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Q9WV18

- GABR1_MOUSE

UniProt

Q9WV18 - GABR1_MOUSE

Protein

Gamma-aminobutyric acid type B receptor subunit 1

Gene

Gabbr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei246 – 2461AgonistBy similarity
    Binding sitei269 – 2691AgonistBy similarity
    Binding sitei286 – 2861AgonistBy similarity
    Binding sitei366 – 3661AgonistBy similarity
    Binding sitei394 – 3941AgonistBy similarity
    Binding sitei465 – 4651AgonistBy similarity

    GO - Molecular functioni

    1. G-protein coupled GABA receptor activity Source: UniProtKB
    2. protein binding Source: MGI

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
    2. gamma-aminobutyric acid signaling pathway Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
    REACT_217868. GABA B receptor activation.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid type B receptor subunit 1
    Short name:
    GABA-B receptor 1
    Short name:
    GABA-B-R1
    Short name:
    GABA-BR1
    Short name:
    GABABR1
    Short name:
    Gb1
    Gene namesi
    Name:Gabbr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1860139. Gabbr1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity; Multi-pass membrane protein By similarity. Cell projectiondendrite By similarity
    Note: Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. Colocalizes with ATF4 in hippocampal neuron dendritic membranes By similarity.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasm Source: MGI
    3. dendrite Source: UniProtKB-SubCell
    4. G-protein coupled receptor dimeric complex Source: MGI
    5. G-protein coupled receptor heterodimeric complex Source: UniProtKB
    6. integral component of plasma membrane Source: UniProtKB
    7. membrane Source: MGI
    8. postsynaptic membrane Source: MGI
    9. presynaptic membrane Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 960944Gamma-aminobutyric acid type B receptor subunit 1PRO_0000012950Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 144PROSITE-ProRule annotation
    Disulfide bondi130 ↔ 156PROSITE-ProRule annotation
    Disulfide bondi219 ↔ 245PROSITE-ProRule annotation
    Disulfide bondi375 ↔ 409PROSITE-ProRule annotation
    Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9WV18.
    PaxDbiQ9WV18.
    PRIDEiQ9WV18.

    PTM databases

    PhosphoSiteiQ9WV18.

    Expressioni

    Tissue specificityi

    Expressed in neuronal tissue including cortex, cerebellum and spinal cord. Not detected in non-neuronal tissues including heart, liver, spleen and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ9WV18.
    BgeeiQ9WV18.
    CleanExiMM_GABBR1.
    GenevestigatoriQ9WV18.

    Interactioni

    Subunit structurei

    Heterodimer of GABBR1 and GABBR2. Homodimers may form, but are inactive. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region By similarity. Interacts with JAKMIP1.By similarity3 Publications

    Protein-protein interaction databases

    BioGridi207643. 3 interactions.
    IntActiQ9WV18. 3 interactions.
    STRINGi10090.ENSMUSP00000025338.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WV18.
    SMRiQ9WV18. Positions 54-159, 164-575.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 590574ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini612 – 63019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini652 – 66615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini688 – 70922CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini731 – 76737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini789 – 80315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini825 – 8328ExtracellularSequence Analysis
    Topological domaini854 – 960107CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei591 – 61121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei631 – 65121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei667 – 68721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei710 – 73021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei768 – 78821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei804 – 82421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei833 – 85321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 9567Sushi 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini97 – 15862Sushi 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni887 – 91529Interaction with ATF4By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili868 – 92457Sequence AnalysisAdd
    BLAST

    Domaini

    Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABBR2. The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably plays a role in the specificity for G-protein coupling.

