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Q9WV48 - SHAN1_RAT

UniProt

Q9WV48 - SHAN1_RAT

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Protein

SH3 and multiple ankyrin repeat domains protein 1

Gene

Shank1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.2 Publications

GO - Molecular functioni

  1. ankyrin repeat binding Source: BHF-UCL
  2. GKAP/Homer scaffold activity Source: BHF-UCL
  3. identical protein binding Source: BHF-UCL
  4. ionotropic glutamate receptor binding Source: RGD
  5. protein complex binding Source: RGD
  6. protein C-terminus binding Source: RGD
  7. receptor signaling complex scaffold activity Source: RGD
  8. scaffold protein binding Source: BHF-UCL
  9. SH3 domain binding Source: BHF-UCL
  10. somatostatin receptor binding Source: UniProtKB

GO - Biological processi

  1. adult behavior Source: Ensembl
  2. associative learning Source: BHF-UCL
  3. cytoskeletal anchoring at plasma membrane Source: UniProtKB
  4. dendritic spine morphogenesis Source: BHF-UCL
  5. determination of affect Source: Ensembl
  6. habituation Source: BHF-UCL
  7. long-term memory Source: BHF-UCL
  8. negative regulation of actin filament bundle assembly Source: BHF-UCL
  9. neuromuscular process controlling balance Source: BHF-UCL
  10. olfactory behavior Source: BHF-UCL
  11. positive regulation of dendritic spine development Source: UniProtKB
  12. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
  13. protein complex assembly Source: BHF-UCL
  14. protein localization to synapse Source: BHF-UCL
  15. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
  16. righting reflex Source: BHF-UCL
  17. social behavior Source: Ensembl
  18. synapse maturation Source: UniProtKB
  19. vocalization behavior Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and multiple ankyrin repeat domains protein 1
Short name:
Shank1
Alternative name(s):
GKAP/SAPAP-interacting protein
SPANK-1
Somatostatin receptor-interacting protein
Short name:
SSTR-interacting protein
Short name:
SSTRIP
Synamon
Gene namesi
Name:Shank1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi621011. Shank1.

Subcellular locationi

Cytoplasm 1 Publication. Cell junction › synapse 1 Publication. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density 1 Publication
Note: Colocalizes with alpha-latrotoxin receptor 1.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-SubCell
  3. dendrite Source: UniProtKB
  4. dendritic spine Source: BHF-UCL
  5. excitatory synapse Source: BHF-UCL
  6. intracellular Source: UniProtKB
  7. ionotropic glutamate receptor complex Source: Ensembl
  8. neuronal postsynaptic density Source: BHF-UCL
  9. neuron projection Source: BHF-UCL
  10. plasma membrane Source: BHF-UCL
  11. postsynaptic membrane Source: RGD
  12. synapse Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21672167SH3 and multiple ankyrin repeat domains protein 1PRO_0000174672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei186 – 1861PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9WV48.
PRIDEiQ9WV48.

PTM databases

PhosphoSiteiQ9WV48.

Expressioni

Tissue specificityi

Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum).

Developmental stagei

Expression increases from low levels at birth to high levels at 3-4 weeks before dropping slightly in adulthood. Expressed in the cortex and the molecular layer of the cerebellum at postnatal day 7. Isoform 2 expression does not change during development of both cortex and cerebellum. Isoform 4 expression decreases significantly during development of cortex but not cerebellum.1 Publication

Gene expression databases

ExpressionAtlasiQ9WV48. baseline and differential.
GenevestigatoriQ9WV48.

Interactioni

Subunit structurei

May homomultimerize via its SAM domain. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2 (By similarity). Interacts with IGSF9.By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Arhgef7Q9ES28-26EBI-80909,EBI-8620514From a different organism.
Dlg4P310163EBI-80909,EBI-375655
Dlgap1P978366EBI-80909,EBI-80901
Dlgap1P97836-52EBI-80909,EBI-6269434
Homer1Q9Z214-24EBI-80909,EBI-2338999
SharpinQ9EQL97EBI-80909,EBI-1394695

Protein-protein interaction databases

BioGridi249365. 5 interactions.
IntActiQ9WV48. 17 interactions.
MINTiMINT-101286.

