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Q9WUV0

- ORC5_MOUSE

UniProt

Q9WUV0 - ORC5_MOUSE

Protein

Origin recognition complex subunit 5

Gene

Orc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi37 – 448ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA replication Source: MGI

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_204269. E2F-enabled inhibition of pre-replication complex formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Origin recognition complex subunit 5
    Gene namesi
    Name:Orc5
    Synonyms:Orc5l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1347044. Orc5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nuclear origin of replication recognition complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Origin recognition complex subunit 5PRO_0000127093Add
    BLAST

    Proteomic databases

    PRIDEiQ9WUV0.

    PTM databases

    PhosphoSiteiQ9WUV0.

    Expressioni

    Gene expression databases

    BgeeiQ9WUV0.
    GenevestigatoriQ9WUV0.

    Interactioni

    Subunit structurei

    Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase By similarity.By similarity

    Protein-protein interaction databases

    BioGridi204981. 1 interaction.
    IntActiQ9WUV0. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WUV0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ORC5 family.Curated

    Phylogenomic databases

    eggNOGiNOG249220.
    GeneTreeiENSGT00390000009380.
    HOGENOMiHOG000252906.
    HOVERGENiHBG007875.
    InParanoidiQ9WUV0.
    KOiK02607.
    OMAiVPCRESQ.
    OrthoDBiEOG7DZ8K4.
    PhylomeDBiQ9WUV0.
    TreeFamiTF101095.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR020796. ORC5.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR12705. PTHR12705. 1 hit.
    PfamiPF14630. ORC5_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9WUV0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHLESMVLC REAQVSTLQS LFGERHHFSF PSIFIYGHTA SGKTYVTQTL    50
    LKTLELPHAF VNCVECFTSR LLLEQILNKL SHLNSSDAGC STEMTCETFN 100
    DFVQLFKQVT SAEHLKDQTV YIVLDKAEYL RDMEANLLPG LLRLQELTDR 150
    NVTVIFLSEI IWEKFRPNTG CFEPFVLYFP DYSIGNLQKI LSHDHPPEYS 200
    ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV VKGEAGERDT 250
    RKLWRNIEPH LKKAMQTVYL REISSSQWEK LQKDNTDPGQ LKGLSAYTHM 300
    ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTNF LKKHEKTSNH 350
    LLGPKPFPLD RLLAILYSIV DSRVAPTANI FSQITSLVTL QLLTIVGHED 400
    QLNGPKYKCT VSLDFIRAIA RMVNFDIIKY LYDFL 435
    Length:435
    Mass (Da):50,217
    Last modified:November 1, 1999 - v1
    Checksum:i1F334E35379F5C69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007360 mRNA. Translation: CAB43767.1.
    AK084683 mRNA. Translation: BAC39250.1.
    AK144983 mRNA. Translation: BAE26167.1.
    AK165912 mRNA. Translation: BAE38456.1.
    AK166537 mRNA. Translation: BAE38839.1.
    BC006927 mRNA. Translation: AAH06927.1.
    CCDSiCCDS19110.1.
    RefSeqiNP_036089.1. NM_011959.2.
    UniGeneiMm.412217.
    Mm.469664.

    Genome annotation databases

    EnsembliENSMUST00000030872; ENSMUSP00000030872; ENSMUSG00000029012.
    GeneIDi26429.
    KEGGimmu:26429.
    UCSCiuc008wpq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007360 mRNA. Translation: CAB43767.1 .
    AK084683 mRNA. Translation: BAC39250.1 .
    AK144983 mRNA. Translation: BAE26167.1 .
    AK165912 mRNA. Translation: BAE38456.1 .
    AK166537 mRNA. Translation: BAE38839.1 .
    BC006927 mRNA. Translation: AAH06927.1 .
    CCDSi CCDS19110.1.
    RefSeqi NP_036089.1. NM_011959.2.
    UniGenei Mm.412217.
    Mm.469664.

    3D structure databases

    ProteinModelPortali Q9WUV0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204981. 1 interaction.
    IntActi Q9WUV0. 2 interactions.

    PTM databases

    PhosphoSitei Q9WUV0.

    Proteomic databases

    PRIDEi Q9WUV0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030872 ; ENSMUSP00000030872 ; ENSMUSG00000029012 .
    GeneIDi 26429.
    KEGGi mmu:26429.
    UCSCi uc008wpq.1. mouse.

    Organism-specific databases

    CTDi 5001.
    MGIi MGI:1347044. Orc5.

    Phylogenomic databases

    eggNOGi NOG249220.
    GeneTreei ENSGT00390000009380.
    HOGENOMi HOG000252906.
    HOVERGENi HBG007875.
    InParanoidi Q9WUV0.
    KOi K02607.
    OMAi VPCRESQ.
    OrthoDBi EOG7DZ8K4.
    PhylomeDBi Q9WUV0.
    TreeFami TF101095.

    Enzyme and pathway databases

    Reactomei REACT_204269. E2F-enabled inhibition of pre-replication complex formation.

    Miscellaneous databases

    NextBioi 304473.
    PROi Q9WUV0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WUV0.
    Genevestigatori Q9WUV0.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR020796. ORC5.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR12705. PTHR12705. 1 hit.
    Pfami PF14630. ORC5_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex."
      Springer J., Kneissl M., Putter V., Grummt F.
      Chromosoma 108:243-249(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart, Lung and Mammary gland.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiORC5_MOUSE
    AccessioniPrimary (citable) accession number: Q9WUV0
    Secondary accession number(s): Q3TMI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3