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Q9WV48

- SHAN1_RAT

UniProt

Q9WV48 - SHAN1_RAT

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Protein
SH3 and multiple ankyrin repeat domains protein 1
Gene
Shank1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.2 Publications

GO - Molecular functioni

  1. GKAP/Homer scaffold activity Source: BHF-UCL
  2. SH3 domain binding Source: BHF-UCL
  3. ankyrin repeat binding Source: BHF-UCL
  4. identical protein binding Source: BHF-UCL
  5. ionotropic glutamate receptor binding Source: RGD
  6. protein C-terminus binding Source: RGD
  7. protein binding Source: IntAct
  8. protein complex binding Source: RGD
  9. receptor signaling complex scaffold activity Source: RGD
  10. scaffold protein binding Source: BHF-UCL
  11. somatostatin receptor binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. adult behavior Source: Ensembl
  2. associative learning Source: BHF-UCL
  3. cytoskeletal anchoring at plasma membrane Source: UniProtKB
  4. dendritic spine morphogenesis Source: BHF-UCL
  5. determination of affect Source: Ensembl
  6. habituation Source: BHF-UCL
  7. long-term memory Source: BHF-UCL
  8. negative regulation of actin filament bundle assembly Source: BHF-UCL
  9. neuromuscular process controlling balance Source: BHF-UCL
  10. olfactory behavior Source: BHF-UCL
  11. positive regulation of dendritic spine development Source: UniProtKB
  12. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
  13. protein complex assembly Source: BHF-UCL
  14. protein localization to synapse Source: BHF-UCL
  15. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
  16. righting reflex Source: BHF-UCL
  17. social behavior Source: Ensembl
  18. synapse maturation Source: UniProtKB
  19. vocalization behavior Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and multiple ankyrin repeat domains protein 1
Short name:
Shank1
Alternative name(s):
GKAP/SAPAP-interacting protein
SPANK-1
Somatostatin receptor-interacting protein
Short name:
SSTR-interacting protein
Short name:
SSTRIP
Synamon
Gene namesi
Name:Shank1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi621011. Shank1.

Subcellular locationi

Cytoplasm. Cell junctionsynapse. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density
Note: Colocalizes with alpha-latrotoxin receptor 1.1 Publication

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-SubCell
  3. dendrite Source: UniProtKB
  4. dendritic spine Source: BHF-UCL
  5. excitatory synapse Source: BHF-UCL
  6. intracellular Source: UniProtKB
  7. ionotropic glutamate receptor complex Source: Ensembl
  8. neuron projection Source: BHF-UCL
  9. neuronal postsynaptic density Source: BHF-UCL
  10. plasma membrane Source: BHF-UCL
  11. postsynaptic membrane Source: RGD
  12. synapse Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21672167SH3 and multiple ankyrin repeat domains protein 1
PRO_0000174672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei186 – 1861Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9WV48.
PRIDEiQ9WV48.

PTM databases

PhosphoSiteiQ9WV48.

Expressioni

Tissue specificityi

Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum).

Developmental stagei

Expression increases from low levels at birth to high levels at 3-4 weeks before dropping slightly in adulthood. Expressed in the cortex and the molecular layer of the cerebellum at postnatal day 7. Isoform 2 expression does not change during development of both cortex and cerebellum. Isoform 4 expression decreases significantly during development of cortex but not cerebellum.1 Publication

Gene expression databases

GenevestigatoriQ9WV48.

