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Protein

Solute carrier family 2, facilitated glucose transporter member 5

Gene

Slc2a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:12031501, PubMed:19091748). Can mediate the uptake of deoxyglucose, but with low efficiency (By similarity). Essential for fructose uptake in the small intestine (PubMed:19091748, PubMed:26071406). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (PubMed:19091748).By similarity3 Publications

Enzyme regulationi

Fructose uptake is inhibited by cytochalasin B.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311FructoseBy similarity
Binding sitei166 – 1661FructoseBy similarity
Binding sitei287 – 2871FructoseBy similarity
Binding sitei386 – 3861FructoseBy similarity

GO - Molecular functioni

  • fructose binding Source: UniProtKB
  • fructose transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • cellular response to fructose stimulus Source: UniProtKB
  • fructose import across plasma membrane Source: UniProtKB
  • regulation of systemic arterial blood pressure mediated by a chemical signal Source: UniProtKB
  • response to fructose Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-189200. Hexose transport.
R-MMU-428776. Class II GLUTs.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 5
Alternative name(s):
Fructose transporter
Glucose transporter type 5, small intestine
Short name:
GLUT-5
Gene namesi
Name:Slc2a5
Synonyms:Glut5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1928369. Slc2a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicBy similarityAdd
BLAST
Transmembranei18 – 3821Helical; Name=1By similarityAdd
BLAST
Topological domaini39 – 6729ExtracellularBy similarityAdd
BLAST
Transmembranei68 – 9023Helical; Name=2By similarityAdd
BLAST
Topological domaini91 – 977CytoplasmicBy similarity
Transmembranei98 – 11821Helical; Name=3By similarityAdd
BLAST
Topological domaini119 – 1257ExtracellularBy similarity
Transmembranei126 – 14823Helical; Name=4By similarityAdd
BLAST
Topological domaini149 – 16012CytoplasmicBy similarityAdd
BLAST
Transmembranei161 – 18121Helical; Name=5By similarityAdd
BLAST
Topological domaini182 – 19110ExtracellularBy similarity
Transmembranei192 – 21221Helical; Name=6By similarityAdd
BLAST
Topological domaini213 – 27664CytoplasmicBy similarityAdd
BLAST
Transmembranei277 – 29721Helical; Name=7By similarityAdd
BLAST
Topological domaini298 – 31215ExtracellularBy similarityAdd
BLAST
Transmembranei313 – 33321Helical; Name=8By similarityAdd
BLAST
Topological domaini334 – 3418CytoplasmicBy similarity
Transmembranei342 – 36221Helical; Name=9By similarityAdd
BLAST
Topological domaini363 – 3708ExtracellularBy similarity
Transmembranei371 – 39323Helical; Name=10By similarityAdd
BLAST
Topological domaini394 – 41118CytoplasmicBy similarityAdd
BLAST
Transmembranei412 – 43221Helical; Name=11By similarityAdd
BLAST
Topological domaini433 – 4386ExtracellularBy similarity
Transmembranei439 – 45921Helical; Name=12By similarityAdd
BLAST
Topological domaini460 – 50142CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice fed a standard diet appear normal and healthy, and display no visible phenotype (PubMed:18417103, PubMed:19091748, PubMed:26071406). Mutant mice show reduced food intake when kept on a high-frucose diet and about 28% reduction of their body weight within seven days. They loose more weight than wild-type mice that receive similar amounts of high-fructose food (PubMed:19091748). Mutant mice show strongly decreased fructose absorption in the jejunum (PubMed:19091748, PubMed:26071406). Contrary to wild-type, mutant mice have a strongly distended colon and caecum when kept on a high-fructose diet. Their intestines look normal when they are fed a standard diet. Contrary to wild-type, mutant mice do not display increased fructose levels in blood serum when kept on a high-fructose diet. Contrary to wild-type, they do not show increased salt absorption in response to fructose, and do not develop high blood pressure in response to fructose feeding. On the contrary, the blood pressure of mutant mice is strongly decreased after five days on a high-fructose diet. Mutant mice develop hypovolemic shock and die after 7 to 10 days on high-fructose diet (PubMed:19091748). Mutant mice display no defects of cochlear morphology or any hearing defects (PubMed:18417103).3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Solute carrier family 2, facilitated glucose transporter member 5PRO_0000050370Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

MaxQBiQ9WV38.
PaxDbiQ9WV38.
PRIDEiQ9WV38.

PTM databases

iPTMnetiQ9WV38.
PhosphoSiteiQ9WV38.

Expressioni

Tissue specificityi

Detected at the apical membrane of villi in the jejunum (PubMed:18496516, PubMed:19091748, PubMed:26071406). Detected in jejunum mucosa (PubMed:26071406). Detected in epididymis and whole testis (at protein level) (PubMed:18417103). Detected in small intestine, kidney and testis (PubMed:12031501, PubMed:18417103, PubMed:19091748). Detected in cochlea, but not in inner or outer cochlear hair cells (PubMed:18417103).4 Publications

Inductioni

Up-regulated in jejunum by dietary fructose intake (at protein level) (PubMed:18496516). Up-regulated in jejunum by dietary fructose intake (PubMed:18496516, PubMed:26071406). Up-regulated by dietary fructose intake in small intestine and testis (PubMed:12031501).2 Publications

Gene expression databases

BgeeiENSMUSG00000028976.
GenevisibleiQ9WV38. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030826.

