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Protein

Apelin receptor

Gene

Aplnr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Gastrulation

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Apelin receptor
Alternative name(s):
Angiotensin receptor-like 1
G-protein coupled receptor APJ
MSR
Gene namesi
Name:Aplnr
Synonyms:Agtrl1, Apj
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1346086. Aplnr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence analysisAdd
BLAST
Transmembranei25 – 4925Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 6415CytoplasmicSequence analysisAdd
BLAST
Transmembranei65 – 8925Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini90 – 989ExtracellularSequence analysis
Transmembranei99 – 12325Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini124 – 14219CytoplasmicSequence analysisAdd
BLAST
Transmembranei143 – 16422Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini165 – 19834ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 24223CytoplasmicSequence analysisAdd
BLAST
Transmembranei243 – 26927Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini270 – 28213ExtracellularSequence analysisAdd
BLAST
Transmembranei283 – 30624Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini307 – 37771CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Apelin receptorPRO_0000069175Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9WV08.
PaxDbiQ9WV08.
PRIDEiQ9WV08.

PTM databases

iPTMnetiQ9WV08.
PhosphoSiteiQ9WV08.
SwissPalmiQ9WV08.

Expressioni

Tissue specificityi

Detected in the endothelium of the primary blood vessels and the forming heart. Might be expressed in a subpopulation of endothelial precursors and a mesenchymal population derived from paraaxial mesoderm.

Developmental stagei

Detected from embryonic day 8 (E8) and throughout the subsequent stages of formation of the cardiovascular system.

Gene expression databases

BgeeiENSMUSG00000044338.
ExpressionAtlasiQ9WV08. baseline and differential.
GenevisibleiQ9WV08. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053638.

Structurei

3D structure databases

ProteinModelPortaliQ9WV08.
SMRiQ9WV08. Positions 1-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiQ9WV08.
KOiK04174.
OMAiVMVFRST.
OrthoDBiEOG091G0BIX.
PhylomeDBiQ9WV08.
TreeFamiTF330024.

Family and domain databases

InterProiIPR020279. Apelin_receptor_C.
IPR003904. APJ_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01416. APJRECEPTOR.
PR00237. GPCRRHODOPSN.
ProDomiPD061381. Apelin_receptor_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WV08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDGYNYYG ADNQSECDYA DWKPSGALIP AIYMLVFLLG TTGNGLVLWT
60 70 80 90 100
VFRTSREKRR SADIFIASLA VADLTFVVTL PLWATYTYRE FDWPFGTFSC
110 120 130 140 150
KLSSYLIFVN MYASVFCLTG LSFDRYLAIV RPVANARLRL RVSGAVATAV
160 170 180 190 200
LWVLAALLAV PVMVFRSTDA SENGTKIQCY MDYSMVATSN SEWAWEVGLG
210 220 230 240 250
VSSTAVGFVV PFTIMLTCYF FIAQTIAGHF RKERIEGLRK RRRLLSIIVV
260 270 280 290 300
LVVTFALCWM PYHLVKTLYM LGSLLHWPCD FDIFLMNVFP YCTCISYVNS
310 320 330 340 350
CLNPFLYAFF DPRFRQACTS MLCCDQSGCK GTPHSSSAEK SASYSSGHSQ
360 370
GPGPNMGKGG EQMHEKSIPY SQETLVD
Length:377
Mass (Da):42,266
Last modified:November 1, 1999 - v1
Checksum:iAA443A7800A24E0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007612 mRNA. Translation: CAB50696.1.
AK075706 mRNA. Translation: BAC35901.1.
AK133580 mRNA. Translation: BAE21731.1.
AK157582 mRNA. Translation: BAE34128.1.
BC039224 mRNA. Translation: AAH39224.1.
CCDSiCCDS16201.1.
RefSeqiNP_035914.1. NM_011784.3.
UniGeneiMm.29368.

Genome annotation databases

EnsembliENSMUST00000057019; ENSMUSP00000053638; ENSMUSG00000044338.
GeneIDi23796.
KEGGimmu:23796.
UCSCiuc008kkb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007612 mRNA. Translation: CAB50696.1.
AK075706 mRNA. Translation: BAC35901.1.
AK133580 mRNA. Translation: BAE21731.1.
AK157582 mRNA. Translation: BAE34128.1.
BC039224 mRNA. Translation: AAH39224.1.
CCDSiCCDS16201.1.
RefSeqiNP_035914.1. NM_011784.3.
UniGeneiMm.29368.

3D structure databases

ProteinModelPortaliQ9WV08.
SMRiQ9WV08. Positions 1-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053638.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9WV08.
PhosphoSiteiQ9WV08.
SwissPalmiQ9WV08.

Proteomic databases

MaxQBiQ9WV08.
PaxDbiQ9WV08.
PRIDEiQ9WV08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057019; ENSMUSP00000053638; ENSMUSG00000044338.
GeneIDi23796.
KEGGimmu:23796.
UCSCiuc008kkb.2. mouse.

Organism-specific databases

CTDi187.
MGIiMGI:1346086. Aplnr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiQ9WV08.
KOiK04174.
OMAiVMVFRST.
OrthoDBiEOG091G0BIX.
PhylomeDBiQ9WV08.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ9WV08.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044338.
ExpressionAtlasiQ9WV08. baseline and differential.
GenevisibleiQ9WV08. MM.

Family and domain databases

InterProiIPR020279. Apelin_receptor_C.
IPR003904. APJ_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01416. APJRECEPTOR.
PR00237. GPCRRHODOPSN.
ProDomiPD061381. Apelin_receptor_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPJ_MOUSE
AccessioniPrimary (citable) accession number: Q9WV08
Secondary accession number(s): Q3TZS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.