Structurei

Secondary structure

1
2167
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi655 – 66713Combined sources
Beta strandi670 – 6723Combined sources
Beta strandi675 – 6806Combined sources
Beta strandi694 – 6963Combined sources
Beta strandi699 – 7057Combined sources
Helixi710 – 7145Combined sources
Beta strandi721 – 7255Combined sources
Helixi735 – 74410Combined sources
Turni745 – 7473Combined sources
Beta strandi748 – 76013Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q3OX-ray1.80A/B654-762[»]
1Q3PX-ray2.25A/B654-762[»]
3L4FX-ray2.80D653-765[»]
3QJMX-ray2.31A/B654-768[»]
3QJNX-ray2.71A/B/C/D/E/F/G/H654-768[»]
ProteinModelPortaliQ9WV48.
SMRiQ9WV48. Positions 656-759, 2101-2162.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WV48.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati195 – 21016ANK 1Add
BLAST
Repeati212 – 24534ANK 2Add
BLAST
Repeati246 – 27833ANK 3Add
BLAST
Repeati279 – 31234ANK 4Add
BLAST
Repeati313 – 34533ANK 5Add
BLAST
Repeati346 – 37833ANK 6Add
BLAST
Repeati379 – 39517ANK 7Add
BLAST
Domaini554 – 61360SH3PROSITE-ProRule annotationAdd
BLAST
Domaini663 – 75795PDZPROSITE-ProRule annotationAdd
BLAST
Domaini2104 – 216764SAMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi929 – 9324Poly-Pro
Compositional biasi1010 – 10156Poly-His
Compositional biasi1022 – 10276Poly-His
Compositional biasi1194 – 11996Poly-Gly
Compositional biasi1850 – 186011Poly-ProAdd
BLAST

