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Q9WUZ5

- TNNI1_MOUSE

UniProt

Q9WUZ5 - TNNI1_MOUSE

Protein

Troponin I, slow skeletal muscle

Gene

Tnni1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi106 – 11712By similarityAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. ventricular cardiac muscle tissue morphogenesis Source: MGI

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Actin-binding, Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Troponin I, slow skeletal muscle
    Alternative name(s):
    Troponin I, slow-twitch isoform
    Gene namesi
    Name:Tnni1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:105073. Tnni1.

    Subcellular locationi

    GO - Cellular componenti

    1. troponin complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 187187Troponin I, slow skeletal musclePRO_0000186140Add
    BLAST

    Proteomic databases

    MaxQBiQ9WUZ5.
    PRIDEiQ9WUZ5.

    PTM databases

    PhosphoSiteiQ9WUZ5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9WUZ5.
    BgeeiQ9WUZ5.
    CleanExiMM_TNNI1.
    GenevestigatoriQ9WUZ5.

    Interactioni

    Subunit structurei

    Binds to actin and tropomyosin.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000121343.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WUZ5.
    SMRiQ9WUZ5. Positions 9-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 4848Involved in binding TNCAdd
    BLAST
    Regioni97 – 11822Involved in binding TNC and actinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the troponin I family.Curated

    Phylogenomic databases

    eggNOGiNOG328514.
    GeneTreeiENSGT00390000002746.
    HOGENOMiHOG000293300.
    HOVERGENiHBG052737.
    InParanoidiQ9WUZ5.
    KOiK10371.
    OMAiCRDLHAK.
    PhylomeDBiQ9WUZ5.
    TreeFamiTF313374.

    Family and domain databases

    InterProiIPR001978. Troponin.
    [Graphical view]
    PfamiPF00992. Troponin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WUZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPEVERKSKI TASRKLMLKS LMLAKAKECW EQEHEEREAE KVRYLSERIP    50
    TLQTRGLSLS ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK 100
    VLDLRGKFKR PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT 150
    EKERPVEVGD WRKNVEAMSG MEGRKKMFDA AKSPTSQ 187
    Length:187
    Mass (Da):21,698
    Last modified:January 23, 2007 - v3
    Checksum:i69B4BA39D0F471D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ242874 mRNA. Translation: CAB48403.1.
    AK012258 mRNA. Translation: BAB28123.1.
    BC023170 mRNA. Translation: AAH23170.1.
    CCDSiCCDS48374.1.
    RefSeqiNP_001106173.1. NM_001112702.1.
    NP_067442.1. NM_021467.5.
    XP_006529445.1. XM_006529382.1.
    UniGeneiMm.44379.

    Genome annotation databases

    EnsembliENSMUST00000148201; ENSMUSP00000123509; ENSMUSG00000026418.
    ENSMUST00000152075; ENSMUSP00000121343; ENSMUSG00000026418.
    ENSMUST00000152208; ENSMUSP00000121966; ENSMUSG00000026418.
    ENSMUST00000154463; ENSMUSP00000122925; ENSMUSG00000026418.
    GeneIDi21952.
    KEGGimmu:21952.
    UCSCiuc011wsm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ242874 mRNA. Translation: CAB48403.1 .
    AK012258 mRNA. Translation: BAB28123.1 .
    BC023170 mRNA. Translation: AAH23170.1 .
    CCDSi CCDS48374.1.
    RefSeqi NP_001106173.1. NM_001112702.1.
    NP_067442.1. NM_021467.5.
    XP_006529445.1. XM_006529382.1.
    UniGenei Mm.44379.

    3D structure databases

    ProteinModelPortali Q9WUZ5.
    SMRi Q9WUZ5. Positions 9-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000121343.

    PTM databases

    PhosphoSitei Q9WUZ5.

    Proteomic databases

    MaxQBi Q9WUZ5.
    PRIDEi Q9WUZ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000148201 ; ENSMUSP00000123509 ; ENSMUSG00000026418 .
    ENSMUST00000152075 ; ENSMUSP00000121343 ; ENSMUSG00000026418 .
    ENSMUST00000152208 ; ENSMUSP00000121966 ; ENSMUSG00000026418 .
    ENSMUST00000154463 ; ENSMUSP00000122925 ; ENSMUSG00000026418 .
    GeneIDi 21952.
    KEGGi mmu:21952.
    UCSCi uc011wsm.1. mouse.

    Organism-specific databases

    CTDi 7135.
    MGIi MGI:105073. Tnni1.

    Phylogenomic databases

    eggNOGi NOG328514.
    GeneTreei ENSGT00390000002746.
    HOGENOMi HOG000293300.
    HOVERGENi HBG052737.
    InParanoidi Q9WUZ5.
    KOi K10371.
    OMAi CRDLHAK.
    PhylomeDBi Q9WUZ5.
    TreeFami TF313374.

    Miscellaneous databases

    ChiTaRSi TNNI1. mouse.
    NextBioi 301620.
    PROi Q9WUZ5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WUZ5.
    Bgeei Q9WUZ5.
    CleanExi MM_TNNI1.
    Genevestigatori Q9WUZ5.

    Family and domain databases

    InterProi IPR001978. Troponin.
    [Graphical view ]
    Pfami PF00992. Troponin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosomal distribution of the mouse troponin gene families."
      Barton P.J.R.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTNNI1_MOUSE
    AccessioniPrimary (citable) accession number: Q9WUZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3