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Q9WUU7 (CATZ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cathepsin Z

EC=3.4.18.1
Gene names
Name:Ctsz
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity By similarity.

Catalytic activity

Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.

Subcellular location

Lysosome.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the peptidase C1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 6341Activation peptide Potential
PRO_0000026287
Chain64 – 306243Cathepsin Z
PRO_0000026288

Sites

Active site941 By similarity
Active site2431 By similarity
Active site2641 By similarity

Amino acid modifications

Glycosylation1861N-linked (GlcNAc...) Potential
Glycosylation2261N-linked (GlcNAc...) Potential
Disulfide bond91 ↔ 134 By similarity
Disulfide bond128 ↔ 166 By similarity
Disulfide bond156 ↔ 172 By similarity
Disulfide bond175 ↔ 181 By similarity
Disulfide bond216 ↔ 299 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WUU7 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 1B94045C3D0A7CFB

FASTA30633,996
        10         20         30         40         50         60 
MASSGSVQQL PLVLLMLLLA SAARARLYFR SGQTCYHPIR GDQLALLGRR TYPRPHEYLS 

        70         80         90        100        110        120 
PADLPKNWDW RNVNGVNYAS VTRNQHIPQY CGSCWAHGST SAMADRINIK RKGAWPSILL 

       130        140        150        160        170        180 
SVQNVIDCGN AGSCEGGNDL PVWEYAHKHG IPDETCNNYQ AKDQDCDKFN QCGTCTEFKE 

       190        200        210        220        230        240 
CHTIQNYTLW RVGDYGSLSG REKMMAEIYA NGPISCGIMA TEMMSNYTGG IYAEHQDQAV 

       250        260        270        280        290        300 
INHIISVAGW GVSNDGIEYW IVRNSWGEPW GEKGWMRIVT STYKGGTGDS YNLAIESACT 


FGDPIV 

« Hide

References

« Hide 'large scale' references
[1]Santamaria I.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization."
Deussing J., von Olshausen I., Peters C.
Biochim. Biophys. Acta 1491:93-106(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Fetus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ242663 mRNA. Translation: CAB44494.1.
AF136277 mRNA. Translation: AAF13143.1.
AF136278 Genomic DNA. Translation: AAF13144.1.
BC008619 mRNA. Translation: AAH08619.1.
CCDSCCDS17152.1.
RefSeqNP_071720.1. NM_022325.4.
UniGeneMm.156919.

3D structure databases

ProteinModelPortalQ9WUU7.
SMRQ9WUU7. Positions 32-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9WUU7. 3 interactions.
MINTMINT-4089955.
STRING10090.ENSMUSP00000016400.

Proteomic databases

MaxQBQ9WUU7.
PaxDbQ9WUU7.
PRIDEQ9WUU7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000016400; ENSMUSP00000016400; ENSMUSG00000016256.
GeneID64138.
KEGGmmu:64138.
UCSCuc008ofd.1. mouse.

Organism-specific databases

CTD1522.
MGIMGI:1891190. Ctsz.

Phylogenomic databases

eggNOGCOG4870.
GeneTreeENSGT00750000117660.
HOVERGENHBG004456.
InParanoidQ9WUU7.
KOK08568.
OMAQCGTCTE.
OrthoDBEOG751NFZ.
PhylomeDBQ9WUU7.
TreeFamTF313225.

Gene expression databases

ArrayExpressQ9WUU7.
BgeeQ9WUU7.
CleanExMM_CTSZ.
GenevestigatorQ9WUU7.

Family and domain databases

InterProIPR025661. Pept_asp_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00640. THIOL_PROTEASE_ASN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCTSZ. mouse.
NextBio319927.
PROQ9WUU7.
SOURCESearch...

Entry information

Entry nameCATZ_MOUSE
AccessionPrimary (citable) accession number: Q9WUU7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot