Reviewed, UniProtKB/Swiss-Prot Q9WV07 (LOXE3_MOUSE)

Names and origin

Protein names

Recommended name:
    Epidermis-type lipoxygenase 3
      Short name=e-LOX-3
    EC=1.13.11.-

Gene names

Name:

Aloxe3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	711 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Lipid metabolism; leukotriene D4 biosynthesis.
Tissue specificity	Skin specific.
Sequence similarities	Belongs to the lipoxygenase family. Contains 1 lipoxygenase domain. Contains 1 PLAT domain.

Ontologies

Keywords
Biological process	Leukotriene biosynthesis
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	leukotriene biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW lipoxygenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 711	711	Epidermis-type lipoxygenase 3		PRO_0000220692
Regions
	Domain	2 – 119	118	PLAT
	Domain	120 – 711	592	Lipoxygenase
Sites
	Metal binding	408	1	Iron; catalytic By similarity
	Metal binding	413	1	Iron; catalytic By similarity
	Metal binding	588	1	Iron; catalytic By similarity
	Metal binding	592	1	Iron; catalytic By similarity
	Metal binding	711	1	Iron; via carboxylate; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9WV07-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 6E2183C7C64540E0	FASTA	711	80,579
	10 20 30 40 50 60 MAVYRLCVTT GSYLKAGTLD NIYATLVGTC GESPKQKLDR VGRDFASGSV QKYKVRCEAE 70 80 90 100 110 120 LGEILLLRLH KERFAFFCKD PWYCSRICVT APDGSAVHFP CYQWIDGYCT VELRPGTART 130 140 150 160 170 180 ICQDSLPLLL DHRKRELRAR QECYRWKIFA PGFPRMVDVS SFQEMESDKK FALTKTVPCA 190 200 210 220 230 240 EQDDNSGNRY LPGFPMKIDI PSLLHMEPNI RYSATKTASL IFNALPASFG MKIRGLLDRK 250 260 270 280 290 300 GSWKRLDDIR NIFWCHKTFT SEYVTEHWCE DSFFGYQYLN GVNPVMLHCL SSLPSKLPVT 310 320 330 340 350 360 NDMVAPLLGP GTCLQTELER GHIFLADYWI LAEAPVHCIN SLQQYVTAPL CLLWLNPQGV 370 380 390 400 410 420 LLPLAIQLSQ TPGPESPIFL PTDCELDWLL AKTWVRNSEF LVHENNTHFL CTHLLCEAFS 430 440 450 460 470 480 MATLRQLPLC HPVYKLLLPH TRYTLQVNTI ARATLLNPDG LVDKVTSIGR QGLIYLMSTG 490 500 510 520 530 540 LAHFTYTDFC LPDSIRARGV LTIPNYHYRD DGLKIWAAIE RFVSEIVSYY YPSDASVQQD 550 560 570 580 590 600 CELQAWVGEI FAQAFLGRES SGFPSRLCTP GELVKYLTAI IFNCSAQHAA FNSGQHDFGA 610 620 630 640 650 660 WMPNAPSSMR QPPPQTKGDT TMKSYLDTLP EVNTTCRNLL LFWLVSQEPK DQRPLGTYPD 670 680 690 700 710 EHFTEEAPRQ SIAAFQNCLA QISKDIRERN QSLALPYAYL DPPLIENSVS I

References

[1]	"cDNA cloning, genomic structure and chromosomal localization of a novel epidermis-type lipoxygenase." Kinzig A., Heidt M., Fuerstenberger G., Marks F., Krieg P. Genomics 58:158-164(1999) [PubMed: 10366447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: NMRI. Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y14695 mRNA. Translation: CAB46101.1.
IPI	IPI00269929.
UniGene	Mm.41989
3D structure databases
HSSP	HSSP built from PDB template 1LOX based on UniProtKB P12530.
ModBase	Search...
Proteomic databases
PRIDE	Q9WV07.
Genome annotation databases
Ensembl	ENSMUSG00000020892. Mus musculus. [Contig view]
KEGG	mmu:23801.
Organism-specific databases
MGI	MGI:1345140. Aloxe3.
Phylogenomic databases
HOGENOM	Q9WV07.
HOVERGEN	Q9WV07.
Gene expression databases
ArrayExpress	Q9WV07.
Bgee	Q9WV07.
CleanEx	MM_ALOXE3.
GermOnline	ENSMUSG00000020892. Mus musculus.
Family and domain databases
InterPro	IPR000907. LipOase. IPR013819. LipOase_C. IPR001024. LipOase_LH2. IPR001885. LipOase_mml. [Graphical view]
Gene3D	G3DSA:2.60.60.20. Lipase_LipOase. 1 hit.
PANTHER	PTHR11771. LipOase. 1 hit.
Pfam	PF00305. Lipoxygenase. 1 hit. PF01477. PLAT. 1 hit. [Graphical view]
PRINTS	PR00087. LIPOXYGENASE. PR00467. MAMLPOXGNASE.
SMART	SM00308. LH2. 1 hit. [Graphical view]
PROSITE	PS00711. LIPOXYGENASE_1. 1 hit. PS00081. LIPOXYGENASE_2. 1 hit. PS51393. LIPOXYGENASE_3. 1 hit. PS50095. PLAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	303419.
SOURCE	Search...

Entry information

Entry name

LOXE3_MOUSE

Accession

Primary (citable) accession number: Q9WV07

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)