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Q9WUU7

- CATZ_MOUSE

UniProt

Q9WUU7 - CATZ_MOUSE

Protein

Cathepsin Z

Gene

Ctsz

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.By similarity

    Catalytic activityi

    Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei94 – 941PROSITE-ProRule annotation
    Active sitei243 – 2431PROSITE-ProRule annotation
    Active sitei264 – 2641PROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. epithelial tube branching involved in lung morphogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    ReactomeiREACT_196539. Metabolism of Angiotensinogen to Angiotensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin Z (EC:3.4.18.1)
    Gene namesi
    Name:Ctsz
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1891190. Ctsz.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. extracellular space Source: Ensembl
    3. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 6341Activation peptideSequence AnalysisPRO_0000026287Add
    BLAST
    Chaini64 – 306243Cathepsin ZPRO_0000026288Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi91 ↔ 134By similarity
    Disulfide bondi128 ↔ 166By similarity
    Disulfide bondi156 ↔ 172By similarity
    Disulfide bondi175 ↔ 181By similarity
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi216 ↔ 299By similarity
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiQ9WUU7.
    PaxDbiQ9WUU7.
    PRIDEiQ9WUU7.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ9WUU7.
    BgeeiQ9WUU7.
    CleanExiMM_CTSZ.
    GenevestigatoriQ9WUU7.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9WUU7. 3 interactions.
    MINTiMINT-4089955.
    STRINGi10090.ENSMUSP00000016400.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WUU7.
    SMRiQ9WUU7. Positions 32-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4870.
    GeneTreeiENSGT00750000117660.
    HOVERGENiHBG004456.
    InParanoidiQ9WUU7.
    KOiK08568.
    OMAiQCGTCTE.
    OrthoDBiEOG751NFZ.
    PhylomeDBiQ9WUU7.
    TreeFamiTF313225.

    Family and domain databases

    InterProiIPR025661. Pept_asp_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WUU7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSGSVQQL PLVLLMLLLA SAARARLYFR SGQTCYHPIR GDQLALLGRR    50
    TYPRPHEYLS PADLPKNWDW RNVNGVNYAS VTRNQHIPQY CGSCWAHGST 100
    SAMADRINIK RKGAWPSILL SVQNVIDCGN AGSCEGGNDL PVWEYAHKHG 150
    IPDETCNNYQ AKDQDCDKFN QCGTCTEFKE CHTIQNYTLW RVGDYGSLSG 200
    REKMMAEIYA NGPISCGIMA TEMMSNYTGG IYAEHQDQAV INHIISVAGW 250
    GVSNDGIEYW IVRNSWGEPW GEKGWMRIVT STYKGGTGDS YNLAIESACT 300
    FGDPIV 306
    Length:306
    Mass (Da):33,996
    Last modified:November 1, 1999 - v1
    Checksum:i1B94045C3D0A7CFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ242663 mRNA. Translation: CAB44494.1.
    AF136277 mRNA. Translation: AAF13143.1.
    AF136278 Genomic DNA. Translation: AAF13144.1.
    BC008619 mRNA. Translation: AAH08619.1.
    CCDSiCCDS17152.1.
    RefSeqiNP_071720.1. NM_022325.4.
    UniGeneiMm.156919.

    Genome annotation databases

    EnsembliENSMUST00000016400; ENSMUSP00000016400; ENSMUSG00000016256.
    GeneIDi64138.
    KEGGimmu:64138.
    UCSCiuc008ofd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ242663 mRNA. Translation: CAB44494.1 .
    AF136277 mRNA. Translation: AAF13143.1 .
    AF136278 Genomic DNA. Translation: AAF13144.1 .
    BC008619 mRNA. Translation: AAH08619.1 .
    CCDSi CCDS17152.1.
    RefSeqi NP_071720.1. NM_022325.4.
    UniGenei Mm.156919.

    3D structure databases

    ProteinModelPortali Q9WUU7.
    SMRi Q9WUU7. Positions 32-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9WUU7. 3 interactions.
    MINTi MINT-4089955.
    STRINGi 10090.ENSMUSP00000016400.

    Proteomic databases

    MaxQBi Q9WUU7.
    PaxDbi Q9WUU7.
    PRIDEi Q9WUU7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000016400 ; ENSMUSP00000016400 ; ENSMUSG00000016256 .
    GeneIDi 64138.
    KEGGi mmu:64138.
    UCSCi uc008ofd.1. mouse.

    Organism-specific databases

    CTDi 1522.
    MGIi MGI:1891190. Ctsz.

    Phylogenomic databases

    eggNOGi COG4870.
    GeneTreei ENSGT00750000117660.
    HOVERGENi HBG004456.
    InParanoidi Q9WUU7.
    KOi K08568.
    OMAi QCGTCTE.
    OrthoDBi EOG751NFZ.
    PhylomeDBi Q9WUU7.
    TreeFami TF313225.

    Enzyme and pathway databases

    Reactomei REACT_196539. Metabolism of Angiotensinogen to Angiotensins.

    Miscellaneous databases

    ChiTaRSi CTSZ. mouse.
    NextBioi 319927.
    PROi Q9WUU7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WUU7.
    Bgeei Q9WUU7.
    CleanExi MM_CTSZ.
    Genevestigatori Q9WUU7.

    Family and domain databases

    InterProi IPR025661. Pept_asp_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Santamaria I.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization."
      Deussing J., von Olshausen I., Peters C.
      Biochim. Biophys. Acta 1491:93-106(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Fetus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCATZ_MOUSE
    AccessioniPrimary (citable) accession number: Q9WUU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3