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Protein

Actin-related protein 2/3 complex subunit 1B

Gene

Arpc1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1B
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:Arpc1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1343142. Arpc1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 372371Actin-related protein 2/3 complex subunit 1BPRO_0000050856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei82 – 821N6-acetyllysineBy similarity
Modified residuei310 – 3101PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9WV32.
MaxQBiQ9WV32.
PaxDbiQ9WV32.
PRIDEiQ9WV32.

PTM databases

iPTMnetiQ9WV32.
PhosphoSiteiQ9WV32.

Expressioni

Gene expression databases

BgeeiQ9WV32.
CleanExiMM_ARPC1B.
ExpressionAtlasiQ9WV32. baseline and differential.
GenevisibleiQ9WV32. MM.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198208. 3 interactions.
IntActiQ9WV32. 2 interactions.
MINTiMINT-4088208.
STRINGi10090.ENSMUSP00000082822.

Structurei

3D structure databases

ProteinModelPortaliQ9WV32.
SMRiQ9WV32. Positions 2-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 4540WD 1Add
BLAST
Repeati50 – 8940WD 2Add
BLAST
Repeati94 – 13542WD 3Add
BLAST
Repeati140 – 17940WD 4Add
BLAST
Repeati242 – 28039WD 5Add
BLAST
Repeati324 – 36744WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1523. Eukaryota.
ENOG410XNWX. LUCA.
GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
HOVERGENiHBG050560.
InParanoidiQ9WV32.
KOiK05757.
OrthoDBiEOG77DJ62.
TreeFamiTF315041.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR030141. ARC1B.
IPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PTHR10709:SF10. PTHR10709:SF10. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WV32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWNKVHELKE
60 70 80 90 100
HNGQVTGIDW APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR
110 120 130 140 150
CVRWAPNENK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNNVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS
210 220 230 240 250
SCGWVHGVCF SASGSRVAWV SHDSTVCLVD ADKKMAVATL ASETLPLLAV
260 270 280 290 300
TFITENSLVA AGHDCFPVLF TYDNAAVTLS FGGRLDVPKQ SSQRGMTARE
310 320 330 340 350
RFQNLDKKAS SEGGAATGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM
360 370
DGGMSIWDVK SLESALKDLK IK
Length:372
Mass (Da):41,064
Last modified:July 27, 2011 - v4
Checksum:i0315BFB6E8697D89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121A → R in AAD43352 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162768 mRNA. Translation: AAD43352.1.
AK002274 mRNA. Translation: BAB21980.1.
AK005378 mRNA. Translation: BAB23985.1.
AK147731 mRNA. Translation: BAE28101.1.
AK148145 mRNA. Translation: BAE28373.1.
AK159371 mRNA. Translation: BAE35028.1.
AK167978 mRNA. Translation: BAE39970.1.
AK168774 mRNA. Translation: BAE40610.1.
AK172124 mRNA. Translation: BAE42835.1.
CH466529 Genomic DNA. Translation: EDL19001.1.
CH466529 Genomic DNA. Translation: EDL19002.1.
BC003441 mRNA. Translation: AAH03441.1.
CCDSiCCDS19856.1.
RefSeqiNP_075631.2. NM_023142.2.
UniGeneiMm.30010.

Genome annotation databases

EnsembliENSMUST00000085679; ENSMUSP00000082822; ENSMUSG00000029622.
GeneIDi11867.
KEGGimmu:11867.
UCSCiuc009amb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162768 mRNA. Translation: AAD43352.1.
AK002274 mRNA. Translation: BAB21980.1.
AK005378 mRNA. Translation: BAB23985.1.
AK147731 mRNA. Translation: BAE28101.1.
AK148145 mRNA. Translation: BAE28373.1.
AK159371 mRNA. Translation: BAE35028.1.
AK167978 mRNA. Translation: BAE39970.1.
AK168774 mRNA. Translation: BAE40610.1.
AK172124 mRNA. Translation: BAE42835.1.
CH466529 Genomic DNA. Translation: EDL19001.1.
CH466529 Genomic DNA. Translation: EDL19002.1.
BC003441 mRNA. Translation: AAH03441.1.
CCDSiCCDS19856.1.
RefSeqiNP_075631.2. NM_023142.2.
UniGeneiMm.30010.

3D structure databases

ProteinModelPortaliQ9WV32.
SMRiQ9WV32. Positions 2-371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198208. 3 interactions.
IntActiQ9WV32. 2 interactions.
MINTiMINT-4088208.
STRINGi10090.ENSMUSP00000082822.

PTM databases

iPTMnetiQ9WV32.
PhosphoSiteiQ9WV32.

Proteomic databases

EPDiQ9WV32.
MaxQBiQ9WV32.
PaxDbiQ9WV32.
PRIDEiQ9WV32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085679; ENSMUSP00000082822; ENSMUSG00000029622.
GeneIDi11867.
KEGGimmu:11867.
UCSCiuc009amb.2. mouse.

Organism-specific databases

CTDi10095.
MGIiMGI:1343142. Arpc1b.

Phylogenomic databases

eggNOGiKOG1523. Eukaryota.
ENOG410XNWX. LUCA.
GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
HOVERGENiHBG050560.
InParanoidiQ9WV32.
KOiK05757.
OrthoDBiEOG77DJ62.
TreeFamiTF315041.

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Miscellaneous databases

PROiQ9WV32.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WV32.
CleanExiMM_ARPC1B.
ExpressionAtlasiQ9WV32. baseline and differential.
GenevisibleiQ9WV32. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR030141. ARC1B.
IPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PTHR10709:SF10. PTHR10709:SF10. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of parental allele-specific expression of genes showing altered expression in parthenogenetic embryos."
    Mann M., Okano K., Oppedisano L., Truscott E., Varmuza S.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J, DBA/2J and NOD.
    Tissue: Cerebellum, Heart, Kidney and Spleen.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiARC1B_MOUSE
AccessioniPrimary (citable) accession number: Q9WV32
Secondary accession number(s): Q9CRC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.