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Protein

SH3 and multiple ankyrin repeat domains protein 1

Gene

Shank1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.2 Publications

GO - Molecular functioni

  • ankyrin repeat binding Source: BHF-UCL
  • GKAP/Homer scaffold activity Source: BHF-UCL
  • identical protein binding Source: BHF-UCL
  • ionotropic glutamate receptor binding Source: RGD
  • protein complex binding Source: RGD
  • protein C-terminus binding Source: RGD
  • receptor signaling complex scaffold activity Source: RGD
  • scaffold protein binding Source: BHF-UCL
  • SH3 domain binding Source: BHF-UCL
  • somatostatin receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-RNO-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and multiple ankyrin repeat domains protein 1
Short name:
Shank1
Alternative name(s):
GKAP/SAPAP-interacting protein
SPANK-1
Somatostatin receptor-interacting protein
Short name:
SSTR-interacting protein
Short name:
SSTRIP
Synamon
Gene namesi
Name:Shank1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621011. Shank1.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB-SubCell
  • dendrite Source: UniProtKB
  • dendritic spine Source: BHF-UCL
  • excitatory synapse Source: BHF-UCL
  • intracellular Source: UniProtKB
  • ionotropic glutamate receptor complex Source: Ensembl
  • neuron projection Source: BHF-UCL
  • plasma membrane Source: BHF-UCL
  • postsynaptic density Source: BHF-UCL
  • postsynaptic membrane Source: RGD
  • synapse Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001746721 – 2167SH3 and multiple ankyrin repeat domains protein 1Add BLAST2167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43Omega-N-methylarginineBy similarity1
Modified residuei186PhosphotyrosineBy similarity1
Modified residuei540PhosphoserineCombined sources1
Modified residuei544Omega-N-methylarginineBy similarity1
Modified residuei671PhosphoserineBy similarity1
Modified residuei791PhosphoserineBy similarity1
Modified residuei898PhosphoserineCombined sources1
Modified residuei958Omega-N-methylarginineBy similarity1
Modified residuei1059Omega-N-methylarginineBy similarity1
Modified residuei1098Omega-N-methylarginineBy similarity1
Modified residuei1109Omega-N-methylarginineBy similarity1
Modified residuei1257Asymmetric dimethylarginineBy similarity1
Modified residuei1291PhosphoserineCombined sources1
Modified residuei1429Omega-N-methylarginineBy similarity1
Modified residuei1442PhosphoserineCombined sources1
Modified residuei1901Omega-N-methylarginineBy similarity1
Modified residuei2022Omega-N-methylarginineBy similarity1
Modified residuei2042Omega-N-methylarginineBy similarity1
Modified residuei2080Omega-N-methylarginineBy similarity1
Isoform 3 (identifier: Q9WV48-3)
Modified residuei638PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9WV48.
PRIDEiQ9WV48.

PTM databases

iPTMnetiQ9WV48.
PhosphoSitePlusiQ9WV48.

Expressioni

Tissue specificityi

Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum).

Developmental stagei

Expression increases from low levels at birth to high levels at 3-4 weeks before dropping slightly in adulthood. Expressed in the cortex and the molecular layer of the cerebellum at postnatal day 7. Isoform 2 expression does not change during development of both cortex and cerebellum. Isoform 4 expression decreases significantly during development of cortex but not cerebellum.1 Publication

Gene expression databases

BgeeiENSRNOG00000019207.
GenevisibleiQ9WV48. RN.

Interactioni

Subunit structurei

May homomultimerize via its SAM domain. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2 (By similarity). Interacts with IGSF9.By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Arhgef7Q9ES28-26EBI-80909,EBI-8620514From a different organism.
Dlg4P310163EBI-80909,EBI-375655
Dlgap1P978366EBI-80909,EBI-80901
Dlgap1P97836-52EBI-80909,EBI-6269434
Homer1Q9Z214-24EBI-80909,EBI-2338999
SharpinQ9EQL97EBI-80909,EBI-1394695

GO - Molecular functioni

  • ankyrin repeat binding Source: BHF-UCL
  • GKAP/Homer scaffold activity Source: BHF-UCL
  • identical protein binding Source: BHF-UCL
  • ionotropic glutamate receptor binding Source: RGD
  • protein complex binding Source: RGD
  • protein C-terminus binding Source: RGD
  • receptor signaling complex scaffold activity Source: RGD
  • scaffold protein binding Source: BHF-UCL
  • SH3 domain binding Source: BHF-UCL
  • somatostatin receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi249365. 5 interactors.
IntActiQ9WV48. 17 interactors.
MINTiMINT-101286.
STRINGi10116.ENSRNOP00000026100.