Structurei

3D structure databases

ProteinModelPortaliQ9WV38.
SMRiQ9WV38. Positions 7-480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni295 – 2973Fructose bindingBy similarity
Regioni418 – 4192Fructose bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ9WV38.
KOiK08143.
OMAiNTISWMP.
OrthoDBiEOG091G0A9K.
TreeFamiTF313762.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002442. Fru_transpt_5.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01194. GLUCTRSPORT5.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKHQEETG ELTLVLALAT LIAAFGSSFQ YGYNVAAVNS PSEFMQQFYN
60 70 80 90 100
DTYYDRNEEN IESFTLTLLW SLTVSMFPFG GFIGSLMVGT LVNKLGRKGA
110 120 130 140 150
LLFNNIFSIL PAILMGCSQI AQSFELIIIS RLLVGICAGI SSNVVPMYLG
160 170 180 190 200
ELAPKNLRGA LGVVPQLFIT VGILVAQLFG LRSLLANEDG WPVLLGLTGV
210 220 230 240 250
PAGLQLLLLP FFPESPRYLL IQKKDEAAAE RALQTLRGWK DVHLEMEEIR
260 270 280 290 300
KEDEAEKAAG FISVWKLFTM QSLRWQLISM IVLMAGQQLS GVNAIYYYAD
310 320 330 340 350
QIYLSAGVKS DDVQYVTAGT GAVNVFMTIL TIFVVELWGR RFLLLVGFST
360 370 380 390 400
CLIACLVLTA ALALQNTISW MPYISIVCVI VYVIGHALGP SPIPALLITE
410 420 430 440 450
IFLQSSRPAA YMIGGSVHWL SNFTVGLIFP FIQMGLGPYS FIIFATICFL
460 470 480 490 500
TTIYIFMVVP ETKGRTFIEI NQIFTMKNKV SDVYPKKEEE LGALPHAILE

Q
Length:501
Mass (Da):55,409
Last modified:July 27, 2011 - v2
Checksum:i4F562A3BF848E5C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841G → S in AAD42235 (PubMed:12031501).Curated
Sequence conflicti87 – 871M → V in AAD42235 (PubMed:12031501).Curated
Sequence conflicti90 – 901T → N in AAD42235 (PubMed:12031501).Curated
Sequence conflicti97 – 993RKG → KKR in AAD42235 (PubMed:12031501).Curated
Sequence conflicti114 – 1141L → F in AAD42235 (PubMed:12031501).Curated
Sequence conflicti236 – 2361L → I in AAD42235 (PubMed:12031501).Curated
Sequence conflicti471 – 4711N → I in AAD42235 (PubMed:12031501).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161071 mRNA. Translation: AAD42235.1.
AK029720 mRNA. Translation: BAC26582.1.
AL606971 Genomic DNA. Translation: CAM14288.1.
CU210939 Genomic DNA. Translation: CAQ51688.1.
CH466594 Genomic DNA. Translation: EDL14883.1.
BC023500 mRNA. Translation: AAH23500.1.
CCDSiCCDS18968.1.
RefSeqiNP_062715.2. NM_019741.3.
XP_006539139.1. XM_006539076.2.
UniGeneiMm.260220.

Genome annotation databases

EnsembliENSMUST00000030826; ENSMUSP00000030826; ENSMUSG00000028976.
GeneIDi56485.
KEGGimmu:56485.
UCSCiuc008vxk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161071 mRNA. Translation: AAD42235.1.
AK029720 mRNA. Translation: BAC26582.1.
AL606971 Genomic DNA. Translation: CAM14288.1.
CU210939 Genomic DNA. Translation: CAQ51688.1.
CH466594 Genomic DNA. Translation: EDL14883.1.
BC023500 mRNA. Translation: AAH23500.1.
CCDSiCCDS18968.1.
RefSeqiNP_062715.2. NM_019741.3.
XP_006539139.1. XM_006539076.2.
UniGeneiMm.260220.

3D structure databases

ProteinModelPortaliQ9WV38.
SMRiQ9WV38. Positions 7-480.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030826.

PTM databases

iPTMnetiQ9WV38.
PhosphoSiteiQ9WV38.

Proteomic databases

MaxQBiQ9WV38.
PaxDbiQ9WV38.
PRIDEiQ9WV38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030826; ENSMUSP00000030826; ENSMUSG00000028976.
GeneIDi56485.
KEGGimmu:56485.
UCSCiuc008vxk.1. mouse.

Organism-specific databases

CTDi6518.
MGIiMGI:1928369. Slc2a5.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ9WV38.
KOiK08143.
OMAiNTISWMP.
OrthoDBiEOG091G0A9K.
TreeFamiTF313762.

Enzyme and pathway databases

ReactomeiR-MMU-189200. Hexose transport.
R-MMU-428776. Class II GLUTs.

Miscellaneous databases

PROiQ9WV38.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028976.
GenevisibleiQ9WV38. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002442. Fru_transpt_5.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01194. GLUCTRSPORT5.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR5_MOUSE
AccessioniPrimary (citable) accession number: Q9WV38
Secondary accession number(s): Q8R1N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.