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Protein

Protein FAM50A

Gene

Fam50a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a DNA-binding protein or transcriptional factor.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM50A
Alternative name(s):
Protein XAP-5
Gene namesi
Name:Fam50a
Synonyms:D0HXS9928E, Xap5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1351626. Fam50a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 339338Protein FAM50APRO_0000068285Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9WV03.
PaxDbiQ9WV03.
PRIDEiQ9WV03.

PTM databases

PhosphoSiteiQ9WV03.

Expressioni

Tissue specificityi

Widely expressed in embryonic and adult tissues.

Gene expression databases

BgeeiQ9WV03.
CleanExiMM_D0HXS9928E.
ExpressionAtlasiQ9WV03. baseline and differential.
GenevisibleiQ9WV03. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109797.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi152 – 1554Nuclear localization signalSequence Analysis

Sequence similaritiesi

Belongs to the FAM50 family.Curated

Phylogenomic databases

eggNOGiNOG252249.
GeneTreeiENSGT00390000004735.
HOGENOMiHOG000283611.
HOVERGENiHBG000678.
InParanoidiQ9WV03.
KOiK13119.
OMAiQLRQEWV.
OrthoDBiEOG7CZK6H.
PhylomeDBiQ9WV03.
TreeFamiTF314738.

Family and domain databases

InterProiIPR007005. XAP5.
[Graphical view]
PANTHERiPTHR12722. PTHR12722. 1 hit.
PfamiPF04921. XAP5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WV03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQYKGAASE AGRAMHLMKK REKQREQMEQ MKQRIAEENI MKSNIDKKFS
60 70 80 90 100
AHYDAVEAEL KSSTVGLVTL NDMKAKQEAL VKEREKQLAK KEQSKELQLK
110 120 130 140 150
LEKLREKERK KEAKRKISSL SFTLEEEEEG VEEEEEMAMY EEELEREEIT
160 170 180 190 200
TKKKKLGKNP DVDTSFLPDR DREEEENRLR EELRQEWEAK QEKIKSEEIE
210 220 230 240 250
ITFSYWDGSG HRRTVKMKKG NTMQQFLQKA LEILRKDFSE LRSAGVEQLM
260 270 280 290 300
YIKEDLIIPH HHSFYDFIVT KARGKSGPLF NFDVHDDVRL LSDATVEKDE
310 320 330
SHAGKVVLRS WYEKNKHIFP ASRWEPYDPE KKWDKYTIR
Length:339
Mass (Da):40,252
Last modified:November 1, 1999 - v1
Checksum:iB7E700854B06F771
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461D → Y in BAB25651 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18505 mRNA. Translation: CAB46282.1.
AK008402 mRNA. Translation: BAB25651.1.
CCDSiCCDS41021.1.
RefSeqiNP_613073.2. NM_138607.3.
UniGeneiMm.4370.

Genome annotation databases

EnsembliENSMUST00000114160; ENSMUSP00000109797; ENSMUSG00000001962.
GeneIDi108160.
KEGGimmu:108160.
UCSCiuc009ton.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18505 mRNA. Translation: CAB46282.1.
AK008402 mRNA. Translation: BAB25651.1.
CCDSiCCDS41021.1.
RefSeqiNP_613073.2. NM_138607.3.
UniGeneiMm.4370.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109797.

PTM databases

PhosphoSiteiQ9WV03.

Proteomic databases

MaxQBiQ9WV03.
PaxDbiQ9WV03.
PRIDEiQ9WV03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114160; ENSMUSP00000109797; ENSMUSG00000001962.
GeneIDi108160.
KEGGimmu:108160.
UCSCiuc009ton.2. mouse.

Organism-specific databases

CTDi9130.
MGIiMGI:1351626. Fam50a.

Phylogenomic databases

eggNOGiNOG252249.
GeneTreeiENSGT00390000004735.
HOGENOMiHOG000283611.
HOVERGENiHBG000678.
InParanoidiQ9WV03.
KOiK13119.
OMAiQLRQEWV.
OrthoDBiEOG7CZK6H.
PhylomeDBiQ9WV03.
TreeFamiTF314738.

Miscellaneous databases

NextBioi360194.
PROiQ9WV03.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WV03.
CleanExiMM_D0HXS9928E.
ExpressionAtlasiQ9WV03. baseline and differential.
GenevisibleiQ9WV03. MM.

Family and domain databases

InterProiIPR007005. XAP5.
[Graphical view]
PANTHERiPTHR12722. PTHR12722. 1 hit.
PfamiPF04921. XAP5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human and mouse XAP-5 and XAP-5-like (X5L) genes: identification of an ancient functional retroposon differentially expressed in testis."
    Sedlack Z., Muenstermann E., Dhorne-Pollet S., Otto C., Bock D., Schuetz G., Poustka A.
    Genomics 61:125-132(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Small intestine.

Entry informationi

Entry nameiFA50A_MOUSE
AccessioniPrimary (citable) accession number: Q9WV03
Secondary accession number(s): Q9D866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1999
Last modified: June 24, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.