Structurei

Secondary structure

12167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi657 – 667Combined sources11
Beta strandi670 – 672Combined sources3
Beta strandi675 – 682Combined sources8
Beta strandi694 – 696Combined sources3
Beta strandi698 – 705Combined sources8
Helixi710 – 713Combined sources4
Beta strandi721 – 725Combined sources5
Helixi735 – 744Combined sources10
Turni745 – 747Combined sources3
Beta strandi748 – 757Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3OX-ray1.80A/B654-762[»]
1Q3PX-ray2.25A/B654-762[»]
3L4FX-ray2.80D653-765[»]
3QJMX-ray2.31A/B654-768[»]
3QJNX-ray2.71A/B/C/D/E/F/G/H654-768[»]
ProteinModelPortaliQ9WV48.
SMRiQ9WV48.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WV48.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati195 – 210ANK 1Add BLAST16
Repeati212 – 245ANK 2Add BLAST34
Repeati246 – 278ANK 3Add BLAST33
Repeati279 – 312ANK 4Add BLAST34
Repeati313 – 345ANK 5Add BLAST33
Repeati346 – 378ANK 6Add BLAST33
Repeati379 – 395ANK 7Add BLAST17
Domaini554 – 613SH3PROSITE-ProRule annotationAdd BLAST60
Domaini663 – 757PDZPROSITE-ProRule annotationAdd BLAST95
Domaini2104 – 2167SAMPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi929 – 932Poly-Pro4
Compositional biasi1010 – 1015Poly-His6
Compositional biasi1022 – 1027Poly-His6
Compositional biasi1194 – 1199Poly-Gly6
Compositional biasi1850 – 1860Poly-ProAdd BLAST11

Sequence similaritiesi

Belongs to the SHANK family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4375. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
HOVERGENiHBG079186.
InParanoidiQ9WV48.
KOiK15009.
OMAiWQNEARR.
OrthoDBiEOG091G00OW.
PhylomeDBiQ9WV48.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032425. FERM_f0.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF16511. FERM_f0. 1 hit.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9WV48-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN
60 70 80 90 100
LASTRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK
110 120 130 140 150
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP
160 170 180 190 200
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD
210 220 230 240 250
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA
260 270 280 290 300
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL
310 320 330 340 350
LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA
360 370 380 390 400
LHICALYNKE TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR
410 420 430 440 450
NHREQDVVPF QESPKYAARR RGPPGAGLTV PPALLRANSD TSMALPDWMV
460 470 480 490 500
FSAPGASSSG TPGPTSGPQG QSQPSAPSTK LSSGTLRSAS SPRGARARSP
510 520 530 540 550
SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS LGSRGRRRKL
560 570 580 590 600
YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV
610 620 630 640 650
GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG
660 670 680 690 700
IDSGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ
710 720 730 740 750
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM
760 770 780 790 800
VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP AISLRSKSMT SELEEMVSPW
810 820 830 840 850
KKKIEYEQQP AAVPSMEKKR TVYQMALNKL DEILAAAQQT ISASESPGPG
860 870 880 890 900
GLASLGKHRP KGFFATESSF DPHHRSQPSY DRPSFLPPGP GLMLRQKSIG
910 920 930 940 950
AAEDDRPYLA PPAMKFSRSL SVPGSEDIPP PPTTSPPEPP YSTPPAPSSS
960 970 980 990 1000
GRLTPSPRGG PFNPSSGGPL PASSPSSFDG PSPPDTRGGG REKSLYHSAA
1010 1020 1030 1040 1050
LPPAHHHPPH HHHHHAPPPQ PHHHHAHPPH PPEMETGGSP DDPPPRLALG
1060 1070 1080 1090 1100
PQPSLRGWRG GGPSPTSGAP SPSHHSSSGG SSGPTQAPAL RYFQLPPRAA
1110 1120 1130 1140 1150
SAAMYVPARS GRGRKGPLVK QTKVEGEPQK GSIPSASSPT SPALPRSEPP
1160 1170 1180 1190 1200
PAGPSEKNSI PIPTIIIKAP STSSSGRSSQ GSSTEAEPPT QPDGAGGGGS
1210 1220 1230 1240 1250
SPSPAPATSP VPPSPSPVPT PASPSGPATL DFTSQFGAAL VGAARREGGW
1260 1270 1280 1290 1300
QNEARRRSTL FLSTDAGDED GGDSGLGPGG PPGPRLRHSK SIDEGMFSAE
1310 1320 1330 1340 1350
PYLRLESGGS SGGYGAYAAG SRAYGGSGSS SAFTSFLPPR PLVHPLTGKA
1360 1370 1380 1390 1400
LDPASPLGLA LAARERALKE SSEGGGTPQP PPRPPSPRYD APPPTLHHHS
1410 1420 1430 1440 1450
PHSPHSPHAR HEPVLRLWGD PARRELGYRA GLGSQEKALT ASPPAARRSL
1460 1470 1480 1490 1500
LHRLPPTAPG VGPLLLQLGP EPPTPHPGVS KAWRTAAPEE PERLPLHVRF
1510 1520 1530 1540 1550
LENCQARPPP AGTRGSSTED GPGVPPPSPR RVLPTSPTSP RGNEENGLPL
1560 1570 1580 1590 1600
LVLPPPAPSV DVDDGEFLFA EPLPPPLEFS NSFEKPESPL TPGPPHPLPD
1610 1620 1630 1640 1650
PPSPATPLPA APPPAVAAAP PTLDSTASSL TSYDSEVATL TQGAPAAPGD
1660 1670 1680 1690 1700
PPAPGPPAPA APAPPAPQPG PDPPPGTDSG IEEVDSRSSS DHPLETISSA
1710 1720 1730 1740 1750
STLSSLSAEG GGNTGGVAGG GAGVASGTEL LDTYVAYLDG QAFGGSGTPG
1760 1770 1780 1790 1800
PPYPPQLMTP SKLRGRALGT SGNLRPGPSG GLRDPVTPTS PTVSVTGAGT
1810 1820 1830 1840 1850
DGLLALSACP GPSTAGVAGG PVAVEPEVPP VPLPAASSLP RKLLPWEEGP
1860 1870 1880 1890 1900
GPPPPPLPGP LSQPQASALA TVKASIISEL SSKLQQFGGS STAGGALPWA
1910 1920 1930 1940 1950
RGGSGGSTDS HHGGASYIPE RTSSLQRQRL SEDSQTSLLS KPSSSIFQNW
1960 1970 1980 1990 2000
PKPPLPPLPT GSGVSSSTAA APGATSPSAS SASASTRHLQ GVEFEMRPPL
2010 2020 2030 2040 2050
LRRAPSPSLL PASDHKVSPA PRPSSLPILP SGPIYPGLFD IRSSPTGGAG
2060 2070 2080 2090 2100
GSTDPFAPVF VPPHPGISGG LGGALSGASR SLSPTRLLSL PPDKPFGAKP
2110 2120 2130 2140 2150
LGFWTKFDVA DWLEWLGLSE HRAQFLDHEI DGSHLPALTK EDYVDLGVTR
2160
VGHRMNIDRA LKFFLER
Length:2,167
Mass (Da):226,335
Last modified:November 1, 1999 - v1
Checksum:i3F478B5A7B18BA86
GO
Isoform 2 (identifier: Q9WV48-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-614: Missing.
     615-654: SQEGRQESRS...PSLIDGIDSG → MALSAVGGGP...PRRRSVWYIY

Show »
Length:1,553
Mass (Da):159,899
Checksum:iB9B7E6A33E26DE48
GO
Isoform 3 (identifier: Q9WV48-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-654: Missing.

Show »
Length:2,158
Mass (Da):225,477
Checksum:iBF18578E26D6578C
GO
Isoform 4 (identifier: Q9WV48-4) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     797-804: Missing.

Show »
Length:2,159
Mass (Da):225,368
Checksum:i912C1737EC330CB1
GO
Isoform 5 (identifier: Q9WV48-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1930-1943: LSEDSQTSLLSKPS → QYRIVVKSSDFGDF
     1944-2167: Missing.

Show »
Length:1,943
Mass (Da):202,919
Checksum:iD290DD45558B73AF
GO

Sequence cautioni

The sequence AAD29417 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF02498 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1141S → T in AAD04569 (PubMed:10488079).Curated1
Sequence conflicti1174S → N in AAD29417 (PubMed:10433268).Curated1
Sequence conflicti1246R → K in AAD04569 (PubMed:10488079).Curated1
Sequence conflicti1323A → T in AAD04569 (PubMed:10488079).Curated1
Sequence conflicti1331S → D in AAD04569 (PubMed:10488079).Curated1
Sequence conflicti1726S → N in AAD29417 (PubMed:10433268).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0060721 – 614Missing in isoform 2. CuratedAdd BLAST614
Alternative sequenceiVSP_006073615 – 654SQEGR…GIDSG → MALSAVGGGPGGGALPQPPP ALSSSWPALGPRRRSVWYIY in isoform 2. CuratedAdd BLAST40
Alternative sequenceiVSP_006074646 – 654Missing in isoform 3. 1 Publication9
Alternative sequenceiVSP_006075797 – 804Missing in isoform 4. 1 Publication8
Alternative sequenceiVSP_0060761930 – 1943LSEDS…LSKPS → QYRIVVKSSDFGDF in isoform 5. CuratedAdd BLAST14
Alternative sequenceiVSP_0060771944 – 2167Missing in isoform 5. CuratedAdd BLAST224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102855 mRNA. Translation: AAD04569.2.
AF131951 mRNA. Translation: AAD29417.1. Different initiation.
AF159046 mRNA. Translation: AAD42975.1.
AF141904 mRNA. Translation: AAF02498.1. Different initiation.
RefSeqiNP_113939.2. NM_031751.3. [Q9WV48-1]
XP_017445247.1. XM_017589758.1. [Q9WV48-1]
XP_017445248.1. XM_017589759.1. [Q9WV48-4]
XP_017445249.1. XM_017589760.1. [Q9WV48-3]
XP_017445250.1. XM_017589761.1. [Q9WV48-5]
UniGeneiRn.225968.

Genome annotation databases

EnsembliENSRNOT00000026100; ENSRNOP00000026100; ENSRNOG00000019207. [Q9WV48-1]
ENSRNOT00000044257; ENSRNOP00000039860; ENSRNOG00000019207. [Q9WV48-3]
ENSRNOT00000092327; ENSRNOP00000075838; ENSRNOG00000019207. [Q9WV48-4]
GeneIDi78957.
KEGGirno:78957.
UCSCiRGD:621011. rat. [Q9WV48-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102855 mRNA. Translation: AAD04569.2.
AF131951 mRNA. Translation: AAD29417.1. Different initiation.
AF159046 mRNA. Translation: AAD42975.1.
AF141904 mRNA. Translation: AAF02498.1. Different initiation.
RefSeqiNP_113939.2. NM_031751.3. [Q9WV48-1]
XP_017445247.1. XM_017589758.1. [Q9WV48-1]
XP_017445248.1. XM_017589759.1. [Q9WV48-4]
XP_017445249.1. XM_017589760.1. [Q9WV48-3]
XP_017445250.1. XM_017589761.1. [Q9WV48-5]
UniGeneiRn.225968.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3OX-ray1.80A/B654-762[»]
1Q3PX-ray2.25A/B654-762[»]
3L4FX-ray2.80D653-765[»]
3QJMX-ray2.31A/B654-768[»]
3QJNX-ray2.71A/B/C/D/E/F/G/H654-768[»]
ProteinModelPortaliQ9WV48.
SMRiQ9WV48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249365. 5 interactors.
IntActiQ9WV48. 17 interactors.
MINTiMINT-101286.
STRINGi10116.ENSRNOP00000026100.

PTM databases

iPTMnetiQ9WV48.
PhosphoSitePlusiQ9WV48.

Proteomic databases

PaxDbiQ9WV48.
PRIDEiQ9WV48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026100; ENSRNOP00000026100; ENSRNOG00000019207. [Q9WV48-1]
ENSRNOT00000044257; ENSRNOP00000039860; ENSRNOG00000019207. [Q9WV48-3]
ENSRNOT00000092327; ENSRNOP00000075838; ENSRNOG00000019207. [Q9WV48-4]
GeneIDi78957.
KEGGirno:78957.
UCSCiRGD:621011. rat. [Q9WV48-1]

Organism-specific databases

CTDi50944.
RGDi621011. Shank1.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4375. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
HOVERGENiHBG079186.
InParanoidiQ9WV48.
KOiK15009.
OMAiWQNEARR.
OrthoDBiEOG091G00OW.
PhylomeDBiQ9WV48.

Enzyme and pathway databases

ReactomeiR-RNO-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

EvolutionaryTraceiQ9WV48.
PROiQ9WV48.

Gene expression databases

BgeeiENSRNOG00000019207.
GenevisibleiQ9WV48. RN.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032425. FERM_f0.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF16511. FERM_f0. 1 hit.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHAN1_RAT
AccessioniPrimary (citable) accession number: Q9WV48
Secondary accession number(s): Q9QZZ8, Q9WU13, Q9WUE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.