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Protein

Origin recognition complex subunit 5

Gene

Orc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA replication Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_274616. Activation of ATR in response to replication stress.
REACT_293164. Removal of licensing factors from origins.
REACT_297337. CDC6 association with the ORC:origin complex.
REACT_304291. Assembly of the ORC complex at the origin of replication.
REACT_315933. Orc1 removal from chromatin.
REACT_336670. Assembly of the pre-replicative complex.
REACT_343561. CDT1 association with the CDC6:ORC:origin complex.
REACT_346857. E2F-enabled inhibition of pre-replication complex formation.
REACT_349855. Association of licensing factors with the pre-replicative complex.
REACT_351504. Activation of the pre-replicative complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 5
Gene namesi
Name:Orc5
Synonyms:Orc5l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1347044. Orc5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear origin of replication recognition complex Source: UniProtKB
  3. nucleoplasm Source: MGI
  4. nucleus Source: MGI
  5. origin recognition complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Origin recognition complex subunit 5PRO_0000127093Add
BLAST

Proteomic databases

MaxQBiQ9WUV0.
PRIDEiQ9WUV0.

PTM databases

PhosphoSiteiQ9WUV0.

Expressioni

Gene expression databases

BgeeiQ9WUV0.
ExpressionAtlasiQ9WUV0. baseline and differential.
GenevestigatoriQ9WUV0.

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity).By similarity

Protein-protein interaction databases

BioGridi204981. 1 interaction.
IntActiQ9WUV0. 2 interactions.

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC5 family.Curated

Phylogenomic databases

eggNOGiNOG249220.
GeneTreeiENSGT00390000009380.
HOGENOMiHOG000252906.
HOVERGENiHBG007875.
InParanoidiQ9WUV0.
KOiK02607.
OMAiIFYSVVD.
OrthoDBiEOG7DZ8K4.
PhylomeDBiQ9WUV0.
TreeFamiTF101095.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR020796. ORC5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12705. PTHR12705. 1 hit.
PfamiPF14630. ORC5_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WUV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLESMVLC REAQVSTLQS LFGERHHFSF PSIFIYGHTA SGKTYVTQTL
60 70 80 90 100
LKTLELPHAF VNCVECFTSR LLLEQILNKL SHLNSSDAGC STEMTCETFN
110 120 130 140 150
DFVQLFKQVT SAEHLKDQTV YIVLDKAEYL RDMEANLLPG LLRLQELTDR
160 170 180 190 200
NVTVIFLSEI IWEKFRPNTG CFEPFVLYFP DYSIGNLQKI LSHDHPPEYS
210 220 230 240 250
ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV VKGEAGERDT
260 270 280 290 300
RKLWRNIEPH LKKAMQTVYL REISSSQWEK LQKDNTDPGQ LKGLSAYTHM
310 320 330 340 350
ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTNF LKKHEKTSNH
360 370 380 390 400
LLGPKPFPLD RLLAILYSIV DSRVAPTANI FSQITSLVTL QLLTIVGHED
410 420 430
QLNGPKYKCT VSLDFIRAIA RMVNFDIIKY LYDFL
Length:435
Mass (Da):50,217
Last modified:November 1, 1999 - v1
Checksum:i1F334E35379F5C69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007360 mRNA. Translation: CAB43767.1.
AK084683 mRNA. Translation: BAC39250.1.
AK144983 mRNA. Translation: BAE26167.1.
AK165912 mRNA. Translation: BAE38456.1.
AK166537 mRNA. Translation: BAE38839.1.
BC006927 mRNA. Translation: AAH06927.1.
CCDSiCCDS19110.1.
RefSeqiNP_036089.1. NM_011959.2.
UniGeneiMm.412217.
Mm.469664.

Genome annotation databases

EnsembliENSMUST00000030872; ENSMUSP00000030872; ENSMUSG00000029012.
GeneIDi26429.
KEGGimmu:26429.
UCSCiuc008wpq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007360 mRNA. Translation: CAB43767.1.
AK084683 mRNA. Translation: BAC39250.1.
AK144983 mRNA. Translation: BAE26167.1.
AK165912 mRNA. Translation: BAE38456.1.
AK166537 mRNA. Translation: BAE38839.1.
BC006927 mRNA. Translation: AAH06927.1.
CCDSiCCDS19110.1.
RefSeqiNP_036089.1. NM_011959.2.
UniGeneiMm.412217.
Mm.469664.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204981. 1 interaction.
IntActiQ9WUV0. 2 interactions.

PTM databases

PhosphoSiteiQ9WUV0.

Proteomic databases

MaxQBiQ9WUV0.
PRIDEiQ9WUV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030872; ENSMUSP00000030872; ENSMUSG00000029012.
GeneIDi26429.
KEGGimmu:26429.
UCSCiuc008wpq.1. mouse.

Organism-specific databases

CTDi5001.
MGIiMGI:1347044. Orc5.

Phylogenomic databases

eggNOGiNOG249220.
GeneTreeiENSGT00390000009380.
HOGENOMiHOG000252906.
HOVERGENiHBG007875.
InParanoidiQ9WUV0.
KOiK02607.
OMAiIFYSVVD.
OrthoDBiEOG7DZ8K4.
PhylomeDBiQ9WUV0.
TreeFamiTF101095.

Enzyme and pathway databases

ReactomeiREACT_274616. Activation of ATR in response to replication stress.
REACT_293164. Removal of licensing factors from origins.
REACT_297337. CDC6 association with the ORC:origin complex.
REACT_304291. Assembly of the ORC complex at the origin of replication.
REACT_315933. Orc1 removal from chromatin.
REACT_336670. Assembly of the pre-replicative complex.
REACT_343561. CDT1 association with the CDC6:ORC:origin complex.
REACT_346857. E2F-enabled inhibition of pre-replication complex formation.
REACT_349855. Association of licensing factors with the pre-replicative complex.
REACT_351504. Activation of the pre-replicative complex.

Miscellaneous databases

NextBioi304473.
PROiQ9WUV0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WUV0.
ExpressionAtlasiQ9WUV0. baseline and differential.
GenevestigatoriQ9WUV0.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR020796. ORC5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12705. PTHR12705. 1 hit.
PfamiPF14630. ORC5_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex."
    Springer J., Kneissl M., Putter V., Grummt F.
    Chromosoma 108:243-249(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart, Lung and Mammary gland.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiORC5_MOUSE
AccessioniPrimary (citable) accession number: Q9WUV0
Secondary accession number(s): Q3TMI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: April 1, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.