Sequence similaritiesi

Belongs to the SHANK family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
HOVERGENiHBG079186.
InParanoidiQ9WV48.
KOiK15009.
OMAiWEEGPGP.
OrthoDBiEOG7X6KZ7.
PhylomeDBiQ9WV48.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9WV48-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN 
        60         70         80         90        100
LASTRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK 
       110        120        130        140        150
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP 
       160        170        180        190        200
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD 
       210        220        230        240        250
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA 
       260        270        280        290        300
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 
       310        320        330        340        350
LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA 
       360        370        380        390        400
LHICALYNKE TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR 
       410        420        430        440        450
NHREQDVVPF QESPKYAARR RGPPGAGLTV PPALLRANSD TSMALPDWMV 
       460        470        480        490        500
FSAPGASSSG TPGPTSGPQG QSQPSAPSTK LSSGTLRSAS SPRGARARSP 
       510        520        530        540        550
SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS LGSRGRRRKL 
       560        570        580        590        600
YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 
       610        620        630        640        650
GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG 
       660        670        680        690        700
IDSGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ 
       710        720        730        740        750
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM 
       760        770        780        790        800
VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP AISLRSKSMT SELEEMVSPW 
       810        820        830        840        850
KKKIEYEQQP AAVPSMEKKR TVYQMALNKL DEILAAAQQT ISASESPGPG 
       860        870        880        890        900
GLASLGKHRP KGFFATESSF DPHHRSQPSY DRPSFLPPGP GLMLRQKSIG 
       910        920        930        940        950
AAEDDRPYLA PPAMKFSRSL SVPGSEDIPP PPTTSPPEPP YSTPPAPSSS 
       960        970        980        990       1000
GRLTPSPRGG PFNPSSGGPL PASSPSSFDG PSPPDTRGGG REKSLYHSAA 
      1010       1020       1030       1040       1050
LPPAHHHPPH HHHHHAPPPQ PHHHHAHPPH PPEMETGGSP DDPPPRLALG 
      1060       1070       1080       1090       1100
PQPSLRGWRG GGPSPTSGAP SPSHHSSSGG SSGPTQAPAL RYFQLPPRAA 
      1110       1120       1130       1140       1150
SAAMYVPARS GRGRKGPLVK QTKVEGEPQK GSIPSASSPT SPALPRSEPP 
      1160       1170       1180       1190       1200
PAGPSEKNSI PIPTIIIKAP STSSSGRSSQ GSSTEAEPPT QPDGAGGGGS 
      1210       1220       1230       1240       1250
SPSPAPATSP VPPSPSPVPT PASPSGPATL DFTSQFGAAL VGAARREGGW 
      1260       1270       1280       1290       1300
QNEARRRSTL FLSTDAGDED GGDSGLGPGG PPGPRLRHSK SIDEGMFSAE 
      1310       1320       1330       1340       1350
PYLRLESGGS SGGYGAYAAG SRAYGGSGSS SAFTSFLPPR PLVHPLTGKA 
      1360       1370       1380       1390       1400
LDPASPLGLA LAARERALKE SSEGGGTPQP PPRPPSPRYD APPPTLHHHS 
      1410       1420       1430       1440       1450
PHSPHSPHAR HEPVLRLWGD PARRELGYRA GLGSQEKALT ASPPAARRSL 
      1460       1470       1480       1490       1500
LHRLPPTAPG VGPLLLQLGP EPPTPHPGVS KAWRTAAPEE PERLPLHVRF 
      1510       1520       1530       1540       1550
LENCQARPPP AGTRGSSTED GPGVPPPSPR RVLPTSPTSP RGNEENGLPL 
      1560       1570       1580       1590       1600
LVLPPPAPSV DVDDGEFLFA EPLPPPLEFS NSFEKPESPL TPGPPHPLPD 
      1610       1620       1630       1640       1650
PPSPATPLPA APPPAVAAAP PTLDSTASSL TSYDSEVATL TQGAPAAPGD 
      1660       1670       1680       1690       1700
PPAPGPPAPA APAPPAPQPG PDPPPGTDSG IEEVDSRSSS DHPLETISSA 
      1710       1720       1730       1740       1750
STLSSLSAEG GGNTGGVAGG GAGVASGTEL LDTYVAYLDG QAFGGSGTPG 
      1760       1770       1780       1790       1800
PPYPPQLMTP SKLRGRALGT SGNLRPGPSG GLRDPVTPTS PTVSVTGAGT 
      1810       1820       1830       1840       1850
DGLLALSACP GPSTAGVAGG PVAVEPEVPP VPLPAASSLP RKLLPWEEGP 
      1860       1870       1880       1890       1900
GPPPPPLPGP LSQPQASALA TVKASIISEL SSKLQQFGGS STAGGALPWA 
      1910       1920       1930       1940       1950
RGGSGGSTDS HHGGASYIPE RTSSLQRQRL SEDSQTSLLS KPSSSIFQNW 
      1960       1970       1980       1990       2000
PKPPLPPLPT GSGVSSSTAA APGATSPSAS SASASTRHLQ GVEFEMRPPL 
      2010       2020       2030       2040       2050
LRRAPSPSLL PASDHKVSPA PRPSSLPILP SGPIYPGLFD IRSSPTGGAG 
      2060       2070       2080       2090       2100
GSTDPFAPVF VPPHPGISGG LGGALSGASR SLSPTRLLSL PPDKPFGAKP 
      2110       2120       2130       2140       2150
LGFWTKFDVA DWLEWLGLSE HRAQFLDHEI DGSHLPALTK EDYVDLGVTR 
      2160 
VGHRMNIDRA LKFFLER
Length:2,167
Mass (Da):226,335
Last modified:November 1, 1999 - v1
Checksum:i3F478B5A7B18BA86
GO
Isoform 2 (identifier: Q9WV48-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-614: Missing.
     615-654: SQEGRQESRS...PSLIDGIDSG → MALSAVGGGP...PRRRSVWYIY

Show »
Length:1,553
Mass (Da):159,899
Checksum:iB9B7E6A33E26DE48
GO
Isoform 3 (identifier: Q9WV48-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-654: Missing.

Show »
Length:2,158
Mass (Da):225,477
Checksum:iBF18578E26D6578C
GO
Isoform 4 (identifier: Q9WV48-4) [UniParc]FASTAAdd to Basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     797-804: Missing.

Show »
Length:2,159
Mass (Da):225,368
Checksum:i912C1737EC330CB1
GO
Isoform 5 (identifier: Q9WV48-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1930-1943: LSEDSQTSLLSKPS → QYRIVVKSSDFGDF
     1944-2167: Missing.

