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Q9WUV0

- ORC5_MOUSE

UniProt

Q9WUV0 - ORC5_MOUSE

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Protein

Origin recognition complex subunit 5

Gene

Orc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA replication Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_204269. E2F-enabled inhibition of pre-replication complex formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 5
Gene namesi
Name:Orc5
Synonyms:Orc5l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1347044. Orc5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nuclear origin of replication recognition complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Origin recognition complex subunit 5PRO_0000127093Add
BLAST

Proteomic databases

MaxQBiQ9WUV0.
PRIDEiQ9WUV0.

PTM databases

PhosphoSiteiQ9WUV0.

Expressioni

Gene expression databases

BgeeiQ9WUV0.
ExpressionAtlasiQ9WUV0. baseline and differential.
GenevestigatoriQ9WUV0.

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity).By similarity

Protein-protein interaction databases

BioGridi204981. 1 interaction.
IntActiQ9WUV0. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9WUV0.
SMRiQ9WUV0. Positions 32-60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC5 family.Curated

Phylogenomic databases

eggNOGiNOG249220.
GeneTreeiENSGT00390000009380.
HOGENOMiHOG000252906.
HOVERGENiHBG007875.
InParanoidiQ9WUV0.
KOiK02607.
OMAiVPCRESQ.
OrthoDBiEOG7DZ8K4.
PhylomeDBiQ9WUV0.
TreeFamiTF101095.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR020796. ORC5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12705. PTHR12705. 1 hit.
PfamiPF14630. ORC5_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WUV0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHLESMVLC REAQVSTLQS LFGERHHFSF PSIFIYGHTA SGKTYVTQTL
60 70 80 90 100
LKTLELPHAF VNCVECFTSR LLLEQILNKL SHLNSSDAGC STEMTCETFN
110 120 130 140 150
DFVQLFKQVT SAEHLKDQTV YIVLDKAEYL RDMEANLLPG LLRLQELTDR
160 170 180 190 200
NVTVIFLSEI IWEKFRPNTG CFEPFVLYFP DYSIGNLQKI LSHDHPPEYS
210 220 230 240 250
ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV VKGEAGERDT
260 270 280 290 300
RKLWRNIEPH LKKAMQTVYL REISSSQWEK LQKDNTDPGQ LKGLSAYTHM
310 320 330 340 350
ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTNF LKKHEKTSNH
360 370 380 390 400
LLGPKPFPLD RLLAILYSIV DSRVAPTANI FSQITSLVTL QLLTIVGHED
410 420 430
QLNGPKYKCT VSLDFIRAIA RMVNFDIIKY LYDFL
Length:435
Mass (Da):50,217
Last modified:November 1, 1999 - v1
Checksum:i1F334E35379F5C69
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007360 mRNA. Translation: CAB43767.1.
AK084683 mRNA. Translation: BAC39250.1.
AK144983 mRNA. Translation: BAE26167.1.
AK165912 mRNA. Translation: BAE38456.1.
AK166537 mRNA. Translation: BAE38839.1.
BC006927 mRNA. Translation: AAH06927.1.
CCDSiCCDS19110.1.
RefSeqiNP_036089.1. NM_011959.2.
UniGeneiMm.412217.
Mm.469664.

Genome annotation databases

EnsembliENSMUST00000030872; ENSMUSP00000030872; ENSMUSG00000029012.
GeneIDi26429.
KEGGimmu:26429.
UCSCiuc008wpq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007360 mRNA. Translation: CAB43767.1 .
AK084683 mRNA. Translation: BAC39250.1 .
AK144983 mRNA. Translation: BAE26167.1 .
AK165912 mRNA. Translation: BAE38456.1 .
AK166537 mRNA. Translation: BAE38839.1 .
BC006927 mRNA. Translation: AAH06927.1 .
CCDSi CCDS19110.1.
RefSeqi NP_036089.1. NM_011959.2.
UniGenei Mm.412217.
Mm.469664.

3D structure databases

ProteinModelPortali Q9WUV0.
SMRi Q9WUV0. Positions 32-60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204981. 1 interaction.
IntActi Q9WUV0. 2 interactions.

PTM databases

PhosphoSitei Q9WUV0.

Proteomic databases

MaxQBi Q9WUV0.
PRIDEi Q9WUV0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030872 ; ENSMUSP00000030872 ; ENSMUSG00000029012 .
GeneIDi 26429.
KEGGi mmu:26429.
UCSCi uc008wpq.1. mouse.

Organism-specific databases

CTDi 5001.
MGIi MGI:1347044. Orc5.

Phylogenomic databases

eggNOGi NOG249220.
GeneTreei ENSGT00390000009380.
HOGENOMi HOG000252906.
HOVERGENi HBG007875.
InParanoidi Q9WUV0.
KOi K02607.
OMAi VPCRESQ.
OrthoDBi EOG7DZ8K4.
PhylomeDBi Q9WUV0.
TreeFami TF101095.

Enzyme and pathway databases

Reactomei REACT_204269. E2F-enabled inhibition of pre-replication complex formation.

Miscellaneous databases

NextBioi 304473.
PROi Q9WUV0.
SOURCEi Search...

Gene expression databases

Bgeei Q9WUV0.
ExpressionAtlasi Q9WUV0. baseline and differential.
Genevestigatori Q9WUV0.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR020796. ORC5.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR12705. PTHR12705. 1 hit.
Pfami PF14630. ORC5_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex."
    Springer J., Kneissl M., Putter V., Grummt F.
    Chromosoma 108:243-249(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart, Lung and Mammary gland.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiORC5_MOUSE
AccessioniPrimary (citable) accession number: Q9WUV0
Secondary accession number(s): Q3TMI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3