Reviewed, UniProtKB/Swiss-Prot Q9WV48 (SHAN1_RAT)

Names and origin

Protein names

Recommended name:
    SH3 and multiple ankyrin repeat domains protein 1
      Short name=Shank1
Alternative name(s):
    GKAP/SAPAP-interacting protein
    SPANK-1
    Synamon
    Somatostatin receptor-interacting protein
      Short name=SSTR-interacting protein
      Short name=SSTRIP

Gene names

Name:

Shank1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	2167 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.
Subunit structure	May homomultimerize via its SAM domain. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2 By similarity. Interacts with IGSF9.
Subcellular location	Cytoplasm. Cell junction › synapse. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Note= Postsynaptic density of neuronal cells. Colocalizes with alpha-latrotoxin receptor 1.
Tissue specificity	Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum).
Developmental stage	Expression increases from low levels at birth to high levels at 3-4 weeks before dropping slightly in adulthood. Expressed in the cortex and the molecular layer of the cerebellum at postnatal day 7. Isoform 2 expression does not change during development of both cortex and cerebellum. Isoform 4 expression decreases significantly during development of cortex but not cerebellum.
Sequence similarities	Belongs to the SHANK family. Contains 7 ANK repeats. Contains 1 PDZ (DHR) domain. Contains 1 SAM (sterile alpha motif) domain. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Cytoplasm Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat SH3 domain
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cytoskeletal anchoring at plasma membrane Ref.5 Non-traceable author statement. Source: UniProtKB
Cellular component	dendrite Ref.5 Non-traceable author statement. Source: UniProtKB intracellular Ref.5 Non-traceable author statement. Source: UniProtKB membrane fraction Ref.5 Inferred from direct assay. Source: UniProtKB
Molecular function	protein binding Ref.1 Ref.5 Ref.8 Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Dlg4	P31016	1	EBI-80909,EBI-375655
Dlgap1	P97836	3	EBI-80909,EBI-80901
Grip1	P97879	1	EBI-80909,EBI-936113
Sharpin	Q9EQL9	4	EBI-80909,EBI-1394695

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Notes: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9WV48-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9WV48-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-614: Missing.
     615-654: SQEGRQESRS...PSLIDGIDSG → MALSAVGGGP...PRRRSVWYIY

Isoform 3 (identifier: Q9WV48-3)

The sequence of this isoform differs from the canonical sequence as follows:
     646-654: Missing.

Isoform 4 (identifier: Q9WV48-4)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     797-804: Missing.

Isoform 5 (identifier: Q9WV48-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1930-1943: LSEDSQTSLLSKPS → QYRIVVKSSDFGDF
     1944-2167: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2167

2167

SH3 and multiple ankyrin repeat domains protein 1

PRO_0000174672

Regions

Repeat

195 – 210

16

ANK 1

Repeat

212 – 245

34

ANK 2

Repeat

246 – 278

33

ANK 3

Repeat

279 – 312

34

ANK 4

Repeat

313 – 345

33

ANK 5

Repeat

346 – 378

33

ANK 6

Repeat

379 – 395

17

ANK 7

Domain

554 – 613

60

SH3

Domain

663 – 757

95

PDZ

Domain

2104 – 2167

64

SAM

Compositional bias

929 – 932

4

Poly-Pro

Compositional bias

1010 – 1015

6

Poly-His

Compositional bias

1022 – 1027

6

Poly-His

Compositional bias

1194 – 1199

6

Poly-Gly

Compositional bias

1850 – 1860

11

Poly-Pro

Amino acid modifications

Modified residue

275

1

Phosphotyrosine By similarity

Natural variations

Alternative sequence

1 – 614

614

Missing in isoform 2.

VSP_006072

Alternative sequence

615 – 654

40

SQEGR…GIDSG → MALSAVGGGPGGGALPQPPP ALSSSWPALGPRRRSVWYIY in isoform 2.

VSP_006073

Alternative sequence

646 – 654

9

Missing in isoform 3.

VSP_006074

Alternative sequence

797 – 804

8

Missing in isoform 4.

VSP_006075

Alternative sequence

1930 – 1943

14

LSEDS…LSKPS → QYRIVVKSSDFGDF in isoform 5.

VSP_006076

Alternative sequence

1944 – 2167

224

Missing in isoform 5.

VSP_006077

Experimental info

Sequence conflict

1141

1

S → T in AAD04569. Ref.1

Sequence conflict

1174

1

S → N in AAD29417. Ref.2

Sequence conflict

1246

1

R → K in AAD04569. Ref.1

Sequence conflict

1323

1

A → T in AAD04569. Ref.1

Sequence conflict

1331

1

S → D in AAD04569. Ref.1

Sequence conflict

1726

1

S → N in AAD29417. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

2167

Helix Strand Turn

Details...

Beta strand

657 – 667

11

Beta strand

675 – 682

8

Beta strand

698 – 705

8

Helix

710 – 713

4

Beta strand

721 – 725

5

Helix

735 – 744

10

Turn

745 – 747

3

Beta strand

748 – 757

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 3F478B5A7B18BA86	FASTA	2,167	226,335
	10 20 30 40 50 60 MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN LASTRGLQGR 70 80 90 100 110 120 SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK QQVLCALSES LQDVLNYGLF 130 140 150 160 170 180 QPATSGRDAN FLEEERLLRE YPQSFEKGVP YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL 190 200 210 220 230 240 KKFLEYVQLG TSDKVARLLD KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI 250 260 270 280 290 300 DFRARDGMTA LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 310 320 330 340 350 360 LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA LHICALYNKE 370 380 390 400 410 420 TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR NHREQDVVPF QESPKYAARR 430 440 450 460 470 480 RGPPGAGLTV PPALLRANSD TSMALPDWMV FSAPGASSSG TPGPTSGPQG QSQPSAPSTK 490 500 510 520 530 540 LSSGTLRSAS SPRGARARSP SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS 550 560 570 580 590 600 LGSRGRRRKL YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 610 620 630 640 650 660 GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG IDSGSDYIIK 670 680 690 700 710 720 EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ YLESVDEGGV AWRAGLRMGD 730 740 750 760 770 780 FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP 790 800 810 820 830 840 AISLRSKSMT SELEEMVSPW KKKIEYEQQP AAVPSMEKKR TVYQMALNKL DEILAAAQQT 850 860 870 880 890 900 ISASESPGPG GLASLGKHRP KGFFATESSF DPHHRSQPSY DRPSFLPPGP GLMLRQKSIG 910 920 930 940 950 960 AAEDDRPYLA PPAMKFSRSL SVPGSEDIPP PPTTSPPEPP YSTPPAPSSS GRLTPSPRGG 970 980 990 1000 1010 1020 PFNPSSGGPL PASSPSSFDG PSPPDTRGGG REKSLYHSAA LPPAHHHPPH HHHHHAPPPQ 1030 1040 1050 1060 