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Protein

Cathepsin Z

Gene

Ctsz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.By similarity

Catalytic activityi

Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941PROSITE-ProRule annotation
Active sitei243 – 2431PROSITE-ProRule annotation
Active sitei264 – 2641PROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. epithelial tube branching involved in lung morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiREACT_281604. Metabolism of Angiotensinogen to Angiotensins.
REACT_303468. Lysosome Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin Z (EC:3.4.18.1)
Gene namesi
Name:Ctsz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1891190. Ctsz.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. extracellular space Source: MGI
  3. extracellular vesicular exosome Source: MGI
  4. intracellular membrane-bounded organelle Source: MGI
  5. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 6341Activation peptideSequence AnalysisPRO_0000026287Add
BLAST
Chaini64 – 306243Cathepsin ZPRO_0000026288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi91 ↔ 134By similarity
Disulfide bondi128 ↔ 166By similarity
Disulfide bondi156 ↔ 172By similarity
Disulfide bondi175 ↔ 181By similarity
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi216 ↔ 299By similarity
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ9WUU7.
PaxDbiQ9WUU7.
PRIDEiQ9WUU7.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9WUU7.
CleanExiMM_CTSZ.
ExpressionAtlasiQ9WUU7. baseline and differential.
GenevestigatoriQ9WUU7.

Interactioni

Protein-protein interaction databases

IntActiQ9WUU7. 3 interactions.
MINTiMINT-4089955.
STRINGi10090.ENSMUSP00000016400.

Structurei

3D structure databases

ProteinModelPortaliQ9WUU7.
SMRiQ9WUU7. Positions 32-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
GeneTreeiENSGT00760000118871.
HOVERGENiHBG004456.
InParanoidiQ9WUU7.
KOiK08568.
OMAiQCGTCTE.
OrthoDBiEOG751NFZ.
PhylomeDBiQ9WUU7.
TreeFamiTF313225.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSGSVQQL PLVLLMLLLA SAARARLYFR SGQTCYHPIR GDQLALLGRR
60 70 80 90 100
TYPRPHEYLS PADLPKNWDW RNVNGVNYAS VTRNQHIPQY CGSCWAHGST
110 120 130 140 150
SAMADRINIK RKGAWPSILL SVQNVIDCGN AGSCEGGNDL PVWEYAHKHG
160 170 180 190 200
IPDETCNNYQ AKDQDCDKFN QCGTCTEFKE CHTIQNYTLW RVGDYGSLSG
210 220 230 240 250
REKMMAEIYA NGPISCGIMA TEMMSNYTGG IYAEHQDQAV INHIISVAGW
260 270 280 290 300
GVSNDGIEYW IVRNSWGEPW GEKGWMRIVT STYKGGTGDS YNLAIESACT

FGDPIV
Length:306
Mass (Da):33,996
Last modified:November 1, 1999 - v1
Checksum:i1B94045C3D0A7CFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242663 mRNA. Translation: CAB44494.1.
AF136277 mRNA. Translation: AAF13143.1.
AF136278 Genomic DNA. Translation: AAF13144.1.
BC008619 mRNA. Translation: AAH08619.1.
CCDSiCCDS17152.1.
RefSeqiNP_071720.1. NM_022325.4.
UniGeneiMm.156919.

Genome annotation databases

EnsembliENSMUST00000016400; ENSMUSP00000016400; ENSMUSG00000016256.
GeneIDi64138.
KEGGimmu:64138.
UCSCiuc008ofd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242663 mRNA. Translation: CAB44494.1.
AF136277 mRNA. Translation: AAF13143.1.
AF136278 Genomic DNA. Translation: AAF13144.1.
BC008619 mRNA. Translation: AAH08619.1.
CCDSiCCDS17152.1.
RefSeqiNP_071720.1. NM_022325.4.
UniGeneiMm.156919.

3D structure databases

ProteinModelPortaliQ9WUU7.
SMRiQ9WUU7. Positions 32-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WUU7. 3 interactions.
MINTiMINT-4089955.
STRINGi10090.ENSMUSP00000016400.

Proteomic databases

MaxQBiQ9WUU7.
PaxDbiQ9WUU7.
PRIDEiQ9WUU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016400; ENSMUSP00000016400; ENSMUSG00000016256.
GeneIDi64138.
KEGGimmu:64138.
UCSCiuc008ofd.1. mouse.

Organism-specific databases

CTDi1522.
MGIiMGI:1891190. Ctsz.

Phylogenomic databases

eggNOGiCOG4870.
GeneTreeiENSGT00760000118871.
HOVERGENiHBG004456.
InParanoidiQ9WUU7.
KOiK08568.
OMAiQCGTCTE.
OrthoDBiEOG751NFZ.
PhylomeDBiQ9WUU7.
TreeFamiTF313225.

Enzyme and pathway databases

ReactomeiREACT_281604. Metabolism of Angiotensinogen to Angiotensins.
REACT_303468. Lysosome Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSiCtsz. mouse.
NextBioi319927.
PROiQ9WUU7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WUU7.
CleanExiMM_CTSZ.
ExpressionAtlasiQ9WUU7. baseline and differential.
GenevestigatoriQ9WUU7.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Santamaria I.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization."
    Deussing J., von Olshausen I., Peters C.
    Biochim. Biophys. Acta 1491:93-106(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Fetus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCATZ_MOUSE
AccessioniPrimary (citable) accession number: Q9WUU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: April 1, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.