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Protein

Troponin I, slow skeletal muscle

Gene

Tnni1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi106 – 11712By similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • regulation of muscle contraction Source: Ensembl
  • transition between fast and slow fiber Source: MGI
  • ventricular cardiac muscle tissue morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_324616. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, slow skeletal muscle
Alternative name(s):
Troponin I, slow-twitch isoform
Gene namesi
Name:Tnni1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:105073. Tnni1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 187186Troponin I, slow skeletal musclePRO_0000186140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylprolineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9WUZ5.
PRIDEiQ9WUZ5.

PTM databases

PhosphoSiteiQ9WUZ5.

Expressioni

Gene expression databases

BgeeiQ9WUZ5.
CleanExiMM_TNNI1.
ExpressionAtlasiQ9WUZ5. baseline and differential.
GenevisibleiQ9WUZ5. MM.

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121343.

Structurei

3D structure databases

ProteinModelPortaliQ9WUZ5.
SMRiQ9WUZ5. Positions 9-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 4847Involved in binding TNCAdd
BLAST
Regioni97 – 11822Involved in binding TNC and actinAdd
BLAST

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiNOG328514.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiQ9WUZ5.
KOiK10371.
OMAiCRELHEK.
PhylomeDBiQ9WUZ5.
TreeFamiTF313374.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEVERKSKI TASRKLMLKS LMLAKAKECW EQEHEEREAE KVRYLSERIP
60 70 80 90 100
TLQTRGLSLS ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK
110 120 130 140 150
VLDLRGKFKR PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT
160 170 180
EKERPVEVGD WRKNVEAMSG MEGRKKMFDA AKSPTSQ
Length:187
Mass (Da):21,698
Last modified:January 23, 2007 - v3
Checksum:i69B4BA39D0F471D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242874 mRNA. Translation: CAB48403.1.
AK012258 mRNA. Translation: BAB28123.1.
BC023170 mRNA. Translation: AAH23170.1.
CCDSiCCDS48374.1.
RefSeqiNP_001106173.1. NM_001112702.1.
NP_067442.1. NM_021467.5.
XP_006529445.1. XM_006529382.2.
XP_011246276.1. XM_011247974.1.
UniGeneiMm.44379.

Genome annotation databases

EnsembliENSMUST00000148201; ENSMUSP00000123509; ENSMUSG00000026418.
ENSMUST00000152075; ENSMUSP00000121343; ENSMUSG00000026418.
ENSMUST00000152208; ENSMUSP00000121966; ENSMUSG00000026418.
ENSMUST00000154463; ENSMUSP00000122925; ENSMUSG00000026418.
GeneIDi21952.
KEGGimmu:21952.
UCSCiuc033flo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242874 mRNA. Translation: CAB48403.1.
AK012258 mRNA. Translation: BAB28123.1.
BC023170 mRNA. Translation: AAH23170.1.
CCDSiCCDS48374.1.
RefSeqiNP_001106173.1. NM_001112702.1.
NP_067442.1. NM_021467.5.
XP_006529445.1. XM_006529382.2.
XP_011246276.1. XM_011247974.1.
UniGeneiMm.44379.

3D structure databases

ProteinModelPortaliQ9WUZ5.
SMRiQ9WUZ5. Positions 9-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121343.

PTM databases

PhosphoSiteiQ9WUZ5.

Proteomic databases

MaxQBiQ9WUZ5.
PRIDEiQ9WUZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000148201; ENSMUSP00000123509; ENSMUSG00000026418.
ENSMUST00000152075; ENSMUSP00000121343; ENSMUSG00000026418.
ENSMUST00000152208; ENSMUSP00000121966; ENSMUSG00000026418.
ENSMUST00000154463; ENSMUSP00000122925; ENSMUSG00000026418.
GeneIDi21952.
KEGGimmu:21952.
UCSCiuc033flo.1. mouse.

Organism-specific databases

CTDi7135.
MGIiMGI:105073. Tnni1.

Phylogenomic databases

eggNOGiNOG328514.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiQ9WUZ5.
KOiK10371.
OMAiCRELHEK.
PhylomeDBiQ9WUZ5.
TreeFamiTF313374.

Enzyme and pathway databases

ReactomeiREACT_324616. Striated Muscle Contraction.

Miscellaneous databases

ChiTaRSiTnni1. mouse.
NextBioi301620.
PROiQ9WUZ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WUZ5.
CleanExiMM_TNNI1.
ExpressionAtlasiQ9WUZ5. baseline and differential.
GenevisibleiQ9WUZ5. MM.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal distribution of the mouse troponin gene families."
    Barton P.J.R.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTNNI1_MOUSE
AccessioniPrimary (citable) accession number: Q9WUZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.