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Q9WV35 (ABEC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable C->U-editing enzyme APOBEC-2
EC=3.5.4.-
Gene names
Name:Apobec2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation By similarity.

Cofactor

Zinc By similarity.

Subunit structure

Homotetramer By similarity.

Tissue specificity

Expressed exclusively in heart and skeletal muscle. Ref.3

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 224224Probable C->U-editing enzyme APOBEC-2
PRO_0000171750

Sites

Active site1001Proton donor By similarity
Metal binding601Zinc; catalytic By similarity
Metal binding981Zinc; catalytic By similarity
Metal binding1281Zinc; catalytic By similarity
Metal binding1311Zinc; catalytic By similarity

Secondary structure

1 ............................. 224
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9WV35 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 75F98BC2CF2EBE0A

FASTA22425,660
        10         20         30         40         50         60 
MAQKEEAAEA AAPASQNGDD LENLEDPEKL KELIDLPPFE IVTGVRLPVN FFKFQFRNVE 

        70         80         90        100        110        120 
YSSGRNKTFL CYVVEVQSKG GQAQATQGYL EDEHAGAHAE EAFFNTILPA FDPALKYNVT 

       130        140        150        160        170        180 
WYVSSSPCAA CADRILKTLS KTKNLRLLIL VSRLFMWEEP EVQAALKKLK EAGCKLRIMK 

       190        200        210        220 
PQDFEYIWQN FVEQEEGESK AFEPWEDIQE NFLYYEEKLA DILK

« Hide

References

« Hide 'large scale' references
[1]"APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family."
Liao W., Hong S.-H., Chan B.H.-J., Rudolph F.B., Clark S.C., Chan L.
Biochem. Biophys. Res. Commun. 260:398-404(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[3]"Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif."
Mariani R., Chen D., Schroefelbauer B., Navarro F., Koenig R., Bollman B., Muenk C., Nymark-McMahon H., Landau N.R.
Cell 114:21-31(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF161699 mRNA. Translation: AAD45361.1.
BC027530 mRNA. Translation: AAH27530.1.
IPIIPI00125150.
RefSeqNP_033824.1. NM_009694.3.
UniGeneMm.281793.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2RPZNMR-A46-224[»]
ProteinModelPortalQ9WV35.
SMRQ9WV35. Positions 46-224.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000047402.

PTM databases

PhosphoSiteQ9WV35.

Proteomic databases

PaxDbQ9WV35.
PRIDEQ9WV35.

Protocols and materials databases

DNASU11811.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046549; ENSMUSP00000047402; ENSMUSG00000040694.
GeneID11811.
KEGGmmu:11811.
UCSCuc008cxx.1. mouse.

Organism-specific databases

CTD10930.
MGIMGI:1343178. Apobec2.

Phylogenomic databases

eggNOGNOG44965.
GeneTreeENSGT00530000062933.
HOGENOMHOG000033754.
HOVERGENHBG107155.
InParanoidQ9WV35.
KOK01500.
OMAQDFEYIW.
OrthoDBEOG47H5QZ.

Gene expression databases

BgeeQ9WV35.
CleanExMM_APOBEC2.
GenevestigatorQ9WV35.
GermOnlineENSMUSG00000040694. Mus musculus.

Family and domain databases

InterProIPR013158. APOBEC_N.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamPF08210. APOBEC_N. 1 hit.
[Graphical view]
SUPFAMSSF53927. Cytidine_deaminase-like. 1 hit.
PROSITEPS00903. CYT_DCMP_DEAMINASES. False negative.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9WV35.
NextBio279683.
SOURCESearch...

Entry information

Entry nameABEC2_MOUSE
AccessionPrimary (citable) accession number: Q9WV35
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1999
Last modified: April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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