Show »
Length:1,943
Mass (Da):202,919
Checksum:iD290DD45558B73AF
GO

Sequence cautioni

The sequence AAD29417.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAF02498.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1141 – 11411S → T in AAD04569. (PubMed:10488079)Curated
Sequence conflicti1174 – 11741S → N in AAD29417. (PubMed:10433268)Curated
Sequence conflicti1246 – 12461R → K in AAD04569. (PubMed:10488079)Curated
Sequence conflicti1323 – 13231A → T in AAD04569. (PubMed:10488079)Curated
Sequence conflicti1331 – 13311S → D in AAD04569. (PubMed:10488079)Curated
Sequence conflicti1726 – 17261S → N in AAD29417. (PubMed:10433268)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 614614Missing in isoform 2. CuratedVSP_006072Add
BLAST
Alternative sequencei615 – 65440SQEGR…GIDSG → MALSAVGGGPGGGALPQPPP ALSSSWPALGPRRRSVWYIY in isoform 2. CuratedVSP_006073Add
BLAST
Alternative sequencei646 – 6549Missing in isoform 3. 1 PublicationVSP_006074
Alternative sequencei797 – 8048Missing in isoform 4. 1 PublicationVSP_006075
Alternative sequencei1930 – 194314LSEDS…LSKPS → QYRIVVKSSDFGDF in isoform 5. CuratedVSP_006076Add
BLAST
Alternative sequencei1944 – 2167224Missing in isoform 5. CuratedVSP_006077Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102855 mRNA. Translation: AAD04569.2.
AF131951 mRNA. Translation: AAD29417.1. Different initiation.
AF159046 mRNA. Translation: AAD42975.1.
AF141904 mRNA. Translation: AAF02498.1. Different initiation.
RefSeqiNP_113939.2. NM_031751.2. [Q9WV48-1]
XP_008757636.1. XM_008759414.1. [Q9WV48-4]
XP_008757637.1. XM_008759415.1. [Q9WV48-3]
XP_008757639.1. XM_008759417.1. [Q9WV48-5]
UniGeneiRn.225968.

Genome annotation databases

EnsembliENSRNOT00000026100; ENSRNOP00000026100; ENSRNOG00000019207. [Q9WV48-1]
ENSRNOT00000044257; ENSRNOP00000039860; ENSRNOG00000019207. [Q9WV48-3]
ENSRNOT00000048805; ENSRNOP00000042890; ENSRNOG00000019207. [Q9WV48-4]
ENSRNOT00000049346; ENSRNOP00000044509; ENSRNOG00000019207. [Q9WV48-5]
GeneIDi78957.
KEGGirno:78957.
UCSCiRGD:621011. rat. [Q9WV48-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102855 mRNA. Translation: AAD04569.2.
AF131951 mRNA. Translation: AAD29417.1. Different initiation.
AF159046 mRNA. Translation: AAD42975.1.
AF141904 mRNA. Translation: AAF02498.1. Different initiation.
RefSeqiNP_113939.2. NM_031751.2. [Q9WV48-1]
XP_008757636.1. XM_008759414.1. [Q9WV48-4]
XP_008757637.1. XM_008759415.1. [Q9WV48-3]
XP_008757639.1. XM_008759417.1. [Q9WV48-5]
UniGeneiRn.225968.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q3OX-ray1.80A/B654-762[»]
1Q3PX-ray2.25A/B654-762[»]
3L4FX-ray2.80D653-765[»]
3QJMX-ray2.31A/B654-768[»]
3QJNX-ray2.71A/B/C/D/E/F/G/H654-768[»]
ProteinModelPortaliQ9WV48.
SMRiQ9WV48. Positions 656-759, 2101-2162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249365. 5 interactions.
IntActiQ9WV48. 17 interactions.
MINTiMINT-101286.

PTM databases

PhosphoSiteiQ9WV48.