Interactioni

Subunit structurei

May homomultimerize via its SAM domain. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2 By similarity. Interacts with IGSF9.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Arhgef7Q9ES28-26EBI-80909,EBI-8620514From a different organism.
Dlg4P310163EBI-80909,EBI-375655
Dlgap1P978366EBI-80909,EBI-80901
Dlgap1P97836-52EBI-80909,EBI-6269434
Homer1Q9Z214-24EBI-80909,EBI-2338999
SharpinQ9EQL97EBI-80909,EBI-1394695

Protein-protein interaction databases

BioGridi249365. 5 interactions.
IntActiQ9WV48. 17 interactions.
MINTiMINT-101286.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi657 – 66711
Beta strandi670 – 6723
Beta strandi675 – 6828
Beta strandi694 – 6963
Beta strandi698 – 7058
Helixi710 – 7134
Beta strandi721 – 7255
Helixi735 – 74410
Turni745 – 7473
Beta strandi748 – 75710

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q3OX-ray1.80A/B654-762[»]
1Q3PX-ray2.25A/B654-762[»]
3L4FX-ray2.80D653-765[»]
3QJMX-ray2.31A/B654-768[»]
3QJNX-ray2.71A/B/C/D/E/F/G/H654-768[»]
ProteinModelPortaliQ9WV48.
SMRiQ9WV48. Positions 656-759, 2101-2162.

Miscellaneous databases

EvolutionaryTraceiQ9WV48.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati195 – 21016ANK 1
Add
BLAST
Repeati212 – 24534ANK 2
Add
BLAST
Repeati246 – 27833ANK 3
Add
BLAST
Repeati279 – 31234ANK 4
Add
BLAST
Repeati313 – 34533ANK 5
Add
BLAST
Repeati346 – 37833ANK 6
Add
BLAST
Repeati379 – 39517ANK 7
Add
BLAST
Domaini554 – 61360SH3
Add
BLAST
Domaini663 – 75795PDZ
Add
BLAST
Domaini2104 – 216764SAM
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi929 – 9324Poly-Pro
Compositional biasi1010 – 10156Poly-His
Compositional biasi1022 – 10276Poly-His
Compositional biasi1194 – 11996Poly-Gly
Compositional biasi1850 – 186011Poly-Pro
Add
BLAST

Sequence similaritiesi

Belongs to the SHANK family.
Contains 7 ANK repeats.
Contains 1 PDZ (DHR) domain.
Contains 1 SH3 domain.

