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Q9WV35

- ABEC2_MOUSE

UniProt

Q9WV35 - ABEC2_MOUSE

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Protein

Probable C->U-editing enzyme APOBEC-2

Gene
Apobec2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation By similarity.

Cofactori

Zinc By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Zinc; catalytic By similarity
Metal bindingi98 – 981Zinc; catalytic By similarity
Active sitei100 – 1001Proton donor By similarity
Metal bindingi128 – 1281Zinc; catalytic By similarity
Metal bindingi131 – 1311Zinc; catalytic By similarity

GO - Molecular functioni

  1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA demethylation Source: UniProtKB
  2. mRNA modification Source: MGI
  3. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C->U-editing enzyme APOBEC-2 (EC:3.5.4.-)
Gene namesi
Name:Apobec2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1343178. Apobec2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Probable C->U-editing enzyme APOBEC-2PRO_0000171750Add
BLAST

Proteomic databases

MaxQBiQ9WV35.
PaxDbiQ9WV35.
PRIDEiQ9WV35.

PTM databases

PhosphoSiteiQ9WV35.

Expressioni

Tissue specificityi

Expressed exclusively in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9WV35.
CleanExiMM_APOBEC2.
GenevestigatoriQ9WV35.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

IntActiQ9WV35. 1 interaction.
MINTiMINT-4086476.
STRINGi10090.ENSMUSP00000047402.

Structurei

Secondary structure

1
224
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi46 – 483
Helixi49 – 557
Beta strandi69 – 757
Beta strandi78 – 814
Beta strandi85 – 917
Helixi99 – 1068
Beta strandi107 – 1093
Beta strandi118 – 1258
Helixi131 – 1399
Beta strandi146 – 1538
Helixi162 – 17211
Beta strandi175 – 1773
Helixi181 – 1899
Beta strandi191 – 1933
Helixi210 – 22314

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RPZNMR-A46-224[»]
ProteinModelPortaliQ9WV35.
SMRiQ9WV35. Positions 46-224.

Miscellaneous databases

EvolutionaryTraceiQ9WV35.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG44965.
GeneTreeiENSGT00530000062933.
HOGENOMiHOG000033754.
HOVERGENiHBG107155.
InParanoidiQ9WV35.
KOiK01500.
OMAiCRLRIMK.
OrthoDBiEOG7VHSZC.
PhylomeDBiQ9WV35.
TreeFamiTF331356.

Family and domain databases

InterProiIPR013158. APOBEC_N.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WV35-1 [UniParc]FASTAAdd to Basket

« Hide

MAQKEEAAEA AAPASQNGDD LENLEDPEKL KELIDLPPFE IVTGVRLPVN    50
FFKFQFRNVE YSSGRNKTFL CYVVEVQSKG GQAQATQGYL EDEHAGAHAE 100
EAFFNTILPA FDPALKYNVT WYVSSSPCAA CADRILKTLS KTKNLRLLIL 150
VSRLFMWEEP EVQAALKKLK EAGCKLRIMK PQDFEYIWQN FVEQEEGESK 200
AFEPWEDIQE NFLYYEEKLA DILK 224
Length:224
Mass (Da):25,660
Last modified:November 1, 1999 - v1
Checksum:i75F98BC2CF2EBE0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF161699 mRNA. Translation: AAD45361.1.
BC027530 mRNA. Translation: AAH27530.1.
CCDSiCCDS28868.1.
RefSeqiNP_033824.1. NM_009694.3.
UniGeneiMm.281793.

Genome annotation databases

EnsembliENSMUST00000046549; ENSMUSP00000047402; ENSMUSG00000040694.
GeneIDi11811.
KEGGimmu:11811.
UCSCiuc008cxx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF161699 mRNA. Translation: AAD45361.1 .
BC027530 mRNA. Translation: AAH27530.1 .
CCDSi CCDS28868.1.
RefSeqi NP_033824.1. NM_009694.3.
UniGenei Mm.281793.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2RPZ NMR - A 46-224 [» ]
ProteinModelPortali Q9WV35.
SMRi Q9WV35. Positions 46-224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9WV35. 1 interaction.
MINTi MINT-4086476.
STRINGi 10090.ENSMUSP00000047402.

PTM databases

PhosphoSitei Q9WV35.

Proteomic databases

MaxQBi Q9WV35.
PaxDbi Q9WV35.
PRIDEi Q9WV35.

Protocols and materials databases

DNASUi 11811.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046549 ; ENSMUSP00000047402 ; ENSMUSG00000040694 .
GeneIDi 11811.
KEGGi mmu:11811.
UCSCi uc008cxx.1. mouse.

Organism-specific databases

CTDi 10930.
MGIi MGI:1343178. Apobec2.

Phylogenomic databases

eggNOGi NOG44965.
GeneTreei ENSGT00530000062933.
HOGENOMi HOG000033754.
HOVERGENi HBG107155.
InParanoidi Q9WV35.
KOi K01500.
OMAi CRLRIMK.
OrthoDBi EOG7VHSZC.
PhylomeDBi Q9WV35.
TreeFami TF331356.

Miscellaneous databases

EvolutionaryTracei Q9WV35.
NextBioi 279683.
PROi Q9WV35.
SOURCEi Search...

Gene expression databases

Bgeei Q9WV35.
CleanExi MM_APOBEC2.
Genevestigatori Q9WV35.

Family and domain databases

InterProi IPR013158. APOBEC_N.
IPR016193. Cytidine_deaminase-like.
[Graphical view ]
Pfami PF08210. APOBEC_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53927. SSF53927. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family."
    Liao W., Hong S.-H., Chan B.H.-J., Rudolph F.B., Clark S.C., Chan L.
    Biochem. Biophys. Res. Commun. 260:398-404(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiABEC2_MOUSE
AccessioniPrimary (citable) accession number: Q9WV35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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