Reviewed,
UniProtKB/Swiss-Prot Q9WV31 (ARC_MOUSE)
Last modified
June 16, 2009.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Activity-regulated cytoskeleton-associated protein Alternative name(s): Activity-regulated gene 3.1 protein homolog Short name=Arg3.1 ARC/ARG3.1 Short name=mArc | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 396 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. Ref.7 Ref.8 UniProtKB Q63053 |
| Subunit structure | Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 By similarity. UniProtKB Q63053 |
| Subcellular location | Cytoplasm › cytoskeleton By similarity. Endosome By similarity. Acrosome. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity. Cell projection › dendrite By similarity. Cell projection › dendritic spine By similarity. Cell junction › synapse By similarity. Note: Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines By similarity. Associated with the sperm tail. |
| Tissue specificity | Expressed in brain and testis. Ref.6 |
| Developmental stage | Detectable in brain from postnatal week 1, in testis from postnatal week 3. Ref.6 |
| Disruption phenotype | Mice show deficits in several forms of long-term memory formation including spatial and fear-related learning, conditioned taste aversion as well as long-term object recognition. They show enhanced early-phase but impaired late-phase long-term potentiation (LTP) as well as impaired long-term depression (LTD). Neurons lacking Arc show an increase in surface levels of AMPA receptors. Ref.7 |
| Miscellaneous | Widely used as activity-dependent neuronal marker to identify recently activated neurons in behavioral studies. Ref.7 |
| Sequence similarities | Belongs to the ARC/ARG3.1 family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 396 | 396 | Activity-regulated cytoskeleton-associated protein | PRO_0000273286 | |||||
Regions | |||||||||
| Region | 89 – 100 | 12 | Binds SH3GL1 or SH3GL3 By similarity UniProtKB Q63053 | ||||||
| Region | 195 – 214 | 20 | Required for binding DNM2 By similarity UniProtKB Q63053 | ||||||
| Coiled coil | 54 – 78 | 25 | Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation." Waltereit R., Dammermann B., Wulff P., Scafidi J., Staubli U., Kauselmann G., Bundman M., Kuhl D. J. Neurosci. 21:5484-5493(2001) [PubMed: 11466419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv. |
| [2] | "The mArc gene, a mouse homolog of rat Arc." Chowdhury S., Lanahan A.A., Worley P.F. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Forebrain. |
| [3] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Dendritic cell and Embryo. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland. |
| [5] | "Characterization of the promoter region of the immediate early gene Arc." Medrano S., Worley P.F., Chowdhury S., Lanahan A., Steward O., Scrable H. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-242. Strain: C57BL/6 X CBA. |
| [6] | "Developmental association of the synaptic activity-regulated protein arc with the mouse acrosomal organelle and the sperm tail." Maier B., Medrano S., Sleight S.B., Visconti P.E., Scrable H. Biol. Reprod. 68:67-76(2003) [PubMed: 12493697] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. |
| [7] | "Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories." Plath N., Ohana O., Dammermann B., Errington M.L., Schmitz D., Gross C., Mao X., Engelsberg A., Mahlke C., Welzl H., Kobalz U., Stawrakakis A., Fernandez E., Waltereit R., Bick-Sander A., Therstappen E., Cooke S.F., Blanquet V. Kuhl D.Neuron 52:437-444(2006) [PubMed: 17088210] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE. |
| [8] | "Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA Receptors." Shepherd J.D., Rumbaugh G., Wu J., Chowdhury S., Plath N., Kuhl D., Huganir R.L., Worley P.F. Neuron 52:475-484(2006) [PubMed: 17088213] [Abstract] Cited for: FUNCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF177701 Genomic DNA. Translation: AAK91587.1. AF162777 mRNA. Translation: AAD43586.1. AK157822 mRNA. Translation: BAE34212.1. AK170446 mRNA. Translation: BAE41804.1. BC023127 mRNA. Translation: AAH23127.1. AF254662 Genomic DNA. Translation: AAG10254.1. | |
| IPI | IPI00125140. |
| RefSeq | NP_061260.1. |
| UniGene | Mm.25405 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9WV31. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000022602. Mus musculus. [Contig view] |
| GeneID | 11838. |
| KEGG | mmu:11838. |
Organism-specific databases | |
| MGI | MGI:88067. Arc. |
Phylogenomic databases | |
| HOVERGEN | Q9WV31. |
| OMA | Q9WV31. RCQETIA. |
Gene expression databases | |
| ArrayExpress | Q9WV31. |
| Bgee | Q9WV31. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 279775. |
| SOURCE | Search... |
Entry information
| Entry name | ARC_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9WV31 Secondary accession number(s): Q9ES15 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


