGGS SGGYGAYAAG SRAYGGSGSS SAFTSFLPPR PLVHPLTGKA 1350
    LDPASPLGLA LAARERALKE SSEGGGTPQP PPRPPSPRYD APPPTLHHHS 1400
    PHSPHSPHAR HEPVLRLWGD PARRELGYRA GLGSQEKALT ASPPAARRSL 1450
    LHRLPPTAPG VGPLLLQLGP EPPTPHPGVS KAWRTAAPEE PERLPLHVRF 1500
    LENCQARPPP AGTRGSSTED GPGVPPPSPR RVLPTSPTSP RGNEENGLPL 1550
    LVLPPPAPSV DVDDGEFLFA EPLPPPLEFS NSFEKPESPL TPGPPHPLPD 1600
    PPSPATPLPA APPPAVAAAP PTLDSTASSL TSYDSEVATL TQGAPAAPGD 1650
    PPAPGPPAPA APAPPAPQPG PDPPPGTDSG IEEVDSRSSS DHPLETISSA 1700
    STLSSLSAEG GGNTGGVAGG GAGVASGTEL LDTYVAYLDG QAFGGSGTPG 1750
    PPYPPQLMTP SKLRGRALGT SGNLRPGPSG GLRDPVTPTS PTVSVTGAGT 1800
    DGLLALSACP GPSTAGVAGG PVAVEPEVPP VPLPAASSLP RKLLPWEEGP 1850
    GPPPPPLPGP LSQPQASALA TVKASIISEL SSKLQQFGGS STAGGALPWA 1900
    RGGSGGSTDS HHGGASYIPE RTSSLQRQRL SEDSQTSLLS KPSSSIFQNW 1950
    PKPPLPPLPT GSGVSSSTAA APGATSPSAS SASASTRHLQ GVEFEMRPPL 2000
    LRRAPSPSLL PASDHKVSPA PRPSSLPILP SGPIYPGLFD IRSSPTGGAG 2050
    GSTDPFAPVF VPPHPGISGG LGGALSGASR SLSPTRLLSL PPDKPFGAKP 2100
    LGFWTKFDVA DWLEWLGLSE HRAQFLDHEI DGSHLPALTK EDYVDLGVTR 2150
    VGHRMNIDRA LKFFLER 2167
    Length:2,167
    Mass (Da):226,335
    Last modified:November 1, 1999 - v1
    Checksum:i3F478B5A7B18BA86
    GO
    Isoform 2 (identifier: Q9WV48-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-614: Missing.
         615-654: SQEGRQESRS...PSLIDGIDSG → MALSAVGGGP...PRRRSVWYIY

    Show »
    Length:1,553
    Mass (Da):159,899
    Checksum:iB9B7E6A33E26DE48
    GO
    Isoform 3 (identifier: Q9WV48-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         646-654: Missing.

    Show »
    Length:2,158
    Mass (Da):225,477
    Checksum:iBF18578E26D6578C
    GO
    Isoform 4 (identifier: Q9WV48-4) [UniParc]FASTAAdd to Basket

    Also known as: A

    The sequence of this isoform differs from the canonical sequence as follows:
         797-804: Missing.

    Show »
    Length:2,159
    Mass (Da):225,368
    Checksum:i912C1737EC330CB1
    GO
    Isoform 5 (identifier: Q9WV48-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1930-1943: LSEDSQTSLLSKPS → QYRIVVKSSDFGDF
         1944-2167: Missing.

    Show »
    Length:1,943
    Mass (Da):202,919
    Checksum:iD290DD45558B73AF
    GO

    Sequence cautioni

    The sequence AAD29417.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAF02498.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 614614Missing in isoform 2. CuratedVSP_006072Add
    BLAST
    Alternative sequencei615 – 65440SQEGR…GIDSG → MALSAVGGGPGGGALPQPPP ALSSSWPALGPRRRSVWYIY in isoform 2. CuratedVSP_006073Add
    BLAST
    Alternative sequencei646 – 6549Missing in isoform 3. 1 PublicationVSP_006074
    Alternative sequencei797 – 8048Missing in isoform 4. 1 PublicationVSP_006075
    Alternative sequencei1930 – 194314LSEDS…LSKPS → QYRIVVKSSDFGDF in isoform 5. CuratedVSP_006076Add
    BLAST
    Alternative sequencei1944 – 2167224Missing in isoform 5. CuratedVSP_006077Add
    BLAST