    Sequence similaritiesi

    Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0683.
    GeneTreeiENSGT00530000063129.
    HOGENOMiHOG000016575.
    HOVERGENiHBG051688.
    InParanoidiQ6PGJ2.
    KOiK04615.
    OMAiSTQFLGV.
    OrthoDBiEOG7D2FCV.
    PhylomeDBiQ9WV18.
    TreeFamiTF313965.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR002455. GPCR3_GABA-B.
    IPR017978. GPCR_3_C.
    IPR002456. GPCR_3_GABA_rcpt_B1.
    IPR028082. Peripla_BP_I.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PANTHERiPTHR10519. PTHR10519. 1 hit.
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF00084. Sushi. 2 hits.
    [Graphical view]
    PRINTSiPR01177. GABAB1RECPTR.
    SMARTiSM00032. CCP. 2 hits.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.
    SSF57535. SSF57535. 2 hits.
    PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    PS50923. SUSHI. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1A (identifier: Q9WV18-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLLLLVPLF LRPLGAGGAQ TPNVTSEGCQ IIHPPWEGGI RYRGLTRDQV    50
    KAINFLPVDY EIEYVCRGER EVVGPKVRKC LANGSWTDMD TPSRCVRICS 100
    KSYLTLENGK VFLTGGDLPA LDGARVDFRC DPDFHLVGSS RSICSQGQWS 150
    TPKPHCQVNR TPHSERRAVY IGALFPMSGG WPGGQACQPA VEMALEDVNS 200
    RRDILPDYEL KLIHHDSKCD PGQATKYLYE LLYNDPIKII LMPGCSSVST 250
    LVAEAARMWN LIVLSYGSSS PALSNRQRFP TFFRTHPSAT LHNPTRVKLF 300
    EKWGWKKIAT IQQTTEVFTS TLDDLEERVK EAGIEITFRQ SFFSDPAVPV 350
    KNLKRQDARI IVGLFYETEA RKVFCEVYKE RLFGKKYVWF LIGWYADNWF 400
    KTYDPSINCT VEEMTEAVEG HITTEIVMLN PANTRSISNM TSQEFVEKLT 450
    KRLKRHPEET GGFQEAPLAY DAIWALALAL NKTSGGGGRS GVRLEDFNYN 500
    NQTITDQIYR AMNSSSFEGV SGHVVFDASG SRMAWTLIEQ LQGGSYKKIG 550
    YYDSTKDDLS WSKTDKWIGG SPPADQTLVI KTFRFLSQKL FISVSVLSSL 600
    GIVLAVVCLS FNIYNSHVRY IQNSQPNLNN LTAVGCSLAL AAVFPLGLDG 650
    YHIGRSQFPF VCQARLWLLG LGFSLGYGSM FTKIWWVHTV FTKKEEKKEW 700
    RKTLEPWKLY ATVGLLVGMD ILTLAIWQIV DPLHRTIETF AKEEPKEDID 750
    VSILPQLEHC SSKKMNTWLG IFYGYKGLLL LLGIFLAYET KSVSTEKIND 800
    HRAVGMAIYN VAVLCLITAP VTMILSSQQD AAFAFASLAI VFSSYITLVV 850
    LFVPKMRRLI TRGEWQSEAQ DTMKTGSSTN NNEEEKSRLL EKENRELEKI 900
    IAEKEERVSE LRHQLQSRQQ IRSRRHPPTP PDPSGGLPRG PSEPPDRLSC 950
    DGSRVHLLYK 960
    Length:960
    Mass (Da):108,216
    Last modified:November 1, 1999 - v1
    Checksum:iE4B5A9401E23E8B4
    GO
    Isoform 1B (identifier: Q9WV18-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-163: MLLLLLVPLF...PHCQVNRTPH → MGPGGPCTPV...PHPRVPPHPS

    Show »
    Length:844
    Mass (Da):95,022
    Checksum:i76CA895396EAFDC0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 82VP → LL in AAD22194. (PubMed:10773016)Curated
    Sequence conflicti46 – 461T → I in AAD22194. (PubMed:10773016)Curated
    Sequence conflicti618 – 6181V → A in AAD22194. (PubMed:10773016)Curated
    Sequence conflicti642 – 6421A → V in AAD22194. (PubMed:10773016)Curated
    Sequence conflicti700 – 7001W → R in AAH56990. (PubMed:15489334)Curated
    Sequence conflicti721 – 7211I → V in AAD22194. (PubMed:10773016)Curated
    Sequence conflicti812 – 8121A → P in AAG29338. (PubMed:11306808)Curated
    Sequence conflicti812 – 8121A → P in AAG29341. (PubMed:11306808)Curated
    Sequence conflicti869 – 8691A → T in AAD22194. (PubMed:10773016)Curated
    Sequence conflicti921 – 9211I → L in AAD22194. (PubMed:10773016)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 163163MLLLL…NRTPH → MGPGGPCTPVGWPLPLLLVM AAGVAPVWASHSPHLPRPHP RVPPHPS in isoform 1B. 2 PublicationsVSP_002041Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF114168 mRNA. Translation: AAD22194.2.
    AF008649 mRNA. Translation: AAG29338.1.
    AF120255 mRNA. Translation: AAG29341.1.
    AL078630 Genomic DNA. No translation available.
    BC054735 mRNA. Translation: AAH54735.1.
    BC056990 mRNA. Translation: AAH56990.1.
    CCDSiCCDS37616.1. [Q9WV18-1]
    RefSeqiNP_062312.3. NM_019439.3. [Q9WV18-1]
    UniGeneiMm.32191.