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
HOVERGENiHBG079186.
InParanoidiQ9WV48.
KOiK15009.
OMAiWEEGPGP.
OrthoDBiEOG7X6KZ7.
PhylomeDBiQ9WV48.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9WV48-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN     50
LASTRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK 100
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP 150
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD 200
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA 250
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 300
LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA 350
LHICALYNKE TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR 400
NHREQDVVPF QESPKYAARR RGPPGAGLTV PPALLRANSD TSMALPDWMV 450
FSAPGASSSG TPGPTSGPQG QSQPSAPSTK LSSGTLRSAS SPRGARARSP 500
SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS LGSRGRRRKL 550
YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 600
GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG 650
IDSGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ 700
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM 750
VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP AISLRSKSMT SELEEMVSPW 800
KKKIEYEQQP AAVPSMEKKR TVYQMALNKL DEILAAAQQT ISASESPGPG 850
GLASLGKHRP KGFFATESSF DPHHRSQPSY DRPSFLPPGP GLMLRQKSIG 900
AAEDDRPYLA PPAMKFSRSL SVPGSEDIPP PPTTSPPEPP YSTPPAPSSS 950
GRLTPSPRGG PFNPSSGGPL PASSPSSFDG PSPPDTRGGG REKSLYHSAA 1000
LPPAHHHPPH HHHHHAPPPQ PHHHHAHPPH PPEMETGGSP DDPPPRLALG 1050
PQPSLRGWRG GGPSPTSGAP SPSHHSSSGG SSGPTQAPAL RYFQLPPRAA 1100
SAAMYVPARS GRGRKGPLVK QTKVEGEPQK GSIPSASSPT SPALPRSEPP 1150
PAGPSEKNSI PIPTIIIKAP STSSSGRSSQ GSSTEAEPPT QPDGAGGGGS 1200
SPSPAPATSP VPPSPSPVPT PASPSGPATL DFTSQFGAAL VGAARREGGW 1250
QNEARRRSTL FLSTDAGDED GGDSGLGPGG PPGPRLRHSK SIDEGMFSAE 1300
PYLRLESGGS SGGYGAYAAG SRAYGGSGSS SAFTSFLPPR PLVHPLTGKA 1350
LDPASPLGLA LAARERALKE SSEGGGTPQP PPRPPSPRYD APPPTLHHHS 1400
PHSPHSPHAR HEPVLRLWGD PARRELGYRA GLGSQEKALT ASPPAARRSL 1450
LHRLPPTAPG VGPLLLQLGP EPPTPHPGVS KAWRTAAPEE PERLPLHVRF 1500
LENCQARPPP AGTRGSSTED GPGVPPPSPR RVLPTSPTSP RGNEENGLPL 1550
LVLPPPAPSV DVDDGEFLFA EPLPPPLEFS NSFEKPESPL TPGPPHPLPD 1600
PPSPATPLPA APPPAVAAAP PTLDSTASSL TSYDSEVATL TQGAPAAPGD 1650
PPAPGPPAPA APAPPAPQPG PDPPPGTDSG IEEVDSRSSS DHPLETISSA 1700
STLSSLSAEG GGNTGGVAGG GAGVASGTEL LDTYVAYLDG QAFGGSGTPG 1750
PPYPPQLMTP SKLRGRALGT SGNLRPGPSG GLRDPVTPTS PTVSVTGAGT 1800
DGLLALSACP GPSTAGVAGG PVAVEPEVPP VPLPAASSLP RKLLPWEEGP 1850
GPPPPPLPGP LSQPQASALA TVKASIISEL SSKLQQFGGS STAGGALPWA 1900
RGGSGGSTDS HHGGASYIPE RTSSLQRQRL SEDSQTSLLS KPSSSIFQNW 1950
PKPPLPPLPT GSGVSSSTAA APGATSPSAS SASASTRHLQ GVEFEMRPPL 2000
LRRAPSPSLL PASDHKVSPA PRPSSLPILP SGPIYPGLFD IRSSPTGGAG 2050
GSTDPFAPVF VPPHPGISGG LGGALSGASR SLSPTRLLSL PPDKPFGAKP 2100
LGFWTKFDVA DWLEWLGLSE HRAQFLDHEI DGSHLPALTK EDYVDLGVTR 2150
VGHRMNIDRA LKFFLER 2167
Length:2,167
Mass (Da):226,335
Last modified:November 1, 1999 - v1
Checksum:i3F478B5A7B18BA86
GO
Isoform 2 (identifier: Q9WV48-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-614: Missing.
     615-654: SQEGRQESRS...PSLIDGIDSG → MALSAVGGGP...PRRRSVWYIY

Show »
Length:1,553
Mass (Da):159,899
Checksum:iB9B7E6A33E26DE48
GO
Isoform 3 (identifier: Q9WV48-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-654: Missing.

Show »
Length:2,158
Mass (Da):225,477
Checksum:iBF18578E26D6578C
GO
Isoform 4 (identifier: Q9WV48-4) [UniParc]FASTAAdd to Basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     797-804: Missing.

Show »
Length:2,159
Mass (Da):225,368
Checksum:i912C1737EC330CB1
GO
Isoform 5 (identifier: Q9WV48-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1930-1943: LSEDSQTSLLSKPS → QYRIVVKSSDFGDF
     1944-2167: Missing.

