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Q9WUZ5 (TNNI1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Troponin I, slow skeletal muscle
Alternative name(s):
Troponin I, slow-twitch isoform
Gene names
Name:Tnni1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Subunit structure

Binds to actin and tropomyosin.

Sequence similarities

Belongs to the troponin I family.

Ontologies

Keywords
   LigandActin-binding
Calcium
Metal-binding
   Molecular functionMuscle protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processventricular cardiac muscle tissue morphogenesis

Inferred from mutant phenotype PubMed 9915769. Source: MGI

   Cellular_componenttroponin complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 187187Troponin I, slow skeletal muscle
PRO_0000186140

Regions

Calcium binding106 – 11712 By similarity
Region1 – 4848Involved in binding TNC
Region97 – 11822Involved in binding TNC and actin

Sequences

Sequence LengthMass (Da)Tools
Q9WUZ5 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 69B4BA39D0F471D4

FASTA18721,698
        10         20         30         40         50         60 
MPEVERKSKI TASRKLMLKS LMLAKAKECW EQEHEEREAE KVRYLSERIP TLQTRGLSLS 

        70         80         90        100        110        120 
ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK VLDLRGKFKR PPLRRVRVSA 

       130        140        150        160        170        180 
DAMLRALLGS KHKVSMDLRA NLKSVKKEDT EKERPVEVGD WRKNVEAMSG MEGRKKMFDA 


AKSPTSQ 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and chromosomal distribution of the mouse troponin gene families."
Barton P.J.R.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ242874 mRNA. Translation: CAB48403.1.
AK012258 mRNA. Translation: BAB28123.1.
BC023170 mRNA. Translation: AAH23170.1.
RefSeqNP_001106173.1. NM_001112702.1.
NP_067442.1. NM_021467.5.
XP_006529445.1. XM_006529382.1.
UniGeneMm.44379.

3D structure databases

ProteinModelPortalQ9WUZ5.
SMRQ9WUZ5. Positions 9-183.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000121343.

PTM databases

PhosphoSiteQ9WUZ5.

Proteomic databases

PRIDEQ9WUZ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000148201; ENSMUSP00000123509; ENSMUSG00000026418.
ENSMUST00000152075; ENSMUSP00000121343; ENSMUSG00000026418.
ENSMUST00000152208; ENSMUSP00000121966; ENSMUSG00000026418.
ENSMUST00000154463; ENSMUSP00000122925; ENSMUSG00000026418.
GeneID21952.
KEGGmmu:21952.
UCSCuc011wsm.1. mouse.

Organism-specific databases

CTD7135.
MGIMGI:105073. Tnni1.

Phylogenomic databases

eggNOGNOG328514.
GeneTreeENSGT00390000002746.
HOGENOMHOG000293300.
HOVERGENHBG052737.
InParanoidQ9WUZ5.
KOK10371.
OMACRDLHAK.
PhylomeDBQ9WUZ5.
TreeFamTF313374.

Gene expression databases

ArrayExpressQ9WUZ5.
BgeeQ9WUZ5.
CleanExMM_TNNI1.
GenevestigatorQ9WUZ5.

Family and domain databases

InterProIPR001978. Troponin.
[Graphical view]
PfamPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTNNI1. mouse.
NextBio301620.
PROQ9WUZ5.
SOURCESearch...

Entry information

Entry nameTNNI1_MOUSE
AccessionPrimary (citable) accession number: Q9WUZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot