Q9WUV6 (CAZA3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F-actin-capping protein subunit alpha-3

Alternative name(s):
CapZ alpha-3

Gene names

Name:

Capza3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid.
Subunit structure	Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53 By similarity.
Tissue specificity	Exclusively expressed in the testis.
Sequence similarities	Belongs to the F-actin-capping protein alpha subunit family.

Ontologies

Keywords
Ligand	Actin-binding
Molecular function	Actin capping
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro actin filament capping Inferred from electronic annotation. Source: UniProtKB-KW spermatid development Inferred from expression pattern Ref.1. Source: RGD
Cellular_component	F-actin capping protein complex Inferred from electronic annotation. Source: InterPro acrosomal vesicle Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	F-actin-capping protein subunit alpha-3		PRO_0000208633

Sequences

	Sequence		Length	Mass (Da)
	Q9WUV6 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 3D753088BCF79BE5	FASTA	299	35,007
	10 20 30 40 50 60 MSLSVLSRQD KEKVIHRLLI QAPPGEFVNA FDDLCLLIRD EKLMHHQGEC AGHQHCQKYC 70 80 90 100 110 120 VPLCIDGNPV LLSHHNVMGD FRFFDYQSKL SFRFDLLQNQ LRDIQSHGII RNENEYLRSV 130 140 150 160 170 180 VMCALKLYVN DHYPNGNCNV LRKTVKNKEF LIACIEKHSY DNGECWNGLW KSKWIFQVNP 190 200 210 220 230 240 FLTQVTGRIF VQAHYFRCVN LHVEVSKDLK ESLEVVNQAQ LALSFARLVE EQENKFQAAV 250 260 270 280 290 IEELQELSNE ALRKILRRDL PVTRTLIDWQ RILSDLNLVM YPKLGYVIYS RSVLCNWII

References

[1]	"Expression of a testis-specific putative actin-capping protein associated with the developing acrosome during rat spermiogenesis." Hurst S., Howes E.A., Coadwell J., Jones R. Mol. Reprod. Dev. 49:81-91(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y12538 mRNA. Translation: CAA73137.1.
IPI	IPI00204411.
UniGene	Rn.42865.
3D structure databases
ProteinModelPortal	Q9WUV6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:2271. rat.
Organism-specific databases
RGD	2271. Capza3.
Phylogenomic databases
eggNOG	NOG257953.
HOGENOM	HOG000036539.
HOVERGEN	HBG050810.
InParanoid	Q9WUV6.
OrthoDB	EOG4C2H9Z.
Gene expression databases
ArrayExpress	Q9WUV6.
Genevestigator	Q9WUV6.
GermOnline	ENSRNOG00000008727. Rattus norvegicus.
Family and domain databases
InterPro	IPR017865. F-actin_cap_asu_CS. IPR002189. WASH_F-actin_cap_alpha. [Graphical view]
PANTHER	PTHR10653. PTHR10653. 1 hit.
Pfam	PF01267. F-actin_cap_A. 1 hit. [Graphical view]
PRINTS	PR00191. FACTINCAPA.
PROSITE	PS00748. F_ACTIN_CAPPING_A_1. 1 hit. PS00749. F_ACTIN_CAPPING_A_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAZA3_RAT

Accession

Primary (citable) accession number: Q9WUV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program