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1141 – 11411S → T in AAD04569. (PubMed:10488079)Curated
    Sequence conflicti1174 – 11741S → N in AAD29417. (PubMed:10433268)Curated
    Sequence conflicti1246 – 12461R → K in AAD04569. (PubMed:10488079)Curated
    Sequence conflicti1323 – 13231A → T in AAD04569. (PubMed:10488079)Curated
    Sequence conflicti1331 – 13311S → D in AAD04569. (PubMed:10488079)Curated
    Sequence conflicti1726 – 17261S → N in AAD29417. (PubMed:10433268)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF102855 mRNA. Translation: AAD04569.2.
    AF131951 mRNA. Translation: AAD29417.1. Different initiation.
    AF159046 mRNA. Translation: AAD42975.1.
    AF141904 mRNA. Translation: AAF02498.1. Different initiation.
    RefSeqiNP_113939.2. NM_031751.2. [Q9WV48-1]
    XP_006229214.1. XM_006229152.1. [Q9WV48-4]
    XP_006229215.1. XM_006229153.1. [Q9WV48-3]
    XP_006229219.1. XM_006229157.1. [Q9WV48-5]
    UniGeneiRn.225968.

    Genome annotation databases

    EnsembliENSRNOT00000026100; ENSRNOP00000026100; ENSRNOG00000019207. [Q9WV48-1]
    ENSRNOT00000044257; ENSRNOP00000039860; ENSRNOG00000019207. [Q9WV48-3]
    ENSRNOT00000048805; ENSRNOP00000042890; ENSRNOG00000019207. [Q9WV48-4]
    ENSRNOT00000049346; ENSRNOP00000044509; ENSRNOG00000019207. [Q9WV48-5]
    GeneIDi78957.
    KEGGirno:78957.
    UCSCiRGD:621011. rat. [Q9WV48-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF102855 mRNA. Translation: AAD04569.2 .
    AF131951 mRNA. Translation: AAD29417.1 . Different initiation.
    AF159046 mRNA. Translation: AAD42975.1 .
    AF141904 mRNA. Translation: AAF02498.1 . Different initiation.
    RefSeqi NP_113939.2. NM_031751.2. [Q9WV48-1 ]
    XP_006229214.1. XM_006229152.1. [Q9WV48-4 ]
    XP_006229215.1. XM_006229153.1. [Q9WV48-3 ]
    XP_006229219.1. XM_006229157.1. [Q9WV48-5 ]
    UniGenei Rn.225968.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Q3O X-ray 1.80 A/B 654-762 [» ]
    1Q3P X-ray 2.25 A/B 654-762 [» ]
    3L4F X-ray 2.80 D 653-765 [» ]
    3QJM X-ray 2.31 A/B 654-768 [» ]
    3QJN X-ray 2.71 A/B/C/D/E/F/G/H 654-768 [» ]
    ProteinModelPortali Q9WV48.
    SMRi Q9WV48. Positions 656-759, 2101-2162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249365. 5 interactions.
    IntActi Q9WV48. 17 interactions.
    MINTi MINT-101286.

    PTM databases

    PhosphoSitei Q9WV48.

    Proteomic databases

    PaxDbi Q9WV48.
    PRIDEi Q9WV48.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026100 ; ENSRNOP00000026100 ; ENSRNOG00000019207 . [Q9WV48-1 ]
    ENSRNOT00000044257 ; ENSRNOP00000039860 ; ENSRNOG00000019207 . [Q9WV48-3 ]
    ENSRNOT00000048805 ; ENSRNOP00000042890 ; ENSRNOG00000019207 . [Q9WV48-4 ]
    ENSRNOT00000049346 ; ENSRNOP00000044509 ; ENSRNOG00000019207 . [Q9WV48-5 ]
    GeneIDi 78957.
    KEGGi rno:78957.
    UCSCi RGD:621011. rat. [Q9WV48-1 ]

    Organism-specific databases

    CTDi 50944.
    RGDi 621011. Shank1.

