Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9WUZ5

- TNNI1_MOUSE

UniProt

Q9WUZ5 - TNNI1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Troponin I, slow skeletal muscle

Gene

Tnni1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi106 – 11712By similarityAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. ventricular cardiac muscle tissue morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_232053. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, slow skeletal muscle
Alternative name(s):
Troponin I, slow-twitch isoform
Gene namesi
Name:Tnni1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:105073. Tnni1.

Subcellular locationi

GO - Cellular componenti

  1. troponin complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187Troponin I, slow skeletal musclePRO_0000186140Add
BLAST

Proteomic databases

MaxQBiQ9WUZ5.
PRIDEiQ9WUZ5.

PTM databases

PhosphoSiteiQ9WUZ5.

Expressioni

Gene expression databases

BgeeiQ9WUZ5.
CleanExiMM_TNNI1.
ExpressionAtlasiQ9WUZ5. baseline and differential.
GenevestigatoriQ9WUZ5.

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121343.

Structurei

3D structure databases

ProteinModelPortaliQ9WUZ5.
SMRiQ9WUZ5. Positions 9-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4848Involved in binding TNCAdd
BLAST
Regioni97 – 11822Involved in binding TNC and actinAdd
BLAST

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiNOG328514.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiQ9WUZ5.
KOiK10371.
OMAiCRDLHAK.
PhylomeDBiQ9WUZ5.
TreeFamiTF313374.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPEVERKSKI TASRKLMLKS LMLAKAKECW EQEHEEREAE KVRYLSERIP
60 70 80 90 100
TLQTRGLSLS ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK
110 120 130 140 150
VLDLRGKFKR PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT
160 170 180
EKERPVEVGD WRKNVEAMSG MEGRKKMFDA AKSPTSQ
Length:187
Mass (Da):21,698
Last modified:January 23, 2007 - v3
Checksum:i69B4BA39D0F471D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242874 mRNA. Translation: CAB48403.1.
AK012258 mRNA. Translation: BAB28123.1.
BC023170 mRNA. Translation: AAH23170.1.
CCDSiCCDS48374.1.
RefSeqiNP_001106173.1. NM_001112702.1.
NP_067442.1. NM_021467.5.
XP_006529445.1. XM_006529382.1.
UniGeneiMm.44379.

Genome annotation databases

EnsembliENSMUST00000148201; ENSMUSP00000123509; ENSMUSG00000026418.
ENSMUST00000152075; ENSMUSP00000121343; ENSMUSG00000026418.
ENSMUST00000152208; ENSMUSP00000121966; ENSMUSG00000026418.
ENSMUST00000154463; ENSMUSP00000122925; ENSMUSG00000026418.
GeneIDi21952.
KEGGimmu:21952.
UCSCiuc011wsm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242874 mRNA. Translation: CAB48403.1 .
AK012258 mRNA. Translation: BAB28123.1 .
BC023170 mRNA. Translation: AAH23170.1 .
CCDSi CCDS48374.1.
RefSeqi NP_001106173.1. NM_001112702.1.
NP_067442.1. NM_021467.5.
XP_006529445.1. XM_006529382.1.
UniGenei Mm.44379.

3D structure databases

ProteinModelPortali Q9WUZ5.
SMRi Q9WUZ5. Positions 9-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000121343.

PTM databases

PhosphoSitei Q9WUZ5.

Proteomic databases

MaxQBi Q9WUZ5.
PRIDEi Q9WUZ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000148201 ; ENSMUSP00000123509 ; ENSMUSG00000026418 .
ENSMUST00000152075 ; ENSMUSP00000121343 ; ENSMUSG00000026418 .
ENSMUST00000152208 ; ENSMUSP00000121966 ; ENSMUSG00000026418 .
ENSMUST00000154463 ; ENSMUSP00000122925 ; ENSMUSG00000026418 .
GeneIDi 21952.
KEGGi mmu:21952.
UCSCi uc011wsm.1. mouse.

Organism-specific databases

CTDi 7135.
MGIi MGI:105073. Tnni1.

Phylogenomic databases

eggNOGi NOG328514.
GeneTreei ENSGT00390000002746.
HOGENOMi HOG000293300.
HOVERGENi HBG052737.
InParanoidi Q9WUZ5.
KOi K10371.
OMAi CRDLHAK.
PhylomeDBi Q9WUZ5.
TreeFami TF313374.

Enzyme and pathway databases

Reactomei REACT_232053. Striated Muscle Contraction.

Miscellaneous databases

ChiTaRSi Tnni1. mouse.
NextBioi 301620.
PROi Q9WUZ5.
SOURCEi Search...

Gene expression databases

Bgeei Q9WUZ5.
CleanExi MM_TNNI1.
ExpressionAtlasi Q9WUZ5. baseline and differential.
Genevestigatori Q9WUZ5.

Family and domain databases

InterProi IPR001978. Troponin.
[Graphical view ]
Pfami PF00992. Troponin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal distribution of the mouse troponin gene families."
    Barton P.J.R.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTNNI1_MOUSE
AccessioniPrimary (citable) accession number: Q9WUZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3