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Protein

Insulin-like peptide INSL6

Gene

Insl6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in sperm development and fertilization.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like peptide INSL6
Short name:
Insulin-like peptide 6
Cleaved into the following 2 chains:
Gene namesi
Name:Insl6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi62061. Insl6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001618123 – 188Insulin-like peptide INSL6Add BLAST166
PeptideiPRO_000001618223 – 51Insulin-like peptide INSL6 B chainSequence analysisAdd BLAST29
PropeptideiPRO_000001618353 – 158Connecting peptideSequence analysisAdd BLAST106
PeptideiPRO_0000016184163 – 188Insulin-like peptide INSL6 A chainSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 169By similarity
Disulfide bondi45 ↔ 182By similarity
Disulfide bondi168 ↔ 173By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9WV41.
PRIDEiQ9WV41.

PTM databases

iPTMnetiQ9WV41.
PhosphoSitePlusiQ9WV41.

Expressioni

Tissue specificityi

Testis and prostate specific.

Gene expression databases

BgeeiENSRNOG00000015868.
GenevisibleiQ9WV41. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021298.

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9YE. Eukaryota.
ENOG41117BC. LUCA.
GeneTreeiENSGT00510000049111.
HOGENOMiHOG000113078.
HOVERGENiHBG052136.
InParanoidiQ9WV41.
KOiK05255.
OMAiFWGNHPQ.
OrthoDBiEOG091G0SQ8.
PhylomeDBiQ9WV41.
TreeFamiTF343788.

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR016179. Insulin-like.
IPR017100. Insulin-like_pep_6.
IPR022353. Insulin_CS.
[Graphical view]
PANTHERiPTHR12004:SF1. PTHR12004:SF1. 1 hit.
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PIRSFiPIRSF037062. Insulin-like_peptide_6. 1 hit.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WV41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQLCCSCLL WLGLLLAPFS QEQEEVTSPT KLCGRDLLVE VIKLCGQNDW
60 70 80 90 100
SRFSMEEQSP MTELVPQYTR KVKTFNPHRS SSSWGRFTNP GVSQKKATHT
110 120 130 140 150
WESQSLPNYQ LKKEELLPKT GVHSYHGGKP YVKSVKFQKK NTDKMSTFSG
160 170 180
LFWGNHPQRK RRGFADKCCA IGCSKEELAV ACLPFVDF
Length:188
Mass (Da):21,442
Last modified:November 1, 1999 - v1
Checksum:i50212AB3CE9982B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159506 mRNA. Translation: AAD40956.1.
RefSeqiNP_072105.1. NM_022583.1.
UniGeneiRn.48708.

Genome annotation databases

EnsembliENSRNOT00000021298; ENSRNOP00000021298; ENSRNOG00000015868.
GeneIDi50546.
KEGGirno:50546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159506 mRNA. Translation: AAD40956.1.
RefSeqiNP_072105.1. NM_022583.1.
UniGeneiRn.48708.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021298.

PTM databases

iPTMnetiQ9WV41.
PhosphoSitePlusiQ9WV41.

Proteomic databases

PaxDbiQ9WV41.
PRIDEiQ9WV41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021298; ENSRNOP00000021298; ENSRNOG00000015868.
GeneIDi50546.
KEGGirno:50546.

Organism-specific databases

CTDi11172.
RGDi62061. Insl6.

Phylogenomic databases

eggNOGiENOG410J9YE. Eukaryota.
ENOG41117BC. LUCA.
GeneTreeiENSGT00510000049111.
HOGENOMiHOG000113078.
HOVERGENiHBG052136.
InParanoidiQ9WV41.
KOiK05255.
OMAiFWGNHPQ.
OrthoDBiEOG091G0SQ8.
PhylomeDBiQ9WV41.
TreeFamiTF343788.

Miscellaneous databases

PROiQ9WV41.

Gene expression databases

BgeeiENSRNOG00000015868.
GenevisibleiQ9WV41. RN.

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR016179. Insulin-like.
IPR017100. Insulin-like_pep_6.
IPR022353. Insulin_CS.
[Graphical view]
PANTHERiPTHR12004:SF1. PTHR12004:SF1. 1 hit.
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PIRSFiPIRSF037062. Insulin-like_peptide_6. 1 hit.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINSL6_RAT
AccessioniPrimary (citable) accession number: Q9WV41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.