Q9WUU7 (CATZ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cathepsin Z
EC=3.4.18.1

Gene names

Name:

Ctsz

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity By similarity.
Catalytic activity	Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.
Subcellular location	Lysosome.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	epithelial tube branching involved in lung morphogenesis Inferred from expression pattern PubMed 17500053. Source: UniProtKB proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Propeptide	23 – 63	41	Activation peptide Potential		PRO_0000026287
	Chain	64 – 306	243	Cathepsin Z		PRO_0000026288
Sites
	Active site	94	1	By similarity
	Active site	243	1	By similarity
	Active site	264	1	By similarity
Amino acid modifications
	Glycosylation	186	1	N-linked (GlcNAc...) Potential
	Glycosylation	226	1	N-linked (GlcNAc...) Potential
	Disulfide bond	91 ↔ 134		By similarity
	Disulfide bond	128 ↔ 166		By similarity
	Disulfide bond	156 ↔ 172		By similarity
	Disulfide bond	175 ↔ 181		By similarity
	Disulfide bond	216 ↔ 299		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9WUU7 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 1B94045C3D0A7CFB	FASTA	306	33,996
	10 20 30 40 50 60 MASSGSVQQL PLVLLMLLLA SAARARLYFR SGQTCYHPIR GDQLALLGRR TYPRPHEYLS 70 80 90 100 110 120 PADLPKNWDW RNVNGVNYAS VTRNQHIPQY CGSCWAHGST SAMADRINIK RKGAWPSILL 130 140 150 160 170 180 SVQNVIDCGN AGSCEGGNDL PVWEYAHKHG IPDETCNNYQ AKDQDCDKFN QCGTCTEFKE 190 200 210 220 230 240 CHTIQNYTLW RVGDYGSLSG REKMMAEIYA NGPISCGIMA TEMMSNYTGG IYAEHQDQAV 250 260 270 280 290 300 INHIISVAGW GVSNDGIEYW IVRNSWGEPW GEKGWMRIVT STYKGGTGDS YNLAIESACT FGDPIV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Santamaria I. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization." Deussing J., von Olshausen I., Peters C. Biochim. Biophys. Acta 1491:93-106(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Fetus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ242663 mRNA. Translation: CAB44494.1. AF136277 mRNA. Translation: AAF13143.1. AF136278 Genomic DNA. Translation: AAF13144.1. BC008619 mRNA. Translation: AAH08619.1.
IPI	IPI00986833.
RefSeq	NP_071720.1. NM_022325.4.
UniGene	Mm.156919.
3D structure databases
ProteinModelPortal	Q9WUU7.
SMR	Q9WUU7. Positions 32-306.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9WUU7. 1 interaction.
STRING	10090.ENSMUSP00000016400.
Protein family/group databases
MEROPS	C01.013.
Proteomic databases
PaxDb	Q9WUU7.
PRIDE	Q9WUU7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000016400; ENSMUSP00000016400; ENSMUSG00000016256.
GeneID	64138.
KEGG	mmu:64138.
Organism-specific databases
CTD	1522.
MGI	MGI:1891190. Ctsz.
Phylogenomic databases
eggNOG	COG4870.
GeneTree	ENSGT00560000076599.
HOVERGEN	HBG004456.
InParanoid	Q9WUU7.
KO	K08568.
OMA	QCGTCTE.
OrthoDB	EOG42Z4QN.
Gene expression databases
ArrayExpress	Q9WUU7.
Bgee	Q9WUU7.
CleanEx	MM_CTSZ.
Genevestigator	Q9WUU7.
GermOnline	ENSMUSG00000016256. Mus musculus.
Family and domain databases
InterPro	IPR025661. Pept_asp_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. [Graphical view]
PANTHER	PTHR12411. PTHR12411. 1 hit.
Pfam	PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
SMART	SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. False negative. PS00639. THIOL_PROTEASE_HIS. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CTSZ. mouse.
NextBio	319927.
SOURCE	Search...

Entry information

Entry name

CATZ_MOUSE

Accession

Primary (citable) accession number: Q9WUU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program