1070 1080 PHHHHAHPPH PPEMETGGSP DDPPPRLALG PQPSLRGWRG GGPSPTSGAP SPSHHSSSGG 1090 1100 1110 1120 1130 1140 SSGPTQAPAL RYFQLPPRAA SAAMYVPARS GRGRKGPLVK QTKVEGEPQK GSIPSASSPT 1150 1160 1170 1180 1190 1200 SPALPRSEPP PAGPSEKNSI PIPTIIIKAP STSSSGRSSQ GSSTEAEPPT QPDGAGGGGS 1210 1220 1230 1240 1250 1260 SPSPAPATSP VPPSPSPVPT PASPSGPATL DFTSQFGAAL VGAARREGGW QNEARRRSTL 1270 1280 1290 1300 1310 1320 FLSTDAGDED GGDSGLGPGG PPGPRLRHSK SIDEGMFSAE PYLRLESGGS SGGYGAYAAG 1330 1340 1350 1360 1370 1380 SRAYGGSGSS SAFTSFLPPR PLVHPLTGKA LDPASPLGLA LAARERALKE SSEGGGTPQP 1390 1400 1410 1420 1430 1440 PPRPPSPRYD APPPTLHHHS PHSPHSPHAR HEPVLRLWGD PARRELGYRA GLGSQEKALT 1450 1460 1470 1480 1490 1500 ASPPAARRSL LHRLPPTAPG VGPLLLQLGP EPPTPHPGVS KAWRTAAPEE PERLPLHVRF 1510 1520 1530 1540 1550 1560 LENCQARPPP AGTRGSSTED GPGVPPPSPR RVLPTSPTSP RGNEENGLPL LVLPPPAPSV 1570 1580 1590 1600 1610 1620 DVDDGEFLFA EPLPPPLEFS NSFEKPESPL TPGPPHPLPD PPSPATPLPA APPPAVAAAP 1630 1640 1650 1660 1670 1680 PTLDSTASSL TSYDSEVATL TQGAPAAPGD PPAPGPPAPA APAPPAPQPG PDPPPGTDSG 1690 1700 1710 1720 1730 1740 IEEVDSRSSS DHPLETISSA STLSSLSAEG GGNTGGVAGG GAGVASGTEL LDTYVAYLDG 1750 1760 1770 1780 1790 1800 QAFGGSGTPG PPYPPQLMTP SKLRGRALGT SGNLRPGPSG GLRDPVTPTS PTVSVTGAGT 1810 1820 1830 1840 1850 1860 DGLLALSACP GPSTAGVAGG PVAVEPEVPP VPLPAASSLP RKLLPWEEGP GPPPPPLPGP 1870 1880 1890 1900 1910 1920 LSQPQASALA TVKASIISEL SSKLQQFGGS STAGGALPWA RGGSGGSTDS HHGGASYIPE 1930 1940 1950 1960 1970 1980 RTSSLQRQRL SEDSQTSLLS KPSSSIFQNW PKPPLPPLPT GSGVSSSTAA APGATSPSAS 1990 2000 2010 2020 2030 2040 SASASTRHLQ GVEFEMRPPL LRRAPSPSLL PASDHKVSPA PRPSSLPILP SGPIYPGLFD 2050 2060 2070 2080 2090 2100 IRSSPTGGAG GSTDPFAPVF VPPHPGISGG LGGALSGASR SLSPTRLLSL PPDKPFGAKP 2110 2120 2130 2140 2150 2160 LGFWTKFDVA DWLEWLGLSE HRAQFLDHEI DGSHLPALTK EDYVDLGVTR VGHRMNIDRA LKFFLER
	Isoform 2 [UniParc]. Checksum: B9B7E6A33E26DE48		1,553	159,899
	10 20 30 40 50 60 MALSAVGGGP GGGALPQPPP ALSSSWPALG PRRRSVWYIY SDYIIKEKTV LLQKKDSEGF 70 80 90 100 110 120 GFVLRGAKAQ TPIEEFTPTP AFPALQYLES VDEGGVAWRA GLRMGDFLIE VNGQNVVKVG 130 140 150 160 170 180 HRQVVNMIRQ GGNTLMVKVV MVTRHPDMDE AVHKKASQQA KRLPPPAISL RSKSMTSELE 190 200 210 220 230 240 EMVSPWKKKI EYEQQPAAVP SMEKKRTVYQ MALNKLDEIL AAAQQTISAS ESPGPGGLAS 250 260 270 280 290 300 LGKHRPKGFF ATESSFDPHH RSQPSYDRPS FLPPGPGLML RQKSIGAAED DRPYLAPPAM 310 320 330 340 350 360 KFSRSLSVPG SEDIPPPPTT SPPEPPYSTP PAPSSSGRLT PSPRGGPFNP SSGGPLPASS 370 380 390 400 410 420 PSSFDGPSPP DTRGGGREKS LYHSAALPPA HHHPPHHHHH HAPPPQPHHH HAHPPHPPEM 430 440 450 460 470 480 ETGGSPDDPP PRLALGPQPS LRGWRGGGPS PTSGAPSPSH HSSSGGSSGP TQAPALRYFQ 490 500 510 520 530 540 LPPRAASAAM YVPARSGRGR KGPLVKQTKV EGEPQKGSIP SASSPTSPAL PRSEPPPAGP 550 560 570 580 590 600 SEKNSIPIPT IIIKAPSTSS SGRSSQGSST EAEPPTQPDG AGGGGSSPSP APATSPVPPS 610 620 630 640 650 660 PSPVPTPASP SGPATLDFTS QFGAALVGAA RREGGWQNEA RRRSTLFLST DAGDEDGGDS 670 680 690 700 710 720 GLGPGGPPGP RLRHSKSIDE GMFSAEPYLR LESGGSSGGY GAYAAGSRAY GGSGSSSAFT 730 740 750 760 770 780 SFLPPRPLVH PLTGKALDPA SPLGLALAAR ERALKESSEG GGTPQPPPRP PSPRYDAPPP 790 800 810 820 830 840 TLHHHSPHSP HSPHARHEPV LRLWGDPARR ELGYRAGLGS QEKALTASPP AARRSLLHRL 850 860 870 880 890 900 PPTAPGVGPL LLQLGPEPPT PHPGVSKAWR TAAPEEPERL PLHVRFLENC QARPPPAGTR 910 920 930 940 950 960 GSSTEDGPGV PPPSPRRVLP TSPTSPRGNE ENGLPLLVLP PPAPSVDVDD GEFLFAEPLP 970 980 990 1000 1010 1020 PPLEFSNSFE KPESPLTPGP PHPLPDPPSP ATPLPAAPPP AVAAAPPTLD STASSLTSYD 1030 1040 1050 1060 1070 1080 SEVATLTQGA PAAPGDPPAP GPPAPAAPAP PAPQPGPDPP PGTDSGIEEV DSRSSSDHPL 1090 1100 1110 1120 1130 1140 ETISSASTLS SLSAEGGGNT GGVAGGGAGV ASGTELLDTY VAYLDGQAFG GSGTPGPPYP 1150 1160 1170 1180 1190 1200 PQLMTPSKLR GRALGTSGNL RPGPSGGLRD PVTPTSPTVS VTGAGTDGLL ALSACPGPST 1210 1220 1230 1240 1250 1260 AGVAGGPVAV EPEVPPVPLP AASSLPRKLL PWEEGPGPPP PPLPGPLSQP QASALATVKA 1270 1280 1290 1300 1310 1320 SIISELSSKL QQFGGSSTAG GALPWARGGS GGSTDSHHGG ASYIPERTSS LQRQRLSEDS 1330 1340 1350 1360 1370 1380 QTSLLSKPSS SIFQNWPKPP LPPLPTGSGV SSSTAAAPGA TSPSASSASA STRHLQGVEF 1390 1400 1410 1420 1430 1440 EMRPPLLRRA PSPSLLPASD HKVSPAPRPS SLPILPSGPI YPGLFDIRSS PTGGAGGSTD 1450 1460 1470 1480 1490 1500 PFAPVFVPPH PGISGGLGGA LSGASRSLSP TRLLSLPPDK PFGAKPLGFW TKFDVADWLE 1510 1520 1530 1540 1550 WLGLSEHRAQ FLDHEIDGSH LPALTKEDYV DLGVTRVGHR MNIDRALKFF LER
	Isoform 3 [UniParc]. Checksum: BF18578E26D6578C		2,158	225,477
	10 20 30 40 50 60 MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN LASTRGLQGR 70 80 90 100 110 120 SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK QQVLCALSES LQDVLNYGLF 130 140 150 160 170 180 QPATSGRDAN FLEEERLLRE YPQSFEKGVP YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL 190 200 210 220 230 240 KKFLEYVQLG TSDKVARLLD KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI 250 260 270 280 290 300 DFRARDGMTA LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 310 320 330 340 350 360 LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA LHICALYNKE 370 380 390 400 410 420 TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR NHREQDVVPF QESPKYAARR 430 440 450 460 470 480 RGPPGAGLTV