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Q9WUV6

- CAZA3_RAT

UniProt

Q9WUV6 - CAZA3_RAT

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Protein

F-actin-capping protein subunit alpha-3

Gene

Capza3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid.

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
  2. actin filament capping Source: UniProtKB-KW
  3. spermatid development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
F-actin-capping protein subunit alpha-3
Alternative name(s):
CapZ alpha-3
Gene namesi
Name:Capza3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2271. Capza3.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: RGD
  2. cytoplasm Source: RGD
  3. F-actin capping protein complex Source: InterPro
  4. WASH complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299F-actin-capping protein subunit alpha-3PRO_0000208633Add
BLAST

Expressioni

Tissue specificityi

Exclusively expressed in the testis.

Gene expression databases

GenevestigatoriQ9WUV6.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9WUV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG257953.
HOGENOMiHOG000036539.
HOVERGENiHBG050810.
InParanoidiQ9WUV6.
PhylomeDBiQ9WUV6.

Family and domain databases

InterProiIPR002189. CapZ_alpha.
IPR017865. F-actin_cap_asu_CS.
[Graphical view]
PANTHERiPTHR10653. PTHR10653. 1 hit.
PfamiPF01267. F-actin_cap_A. 1 hit.
[Graphical view]
PRINTSiPR00191. FACTINCAPA.
PROSITEiPS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUV6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSVLSRQD KEKVIHRLLI QAPPGEFVNA FDDLCLLIRD EKLMHHQGEC
60 70 80 90 100
AGHQHCQKYC VPLCIDGNPV LLSHHNVMGD FRFFDYQSKL SFRFDLLQNQ
110 120 130 140 150
LRDIQSHGII RNENEYLRSV VMCALKLYVN DHYPNGNCNV LRKTVKNKEF
160 170 180 190 200
LIACIEKHSY DNGECWNGLW KSKWIFQVNP FLTQVTGRIF VQAHYFRCVN
210 220 230 240 250
LHVEVSKDLK ESLEVVNQAQ LALSFARLVE EQENKFQAAV IEELQELSNE
260 270 280 290
ALRKILRRDL PVTRTLIDWQ RILSDLNLVM YPKLGYVIYS RSVLCNWII
Length:299
Mass (Da):35,007
Last modified:November 1, 1999 - v1
Checksum:i3D753088BCF79BE5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12538 mRNA. Translation: CAA73137.1.
UniGeneiRn.42865.

Genome annotation databases

UCSCiRGD:2271. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12538 mRNA. Translation: CAA73137.1 .
UniGenei Rn.42865.

3D structure databases

ProteinModelPortali Q9WUV6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2271. rat.

Organism-specific databases

RGDi 2271. Capza3.

Phylogenomic databases

eggNOGi NOG257953.
HOGENOMi HOG000036539.
HOVERGENi HBG050810.
InParanoidi Q9WUV6.
PhylomeDBi Q9WUV6.

Miscellaneous databases

PROi Q9WUV6.

Gene expression databases

Genevestigatori Q9WUV6.

Family and domain databases

InterProi IPR002189. CapZ_alpha.
IPR017865. F-actin_cap_asu_CS.
[Graphical view ]
PANTHERi PTHR10653. PTHR10653. 1 hit.
Pfami PF01267. F-actin_cap_A. 1 hit.
[Graphical view ]
PRINTSi PR00191. FACTINCAPA.
PROSITEi PS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of a testis-specific putative actin-capping protein associated with the developing acrosome during rat spermiogenesis."
    Hurst S., Howes E.A., Coadwell J., Jones R.
    Mol. Reprod. Dev. 49:81-91(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCAZA3_RAT
AccessioniPrimary (citable) accession number: Q9WUV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 1, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3