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Protein

MAGUK p55 subfamily member 2

Gene

Mpp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (PubMed:26880549). Seems to negatively regulate SRC function in epithelial cells (By similarity).By similarity1 Publication

GO - Molecular functioni

  • ion channel binding Source: UniProtKB
  • PDZ domain binding Source: Ensembl

GO - Biological processi

  • excitatory postsynaptic potential Source: UniProtKB
  • long-term synaptic potentiation Source: UniProtKB
  • protein homooligomerization Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 2
Alternative name(s):
Discs large homolog 2
Protein MPP2
Gene namesi
Name:Mpp2Imported
Synonyms:Dlgh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1858257. Mpp2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945741 – 552MAGUK p55 subfamily member 2Add BLAST552

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineBy similarity1
Modified residuei117PhosphothreonineCombined sources1
Modified residuei121PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by SRC.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WV34.
PaxDbiQ9WV34.
PeptideAtlasiQ9WV34.
PRIDEiQ9WV34.

PTM databases

iPTMnetiQ9WV34.
PhosphoSitePlusiQ9WV34.
SwissPalmiQ9WV34.

Expressioni

Tissue specificityi

Expressed in pyramidal neurons of CA1 region of the hippoocampus.1 Publication

Gene expression databases

BgeeiENSMUSG00000017314.
GenevisibleiQ9WV34. MM.

Interactioni

Subunit structurei

Can homomultimerise. Interacts with CACNG2. Interacts (via the SH3-Guanylate kinase-like sub-module) with DLG4/PSD95 and DLGAP1/GKAP. Interacts (via the PDZ domain) with CADM1 (via C-terminus) (By similarity). Interacts with KCNN2/SK2 (via N-terminal domain) (PubMed:26880549). Interacts with SRC (By similarity).By similarity1 Publication

GO - Molecular functioni

  • ion channel binding Source: UniProtKB
  • PDZ domain binding Source: Ensembl

Protein-protein interaction databases

BioGridi206171. 3 interactors.
IntActiQ9WV34. 4 interactors.
MINTiMINT-4102340.
STRINGi10090.ENSMUSP00000017458.

Structurei

3D structure databases

ProteinModelPortaliQ9WV34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 59L27 1PROSITE-ProRule annotationAdd BLAST52
Domaini60 – 118L27 2PROSITE-ProRule annotationAdd BLAST59
Domaini140 – 219PDZPROSITE-ProRule annotationAdd BLAST80
Domaini225 – 293SH3PROSITE-ProRule annotationAdd BLAST69
Domaini350 – 537Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST188

Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ9WV34.
OMAiSPGLDPT.
OrthoDBiEOG091G065I.
PhylomeDBiQ9WV34.
TreeFamiTF314263.

Family and domain databases

CDDicd12037. SH3_MPP2. 1 hit.
Gene3Di1.10.287.650. 2 hits.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR035602. MPP2_SH3.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9WV34-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVAATNSES AMQQVLDNLG SLPNATGAAE LDLIFLRGIM ESPIVRSLAK
60 70 80 90 100
AHERLEETKL EAVRDNNLEL VQEILRDLAE LAEQSSTAAE LARILQEPHF
110 120 130 140 150
QSLLETHDSV ASKTYETPPP SPGLDPTFSN QPVPPDAVRM VGIRKTAGEH
160 170 180 190 200
LGVTFRVEGG ELVIARILHG GMVAQQGLLH VGDIIKEVNG QPVGSDPRAL
210 220 230 240 250
QELLRSASGS VILKILPSYQ EPHLPRQVFV KCHFDYDPAR DSLSPCKEAG
260 270 280 290 300
LRFNAGDLLQ IVNQDDANWW QACHVEGGSA GLIPSQLLEE KRKAFVKRDL
310 320 330 340 350
ELTPTSGTLC GSLSGKKKKR MMYLTTKNAE FDRHELLIYE EVARMPPFRR
360 370 380 390 400
KTLVLIGAQG VGRRSLKNKL ILWDPDRYGT TVPYTSRRPK DSEREGQGYS
410 420 430 440 450
FVSRGEMEAD IRAGRYLEHG EYEGNLYGTR IDSIRGVVAS GKVCVLDVNP
460 470 480 490 500
QAVKVLRTAE FVPYVVFIEA PDYETLRAMN RAALESGVST KQLTEADLRR
510 520 530 540 550
TVEESSRIQR GYGHYFDLSL VNSNLERTFR ELQTAMEKLR TEPQWVPVSW

VY
Length:552
Mass (Da):61,555
Last modified:November 1, 1999 - v1
Checksum:iE932CD208309E0FA
GO
Isoform 2 (identifier: Q9WV34-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MPVAATNSES → MACSPGSEGSLEGISLGSSEEAELRRE

Note: No experimental confirmation available.
Show »
Length:569
Mass (Da):63,331
Checksum:iAA5BE8652F410F0D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215I → T in BAE42909 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0229521 – 10MPVAATNSES → MACSPGSEGSLEGISLGSSE EAELRRE in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162685 mRNA. Translation: AAD44342.1.
AK141422 mRNA. Translation: BAE24680.1.
AK161577 mRNA. Translation: BAE36473.1.
AK172253 mRNA. Translation: BAE42909.1.
AL591145 Genomic DNA. Translation: CAM23252.1.
BC053026 mRNA. Translation: AAH53026.1.
CCDSiCCDS25485.1. [Q9WV34-1]
RefSeqiNP_057904.1. NM_016695.3. [Q9WV34-1]
XP_006533746.1. XM_006533683.3. [Q9WV34-2]
XP_006533747.1. XM_006533684.3. [Q9WV34-1]
XP_006533748.1. XM_006533685.3. [Q9WV34-1]
UniGeneiMm.36242.

Genome annotation databases

EnsembliENSMUST00000017458; ENSMUSP00000017458; ENSMUSG00000017314. [Q9WV34-1]
ENSMUST00000100398; ENSMUSP00000097967; ENSMUSG00000017314. [Q9WV34-2]
GeneIDi50997.
KEGGimmu:50997.
UCSCiuc007lqk.2. mouse. [Q9WV34-2]
uc007lql.2. mouse. [Q9WV34-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMPP2_MOUSE
AccessioniPrimary (citable) accession number: Q9WV34
Secondary accession number(s): B1AQF8
, Q3T9W1, Q3TT52, Q3URK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 1, 1999
Last modified: September 27, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families