PPALLRANSD TSMALPDWMV FSAPGASSSG TPGPTSGPQG QSQPSAPSTK 490 500 510 520 530 540 LSSGTLRSAS SPRGARARSP SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS 550 560 570 580 590 600 LGSRGRRRKL YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 610 620 630 640 650 660 GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSDYII KEKTVLLQKK 670 680 690 700 710 720 DSEGFGFVLR GAKAQTPIEE FTPTPAFPAL QYLESVDEGG VAWRAGLRMG DFLIEVNGQN 730 740 750 760 770 780 VVKVGHRQVV NMIRQGGNTL MVKVVMVTRH PDMDEAVHKK ASQQAKRLPP PAISLRSKSM 790 800 810 820 830 840 TSELEEMVSP WKKKIEYEQQ PAAVPSMEKK RTVYQMALNK LDEILAAAQQ TISASESPGP 850 860 870 880 890 900 GGLASLGKHR PKGFFATESS FDPHHRSQPS YDRPSFLPPG PGLMLRQKSI GAAEDDRPYL 910 920 930 940 950 960 APPAMKFSRS LSVPGSEDIP PPPTTSPPEP PYSTPPAPSS SGRLTPSPRG GPFNPSSGGP 970 980 990 1000 1010 1020 LPASSPSSFD GPSPPDTRGG GREKSLYHSA ALPPAHHHPP HHHHHHAPPP QPHHHHAHPP 1030 1040 1050 1060 1070 1080 HPPEMETGGS PDDPPPRLAL GPQPSLRGWR GGGPSPTSGA PSPSHHSSSG GSSGPTQAPA 1090 1100 1110 1120 1130 1140 LRYFQLPPRA ASAAMYVPAR SGRGRKGPLV KQTKVEGEPQ KGSIPSASSP TSPALPRSEP 1150 1160 1170 1180 1190 1200 PPAGPSEKNS IPIPTIIIKA PSTSSSGRSS QGSSTEAEPP TQPDGAGGGG SSPSPAPATS 1210 1220 1230 1240 1250 1260 PVPPSPSPVP TPASPSGPAT LDFTSQFGAA LVGAARREGG WQNEARRRST LFLSTDAGDE 1270 1280 1290 1300 1310 1320 DGGDSGLGPG GPPGPRLRHS KSIDEGMFSA EPYLRLESGG SSGGYGAYAA GSRAYGGSGS 1330 1340 1350 1360 1370 1380 SSAFTSFLPP RPLVHPLTGK ALDPASPLGL ALAARERALK ESSEGGGTPQ PPPRPPSPRY 1390 1400 1410 1420 1430 1440 DAPPPTLHHH SPHSPHSPHA RHEPVLRLWG DPARRELGYR AGLGSQEKAL TASPPAARRS 1450 1460 1470 1480 1490 1500 LLHRLPPTAP GVGPLLLQLG PEPPTPHPGV SKAWRTAAPE EPERLPLHVR FLENCQARPP 1510 1520 1530 1540 1550 1560 PAGTRGSSTE DGPGVPPPSP RRVLPTSPTS PRGNEENGLP LLVLPPPAPS VDVDDGEFLF 1570 1580 1590 1600 1610 1620 AEPLPPPLEF SNSFEKPESP LTPGPPHPLP DPPSPATPLP AAPPPAVAAA PPTLDSTASS 1630 1640 1650 1660 1670 1680 LTSYDSEVAT LTQGAPAAPG DPPAPGPPAP AAPAPPAPQP GPDPPPGTDS GIEEVDSRSS 1690 1700 1710 1720 1730 1740 SDHPLETISS ASTLSSLSAE GGGNTGGVAG GGAGVASGTE LLDTYVAYLD GQAFGGSGTP 1750 1760 1770 1780 1790 1800 GPPYPPQLMT PSKLRGRALG TSGNLRPGPS GGLRDPVTPT SPTVSVTGAG TDGLLALSAC 1810 1820 1830 1840 1850 1860 PGPSTAGVAG GPVAVEPEVP PVPLPAASSL PRKLLPWEEG PGPPPPPLPG PLSQPQASAL 1870 1880 1890 1900 1910 1920 ATVKASIISE LSSKLQQFGG SSTAGGALPW ARGGSGGSTD SHHGGASYIP ERTSSLQRQR 1930 1940 1950 1960 1970 1980 LSEDSQTSLL SKPSSSIFQN WPKPPLPPLP TGSGVSSSTA AAPGATSPSA SSASASTRHL 1990 2000 2010 2020 2030 2040 QGVEFEMRPP LLRRAPSPSL LPASDHKVSP APRPSSLPIL PSGPIYPGLF DIRSSPTGGA 2050 2060 2070 2080 2090 2100 GGSTDPFAPV FVPPHPGISG GLGGALSGAS RSLSPTRLLS LPPDKPFGAK PLGFWTKFDV 2110 2120 2130 2140 2150 ADWLEWLGLS EHRAQFLDHE IDGSHLPALT KEDYVDLGVT RVGHRMNIDR ALKFFLER
