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Q9WUV6

- CAZA3_RAT

UniProt

Q9WUV6 - CAZA3_RAT

Protein

F-actin-capping protein subunit alpha-3

Gene

Capza3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid.

    GO - Biological processi

    1. actin cytoskeleton organization Source: InterPro
    2. actin filament capping Source: UniProtKB-KW
    3. spermatid development Source: RGD

    Keywords - Molecular functioni

    Actin capping

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-actin-capping protein subunit alpha-3
    Alternative name(s):
    CapZ alpha-3
    Gene namesi
    Name:Capza3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2271. Capza3.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: RGD
    2. cytoplasm Source: RGD
    3. F-actin capping protein complex Source: InterPro
    4. WASH complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299F-actin-capping protein subunit alpha-3PRO_0000208633Add
    BLAST

    Expressioni

    Tissue specificityi

    Exclusively expressed in the testis.

    Gene expression databases

    GenevestigatoriQ9WUV6.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WUV6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG257953.
    HOGENOMiHOG000036539.
    HOVERGENiHBG050810.
    InParanoidiQ9WUV6.
    PhylomeDBiQ9WUV6.

    Family and domain databases

    InterProiIPR002189. CapZ_alpha.
    IPR017865. F-actin_cap_asu_CS.
    [Graphical view]
    PANTHERiPTHR10653. PTHR10653. 1 hit.
    PfamiPF01267. F-actin_cap_A. 1 hit.
    [Graphical view]
    PRINTSiPR00191. FACTINCAPA.
    PROSITEiPS00748. F_ACTIN_CAPPING_A_1. 1 hit.
    PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WUV6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSVLSRQD KEKVIHRLLI QAPPGEFVNA FDDLCLLIRD EKLMHHQGEC    50
    AGHQHCQKYC VPLCIDGNPV LLSHHNVMGD FRFFDYQSKL SFRFDLLQNQ 100
    LRDIQSHGII RNENEYLRSV VMCALKLYVN DHYPNGNCNV LRKTVKNKEF 150
    LIACIEKHSY DNGECWNGLW KSKWIFQVNP FLTQVTGRIF VQAHYFRCVN 200
    LHVEVSKDLK ESLEVVNQAQ LALSFARLVE EQENKFQAAV IEELQELSNE 250
    ALRKILRRDL PVTRTLIDWQ RILSDLNLVM YPKLGYVIYS RSVLCNWII 299
    Length:299
    Mass (Da):35,007
    Last modified:November 1, 1999 - v1
    Checksum:i3D753088BCF79BE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12538 mRNA. Translation: CAA73137.1.
    UniGeneiRn.42865.

    Genome annotation databases

    UCSCiRGD:2271. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12538 mRNA. Translation: CAA73137.1 .
    UniGenei Rn.42865.

    3D structure databases

    ProteinModelPortali Q9WUV6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:2271. rat.

    Organism-specific databases

    RGDi 2271. Capza3.

    Phylogenomic databases

    eggNOGi NOG257953.
    HOGENOMi HOG000036539.
    HOVERGENi HBG050810.
    InParanoidi Q9WUV6.
    PhylomeDBi Q9WUV6.

    Miscellaneous databases

    PROi Q9WUV6.

    Gene expression databases

    Genevestigatori Q9WUV6.

    Family and domain databases

    InterProi IPR002189. CapZ_alpha.
    IPR017865. F-actin_cap_asu_CS.
    [Graphical view ]
    PANTHERi PTHR10653. PTHR10653. 1 hit.
    Pfami PF01267. F-actin_cap_A. 1 hit.
    [Graphical view ]
    PRINTSi PR00191. FACTINCAPA.
    PROSITEi PS00748. F_ACTIN_CAPPING_A_1. 1 hit.
    PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of a testis-specific putative actin-capping protein associated with the developing acrosome during rat spermiogenesis."
      Hurst S., Howes E.A., Coadwell J., Jones R.
      Mol. Reprod. Dev. 49:81-91(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiCAZA3_RAT
    AccessioniPrimary (citable) accession number: Q9WUV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3