Show »
Length:1,943
Mass (Da):202,919
Checksum:iD290DD45558B73AF
GO

Sequence cautioni

The sequence AAD29417.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAF02498.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 614614Missing in isoform 2.
VSP_006072Add
BLAST
Alternative sequencei615 – 65440SQEGR…GIDSG → MALSAVGGGPGGGALPQPPP ALSSSWPALGPRRRSVWYIY in isoform 2.
VSP_006073Add
BLAST
Alternative sequencei646 – 6549Missing in isoform 3.
VSP_006074
Alternative sequencei797 – 8048Missing in isoform 4.
VSP_006075
Alternative sequencei1930 – 194314LSEDS…LSKPS → QYRIVVKSSDFGDF in isoform 5.
VSP_006076Add
BLAST
Alternative sequencei1944 – 2167224Missing in isoform 5.
VSP_006077Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1141 – 11411S → T in AAD04569. 1 Publication
Sequence conflicti1174 – 11741S → N in AAD29417. 1 Publication
Sequence conflicti1246 – 12461R → K in AAD04569. 1 Publication
Sequence conflicti1323 – 13231A → T in AAD04569. 1 Publication
Sequence conflicti1331 – 13311S → D in AAD04569. 1 Publication
Sequence conflicti1726 – 17261S → N in AAD29417. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102855 mRNA. Translation: AAD04569.2.
AF131951 mRNA. Translation: AAD29417.1. Different initiation.
AF159046 mRNA. Translation: AAD42975.1.
AF141904 mRNA. Translation: AAF02498.1. Different initiation.
RefSeqiNP_113939.2. NM_031751.2. [Q9WV48-1]
XP_006229214.1. XM_006229152.1. [Q9WV48-4]
XP_006229215.1. XM_006229153.1. [Q9WV48-3]
XP_006229219.1. XM_006229157.1. [Q9WV48-5]
UniGeneiRn.225968.

Genome annotation databases

EnsembliENSRNOT00000026100; ENSRNOP00000026100; ENSRNOG00000019207. [Q9WV48-1]
ENSRNOT00000044257; ENSRNOP00000039860; ENSRNOG00000019207. [Q9WV48-3]
ENSRNOT00000048805; ENSRNOP00000042890; ENSRNOG00000019207. [Q9WV48-4]
ENSRNOT00000049346; ENSRNOP00000044509; ENSRNOG00000019207. [Q9WV48-5]
GeneIDi78957.
KEGGirno:78957.
UCSCiRGD:621011. rat. [Q9WV48-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102855 mRNA. Translation: AAD04569.2 .
AF131951 mRNA. Translation: AAD29417.1 . Different initiation.
AF159046 mRNA. Translation: AAD42975.1 .
AF141904 mRNA. Translation: AAF02498.1 . Different initiation.
RefSeqi NP_113939.2. NM_031751.2. [Q9WV48-1 ]
XP_006229214.1. XM_006229152.1. [Q9WV48-4 ]
XP_006229215.1. XM_006229153.1. [Q9WV48-3 ]
XP_006229219.1. XM_006229157.1. [Q9WV48-5 ]
UniGenei Rn.225968.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Q3O X-ray 1.80 A/B 654-762 [» ]
1Q3P X-ray 2.25 A/B 654-762 [» ]
3L4F X-ray 2.80 D 653-765 [» ]
3QJM X-ray 2.31 A/B 654-768 [» ]
3QJN X-ray 2.71 A/B/C/D/E/F/G/H 654-768 [» ]
ProteinModelPortali Q9WV48.
SMRi Q9WV48. Positions 656-759, 2101-2162.
ModBasei Search...

Protein-protein interaction databases

BioGridi 249365. 5 interactions.
IntActi Q9WV48. 17 interactions.
MINTi MINT-101286.

PTM databases

PhosphoSitei Q9WV48.

