ID HNF4G_MOUSE Reviewed; 408 AA. AC Q9WUU6; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2000, sequence version 2. DT 27-MAR-2024, entry version 180. DE RecName: Full=Hepatocyte nuclear factor 4-gamma; DE Short=HNF-4-gamma; DE AltName: Full=Nuclear receptor subfamily 2 group A member 2; GN Name=Hnf4g; Synonyms=Nr2a2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=10786614; DOI=10.1016/s0167-4781(99)00232-8; RA Taraviras S., Mantamadiotis T., Dong-Si T., Mincheva A., Lichter P., RA Drewes T., Ryffel G.U., Monaghan A.P., Schutz G.; RT "Primary structure, chromosomal mapping, expression and transcriptional RT activity of murine hepatocyte nuclear factor 4gamma."; RL Biochim. Biophys. Acta 1490:21-32(2000). CC -!- FUNCTION: Transcription factor. Has a lower transcription activation CC potential than HNF4-alpha (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2 CC subfamily. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAB43724.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ242626; CAB43724.1; ALT_INIT; mRNA. DR CCDS; CCDS17226.1; -. DR RefSeq; NP_038948.1; NM_013920.2. DR AlphaFoldDB; Q9WUU6; -. DR SMR; Q9WUU6; -. DR BioGRID; 206019; 6. DR IntAct; Q9WUU6; 6. DR STRING; 10090.ENSMUSP00000104030; -. DR iPTMnet; Q9WUU6; -. DR PhosphoSitePlus; Q9WUU6; -. DR MaxQB; Q9WUU6; -. DR PaxDb; 10090-ENSMUSP00000104031; -. DR ProteomicsDB; 269608; -. DR DNASU; 30942; -. DR GeneID; 30942; -. DR KEGG; mmu:30942; -. DR AGR; MGI:1353604; -. DR CTD; 3174; -. DR MGI; MGI:1353604; Hnf4g. DR eggNOG; KOG4215; Eukaryota. DR InParanoid; Q9WUU6; -. DR OrthoDB; 5400963at2759; -. DR Reactome; R-MMU-383280; Nuclear Receptor transcription pathway. DR BioGRID-ORCS; 30942; 2 hits in 77 CRISPR screens. DR ChiTaRS; Hnf4g; mouse. DR PRO; PR:Q9WUU6; -. DR Proteomes; UP000000589; Unplaced. DR RNAct; Q9WUU6; Protein. DR GO; GO:0005829; C:cytosol; ISO:MGI. DR GO; GO:0045171; C:intercellular bridge; ISO:MGI. DR GO; GO:0072686; C:mitotic spindle; ISO:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005667; C:transcription regulator complex; ISS:MGI. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI. DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central. DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IDA:MGI. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd06960; NR_DBD_HNF4A; 1. DR CDD; cd06931; NR_LBD_HNF4_like; 1. DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1. DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1. DR InterPro; IPR049636; HNF4-like_DBD. DR InterPro; IPR049635; HNF4_LBD. DR InterPro; IPR035500; NHR-like_dom_sf. DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd. DR InterPro; IPR001723; Nuclear_hrmn_rcpt. DR InterPro; IPR001628; Znf_hrmn_rcpt. DR InterPro; IPR013088; Znf_NHR/GATA. DR PANTHER; PTHR24083:SF42; HEPATOCYTE NUCLEAR FACTOR 4-GAMMA; 1. DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1. DR Pfam; PF00104; Hormone_recep; 1. DR Pfam; PF00105; zf-C4; 1. DR PRINTS; PR01282; COUPTNFACTOR. DR PRINTS; PR00398; STRDHORMONER. DR PRINTS; PR00047; STROIDFINGER. DR SMART; SM00430; HOLI; 1. DR SMART; SM00399; ZnF_C4; 1. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1. DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1. DR PROSITE; PS51843; NR_LBD; 1. DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1. DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1. PE 2: Evidence at transcript level; KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Receptor; KW Reference proteome; Transcription; Transcription regulation; Zinc; KW Zinc-finger. FT CHAIN 1..408 FT /note="Hepatocyte nuclear factor 4-gamma" FT /id="PRO_0000053563" FT DOMAIN 99..328 FT /note="NR LBD" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189" FT DNA_BIND 9..84 FT /note="Nuclear receptor" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407" FT ZN_FING 12..32 FT /note="NR C4-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407" FT ZN_FING 48..72 FT /note="NR C4-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407" FT REGION 369..408 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 383..408 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 94 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P22449" FT MOD_RES 370 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:P49698" FT MOD_RES 373 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:P49698" FT MOD_RES 377 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P49698" SQ SEQUENCE 408 AA; 45897 MW; 5E4AF2E53BCDC7F1 CRC64; MNTTDSGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF SRQCVVDKDK RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTYEGSN IPSINTLAQA EVRSCQISVP SPSSSTDINI KKIASISDVC ESMKQQLLVL VEWAKYIPAF CELPLDDQVA LLRAHAGEHL LLGATKRSMM YKDILLLGNH YVIHRNSCEV EVSRVANRVL DELVRPFQEI QIDDNEYACL KAIVFFDPDA KGLSDPVKIK NMRFQVQISL EDYINDRQYD SRGRFGELLL LLPTLQSITW QMIEQIQFVK LFGMVKIDNL LQEMLLGGAA NDGSHLHHPM HPHLSQDPLT GQTILLGPMS TLVHTDQIAT PETPLPSPPQ GSGQEPYKIT ANQASVISHQ SLSKQKQL //