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Protein

MAGUK p55 subfamily member 2

Gene

Mpp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 2
Alternative name(s):
Discs large homolog 2
Protein MPP2
Gene namesi
Name:Mpp2
Synonyms:Dlgh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1858257. Mpp2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945741 – 552MAGUK p55 subfamily member 2Add BLAST552

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphothreonineCombined sources1
Modified residuei121PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WV34.
PaxDbiQ9WV34.
PeptideAtlasiQ9WV34.
PRIDEiQ9WV34.

PTM databases

iPTMnetiQ9WV34.
PhosphoSitePlusiQ9WV34.
SwissPalmiQ9WV34.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017314.
GenevisibleiQ9WV34. MM.

Interactioni

Protein-protein interaction databases

BioGridi206171. 1 interactor.
IntActiQ9WV34. 4 interactors.
MINTiMINT-4102340.
STRINGi10090.ENSMUSP00000017458.

Structurei

3D structure databases

ProteinModelPortaliQ9WV34.
SMRiQ9WV34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 59L27 1PROSITE-ProRule annotationAdd BLAST52
Domaini60 – 118L27 2PROSITE-ProRule annotationAdd BLAST59
Domaini140 – 219PDZPROSITE-ProRule annotationAdd BLAST80
Domaini225 – 293SH3PROSITE-ProRule annotationAdd BLAST69
Domaini350 – 537Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST188

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 2 L27 domains.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ9WV34.
OMAiKLIMSDQ.
OrthoDBiEOG091G065I.
PhylomeDBiQ9WV34.
TreeFamiTF314263.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9WV34-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVAATNSES AMQQVLDNLG SLPNATGAAE LDLIFLRGIM ESPIVRSLAK
60 70 80 90 100
AHERLEETKL EAVRDNNLEL VQEILRDLAE LAEQSSTAAE LARILQEPHF
110 120 130 140 150
QSLLETHDSV ASKTYETPPP SPGLDPTFSN QPVPPDAVRM VGIRKTAGEH
160 170 180 190 200
LGVTFRVEGG ELVIARILHG GMVAQQGLLH VGDIIKEVNG QPVGSDPRAL
210 220 230 240 250
QELLRSASGS VILKILPSYQ EPHLPRQVFV KCHFDYDPAR DSLSPCKEAG
260 270 280 290 300
LRFNAGDLLQ IVNQDDANWW QACHVEGGSA GLIPSQLLEE KRKAFVKRDL
310 320 330 340 350
ELTPTSGTLC GSLSGKKKKR MMYLTTKNAE FDRHELLIYE EVARMPPFRR
360 370 380 390 400
KTLVLIGAQG VGRRSLKNKL ILWDPDRYGT TVPYTSRRPK DSEREGQGYS
410 420 430 440 450
FVSRGEMEAD IRAGRYLEHG EYEGNLYGTR IDSIRGVVAS GKVCVLDVNP
460 470 480 490 500
QAVKVLRTAE FVPYVVFIEA PDYETLRAMN RAALESGVST KQLTEADLRR
510 520 530 540 550
TVEESSRIQR GYGHYFDLSL VNSNLERTFR ELQTAMEKLR TEPQWVPVSW

VY
Length:552
Mass (Da):61,555
Last modified:November 1, 1999 - v1
Checksum:iE932CD208309E0FA
GO
Isoform 2 (identifier: Q9WV34-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MPVAATNSES → MACSPGSEGSLEGISLGSSEEAELRRE

Note: No experimental confirmation available.
Show »
Length:569
Mass (Da):63,331
Checksum:iAA5BE8652F410F0D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215I → T in BAE42909 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0229521 – 10MPVAATNSES → MACSPGSEGSLEGISLGSSE EAELRRE in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162685 mRNA. Translation: AAD44342.1.
AK141422 mRNA. Translation: BAE24680.1.
AK161577 mRNA. Translation: BAE36473.1.
AK172253 mRNA. Translation: BAE42909.1.
AL591145 Genomic DNA. Translation: CAM23252.1.
BC053026 mRNA. Translation: AAH53026.1.
CCDSiCCDS25485.1. [Q9WV34-1]
RefSeqiNP_057904.1. NM_016695.3. [Q9WV34-1]
XP_006533746.1. XM_006533683.3. [Q9WV34-2]
XP_006533747.1. XM_006533684.3. [Q9WV34-1]
XP_006533748.1. XM_006533685.3. [Q9WV34-1]
UniGeneiMm.36242.

Genome annotation databases

EnsembliENSMUST00000017458; ENSMUSP00000017458; ENSMUSG00000017314. [Q9WV34-1]
ENSMUST00000100398; ENSMUSP00000097967; ENSMUSG00000017314. [Q9WV34-2]
GeneIDi50997.
KEGGimmu:50997.
UCSCiuc007lqk.2. mouse. [Q9WV34-2]
uc007lql.2. mouse. [Q9WV34-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162685 mRNA. Translation: AAD44342.1.
AK141422 mRNA. Translation: BAE24680.1.
AK161577 mRNA. Translation: BAE36473.1.
AK172253 mRNA. Translation: BAE42909.1.
AL591145 Genomic DNA. Translation: CAM23252.1.
BC053026 mRNA. Translation: AAH53026.1.
CCDSiCCDS25485.1. [Q9WV34-1]
RefSeqiNP_057904.1. NM_016695.3. [Q9WV34-1]
XP_006533746.1. XM_006533683.3. [Q9WV34-2]
XP_006533747.1. XM_006533684.3. [Q9WV34-1]
XP_006533748.1. XM_006533685.3. [Q9WV34-1]
UniGeneiMm.36242.

3D structure databases

ProteinModelPortaliQ9WV34.
SMRiQ9WV34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206171. 1 interactor.
IntActiQ9WV34. 4 interactors.
MINTiMINT-4102340.
STRINGi10090.ENSMUSP00000017458.

PTM databases

iPTMnetiQ9WV34.
PhosphoSitePlusiQ9WV34.
SwissPalmiQ9WV34.

Proteomic databases

EPDiQ9WV34.
PaxDbiQ9WV34.
PeptideAtlasiQ9WV34.
PRIDEiQ9WV34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017458; ENSMUSP00000017458; ENSMUSG00000017314. [Q9WV34-1]
ENSMUST00000100398; ENSMUSP00000097967; ENSMUSG00000017314. [Q9WV34-2]
GeneIDi50997.
KEGGimmu:50997.
UCSCiuc007lqk.2. mouse. [Q9WV34-2]
uc007lql.2. mouse. [Q9WV34-1]

Organism-specific databases

CTDi4355.
MGIiMGI:1858257. Mpp2.

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ9WV34.
OMAiKLIMSDQ.
OrthoDBiEOG091G065I.
PhylomeDBiQ9WV34.
TreeFamiTF314263.

Miscellaneous databases

ChiTaRSiMpp2. mouse.
PROiQ9WV34.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017314.
GenevisibleiQ9WV34. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPP2_MOUSE
AccessioniPrimary (citable) accession number: Q9WV34
Secondary accession number(s): B1AQF8
, Q3T9W1, Q3TT52, Q3URK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.