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00510000046474.
    HOGENOMi HOG000293276.
    HOVERGENi HBG079186.
    InParanoidi Q9WV48.
    KOi K15009.
    OMAi WEEGPGP.
    OrthoDBi EOG7X6KZ7.
    PhylomeDBi Q9WV48.

    Miscellaneous databases

    EvolutionaryTracei Q9WV48.
    NextBioi 614372.
    PROi Q9WV48.

    Gene expression databases

    Genevestigatori Q9WV48.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    1.25.40.20. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001478. PDZ.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    PF00595. PDZ. 1 hit.
    PF00536. SAM_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 6 hits.
    SM00228. PDZ. 1 hit.
    SM00454. SAM. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF48403. SSF48403. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    PS50106. PDZ. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein."
      Yao I., Hata Y., Hirao K., Deguchi M., Ide N., Takeuchi M., Takai Y.
      J. Biol. Chem. 274:27463-27466(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), INTERACTION WITH DLGAP1 AND DLG4.
      Tissue: Brain.
    2. "Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin."
      Naisbitt S., Kim E., Tu J.C., Xiao B., Sala C., Valtschanoff J., Weinberg R.J., Worley P.F., Sheng M.
      Neuron 23:569-582(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), INTERACTION WITH DLGAP1.
      Strain: Sprague-Dawley.
    3. "The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family."
      Tobaben S., Suedhof T.C., Stahl B.
      J. Biol. Chem. 275:36204-36210(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Characterization of the shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development."
      Lim S., Naisbitt S., Yoon J., Hwang J.-I., Suh P.-G., Sheng M., Kim E.
      J. Biol. Chem. 274:29510-29518(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORMS 1; 2; 3; 4 AND 5), DEVELOPMENTAL STAGE.
      Tissue: Brain.
    5. "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain."
      Zitzer H., Hoenck H.-H., Baechner D., Richter D., Kreienkamp H.-J.
      J. Biol. Chem. 274:32997-33001(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 4).
      Tissue: Brain.
    6. "Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins."
      Tu J.C., Xiao B., Naisbitt S., Yuan J.P., Petralia R.S., Brakeman P., Doan A., Aakalu V.K., Lanahan A.A., Sheng M., Worley P.F.
      Neuron 23:583-592(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HOMER1, SUBCELLULAR LOCATION.
    7. "Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin."
      Bockers T.M., Mameza M.G., Kreutz M.R., Bockmann J., Weise C., Buck F., Richter D., Gundelfinger E.D., Kreienkamp H.-J.
      J. Biol. Chem. 276:40104-40112(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SPTAN1.
    8. "Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins."
      Lim S., Sala C., Yoon J., Park S., Kuroda S., Sheng M., Kim E.
      Mol. Cell. Neurosci. 17:385-397(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SHARPIN.
    9. "Regulation of dendritic spine morphology and synaptic function by Shank and Homer."
      Sala C., Piech V., Wilson N.R., Passafaro M., Liu G., Sheng M.
      Neuron 31:115-130(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "The Shank family of scaffold proteins."
      Sheng M., Kim E.
      J. Cell Sci. 113:1851-1856(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    11. "The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation."
      Shi S.-H., Cheng T., Jan L.Y., Jan Y.-N.
      Proc. Natl. Acad. Sci. U.S.A. 101:13346-13351(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IGSF9.
    12. Cited for: FUNCTION.
    13. "Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization."
      Im Y.J., Lee J.H., Park S.H., Park S.J., Rho S.-H., Kang G.B., Kim E., Eom S.H.
      J. Biol. Chem. 278:48099-48104(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 654-762 IN COMPLEX WITH DLGAP1, SUBUNIT.

    Entry informationi

    Entry nameiSHAN1_RAT
    AccessioniPrimary (citable) accession number: Q9WV48
    Secondary accession number(s): Q9QZZ8, Q9WU13, Q9WUE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 139 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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