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Protein

Actin-related protein 2/3 complex subunit 1B

Gene

Arpc1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1B
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:Arpc1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1343142. Arpc1b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508561 – 372Actin-related protein 2/3 complex subunit 1BAdd BLAST372

Proteomic databases

EPDiQ9WV32.
MaxQBiQ9WV32.
PaxDbiQ9WV32.
PRIDEiQ9WV32.

PTM databases

iPTMnetiQ9WV32.
PhosphoSitePlusiQ9WV32.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029622.
CleanExiMM_ARPC1B.
ExpressionAtlasiQ9WV32. baseline and differential.
GenevisibleiQ9WV32. MM.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198208. 3 interactors.
IntActiQ9WV32. 3 interactors.
MINTiMINT-4088208.
STRINGi10090.ENSMUSP00000082822.

Structurei

3D structure databases

ProteinModelPortaliQ9WV32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 45WD 1Add BLAST40
Repeati50 – 89WD 2Add BLAST40
Repeati94 – 135WD 3Add BLAST42
Repeati140 – 179WD 4Add BLAST40
Repeati242 – 280WD 5Add BLAST39
Repeati324 – 367WD 6Add BLAST44

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1523. Eukaryota.
ENOG410XNWX. LUCA.
GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
HOVERGENiHBG050560.
InParanoidiQ9WV32.
KOiK05757.
TreeFamiTF315041.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR030141. ARC1B.
IPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PANTHERiPTHR10709. PTHR10709. 1 hit.
PTHR10709:SF10. PTHR10709:SF10. 1 hit.
PfamiView protein in Pfam
PF00400. WD40. 2 hits.
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiView protein in SMART
SM00320. WD40. 5 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WV32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWNKVHELKE
60 70 80 90 100
HNGQVTGIDW APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR
110 120 130 140 150
CVRWAPNENK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNNVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS
210 220 230 240 250
SCGWVHGVCF SASGSRVAWV SHDSTVCLVD ADKKMAVATL ASETLPLLAV
260 270 280 290 300
TFITENSLVA AGHDCFPVLF TYDNAAVTLS FGGRLDVPKQ SSQRGMTARE
310 320 330 340 350
RFQNLDKKAS SEGGAATGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM
360 370
DGGMSIWDVK SLESALKDLK IK
Length:372
Mass (Da):41,064
Last modified:July 27, 2011 - v4
Checksum:i0315BFB6E8697D89
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112A → R in AAD43352 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162768 mRNA. Translation: AAD43352.1.
AK002274 mRNA. Translation: BAB21980.1.
AK005378 mRNA. Translation: BAB23985.1.
AK147731 mRNA. Translation: BAE28101.1.
AK148145 mRNA. Translation: BAE28373.1.
AK159371 mRNA. Translation: BAE35028.1.
AK167978 mRNA. Translation: BAE39970.1.
AK168774 mRNA. Translation: BAE40610.1.
AK172124 mRNA. Translation: BAE42835.1.
CH466529 Genomic DNA. Translation: EDL19001.1.
CH466529 Genomic DNA. Translation: EDL19002.1.
BC003441 mRNA. Translation: AAH03441.1.
CCDSiCCDS19856.1.
RefSeqiNP_075631.2. NM_023142.2.
UniGeneiMm.30010.

Genome annotation databases

EnsembliENSMUST00000085679; ENSMUSP00000082822; ENSMUSG00000029622.
GeneIDi11867.
KEGGimmu:11867.
UCSCiuc009amb.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiARC1B_MOUSE
AccessioniPrimary (citable) accession number: Q9WV32
Secondary accession number(s): Q9CRC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 27, 2011
Last modified: November 22, 2017
This is version 137 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families