Proteomic databases

PaxDbi Q9WV48.
PRIDEi Q9WV48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026100 ; ENSRNOP00000026100 ; ENSRNOG00000019207 . [Q9WV48-1 ]
ENSRNOT00000044257 ; ENSRNOP00000039860 ; ENSRNOG00000019207 . [Q9WV48-3 ]
ENSRNOT00000048805 ; ENSRNOP00000042890 ; ENSRNOG00000019207 . [Q9WV48-4 ]
ENSRNOT00000049346 ; ENSRNOP00000044509 ; ENSRNOG00000019207 . [Q9WV48-5 ]
GeneIDi 78957.
KEGGi rno:78957.
UCSCi RGD:621011. rat. [Q9WV48-1 ]

Organism-specific databases

CTDi 50944.
RGDi 621011. Shank1.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00510000046474.
HOGENOMi HOG000293276.
HOVERGENi HBG079186.
InParanoidi Q9WV48.
KOi K15009.
OMAi WEEGPGP.
OrthoDBi EOG7X6KZ7.
PhylomeDBi Q9WV48.

Miscellaneous databases

EvolutionaryTracei Q9WV48.
NextBioi 614372.
PROi Q9WV48.

Gene expression databases

Genevestigatori Q9WV48.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein."
    Yao I., Hata Y., Hirao K., Deguchi M., Ide N., Takeuchi M., Takai Y.
    J. Biol. Chem. 274:27463-27466(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), INTERACTION WITH DLGAP1 AND DLG4.
    Tissue: Brain.
  2. "Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin."
    Naisbitt S., Kim E., Tu J.C., Xiao B., Sala C., Valtschanoff J., Weinberg R.J., Worley P.F., Sheng M.
    Neuron 23:569-582(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), INTERACTION WITH DLGAP1.
    Strain: Sprague-Dawley.
  3. "The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family."
    Tobaben S., Suedhof T.C., Stahl B.
    J. Biol. Chem. 275:36204-36210(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Characterization of the shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development."
    Lim S., Naisbitt S., Yoon J., Hwang J.-I., Suh P.-G., Sheng M., Kim E.
    J. Biol. Chem. 274:29510-29518(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORMS 1; 2; 3; 4 AND 5), DEVELOPMENTAL STAGE.
    Tissue: Brain.
  5. "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain."
    Zitzer H., Hoenck H.-H., Baechner D., Richter D., Kreienkamp H.-J.
    J. Biol. Chem. 274:32997-33001(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 4).
    Tissue: Brain.
  6. "Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins."
    Tu J.C., Xiao B., Naisbitt S., Yuan J.P., Petralia R.S., Brakeman P., Doan A., Aakalu V.K., Lanahan A.A., Sheng M., Worley P.F.
    Neuron 23:583-592(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOMER1, SUBCELLULAR LOCATION.
  7. "Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin."
    Bockers T.M., Mameza M.G., Kreutz M.R., Bockmann J., Weise C., Buck F., Richter D., Gundelfinger E.D., Kreienkamp H.-J.
    J. Biol. Chem. 276:40104-40112(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SPTAN1.
  8. "Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins."
    Lim S., Sala C., Yoon J., Park S., Kuroda S., Sheng M., Kim E.
    Mol. Cell. Neurosci. 17:385-397(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SHARPIN.
  9. "Regulation of dendritic spine morphology and synaptic function by Shank and Homer."
    Sala C., Piech V., Wilson N.R., Passafaro M., Liu G., Sheng M.
    Neuron 31:115-130(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "The Shank family of scaffold proteins."
    Sheng M., Kim E.
    J. Cell Sci. 113:1851-1856(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. "The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation."
    Shi S.-H., Cheng T., Jan L.Y., Jan Y.-N.
    Proc. Natl. Acad. Sci. U.S.A. 101:13346-13351(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IGSF9.
  12. Cited for: FUNCTION.
  13. "Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization."
    Im Y.J., Lee J.H., Park S.H., Park S.J., Rho S.-H., Kang G.B., Kim E., Eom S.H.
    J. Biol. Chem. 278:48099-48104(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 654-762 IN COMPLEX WITH DLGAP1, SUBUNIT.

Entry informationi

Entry nameiSHAN1_RAT
AccessioniPrimary (citable) accession number: Q9WV48
Secondary accession number(s): Q9QZZ8, Q9WU13, Q9WUE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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