Proteomic databases

PaxDbiQ9WV48.
PRIDEiQ9WV48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026100; ENSRNOP00000026100; ENSRNOG00000019207. [Q9WV48-1]
ENSRNOT00000044257; ENSRNOP00000039860; ENSRNOG00000019207. [Q9WV48-3]
ENSRNOT00000048805; ENSRNOP00000042890; ENSRNOG00000019207. [Q9WV48-4]
ENSRNOT00000049346; ENSRNOP00000044509; ENSRNOG00000019207. [Q9WV48-5]
GeneIDi78957.
KEGGirno:78957.
UCSCiRGD:621011. rat. [Q9WV48-1]

Organism-specific databases

CTDi50944.
RGDi621011. Shank1.

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
HOVERGENiHBG079186.
InParanoidiQ9WV48.
KOiK15009.
OMAiWEEGPGP.
OrthoDBiEOG7X6KZ7.
PhylomeDBiQ9WV48.

Miscellaneous databases

EvolutionaryTraceiQ9WV48.
NextBioi614372.
PROiQ9WV48.

Gene expression databases

ExpressionAtlasiQ9WV48. baseline and differential.
GenevestigatoriQ9WV48.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein."
    Yao I., Hata Y., Hirao K., Deguchi M., Ide N., Takeuchi M., Takai Y.
    J. Biol. Chem. 274:27463-27466(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), INTERACTION WITH DLGAP1 AND DLG4.
    Tissue: Brain.
  2. "Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin."
    Naisbitt S., Kim E., Tu J.C., Xiao B., Sala C., Valtschanoff J., Weinberg R.J., Worley P.F., Sheng M.
    Neuron 23:569-582(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), INTERACTION WITH DLGAP1.
    Strain: Sprague-Dawley.
  3. "The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family."
    Tobaben S., Suedhof T.C., Stahl B.
    J. Biol. Chem. 275:36204-36210(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Characterization of the shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development."
    Lim S., Naisbitt S., Yoon J., Hwang J.-I., Suh P.-G., Sheng M., Kim E.
    J. Biol. Chem. 274:29510-29518(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORMS 1; 2; 3; 4 AND 5), DEVELOPMENTAL STAGE.
    Tissue: Brain.
  5. "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain."
    Zitzer H., Hoenck H.-H., Baechner D., Richter D., Kreienkamp H.-J.
    J. Biol. Chem. 274:32997-33001(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 4).
    Tissue: Brain.
  6. "Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins."
    Tu J.C., Xiao B., Naisbitt S., Yuan J.P., Petralia R.S., Brakeman P., Doan A., Aakalu V.K., Lanahan A.A., Sheng M., Worley P.F.
    Neuron 23:583-592(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOMER1, SUBCELLULAR LOCATION.
  7. "Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin."
    Bockers T.M., Mameza M.G., Kreutz M.R., Bockmann J., Weise C., Buck F., Richter D., Gundelfinger E.D., Kreienkamp H.-J.
    J. Biol. Chem. 276:40104-40112(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SPTAN1.
  8. "Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins."
    Lim S., Sala C., Yoon J., Park S., Kuroda S., Sheng M., Kim E.
    Mol. Cell. Neurosci. 17:385-397(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SHARPIN.
  9. "Regulation of dendritic spine morphology and synaptic function by Shank and Homer."
    Sala C., Piech V., Wilson N.R., Passafaro M., Liu G., Sheng M.
    Neuron 31:115-130(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "The Shank family of scaffold proteins."
    Sheng M., Kim E.
    J. Cell Sci. 113:1851-1856(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. "The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation."
    Shi S.-H., Cheng T., Jan L.Y., Jan Y.-N.
    Proc. Natl. Acad. Sci. U.S.A. 101:13346-13351(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IGSF9.
  12. Cited for: FUNCTION.
  13. "Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization."
    Im Y.J., Lee J.H., Park S.H., Park S.J., Rho S.-H., Kang G.B., Kim E., Eom S.H.
    J. Biol. Chem. 278:48099-48104(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 654-762 IN COMPLEX WITH DLGAP1, SUBUNIT.
+Additional computationally mapped references.

Entry informationi

Entry nameiSHAN1_RAT
AccessioniPrimary (citable) accession number: Q9WV48
Secondary accession number(s): Q9QZZ8, Q9WU13, Q9WUE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: February 4, 2015
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.