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Q9WUV6 (CAZA3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-actin-capping protein subunit alpha-3
Alternative name(s):
CapZ alpha-3
Gene names
Name:Capza3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid.

Subunit structure

Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53 By similarity.

Tissue specificity

Exclusively expressed in the testis.

Sequence similarities

Belongs to the F-actin-capping protein alpha subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299F-actin-capping protein subunit alpha-3
PRO_0000208633

Sequences

Sequence LengthMass (Da)Tools
Q9WUV6 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 3D753088BCF79BE5

FASTA29935,007
        10         20         30         40         50         60 
MSLSVLSRQD KEKVIHRLLI QAPPGEFVNA FDDLCLLIRD EKLMHHQGEC AGHQHCQKYC 

        70         80         90        100        110        120 
VPLCIDGNPV LLSHHNVMGD FRFFDYQSKL SFRFDLLQNQ LRDIQSHGII RNENEYLRSV 

       130        140        150        160        170        180 
VMCALKLYVN DHYPNGNCNV LRKTVKNKEF LIACIEKHSY DNGECWNGLW KSKWIFQVNP 

       190        200        210        220        230        240 
FLTQVTGRIF VQAHYFRCVN LHVEVSKDLK ESLEVVNQAQ LALSFARLVE EQENKFQAAV 

       250        260        270        280        290 
IEELQELSNE ALRKILRRDL PVTRTLIDWQ RILSDLNLVM YPKLGYVIYS RSVLCNWII 

« Hide

References

[1]"Expression of a testis-specific putative actin-capping protein associated with the developing acrosome during rat spermiogenesis."
Hurst S., Howes E.A., Coadwell J., Jones R.
Mol. Reprod. Dev. 49:81-91(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y12538 mRNA. Translation: CAA73137.1.
UniGeneRn.42865.

3D structure databases

ProteinModelPortalQ9WUV6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:2271. rat.

Organism-specific databases

RGD2271. Capza3.

Phylogenomic databases

eggNOGNOG257953.
HOGENOMHOG000036539.
HOVERGENHBG050810.
InParanoidQ9WUV6.
PhylomeDBQ9WUV6.

Gene expression databases

GenevestigatorQ9WUV6.

Family and domain databases

InterProIPR002189. CapZ_alpha.
IPR017865. F-actin_cap_asu_CS.
[Graphical view]
PANTHERPTHR10653. PTHR10653. 1 hit.
PfamPF01267. F-actin_cap_A. 1 hit.
[Graphical view]
PRINTSPR00191. FACTINCAPA.
PROSITEPS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9WUV6.

Entry information

Entry nameCAZA3_RAT
AccessionPrimary (citable) accession number: Q9WUV6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families