	Isoform 4 (A) [UniParc]. Checksum: 912C1737EC330CB1		2,159	225,368
	10 20 30 40 50 60 MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN LASTRGLQGR 70 80 90 100 110 120 SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK QQVLCALSES LQDVLNYGLF 130 140 150 160 170 180 QPATSGRDAN FLEEERLLRE YPQSFEKGVP YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL 190 200 210 220 230 240 KKFLEYVQLG TSDKVARLLD KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI 250 260 270 280 290 300 DFRARDGMTA LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 310 320 330 340 350 360 LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA LHICALYNKE 370 380 390 400 410 420 TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR NHREQDVVPF QESPKYAARR 430 440 450 460 470 480 RGPPGAGLTV PPALLRANSD TSMALPDWMV FSAPGASSSG TPGPTSGPQG QSQPSAPSTK 490 500 510 520 530 540 LSSGTLRSAS SPRGARARSP SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS 550 560 570 580 590 600 LGSRGRRRKL YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 610 620 630 640 650 660 GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG IDSGSDYIIK 670 680 690 700 710 720 EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ YLESVDEGGV AWRAGLRMGD 730 740 750 760 770 780 FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP 790 800 810 820 830 840 AISLRSKSMT SELEEMEYEQ QPAAVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG 850 860 870 880 890 900 PGGLASLGKH RPKGFFATES SFDPHHRSQP SYDRPSFLPP GPGLMLRQKS IGAAEDDRPY 910 920 930 940 950 960 LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPAPS SSGRLTPSPR GGPFNPSSGG 970 980 990 1000 1010 1020 PLPASSPSSF DGPSPPDTRG GGREKSLYHS AALPPAHHHP PHHHHHHAPP PQPHHHHAHP 1030 1040 1050 1060 1070 1080 PHPPEMETGG SPDDPPPRLA LGPQPSLRGW RGGGPSPTSG APSPSHHSSS GGSSGPTQAP 1090 1100 1110 1120 1130 1140 ALRYFQLPPR AASAAMYVPA RSGRGRKGPL VKQTKVEGEP QKGSIPSASS PTSPALPRSE 1150 1160 1170 1180 1190 1200 PPPAGPSEKN SIPIPTIIIK APSTSSSGRS SQGSSTEAEP PTQPDGAGGG GSSPSPAPAT 1210 1220 1230 1240 1250 1260 SPVPPSPSPV PTPASPSGPA TLDFTSQFGA ALVGAARREG GWQNEARRRS TLFLSTDAGD 1270 1280 1290 1300 1310 1320 EDGGDSGLGP GGPPGPRLRH SKSIDEGMFS AEPYLRLESG GSSGGYGAYA AGSRAYGGSG 1330 1340 1350 1360 1370 1380 SSSAFTSFLP PRPLVHPLTG KALDPASPLG LALAARERAL KESSEGGGTP QPPPRPPSPR 1390 1400 1410 1420 1430 1440 YDAPPPTLHH HSPHSPHSPH