Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9WV35

- ABEC2_MOUSE

UniProt

Q9WV35 - ABEC2_MOUSE

Protein

Probable C->U-editing enzyme APOBEC-2

Gene

Apobec2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation By similarity.By similarity

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Zinc; catalyticBy similarity
    Metal bindingi98 – 981Zinc; catalyticBy similarity
    Active sitei100 – 1001Proton donorBy similarity
    Metal bindingi128 – 1281Zinc; catalyticBy similarity
    Metal bindingi131 – 1311Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA demethylation Source: UniProtKB
    2. mRNA modification Source: MGI
    3. mRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    mRNA processing

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable C->U-editing enzyme APOBEC-2 (EC:3.5.4.-)
    Gene namesi
    Name:Apobec2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1343178. Apobec2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224Probable C->U-editing enzyme APOBEC-2PRO_0000171750Add
    BLAST

    Proteomic databases

    MaxQBiQ9WV35.
    PaxDbiQ9WV35.
    PRIDEiQ9WV35.

    PTM databases

    PhosphoSiteiQ9WV35.

    Expressioni

    Tissue specificityi

    Expressed exclusively in heart and skeletal muscle.1 Publication

    Gene expression databases

    BgeeiQ9WV35.
    CleanExiMM_APOBEC2.
    GenevestigatoriQ9WV35.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    IntActiQ9WV35. 1 interaction.
    MINTiMINT-4086476.
    STRINGi10090.ENSMUSP00000047402.

    Structurei

    Secondary structure

    1
    224
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi46 – 483
    Helixi49 – 557
    Beta strandi69 – 757
    Beta strandi78 – 814
    Beta strandi85 – 917
    Helixi99 – 1068
    Beta strandi107 – 1093
    Beta strandi118 – 1258
    Helixi131 – 1399
    Beta strandi146 – 1538
    Helixi162 – 17211
    Beta strandi175 – 1773
    Helixi181 – 1899
    Beta strandi191 – 1933
    Helixi210 – 22314

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2RPZNMR-A46-224[»]
    ProteinModelPortaliQ9WV35.
    SMRiQ9WV35. Positions 46-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9WV35.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG44965.
    GeneTreeiENSGT00530000062933.
    HOGENOMiHOG000033754.
    HOVERGENiHBG107155.
    InParanoidiQ9WV35.
    KOiK01500.
    OMAiCRLRIMK.
    OrthoDBiEOG7VHSZC.
    PhylomeDBiQ9WV35.
    TreeFamiTF331356.

    Family and domain databases

    InterProiIPR013158. APOBEC_N.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view]
    PfamiPF08210. APOBEC_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9WV35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQKEEAAEA AAPASQNGDD LENLEDPEKL KELIDLPPFE IVTGVRLPVN    50
    FFKFQFRNVE YSSGRNKTFL CYVVEVQSKG GQAQATQGYL EDEHAGAHAE 100
    EAFFNTILPA FDPALKYNVT WYVSSSPCAA CADRILKTLS KTKNLRLLIL 150
    VSRLFMWEEP EVQAALKKLK EAGCKLRIMK PQDFEYIWQN FVEQEEGESK 200
    AFEPWEDIQE NFLYYEEKLA DILK 224
    Length:224
    Mass (Da):25,660
    Last modified:November 1, 1999 - v1
    Checksum:i75F98BC2CF2EBE0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161699 mRNA. Translation: AAD45361.1.
    BC027530 mRNA. Translation: AAH27530.1.
    CCDSiCCDS28868.1.
    RefSeqiNP_033824.1. NM_009694.3.
    UniGeneiMm.281793.

    Genome annotation databases

    EnsembliENSMUST00000046549; ENSMUSP00000047402; ENSMUSG00000040694.
    GeneIDi11811.
    KEGGimmu:11811.
    UCSCiuc008cxx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161699 mRNA. Translation: AAD45361.1 .
    BC027530 mRNA. Translation: AAH27530.1 .
    CCDSi CCDS28868.1.
    RefSeqi NP_033824.1. NM_009694.3.
    UniGenei Mm.281793.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2RPZ NMR - A 46-224 [» ]
    ProteinModelPortali Q9WV35.
    SMRi Q9WV35. Positions 46-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9WV35. 1 interaction.
    MINTi MINT-4086476.
    STRINGi 10090.ENSMUSP00000047402.

    PTM databases

    PhosphoSitei Q9WV35.

    Proteomic databases

    MaxQBi Q9WV35.
    PaxDbi Q9WV35.
    PRIDEi Q9WV35.

    Protocols and materials databases

    DNASUi 11811.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046549 ; ENSMUSP00000047402 ; ENSMUSG00000040694 .
    GeneIDi 11811.
    KEGGi mmu:11811.
    UCSCi uc008cxx.1. mouse.

    Organism-specific databases

    CTDi 10930.
    MGIi MGI:1343178. Apobec2.

    Phylogenomic databases

    eggNOGi NOG44965.
    GeneTreei ENSGT00530000062933.
    HOGENOMi HOG000033754.
    HOVERGENi HBG107155.
    InParanoidi Q9WV35.
    KOi K01500.
    OMAi CRLRIMK.
    OrthoDBi EOG7VHSZC.
    PhylomeDBi Q9WV35.
    TreeFami TF331356.

    Miscellaneous databases

    EvolutionaryTracei Q9WV35.
    NextBioi 279683.
    PROi Q9WV35.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WV35.
    CleanExi MM_APOBEC2.
    Genevestigatori Q9WV35.

    Family and domain databases

    InterProi IPR013158. APOBEC_N.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view ]
    Pfami PF08210. APOBEC_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family."
      Liao W., Hong S.-H., Chan B.H.-J., Rudolph F.B., Clark S.C., Chan L.
      Biochem. Biophys. Res. Commun. 260:398-404(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    3. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiABEC2_MOUSE
    AccessioniPrimary (citable) accession number: Q9WV35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3