    Genome annotation databases

    EnsembliENSMUST00000025338; ENSMUSP00000025338; ENSMUSG00000024462. [Q9WV18-1]
    ENSMUST00000172792; ENSMUSP00000134268; ENSMUSG00000024462. [Q9WV18-2]
    GeneIDi54393.
    KEGGimmu:54393.
    UCSCiuc008cma.1. mouse. [Q9WV18-1]
    uc008cmd.1. mouse. [Q9WV18-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF114168 mRNA. Translation: AAD22194.2 .
    AF008649 mRNA. Translation: AAG29338.1 .
    AF120255 mRNA. Translation: AAG29341.1 .
    AL078630 Genomic DNA. No translation available.
    BC054735 mRNA. Translation: AAH54735.1 .
    BC056990 mRNA. Translation: AAH56990.1 .
    CCDSi CCDS37616.1. [Q9WV18-1 ]
    RefSeqi NP_062312.3. NM_019439.3. [Q9WV18-1 ]
    UniGenei Mm.32191.

    3D structure databases

    ProteinModelPortali Q9WV18.
    SMRi Q9WV18. Positions 54-159, 164-575.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207643. 3 interactions.
    IntActi Q9WV18. 3 interactions.
    STRINGi 10090.ENSMUSP00000025338.

    Chemistry

    GuidetoPHARMACOLOGYi 240.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9WV18.

    Proteomic databases

    MaxQBi Q9WV18.
    PaxDbi Q9WV18.
    PRIDEi Q9WV18.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025338 ; ENSMUSP00000025338 ; ENSMUSG00000024462 . [Q9WV18-1 ]
    ENSMUST00000172792 ; ENSMUSP00000134268 ; ENSMUSG00000024462 . [Q9WV18-2 ]
    GeneIDi 54393.
    KEGGi mmu:54393.
    UCSCi uc008cma.1. mouse. [Q9WV18-1 ]
    uc008cmd.1. mouse. [Q9WV18-2 ]

    Organism-specific databases

    CTDi 2550.
    MGIi MGI:1860139. Gabbr1.

    Phylogenomic databases

    eggNOGi COG0683.
    GeneTreei ENSGT00530000063129.
    HOGENOMi HOG000016575.
    HOVERGENi HBG051688.
    InParanoidi Q6PGJ2.
    KOi K04615.
    OMAi STQFLGV.
    OrthoDBi EOG7D2FCV.
    PhylomeDBi Q9WV18.
    TreeFami TF313965.

    Enzyme and pathway databases

    Reactomei REACT_208837. Activation of G protein gated Potassium channels.
    REACT_217868. GABA B receptor activation.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Miscellaneous databases

    ChiTaRSi GABBR1. mouse.
    NextBioi 311240.
    PROi Q9WV18.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WV18.
    Bgeei Q9WV18.
    CleanExi MM_GABBR1.
    Genevestigatori Q9WV18.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR002455. GPCR3_GABA-B.
    IPR017978. GPCR_3_C.
    IPR002456. GPCR_3_GABA_rcpt_B1.
    IPR028082. Peripla_BP_I.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    PANTHERi PTHR10519. PTHR10519. 1 hit.
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF00084. Sushi. 2 hits.
    [Graphical view ]
    PRINTSi PR01177. GABAB1RECPTR.
    SMARTi SM00032. CCP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    SSF57535. SSF57535. 2 hits.
    PROSITEi PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    PS50923. SUSHI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor."
      Sullivan R., Chateauneuf A., Coulombe N., Kolakowski L.F. Jr., Johnson M.P., Hebert T.E., Ethier N., Belley M., Metters K., Abramovitz M., O'Neill G.P., Ng G.Y.K.
      J. Pharmacol. Exp. Ther. 293:460-467(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A), FUNCTION, INTERACTION WITH GABBR2, SUBCELLULAR LOCATION.
    2. "The murine GABA(B) receptor 1: cDNA cloning, tissue distribution, structure of the Gabbr1 gene, and mapping to chromosome 17."
      Lamp K., Humeny A., Nikolic Z., Imai K., Adamski J., Schiebel K., Becker C.M.
      Cytogenet. Cell Genet. 92:116-121(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B), TISSUE SPECIFICITY.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1A AND 1B).
      Strain: C57BL/6.
      Tissue: Brain.
    5. "Role of heteromer formation in GABAB receptor function."
      Kuner R., Koehr G., Gruenewald S., Eisenhardt G., Bach A., Kornau H.-C.
      Science 283:74-77(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GABBR2.
    6. Cited for: INTERACTION WITH JAKMIP1.

    Entry informationi

    Entry nameiGABR1_MOUSE
    AccessioniPrimary (citable) accession number: Q9WV18
    Secondary accession number(s): Q6PGJ2
    , Q9WU48, Q9WV15, Q9WV16, Q9WV17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3