ARHEPVLRLW GDPARRELGY RAGLGSQEKA LTASPPAARR 1450 1460 1470 1480 1490 1500 SLLHRLPPTA PGVGPLLLQL GPEPPTPHPG VSKAWRTAAP EEPERLPLHV RFLENCQARP 1510 1520 1530 1540 1550 1560 PPAGTRGSST EDGPGVPPPS PRRVLPTSPT SPRGNEENGL PLLVLPPPAP SVDVDDGEFL 1570 1580 1590 1600 1610 1620 FAEPLPPPLE FSNSFEKPES PLTPGPPHPL PDPPSPATPL PAAPPPAVAA APPTLDSTAS 1630 1640 1650 1660 1670 1680 SLTSYDSEVA TLTQGAPAAP GDPPAPGPPA PAAPAPPAPQ PGPDPPPGTD SGIEEVDSRS 1690 1700 1710 1720 1730 1740 SSDHPLETIS SASTLSSLSA EGGGNTGGVA GGGAGVASGT ELLDTYVAYL DGQAFGGSGT 1750 1760 1770 1780 1790 1800 PGPPYPPQLM TPSKLRGRAL GTSGNLRPGP SGGLRDPVTP TSPTVSVTGA GTDGLLALSA 1810 1820 1830 1840 1850 1860 CPGPSTAGVA GGPVAVEPEV PPVPLPAASS LPRKLLPWEE GPGPPPPPLP GPLSQPQASA 1870 1880 1890 1900 1910 1920 LATVKASIIS ELSSKLQQFG GSSTAGGALP WARGGSGGST DSHHGGASYI PERTSSLQRQ 1930 1940 1950 1960 1970 1980 RLSEDSQTSL LSKPSSSIFQ NWPKPPLPPL PTGSGVSSST AAAPGATSPS ASSASASTRH 1990 2000 2010 2020 2030 2040 LQGVEFEMRP PLLRRAPSPS LLPASDHKVS PAPRPSSLPI LPSGPIYPGL FDIRSSPTGG 2050 2060 2070 2080 2090 2100 AGGSTDPFAP VFVPPHPGIS GGLGGALSGA SRSLSPTRLL SLPPDKPFGA KPLGFWTKFD 2110 2120 2130 2140 2150 VADWLEWLGL SEHRAQFLDH EIDGSHLPAL TKEDYVDLGV TRVGHRMNID RALKFFLER
	Isoform 5 [UniParc]. Checksum: D290DD45558B73AF		1,943	202,919
	10 20 30 40 50 60 MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN LASTRGLQGR 70 80 90 100 110 120 SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK QQVLCALSES LQDVLNYGLF 130 140 150 160 170 180 QPATSGRDAN FLEEERLLRE YPQSFEKGVP YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL 190 200 210 220 230 240 KKFLEYVQLG TSDKVARLLD KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI 250 260 270 280 290 300 DFRARDGMTA LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 310 320 330 340 350 360 LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA LHICALYNKE 370 380 390 400 410 420 TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR NHREQDVVPF QESPKYAARR 430 440 450 460 470 480 RGPPGAGLTV PPALLRANSD TSMALPDWMV FSAPGASSSG TPGPTSGPQG QSQPSAPSTK 490 500 510 520 530 540 LSSGTLRSAS SPRGARARSP SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS 550 560 570 580 590 600 LGSRGRRRKL YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 610 620 630 640 650 660 GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG IDSGSDYIIK 670 680 690 700 710 720 EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ YLESVDEGGV AWRAGLRMGD 730 740 750 760 770 780 FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP 790 800 810 820 830 