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Protein

Activity-regulated cytoskeleton-associated protein

Gene

Arc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.By similarity2 Publications

Miscellaneous

Widely used as activity-dependent neuronal marker to identify recently activated neurons in behavioral studies.1 Publication

GO - Molecular functioni

  • actin binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processEndocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Activity-regulated cytoskeleton-associated protein
Alternative name(s):
ARC/ARG3.1
Short name:
mArc
Activity-regulated gene 3.1 protein homolog
Short name:
Arg3.1
Gene namesi
Name:ArcImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88067. Arc.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Mice show deficits in several forms of long-term memory formation including spatial and fear-related learning, conditioned taste aversion as well as long-term object recognition. They show enhanced early-phase but impaired late-phase long-term potentiation (LTP) as well as impaired long-term depression (LTD). Neurons lacking Arc show an increase in surface levels of AMPA receptors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002732861 – 396Activity-regulated cytoskeleton-associated proteinAdd BLAST396

Proteomic databases

PaxDbiQ9WV31.
PeptideAtlasiQ9WV31.
PRIDEiQ9WV31.

PTM databases

iPTMnetiQ9WV31.
PhosphoSitePlusiQ9WV31.
SwissPalmiQ9WV31.

Expressioni

Tissue specificityi

Expressed in brain and testis.1 Publication

Developmental stagei

Detectable in brain from postnatal week 1, in testis from postnatal week 3.1 Publication

Gene expression databases

BgeeiENSMUSG00000022602.
GenevisibleiQ9WV31. MM.

Interactioni

Subunit structurei

Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin binding Source: MGI

Protein-protein interaction databases

BioGridi198182. 5 interactors.
DIPiDIP-31565N.
IntActiQ9WV31. 8 interactors.
STRINGi10090.ENSMUSP00000023268.

Structurei

3D structure databases

ProteinModelPortaliQ9WV31.
SMRiQ9WV31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni89 – 100Binds SH3GL1 or SH3GL3By similarityAdd BLAST12
Regioni195 – 214Required for binding DNM2By similarityAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili54 – 78Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the ARC/ARG3.1 family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIAZ. Eukaryota.
ENOG410YF34. LUCA.
GeneTreeiENSGT00390000003914.
HOGENOMiHOG000034037.
HOVERGENiHBG080862.
InParanoidiQ9WV31.
KOiK15867.
OMAiLERWVKR.
OrthoDBiEOG091G07HQ.
PhylomeDBiQ9WV31.
TreeFamiTF335604.

Family and domain databases

InterProiView protein in InterPro
IPR023263. Activity-reg_cytoskelet-assoc.
PANTHERiPTHR15962. PTHR15962. 1 hit.
PRINTSiPR02027. ARCARG31.

Sequencei

Sequence statusi: Complete.

Q9WV31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELDHMTTGG LHAYPAPRGG PAAKPNVILQ IGKCRAEMLE HVRRTHRHLL
60 70 80 90 100
TEVSKQVERE LKGLHRSVGK LENNLDGYVP TGDSQRWKKS IKACLCRCQE
110 120 130 140 150
TIANLERWVK REMHVWREVF YRLERWADRL ESMGGKYPVG SEPARHTVSV
160 170 180 190 200
GVGGPEPYCQ EADGYDYTVS PYAITPPPAA GELPEQESVE AQQYQSWGPG
210 220 230 240 250
EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS QIQNHMNGPA
260 270 280 290 300
KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELEL PQKQGEPLDQ
310 320 330 340 350
FLWRKRDLYQ TLYVDAEEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ
360 370 380 390
RGMEVQDGLE QAAEPSGTPL PTEDETEALT PALTSESVAS DRTQPE
Length:396
Mass (Da):45,321
Last modified:November 1, 1999 - v1
Checksum:iF4D3505FD477D18A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177701 Genomic DNA. Translation: AAK91587.1.
AF162777 mRNA. Translation: AAD43586.1.
AK157822 mRNA. Translation: BAE34212.1.
AK170446 mRNA. Translation: BAE41804.1.
BC023127 mRNA. Translation: AAH23127.1.
AF254662 Genomic DNA. Translation: AAG10254.1.
CCDSiCCDS37102.1.
RefSeqiNP_001263613.1. NM_001276684.1.
NP_061260.1. NM_018790.3.
UniGeneiMm.491310.

Genome annotation databases

EnsembliENSMUST00000023268; ENSMUSP00000023268; ENSMUSG00000022602.
ENSMUST00000110009; ENSMUSP00000105636; ENSMUSG00000022602.
GeneIDi11838.
KEGGimmu:11838.
UCSCiuc007wfn.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiARC_MOUSE
AccessioniPrimary (citable) accession number: Q9WV31
Secondary accession number(s): Q9ES15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 1, 1999
Last modified: June 7, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families