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Protein

Probable C->U-editing enzyme APOBEC-2

Gene

Apobec2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation (By similarity).By similarity

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Zinc; catalyticBy similarity
Metal bindingi98 – 981Zinc; catalyticBy similarity
Active sitei100 – 1001Proton donorBy similarity
Metal bindingi128 – 1281Zinc; catalyticBy similarity
Metal bindingi131 – 1311Zinc; catalyticBy similarity

GO - Molecular functioni

  1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA demethylation Source: UniProtKB
  2. mRNA modification Source: MGI
  3. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C->U-editing enzyme APOBEC-2 (EC:3.5.4.-)
Gene namesi
Name:Apobec2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1343178. Apobec2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Probable C->U-editing enzyme APOBEC-2PRO_0000171750Add
BLAST

Proteomic databases

MaxQBiQ9WV35.
PaxDbiQ9WV35.
PRIDEiQ9WV35.

PTM databases

PhosphoSiteiQ9WV35.

Expressioni

Tissue specificityi

Expressed exclusively in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9WV35.
CleanExiMM_APOBEC2.
GenevestigatoriQ9WV35.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ9WV35. 1 interaction.
MINTiMINT-4086476.
STRINGi10090.ENSMUSP00000047402.

Structurei

Secondary structure

1
224
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi46 – 483Combined sources
Helixi49 – 557Combined sources
Beta strandi69 – 757Combined sources
Beta strandi78 – 814Combined sources
Beta strandi85 – 917Combined sources
Helixi99 – 1068Combined sources
Beta strandi107 – 1093Combined sources
Beta strandi118 – 1258Combined sources
Helixi131 – 1399Combined sources
Beta strandi146 – 1538Combined sources
Helixi162 – 17211Combined sources
Beta strandi175 – 1773Combined sources
Helixi181 – 1899Combined sources
Beta strandi191 – 1933Combined sources
Helixi210 – 22314Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RPZNMR-A46-224[»]
ProteinModelPortaliQ9WV35.
SMRiQ9WV35. Positions 46-224.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WV35.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 169106CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG44965.
GeneTreeiENSGT00530000062933.
HOGENOMiHOG000033754.
HOVERGENiHBG107155.
InParanoidiQ9WV35.
KOiK18772.
OMAiCRLRIMK.
OrthoDBiEOG7VHSZC.
PhylomeDBiQ9WV35.
TreeFamiTF331356.

Family and domain databases

InterProiIPR013158. APOBEC_N.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKEEAAEA AAPASQNGDD LENLEDPEKL KELIDLPPFE IVTGVRLPVN
60 70 80 90 100
FFKFQFRNVE YSSGRNKTFL CYVVEVQSKG GQAQATQGYL EDEHAGAHAE
110 120 130 140 150
EAFFNTILPA FDPALKYNVT WYVSSSPCAA CADRILKTLS KTKNLRLLIL
160 170 180 190 200
VSRLFMWEEP EVQAALKKLK EAGCKLRIMK PQDFEYIWQN FVEQEEGESK
210 220
AFEPWEDIQE NFLYYEEKLA DILK
Length:224
Mass (Da):25,660
Last modified:November 1, 1999 - v1
Checksum:i75F98BC2CF2EBE0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161699 mRNA. Translation: AAD45361.1.
BC027530 mRNA. Translation: AAH27530.1.
CCDSiCCDS28868.1.
RefSeqiNP_033824.1. NM_009694.3.
UniGeneiMm.281793.

Genome annotation databases

EnsembliENSMUST00000046549; ENSMUSP00000047402; ENSMUSG00000040694.
GeneIDi11811.
KEGGimmu:11811.
UCSCiuc008cxx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161699 mRNA. Translation: AAD45361.1.
BC027530 mRNA. Translation: AAH27530.1.
CCDSiCCDS28868.1.
RefSeqiNP_033824.1. NM_009694.3.
UniGeneiMm.281793.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RPZNMR-A46-224[»]
ProteinModelPortaliQ9WV35.
SMRiQ9WV35. Positions 46-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WV35. 1 interaction.
MINTiMINT-4086476.
STRINGi10090.ENSMUSP00000047402.

PTM databases

PhosphoSiteiQ9WV35.

Proteomic databases

MaxQBiQ9WV35.
PaxDbiQ9WV35.
PRIDEiQ9WV35.

Protocols and materials databases

DNASUi11811.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046549; ENSMUSP00000047402; ENSMUSG00000040694.
GeneIDi11811.
KEGGimmu:11811.
UCSCiuc008cxx.1. mouse.

Organism-specific databases

CTDi10930.
MGIiMGI:1343178. Apobec2.

Phylogenomic databases

eggNOGiNOG44965.
GeneTreeiENSGT00530000062933.
HOGENOMiHOG000033754.
HOVERGENiHBG107155.
InParanoidiQ9WV35.
KOiK18772.
OMAiCRLRIMK.
OrthoDBiEOG7VHSZC.
PhylomeDBiQ9WV35.
TreeFamiTF331356.

Miscellaneous databases

EvolutionaryTraceiQ9WV35.
NextBioi279683.
PROiQ9WV35.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WV35.
CleanExiMM_APOBEC2.
GenevestigatoriQ9WV35.

Family and domain databases

InterProiIPR013158. APOBEC_N.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family."
    Liao W., Hong S.-H., Chan B.H.-J., Rudolph F.B., Clark S.C., Chan L.
    Biochem. Biophys. Res. Commun. 260:398-404(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiABEC2_MOUSE
AccessioniPrimary (citable) accession number: Q9WV35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1999
Last modified: April 1, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.