840 AISLRSKSMT SELEEMVSPW KKKIEYEQQP AAVPSMEKKR TVYQMALNKL DEILAAAQQT 850 860 870 880 890 900 ISASESPGPG GLASLGKHRP KGFFATESSF DPHHRSQPSY DRPSFLPPGP GLMLRQKSIG 910 920 930 940 950 960 AAEDDRPYLA PPAMKFSRSL SVPGSEDIPP PPTTSPPEPP YSTPPAPSSS GRLTPSPRGG 970 980 990 1000 1010 1020 PFNPSSGGPL PASSPSSFDG PSPPDTRGGG REKSLYHSAA LPPAHHHPPH HHHHHAPPPQ 1030 1040 1050 1060 1070 1080 PHHHHAHPPH PPEMETGGSP DDPPPRLALG PQPSLRGWRG GGPSPTSGAP SPSHHSSSGG 1090 1100 1110 1120 1130 1140 SSGPTQAPAL RYFQLPPRAA SAAMYVPARS GRGRKGPLVK QTKVEGEPQK GSIPSASSPT 1150 1160 1170 1180 1190 1200 SPALPRSEPP PAGPSEKNSI PIPTIIIKAP STSSSGRSSQ GSSTEAEPPT QPDGAGGGGS 1210 1220 1230 1240 1250 1260 SPSPAPATSP VPPSPSPVPT PASPSGPATL DFTSQFGAAL VGAARREGGW QNEARRRSTL 1270 1280 1290 1300 1310 1320 FLSTDAGDED GGDSGLGPGG PPGPRLRHSK SIDEGMFSAE PYLRLESGGS SGGYGAYAAG 1330 1340 1350 1360 1370 1380 SRAYGGSGSS SAFTSFLPPR PLVHPLTGKA LDPASPLGLA LAARERALKE SSEGGGTPQP 1390 1400 1410 1420 1430 1440 PPRPPSPRYD APPPTLHHHS PHSPHSPHAR HEPVLRLWGD PARRELGYRA GLGSQEKALT 1450 1460 1470 1480 1490 1500 ASPPAARRSL LHRLPPTAPG VGPLLLQLGP EPPTPHPGVS KAWRTAAPEE PERLPLHVRF 1510 1520 1530 1540 1550 1560 LENCQARPPP AGTRGSSTED GPGVPPPSPR RVLPTSPTSP RGNEENGLPL LVLPPPAPSV 1570 1580 1590 1600 1610 1620 DVDDGEFLFA EPLPPPLEFS NSFEKPESPL TPGPPHPLPD PPSPATPLPA APPPAVAAAP 1630 1640 1650 1660 1670 1680 PTLDSTASSL TSYDSEVATL TQGAPAAPGD PPAPGPPAPA APAPPAPQPG PDPPPGTDSG 1690 1700 1710 1720 1730 1740 IEEVDSRSSS DHPLETISSA STLSSLSAEG GGNTGGVAGG GAGVASGTEL LDTYVAYLDG 1750 1760 1770 1780 1790 1800 QAFGGSGTPG PPYPPQLMTP SKLRGRALGT SGNLRPGPSG GLRDPVTPTS PTVSVTGAGT 1810 1820 1830 1840 1850 1860 DGLLALSACP GPSTAGVAGG PVAVEPEVPP VPLPAASSLP RKLLPWEEGP GPPPPPLPGP 1870 1880 1890 1900 1910 1920 LSQPQASALA TVKASIISEL SSKLQQFGGS STAGGALPWA RGGSGGSTDS HHGGASYIPE 1930 1940 RTSSLQRQRQ YRIVVKSSDF GDF

References

[1]	"Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein." Yao I., Hata Y., Hirao K., Deguchi M., Ide N., Takeuchi M., Takai Y. J. Biol. Chem. 274:27463-27466(1999) [PubMed: 10488079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), INTERACTION WITH DLGAP1 AND DLG4. Tissue: Brain.
[2]	"Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin." Naisbitt S., Kim E., Tu J.C., Xiao B., Sala C., Valtschanoff J., Weinberg R.J., Worley P.F., Sheng M. Neuron 23:569-582(1999) [PubMed: 10433268] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), INTERACTION WITH DLGAP1. Strain: Sprague-Dawley.
[3]	"The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family." Tobaben S.,