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Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

Gene

St6galnac3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins.1 Publication

Catalytic activityi

CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-4085001. Sialic acid metabolism.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Chemistry databases

SwissLipidsiSLP:000000783.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (EC:2.4.99.-)
Alternative name(s):
GalNAc alpha-2,6-sialyltransferase III
ST6GalNAc III
Short name:
ST6GalNAcIII
STY
Sialyltransferase 7C
Short name:
SIAT7-C
Gene namesi
Name:St6galnac3
Synonyms:Siat7c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1341828. St6galnac3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini29 – 305LumenalSequence analysisAdd BLAST277

GO - Cellular componenti

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492761 – 305Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 229By similarity
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9WUV2.
PaxDbiQ9WUV2.
PRIDEiQ9WUV2.

Expressioni

Tissue specificityi

High expression in brain, lung and heart and to a lesser extent in kidney, mammary gland, spleen, testis and thymus.1 Publication

Developmental stagei

In brain, expression reaches maximum levels at day 12 of the embryonic stage. Keeps almost similar levels during mouse development.1 Publication

Gene expression databases

BgeeiENSMUSG00000052544.
ExpressionAtlasiQ9WUV2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068598.

Structurei

3D structure databases

ProteinModelPortaliQ9WUV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00550000074444.
HOGENOMiHOG000293316.
HOVERGENiHBG058710.
InParanoidiQ9WUV2.
KOiK03373.
OMAiRPLRTHY.
OrthoDBiEOG091G0H9S.
PhylomeDBiQ9WUV2.
TreeFamiTF352818.

Family and domain databases

InterProiView protein in InterPro
IPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
PfamiView protein in Pfam
PF00777. Glyco_transf_29. 1 hit.
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WUV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACILKRKPV LVVSFIALCI LLLAMRLVND ATFPLLLNCF GQPKTKWIPL
60 70 80 90 100
PYTFRQPLRT HYGYINVRTQ EPLQLNCNHC AIVSNSGQMV GQKVGEEIDH
110 120 130 140 150
ASCIWRMNNA PTKGFEEDVG YMTMVRVVSH TSVPLLLKNP DYFFKEASRT
160 170 180 190 200
IYVIWGPFRN MRKDGNGIVY NMLKKTVDAY PDAQIYVTTE QQMTHCDRVF
210 220 230 240 250
KDETGKDRVQ SGSYLSTGWF TFILAMDACY SIHVYGMINE TYCKTEGYRK
260 270 280 290 300
VPYHYYEQGK DECNEYLLHE HAPYGGHRFI TEKKVFAKWA KKHRIVFTHP

NWTLS
Length:305
Mass (Da):35,414
Last modified:March 1, 2001 - v2
Checksum:i63C7498615BF6A3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11342 mRNA. Translation: CAA72181.2.
Y11343
, Y11344, Y11345, Y11346 Genomic DNA. Translation: CAB95031.1.
BC058387 mRNA. Translation: AAH58387.1.
CCDSiCCDS38677.1.
RefSeqiNP_035502.1. NM_011372.2.
UniGeneiMm.296453.
Mm.440929.

Genome annotation databases

EnsembliENSMUST00000200397; ENSMUSP00000143747; ENSMUSG00000052544.
GeneIDi20447.
KEGGimmu:20447.
UCSCiuc008rtw.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSIA7C_MOUSE
AccessioniPrimary (citable) accession number: Q9WUV2
Secondary accession number(s): Q9JHP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2001
Last modified: July 5, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families