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Protein

C->U-editing enzyme APOBEC-2

Gene

Apobec2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.By similarity

Catalytic activityi

Cytosine(6666) in apolipoprotein B mRNA + H2O = uracil(6666) in apolipoprotein B mRNA + NH3.

Cofactori

Zn2+By similarityNote: Binds 1 Zn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc; catalyticBy similarity1
Metal bindingi98Zinc; catalyticBy similarity1
Active sitei100Proton donorBy similarity1
Metal bindingi128Zinc; catalyticBy similarity1
Metal bindingi131Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

  • DNA demethylation Source: UniProtKB
  • mRNA modification Source: MGI
  • mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
C->U-editing enzyme APOBEC-2 (EC:3.5.4.36)
Alternative name(s):
mRNA(cytosine(6666)) deaminase 2
Gene namesi
Name:Apobec2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1343178. Apobec2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001717501 – 224C->U-editing enzyme APOBEC-2Add BLAST224

Proteomic databases

MaxQBiQ9WV35.
PaxDbiQ9WV35.
PeptideAtlasiQ9WV35.
PRIDEiQ9WV35.

PTM databases

iPTMnetiQ9WV35.
PhosphoSitePlusiQ9WV35.

Expressioni

Tissue specificityi

Expressed exclusively in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000040694.
CleanExiMM_APOBEC2.
GenevisibleiQ9WV35. MM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ9WV35. 1 interactor.
MINTiMINT-4086476.
STRINGi10090.ENSMUSP00000047402.

Structurei

Secondary structure

1224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi46 – 48Combined sources3
Helixi49 – 55Combined sources7
Beta strandi69 – 75Combined sources7
Beta strandi78 – 81Combined sources4
Beta strandi85 – 91Combined sources7
Helixi99 – 106Combined sources8
Beta strandi107 – 109Combined sources3
Beta strandi118 – 125Combined sources8
Helixi131 – 139Combined sources9
Beta strandi146 – 153Combined sources8
Helixi162 – 172Combined sources11
Beta strandi175 – 177Combined sources3
Helixi181 – 189Combined sources9
Beta strandi191 – 193Combined sources3
Helixi210 – 223Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RPZNMR-A46-224[»]
ProteinModelPortaliQ9WV35.
SMRiQ9WV35.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WV35.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 169CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IX13. Eukaryota.
ENOG4111K4B. LUCA.
GeneTreeiENSGT00530000062933.
HOGENOMiHOG000033754.
HOVERGENiHBG107155.
InParanoidiQ9WV35.
KOiK18772.
OMAiQSKAFEP.
OrthoDBiEOG091G0JNJ.
PhylomeDBiQ9WV35.
TreeFamiTF331356.

Family and domain databases

InterProiIPR013158. APOBEC_N.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKEEAAEA AAPASQNGDD LENLEDPEKL KELIDLPPFE IVTGVRLPVN
60 70 80 90 100
FFKFQFRNVE YSSGRNKTFL CYVVEVQSKG GQAQATQGYL EDEHAGAHAE
110 120 130 140 150
EAFFNTILPA FDPALKYNVT WYVSSSPCAA CADRILKTLS KTKNLRLLIL
160 170 180 190 200
VSRLFMWEEP EVQAALKKLK EAGCKLRIMK PQDFEYIWQN FVEQEEGESK
210 220
AFEPWEDIQE NFLYYEEKLA DILK
Length:224
Mass (Da):25,660
Last modified:November 1, 1999 - v1
Checksum:i75F98BC2CF2EBE0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161699 mRNA. Translation: AAD45361.1.
BC027530 mRNA. Translation: AAH27530.1.
CCDSiCCDS28868.1.
RefSeqiNP_033824.1. NM_009694.3.
UniGeneiMm.281793.

Genome annotation databases

EnsembliENSMUST00000046549; ENSMUSP00000047402; ENSMUSG00000040694.
GeneIDi11811.
KEGGimmu:11811.
UCSCiuc008cxx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161699 mRNA. Translation: AAD45361.1.
BC027530 mRNA. Translation: AAH27530.1.
CCDSiCCDS28868.1.
RefSeqiNP_033824.1. NM_009694.3.
UniGeneiMm.281793.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RPZNMR-A46-224[»]
ProteinModelPortaliQ9WV35.
SMRiQ9WV35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WV35. 1 interactor.
MINTiMINT-4086476.
STRINGi10090.ENSMUSP00000047402.

PTM databases

iPTMnetiQ9WV35.
PhosphoSitePlusiQ9WV35.

Proteomic databases

MaxQBiQ9WV35.
PaxDbiQ9WV35.
PeptideAtlasiQ9WV35.
PRIDEiQ9WV35.

Protocols and materials databases

DNASUi11811.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046549; ENSMUSP00000047402; ENSMUSG00000040694.
GeneIDi11811.
KEGGimmu:11811.
UCSCiuc008cxx.1. mouse.

Organism-specific databases

CTDi10930.
MGIiMGI:1343178. Apobec2.

Phylogenomic databases

eggNOGiENOG410IX13. Eukaryota.
ENOG4111K4B. LUCA.
GeneTreeiENSGT00530000062933.
HOGENOMiHOG000033754.
HOVERGENiHBG107155.
InParanoidiQ9WV35.
KOiK18772.
OMAiQSKAFEP.
OrthoDBiEOG091G0JNJ.
PhylomeDBiQ9WV35.
TreeFamiTF331356.

Miscellaneous databases

EvolutionaryTraceiQ9WV35.
PROiQ9WV35.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040694.
CleanExiMM_APOBEC2.
GenevisibleiQ9WV35. MM.

Family and domain databases

InterProiIPR013158. APOBEC_N.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABEC2_MOUSE
AccessioniPrimary (citable) accession number: Q9WV35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.